KR102593668B1 - 유도 기질 부재 하의 사상 진균 세포에서의 단백질 생산 - Google Patents

유도 기질 부재 하의 사상 진균 세포에서의 단백질 생산 Download PDF

Info

Publication number
KR102593668B1
KR102593668B1 KR1020197010929A KR20197010929A KR102593668B1 KR 102593668 B1 KR102593668 B1 KR 102593668B1 KR 1020197010929 A KR1020197010929 A KR 1020197010929A KR 20197010929 A KR20197010929 A KR 20197010929A KR 102593668 B1 KR102593668 B1 KR 102593668B1
Authority
KR
South Korea
Prior art keywords
seq
promoter
protein
ace3
ala
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
KR1020197010929A
Other languages
English (en)
Korean (ko)
Other versions
KR20190057088A (ko
Inventor
마이클 워드
윈 루오
펠리페 오세아스 벤데주
마리 발꼬넨
마르꾸 살로헤이모
니나 아로
띠나 빠꿀라
Original Assignee
다니스코 유에스 인크.
브이티티 테크니컬 리서치 센터 오브 핀란드 리미티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 다니스코 유에스 인크., 브이티티 테크니컬 리서치 센터 오브 핀란드 리미티드 filed Critical 다니스코 유에스 인크.
Publication of KR20190057088A publication Critical patent/KR20190057088A/ko
Application granted granted Critical
Publication of KR102593668B1 publication Critical patent/KR102593668B1/ko
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C12N9/2405—Glucanases
    • C12N9/2434—Glucanases acting on beta-1,4-glucosidic bonds
    • C12N9/2437—Cellulases (3.2.1.4; 3.2.1.74; 3.2.1.91; 3.2.1.150)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01004—Cellulase (3.2.1.4), i.e. endo-1,4-beta-glucanase

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Mycology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Botany (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
KR1020197010929A 2016-10-04 2017-10-03 유도 기질 부재 하의 사상 진균 세포에서의 단백질 생산 Active KR102593668B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662403787P 2016-10-04 2016-10-04
US62/403,787 2016-10-04
PCT/US2017/054983 WO2018067599A1 (en) 2016-10-04 2017-10-03 Protein production in filamentous fungal cells in the absence of inducing substrates

Publications (2)

Publication Number Publication Date
KR20190057088A KR20190057088A (ko) 2019-05-27
KR102593668B1 true KR102593668B1 (ko) 2023-10-24

Family

ID=60245185

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020197010929A Active KR102593668B1 (ko) 2016-10-04 2017-10-03 유도 기질 부재 하의 사상 진균 세포에서의 단백질 생산

Country Status (6)

Country Link
US (2) US10876103B2 (enExample)
EP (1) EP3523415A1 (enExample)
JP (2) JP7285780B2 (enExample)
KR (1) KR102593668B1 (enExample)
CN (1) CN109790510B (enExample)
WO (1) WO2018067599A1 (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110760537A (zh) * 2018-07-27 2020-02-07 中国农业科学院饲料研究所 用于快速筛选重组菌株的重组表达载体及应用
BR112021010338A2 (pt) * 2018-11-28 2021-11-16 Novozymes As Células hospedeiras fúngicas filamentosas modificadas
US20220259270A1 (en) * 2019-07-16 2022-08-18 Centro Nacional De Pesquisa Em Energia E Materiais Modified trichoderma fungal strain for the production of an enzyme cocktail
FI4055177T3 (fi) * 2019-11-08 2024-10-31 Danisco Us Inc Parantuneen proteiinituottavuuden fenotyyppejä käsittäviä sienikantoja ja menetelmiä niitä varten
BR112022009620A2 (pt) * 2019-11-18 2022-08-02 Kao Corp Fungo filamentoso mutante e método para a produção de proteína usando o mesmo
CN113106114B (zh) * 2020-01-13 2024-04-12 中国科学院分子植物科学卓越创新中心 调控里氏木霉蛋白表达效率的因子、调控方法及应用
JP2023523925A (ja) * 2020-04-22 2023-06-08 ダニスコ・ユーエス・インク 糸状菌細胞におけるタンパク質産生の増強のための組成物及び方法
JP2022161526A (ja) * 2021-04-09 2022-10-21 花王株式会社 改変糸状菌、及びそれを用いたタンパク質の製造方法
CN116813728B (zh) * 2023-07-07 2024-08-09 山东大学 一种真菌木质纤维素降解酶合成调控蛋白突变体及其应用
CN118389304A (zh) * 2023-12-28 2024-07-26 福州道福生物科技有限公司 一种生产索马甜ⅰ蛋白的重组里氏木霉菌株及其构建方法与应用
WO2025165968A1 (en) 2024-01-31 2025-08-07 Danisco Us Inc. Conditional regulation of protein function in filamentous fungal cells

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011151512A2 (en) * 2010-06-04 2011-12-08 Teknologian Tutkimuskeskus Vtt Method for protein production in filamentous fungi

Family Cites Families (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU607398B2 (en) 1985-08-29 1991-03-07 Genencor Inc. Heterologous polypeptides expressed in filamentous fungi, processes for making same, and vectors for making same
GB8610600D0 (en) 1986-04-30 1986-06-04 Novo Industri As Transformation of trichoderma
WO1992006221A1 (en) 1990-10-05 1992-04-16 Genencor International, Inc. Methods for treating cotton-containing fabrics with cellulase
ES2170748T3 (es) 1990-10-05 2002-08-16 Genencor Int Procedimientos para el tratamiento de tejidos que contienen algodon con celulasa.
WO1992006183A1 (en) 1990-10-05 1992-04-16 Genencor International, Inc. Methods for treating cotton-containing fabrics with cellulase
DK1225227T3 (da) 1990-12-10 2009-06-22 Genencor Int Forbedret forsukring af cellulose ved kloning og amplifikation af beta-glucosidase genet af trichoderma
US6017870A (en) 1996-10-09 2000-01-25 Genencor International, Inc. Purified cellulase and method of producing
DE69822142T2 (de) 1997-04-07 2005-03-03 Unilever N.V. Transformation von schimmeln durch agrobacterium, insbesondere von der gattung aspergillus
US6268328B1 (en) 1998-12-18 2001-07-31 Genencor International, Inc. Variant EGIII-like cellulase compositions
DE60143086D1 (de) 2000-08-04 2010-10-28 Genencor Int Mutierte trichoderma reesei egiii cellulasen, dafür kodierende dna und verfahren zu deren herstellung
US6982159B2 (en) 2001-09-21 2006-01-03 Genencor International, Inc. Trichoderma β-glucosidase
US7056721B2 (en) 2001-12-18 2006-06-06 Genencor International, Inc. EGVI endoglucanase and nucleic acids encoding the same
US7045332B2 (en) 2001-12-18 2006-05-16 Genencor International, Inc. BGL4 β-glucosidase and nucleic acids encoding the same
US7045331B2 (en) 2001-12-18 2006-05-16 Genencor International, Inc. EGVII endoglucanase and nucleic acids encoding the same
US7049125B2 (en) 2001-12-18 2006-05-23 Genencor International, Inc. EGVIII endoglucanase and nucleic acids encoding the same
US7005289B2 (en) 2001-12-18 2006-02-28 Genencor International, Inc. BGL5 β-glucosidase and nucleic acids encoding the same
WO2004016760A2 (en) 2002-08-16 2004-02-26 Genencor International, Inc. Novel variant hyprocrea jecorina cbh1 cellulases
JP5366286B2 (ja) 2002-09-10 2013-12-11 ジェネンコー・インターナショナル・インク 高濃度糖類混合物を用いた遺伝子発現の誘発
EP1556512B1 (en) 2002-11-07 2016-06-15 Danisco US Inc. Bgl6 beta-glucosidase and nucleic acids encoding the same
US7407788B2 (en) 2002-11-21 2008-08-05 Danisco A/S, Genencor Division BGL7 beta-glucosidase and nucleic acids encoding the same
EP1606392A4 (en) 2003-03-21 2007-10-17 Genencor Int NEW CBH1 HOMOLOGO AND CBH1 CELLULASE VARIANTS
EP2385104A1 (en) 2003-04-01 2011-11-09 Danisco US Inc. Variant Scytalidium thermophilium CBH1
DK1862539T3 (da) 2003-05-29 2012-05-14 Danisco Us Inc Nye trichodermagener
US8097445B2 (en) 2004-03-25 2012-01-17 Danisco Us Inc. Exo-endo cellulase fusion protein
BRPI0509212A (pt) 2004-03-25 2007-08-28 Genencor Int proteìna de fusão de celulase e construto de fusão de celulase heterólogo codificando a mesma
AU2005229437A1 (en) * 2004-04-02 2005-10-13 Dsm Ip Assets B.V. Filamentous fungal mutants with improved homologous recombination efficiency
US7413887B2 (en) 2004-05-27 2008-08-19 Genecor International, Inc. Trichoderma reesei glucoamylase and homologs thereof
US8008056B2 (en) 2004-12-30 2011-08-30 Danisco Us Inc. Variant Hypocrea jecorina CBH2 cellulases
US20070231819A1 (en) * 2006-03-15 2007-10-04 Christopher Lawrence Targeted and non-targeted gene insertions using a linear minimal element construct
US8143046B2 (en) 2007-02-07 2012-03-27 Danisco Us Inc., Genencor Division Variant Buttiauxella sp. phytases having altered properties
US20090253173A1 (en) * 2008-04-08 2009-10-08 Danisco Us Inc., Genencor Division Filamentous fungi with inactivated protease genes for altered protein production
CN102057041B (zh) 2008-06-06 2014-10-15 丹尼斯科美国公司 包含具有与非纤维素物质降低的亲和力的纤维素酶变体的组合物和方法
CN102803482B (zh) 2009-06-03 2015-04-29 丹尼斯科美国公司 具有改善的表达、活性和/或稳定性的纤维素酶变体，及其用途
EP2480660B1 (en) 2009-09-23 2020-08-05 Danisco US Inc. Novel glycosyl hydrolase enzymes and uses thereof
EP2599864B1 (en) 2009-11-20 2017-08-02 Danisco US Inc. Beta-glucosidase variants with improved properties
CN101831452B (zh) * 2010-04-22 2012-09-05 中国农业科学院生物技术研究所 通过重组瑞氏木霉以诱导型方式高效表达和生产t4溶菌酶的方法
US8962295B2 (en) 2010-06-01 2015-02-24 California Institute Of Technology Stable, functional chimeric cellobiohydrolase class I enzymes
CN102939382B (zh) * 2010-06-03 2017-02-15 丹尼斯科美国公司 丝状真菌宿主菌株和dna构建体以及它们的使用方法
RU2013122800A (ru) * 2010-10-20 2014-11-27 ДАНИСКО ЮЭс ИНК. Термостабильная целлюлаза из trichoderma
MX2013010510A (es) 2011-03-17 2013-10-07 Danisco Inc Enzimas glocosil hidrolasa y usos de estas para la hidrolisis de biomasa.
EP2686434B1 (en) 2011-03-17 2021-07-14 Danisco US Inc. Method for reducing viscosity in saccharification process
EP2686427A1 (en) 2011-03-17 2014-01-22 Danisco US Inc. Cellulase compositions and methods of using the same for improved conversion of lignocellulosic biomass into fermentable sugars
CN102311951B (zh) * 2011-07-13 2013-03-20 深圳大学 里氏木霉组成型表达盒、表达载体、重组菌株及其应用
WO2013096056A1 (en) 2011-12-21 2013-06-27 Danisco Us Inc. Improving fungal gene expression using insulator dna sequences
BR112014016587A2 (pt) 2012-01-05 2020-10-27 Novartis Ag células fúngicas filamentosas deficientes de protease e métodos de uso das mesmas
WO2014047520A1 (en) 2012-09-20 2014-03-27 Danisco Us Inc. Microtiter plates for controlled release of culture components to cell cultures
JP2015533294A (ja) 2012-10-31 2015-11-24 ダニスコ・ユーエス・インク ニューロスポラ・クラッサ（Ｎｅｕｒｏｓｐｏｒａｃｒａｓｓａ）由来のβ−グルコシダーゼ
BR112015009201A2 (pt) 2012-10-31 2017-11-14 Danisco Us Inc composição compreendeendo um polipeptídeo recombinante, ácido nucleico codificando o mesmo, célula hospedeira, bem como métodos para produzir uma beta-glucosidase e para hidrolisar um substrato de biomassa lignocelulósica
US20150252343A1 (en) 2012-10-31 2015-09-10 Danisco Us Inc. Beta-glucosidase from magnaporthe grisea
EP2931888A1 (en) 2012-12-12 2015-10-21 Danisco US Inc. Variants of cellobiohydrolases
KR20150093190A (ko) 2012-12-12 2015-08-17 다니스코 유에스 인크. 셀로바이오하이드롤라제의 변이체
EP2931889A1 (en) 2012-12-12 2015-10-21 Danisco US Inc. Variants of cellobiohydrolases
MX2015007233A (es) 2012-12-12 2015-10-29 Danisco Us Inc Variantes de celobiohidrolasas.
US20150315560A1 (en) 2012-12-12 2015-11-05 Danisco Us Inc. Variants of cellobiohydrolases
DK3019602T3 (en) * 2013-07-10 2018-11-12 Glykos Finland Oy MULTIPLE PROTEASE-DEFECTED FILAMENTARY FUNGAL CELLS AND PROCEDURES FOR USE THEREOF
BR112016012627A2 (pt) 2013-12-04 2017-09-26 Danisco Us Inc composições compreendendo um polipeptídeo de beta-glicosidase e métodos de uso
US20170349922A1 (en) 2014-10-27 2017-12-07 Danisco Us Inc. Compositions and methods related to beta-glucosidase
US11427829B2 (en) 2014-12-16 2022-08-30 Danisco Us Inc Fungal genome modification systems and methods of use
WO2017177289A1 (en) * 2016-04-15 2017-10-19 Vtt International Oy Process for conversion of biomass into fermentable sugars with integrated enzyme
CN106978360B (zh) * 2017-04-24 2020-08-04 上海交通大学 一株高产纤维素酶里氏木霉重组菌株及其应用
CN113106114B (zh) * 2020-01-13 2024-04-12 中国科学院分子植物科学卓越创新中心 调控里氏木霉蛋白表达效率的因子、调控方法及应用
JP2023523925A (ja) * 2020-04-22 2023-06-08 ダニスコ・ユーエス・インク 糸状菌細胞におけるタンパク質産生の増強のための組成物及び方法

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011151512A2 (en) * 2010-06-04 2011-12-08 Teknologian Tutkimuskeskus Vtt Method for protein production in filamentous fungi

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
hypothetical protein M419DRAFT_98455 [Trichoderma reesei RUT C-30], GenBank: ETS02557.1, 2015.03.23.*
Microbiology (2012), 158, pp. 58-68.*

Also Published As

Publication number Publication date
US10876103B2 (en) 2020-12-29
JP7605902B2 (ja) 2024-12-24
CN109790510A (zh) 2019-05-21
EP3523415A1 (en) 2019-08-14
JP2023109919A (ja) 2023-08-08
US20190309276A1 (en) 2019-10-10
US20220145278A1 (en) 2022-05-12
CN109790510B (zh) 2024-04-12
JP2019528797A (ja) 2019-10-17
KR20190057088A (ko) 2019-05-27
JP7285780B2 (ja) 2023-06-02
WO2018067599A1 (en) 2018-04-12

Similar Documents

Publication Publication Date Title
KR102593668B1 (ko) 유도 기질 부재 하의 사상 진균 세포에서의 단백질 생산
AU2021203937B2 (en) Compositions and methods for rapid and dynamic flux control using synthetic metabolic valves
CN108026523B (zh) 向导rna组装载体
KR102092422B1 (ko) 유전자 조작된 미생물로부터 뮤콘산의 생산
KR101047167B1 (ko) 피치아 파스토리스에서의 단백질 글라이코실화 변형
KR102319845B1 (ko) 조류 숙주 세포에 대한 crispr-cas 시스템
KR100820367B1 (ko) 피히아 파스토리스에서의 단백질 글리코실화 변형
DK2324120T3 (en) Manipulating SNF1 protein kinase OF REVISION OF OIL CONTENT IN OLEAGINOUS ORGANISMS
CN109563505A (zh) 用于真核细胞的组装系统
CN101842479A (zh) 用于改良宿主细胞内蛋白质生产的信号序列和共表达的分子伴侣
AU2016273213B2 (en) T cell receptor library
CN109996874A (zh) 10-甲基硬脂酸的异源性产生
CA3109035A1 (en) Microorganisms engineered to use unconventional sources of nitrogen
KR20180084135A (ko) 감소된 clr2 활성을 갖는 사상 진균에서 단백질을 생산하는 방법
KR20240005196A (ko) 유전자 조작된 미생물로부터 개선된 뮤콘산 생산
CN108368490A (zh) 真菌产生fdca
CN111148833B (zh) 改变细胞具有的双链dna的目标部位的方法
CN108949825A (zh) 一种靶向her2的car-t细胞的制备方法及应用
AU2017233862B2 (en) Methods and compositions for increased double stranded RNA production
KR102691949B1 (ko) 락트산 생성을 위한 미생물 및 방법
CN113039278A (zh) 通过指导的内切核酸酶和单链寡核苷酸进行基因组编辑
KR20180081817A (ko) 감소된 clr1 활성을 갖는 사상 진균에서 단백질을 생산하는 방법
CN101627109A (zh) 用于生产正丁醇的工程化改造的微生物及相关方法
CA3226763A1 (en) Burden-addicted production strains
CN116547263A (zh) 用修饰酶产生取代大麻素和前体的方法和细胞

Legal Events

Date Code Title Description
PA0105 International application

Patent event date: 20190416

Patent event code: PA01051R01D

Comment text: International Patent Application

PG1501 Laying open of application
AMND Amendment
PA0201 Request for examination

Patent event code: PA02012R01D

Patent event date: 20200929

Comment text: Request for Examination of Application

AMND Amendment
E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

Comment text: Notification of reason for refusal

Patent event date: 20220129

Patent event code: PE09021S01D

AMND Amendment
PE0601 Decision on rejection of patent

Patent event date: 20220922

Comment text: Decision to Refuse Application

Patent event code: PE06012S01D

Patent event date: 20220129

Comment text: Notification of reason for refusal

Patent event code: PE06011S01I

X091 Application refused [patent]
AMND Amendment
PX0901 Re-examination

Patent event code: PX09011S01I

Patent event date: 20220922

Comment text: Decision to Refuse Application

Patent event code: PX09012R01I

Patent event date: 20220428

Comment text: Amendment to Specification, etc.

Patent event code: PX09012R01I

Patent event date: 20201005

Comment text: Amendment to Specification, etc.

Patent event code: PX09012R01I

Patent event date: 20200929

Comment text: Amendment to Specification, etc.

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

Comment text: Notification of reason for refusal

Patent event date: 20230109

Patent event code: PE09021S01D

AMND Amendment
PX0701 Decision of registration after re-examination

Patent event date: 20230727

Comment text: Decision to Grant Registration

Patent event code: PX07013S01D

Patent event date: 20230308

Comment text: Amendment to Specification, etc.

Patent event code: PX07012R01I

Patent event date: 20221213

Comment text: Amendment to Specification, etc.

Patent event code: PX07012R01I

Patent event date: 20220922

Comment text: Decision to Refuse Application

Patent event code: PX07011S01I

Patent event date: 20220428

Comment text: Amendment to Specification, etc.

Patent event code: PX07012R01I

Patent event date: 20201005

Comment text: Amendment to Specification, etc.

Patent event code: PX07012R01I

Patent event date: 20200929

Comment text: Amendment to Specification, etc.

Patent event code: PX07012R01I

X701 Decision to grant (after re-examination)
GRNT Written decision to grant
PR0701 Registration of establishment

Comment text: Registration of Establishment

Patent event date: 20231020

Patent event code: PR07011E01D

PR1002 Payment of registration fee

Payment date: 20231020

End annual number: 3

Start annual number: 1

PG1601 Publication of registration