KR102587176B1 - 혈장으로부터 태아 또는 종양 메틸롬의 비침습적 결정 - Google Patents
혈장으로부터 태아 또는 종양 메틸롬의 비침습적 결정 Download PDFInfo
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- KR102587176B1 KR102587176B1 KR1020227013227A KR20227013227A KR102587176B1 KR 102587176 B1 KR102587176 B1 KR 102587176B1 KR 1020227013227 A KR1020227013227 A KR 1020227013227A KR 20227013227 A KR20227013227 A KR 20227013227A KR 102587176 B1 KR102587176 B1 KR 102587176B1
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6881—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for tissue or cell typing, e.g. human leukocyte antigen [HLA] probes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
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- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2523/00—Reactions characterised by treatment of reaction samples
- C12Q2523/10—Characterised by chemical treatment
- C12Q2523/125—Bisulfite(s)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2535/00—Reactions characterised by the assay type for determining the identity of a nucleotide base or a sequence of oligonucleotides
- C12Q2535/122—Massive parallel sequencing
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/112—Disease subtyping, staging or classification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/154—Methylation markers
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- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Analytical Chemistry (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Pathology (AREA)
- Hospice & Palliative Care (AREA)
- Oncology (AREA)
- Cell Biology (AREA)
- Bioinformatics & Computational Biology (AREA)
- Evolutionary Biology (AREA)
- Medical Informatics (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Theoretical Computer Science (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Ultra Sonic Daignosis Equipment (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020237033920A KR20230145530A (ko) | 2012-09-20 | 2013-09-20 | 혈장으로부터 태아 또는 종양 메틸롬의 비침습적 결정 |
Applications Claiming Priority (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261703512P | 2012-09-20 | 2012-09-20 | |
| US61/703,512 | 2012-09-20 | ||
| US13/842,209 | 2013-03-15 | ||
| US13/842,209 US9732390B2 (en) | 2012-09-20 | 2013-03-15 | Non-invasive determination of methylome of fetus or tumor from plasma |
| US201361830571P | 2013-06-03 | 2013-06-03 | |
| US61/830,571 | 2013-06-03 | ||
| KR1020217030373A KR102390711B1 (ko) | 2012-09-20 | 2013-09-20 | 혈장으로부터 태아 또는 종양 메틸롬의 비침습적 결정 |
| PCT/AU2013/001088 WO2014043763A1 (en) | 2012-09-20 | 2013-09-20 | Non-invasive determination of methylome of fetus or tumor from plasma |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020217030373A Division KR102390711B1 (ko) | 2012-09-20 | 2013-09-20 | 혈장으로부터 태아 또는 종양 메틸롬의 비침습적 결정 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020237033920A Division KR20230145530A (ko) | 2012-09-20 | 2013-09-20 | 혈장으로부터 태아 또는 종양 메틸롬의 비침습적 결정 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20220065034A KR20220065034A (ko) | 2022-05-19 |
| KR102587176B1 true KR102587176B1 (ko) | 2023-10-06 |
Family
ID=50340462
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020207019527A Active KR102307424B1 (ko) | 2012-09-20 | 2013-09-20 | 혈장으로부터 태아 또는 종양 메틸롬의 비침습적 결정 |
| KR1020217030373A Active KR102390711B1 (ko) | 2012-09-20 | 2013-09-20 | 혈장으로부터 태아 또는 종양 메틸롬의 비침습적 결정 |
| KR1020157010184A Active KR102148547B1 (ko) | 2012-09-20 | 2013-09-20 | 혈장으로부터 태아 또는 종양 메틸롬의 비침습적 결정 |
| KR1020237033920A Ceased KR20230145530A (ko) | 2012-09-20 | 2013-09-20 | 혈장으로부터 태아 또는 종양 메틸롬의 비침습적 결정 |
| KR1020227013227A Active KR102587176B1 (ko) | 2012-09-20 | 2013-09-20 | 혈장으로부터 태아 또는 종양 메틸롬의 비침습적 결정 |
Family Applications Before (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020207019527A Active KR102307424B1 (ko) | 2012-09-20 | 2013-09-20 | 혈장으로부터 태아 또는 종양 메틸롬의 비침습적 결정 |
| KR1020217030373A Active KR102390711B1 (ko) | 2012-09-20 | 2013-09-20 | 혈장으로부터 태아 또는 종양 메틸롬의 비침습적 결정 |
| KR1020157010184A Active KR102148547B1 (ko) | 2012-09-20 | 2013-09-20 | 혈장으로부터 태아 또는 종양 메틸롬의 비침습적 결정 |
| KR1020237033920A Ceased KR20230145530A (ko) | 2012-09-20 | 2013-09-20 | 혈장으로부터 태아 또는 종양 메틸롬의 비침습적 결정 |
Country Status (28)
| Country | Link |
|---|---|
| EP (6) | EP4056712B1 (enExample) |
| JP (6) | JP6317354B2 (enExample) |
| KR (5) | KR102307424B1 (enExample) |
| CN (2) | CN104781422B (enExample) |
| AU (5) | AU2013317708C1 (enExample) |
| BR (3) | BR122021021825B1 (enExample) |
| CA (2) | CA2884066C (enExample) |
| CY (1) | CY1124139T1 (enExample) |
| DK (4) | DK4056712T3 (enExample) |
| EA (1) | EA201500327A1 (enExample) |
| ES (4) | ES2969567T3 (enExample) |
| FI (2) | FI3536807T3 (enExample) |
| HR (3) | HRP20241142T1 (enExample) |
| HU (3) | HUE068129T2 (enExample) |
| IL (4) | IL299444B2 (enExample) |
| LT (2) | LT3354747T (enExample) |
| MX (1) | MX360034B (enExample) |
| MY (2) | MY173356A (enExample) |
| NZ (2) | NZ706269A (enExample) |
| PH (2) | PH12022552061A1 (enExample) |
| PL (4) | PL3536807T3 (enExample) |
| PT (4) | PT3354747T (enExample) |
| SG (2) | SG10201705198UA (enExample) |
| SI (1) | SI4056712T1 (enExample) |
| SM (1) | SMT202100256T1 (enExample) |
| TW (4) | TWI707953B (enExample) |
| WO (1) | WO2014043763A1 (enExample) |
| ZA (1) | ZA201501772B (enExample) |
Families Citing this family (94)
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| CN101153336B (zh) | 2006-09-27 | 2011-09-07 | 香港中文大学 | 检测dna甲基化程度的方法和试剂盒 |
| US9892230B2 (en) | 2012-03-08 | 2018-02-13 | The Chinese University Of Hong Kong | Size-based analysis of fetal or tumor DNA fraction in plasma |
| US10706957B2 (en) | 2012-09-20 | 2020-07-07 | The Chinese University Of Hong Kong | Non-invasive determination of methylome of tumor from plasma |
| US9732390B2 (en) | 2012-09-20 | 2017-08-15 | The Chinese University Of Hong Kong | Non-invasive determination of methylome of fetus or tumor from plasma |
| LT3354747T (lt) * | 2012-09-20 | 2021-04-12 | The Chinese University Of Hong Kong | Neinvazinis naviko metilomos nustatymas iš plazmos |
| US20130309666A1 (en) | 2013-01-25 | 2013-11-21 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
| EP3029148B1 (en) * | 2013-07-30 | 2018-06-27 | BGI Genomics Co., Limited | Method for determining nucleic acid composition of nucleic acid mixture |
| US10174375B2 (en) * | 2013-09-20 | 2019-01-08 | The Chinese University Of Hong Kong | Sequencing analysis of circulating DNA to detect and monitor autoimmune diseases |
| US12054771B2 (en) * | 2014-02-18 | 2024-08-06 | Bionano Genomics, Inc. | Methods of determining nucleic acid structural information |
| US12492429B2 (en) | 2014-04-21 | 2025-12-09 | Natera, Inc. | Detecting mutations and ploidy in chromosomal segments |
| EP3957749A1 (en) * | 2014-04-21 | 2022-02-23 | Natera, Inc. | Detecting tumour specific mutations in biopsies with whole exome sequencing and in cell-free samples |
| EP2942400A1 (en) | 2014-05-09 | 2015-11-11 | Lifecodexx AG | Multiplex detection of DNA that originates from a specific cell-type |
| CN107223159A (zh) | 2014-05-09 | 2017-09-29 | 科戴克斯生命股份公司 | 源自特定细胞类型的dna的检测及相关方法 |
| TWI895765B (zh) * | 2014-07-18 | 2025-09-01 | 香港中文大學 | Dna混合物中之組織甲基化模式分析 |
| WO2016010401A1 (ko) * | 2014-07-18 | 2016-01-21 | 에스케이텔레콘 주식회사 | 산모의 혈청 dna를 이용한 태아의 단일유전자 유전변이의 예측방법 |
| KR102696857B1 (ko) | 2014-07-25 | 2024-08-19 | 유니버시티 오브 워싱톤 | 무세포 dna를 생성하는 조직 및/또는 세포 유형을 결정하는 방법 및 이를 사용하여 질환 또는 장애를 확인하는 방법 |
| GB2552267B (en) * | 2014-12-31 | 2020-06-10 | Guardant Health Inc | Detection and treatment of disease exhibiting disease cell heterogeneity and systems and methods for communicating test results |
| US10364467B2 (en) | 2015-01-13 | 2019-07-30 | The Chinese University Of Hong Kong | Using size and number aberrations in plasma DNA for detecting cancer |
| CA2976303A1 (en) | 2015-02-10 | 2016-08-18 | The Chinese University Of Hong Kong | Detecting mutations for cancer screening and fetal analysis |
| CN108138233B (zh) | 2015-07-20 | 2022-08-26 | 香港中文大学 | Dna混合物中组织的单倍型的甲基化模式分析 |
| HUE057821T2 (hu) | 2015-07-23 | 2022-06-28 | Univ Hong Kong Chinese | Sejtmentes DNS fragmentációs mintázatának elemzése |
| IL285795B (en) | 2015-08-12 | 2022-07-01 | Univ Hong Kong Chinese | Single-molecule sequencing of plasma dna |
| US10457990B2 (en) | 2015-09-22 | 2019-10-29 | The Chinese University Of Hong Kong | Accurate deduction of fetal DNA fraction with shallow-depth sequencing of maternal plasma |
| US10260088B2 (en) * | 2015-10-30 | 2019-04-16 | New England Biolabs, Inc. | Compositions and methods for analyzing modified nucleotides |
| CN108368548A (zh) * | 2015-11-09 | 2018-08-03 | 普罗格尼迪公司 | 用于确定dna分子的来源的方法 |
| EP3168309B8 (en) | 2015-11-10 | 2020-06-03 | Eurofins LifeCodexx GmbH | Detection of foetal chromosomal aneuploidies using dna regions that are differentially methylated between the foetus and the pregnant female |
| AU2016370835B2 (en) * | 2015-12-17 | 2020-02-13 | Illumina, Inc. | Distinguishing methylation levels in complex biological samples |
| EP3411505A4 (en) * | 2016-02-02 | 2020-01-15 | Guardant Health, Inc. | EVIDENCE OF CANCER DEVELOPMENT AND DIAGNOSTICS |
| US11514289B1 (en) | 2016-03-09 | 2022-11-29 | Freenome Holdings, Inc. | Generating machine learning models using genetic data |
| EP4425178A3 (en) * | 2016-05-03 | 2024-12-18 | University Health Network | Methods of capturing cell-free methylated dna and uses of same |
| US12300356B2 (en) | 2016-05-04 | 2025-05-13 | Queen's University At Kingston | Cell-free detection of methylated tumour DNA |
| EP3885447B1 (en) * | 2016-05-30 | 2024-01-10 | The Chinese University Of Hong Kong | Detecting hematological disorders using cell-free dna in blood |
| EP3472358B1 (en) * | 2016-06-16 | 2021-08-18 | The Johns Hopkins University | Methods and system for epigenetic analysis |
| CN107779485B (zh) | 2016-08-24 | 2022-03-18 | 中国科学院分子细胞科学卓越创新中心 | Cmd1酶催化的5-甲基胞嘧啶核酸的新修饰及其应用 |
| US11512306B2 (en) | 2016-10-19 | 2022-11-29 | The Chinese University Of Hong Kong | Gestational age assessment by methylation and size profiling of maternal plasma DNA |
| EP3535415A4 (en) | 2016-10-24 | 2020-07-01 | The Chinese University of Hong Kong | TUMOR DETECTION METHODS AND SYSTEMS |
| IL315032A (en) | 2016-11-30 | 2024-10-01 | Univ Hong Kong Chinese | Analysis of cell-free dna in urine and other samples |
| ES2983411T3 (es) * | 2016-12-13 | 2024-10-23 | Bellwether Bio Inc | Determinación de un estado fisiológico en un individuo analizando los puntos finales de fragmentos de ADN libre de células en una muestra biológica |
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