KR102474489B1 - 안구 질환을 치료하기 위한 abcb5(+) 줄기 세포 - Google Patents
안구 질환을 치료하기 위한 abcb5(+) 줄기 세포 Download PDFInfo
- Publication number
- KR102474489B1 KR102474489B1 KR1020227011673A KR20227011673A KR102474489B1 KR 102474489 B1 KR102474489 B1 KR 102474489B1 KR 1020227011673 A KR1020227011673 A KR 1020227011673A KR 20227011673 A KR20227011673 A KR 20227011673A KR 102474489 B1 KR102474489 B1 KR 102474489B1
- Authority
- KR
- South Korea
- Prior art keywords
- abcb5
- cells
- cell
- stem cells
- ocular
- Prior art date
Links
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0696—Artificially induced pluripotent stem cells, e.g. iPS
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/30—Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
- A61K9/0051—Ocular inserts, ocular implants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
- A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
- A61L27/3834—Cells able to produce different cell types, e.g. hematopoietic stem cells, mesenchymal stem cells, marrow stromal cells, embryonic stem cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
- A61L27/3839—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by the site of application in the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0618—Cells of the nervous system
- C12N5/0621—Eye cells, e.g. cornea, iris pigmented cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0618—Cells of the nervous system
- C12N5/0623—Stem cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0662—Stem cells
- C12N5/0668—Mesenchymal stem cells from other natural sources
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/16—Materials or treatment for tissue regeneration for reconstruction of eye parts, e.g. intraocular lens, cornea
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/02—Atmosphere, e.g. low oxygen conditions
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/60—Transcription factors
- C12N2501/602—Sox-2
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/60—Transcription factors
- C12N2501/603—Oct-3/4
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/60—Transcription factors
- C12N2501/604—Klf-4
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Developmental Biology & Embryology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Ophthalmology & Optometry (AREA)
- Epidemiology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Transplantation (AREA)
- Botany (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Dermatology (AREA)
- Immunology (AREA)
- Virology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Rheumatology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361766424P | 2013-02-19 | 2013-02-19 | |
US61/766,424 | 2013-02-19 | ||
KR1020157025733A KR102385934B1 (ko) | 2013-02-19 | 2014-02-19 | 안구 질환을 치료하기 위한 abcb5(+) 줄기 세포 |
PCT/US2014/017076 WO2014130518A1 (en) | 2013-02-19 | 2014-02-19 | Abcb5(+) stem cells for treating ocular disease |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1020157025733A Division KR102385934B1 (ko) | 2013-02-19 | 2014-02-19 | 안구 질환을 치료하기 위한 abcb5(+) 줄기 세포 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR20220048048A KR20220048048A (ko) | 2022-04-19 |
KR102474489B1 true KR102474489B1 (ko) | 2022-12-06 |
Family
ID=51391751
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1020227011673A KR102474489B1 (ko) | 2013-02-19 | 2014-02-19 | 안구 질환을 치료하기 위한 abcb5(+) 줄기 세포 |
KR1020157025733A KR102385934B1 (ko) | 2013-02-19 | 2014-02-19 | 안구 질환을 치료하기 위한 abcb5(+) 줄기 세포 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1020157025733A KR102385934B1 (ko) | 2013-02-19 | 2014-02-19 | 안구 질환을 치료하기 위한 abcb5(+) 줄기 세포 |
Country Status (9)
Country | Link |
---|---|
US (3) | US9801912B2 (ja) |
EP (2) | EP3865573A1 (ja) |
JP (2) | JP7027026B2 (ja) |
KR (2) | KR102474489B1 (ja) |
AU (1) | AU2014219026B2 (ja) |
CA (1) | CA2901931C (ja) |
DK (1) | DK2964238T3 (ja) |
ES (1) | ES2860573T3 (ja) |
WO (1) | WO2014130518A1 (ja) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6846883B2 (en) | 2000-06-05 | 2005-01-25 | The Brigham And Women's Hospital, Inc. | Gene encoding a multidrug resistance human P-glycoprotein homologue on chromosome 7p15-21 and uses thereof |
WO2007143139A1 (en) | 2006-05-31 | 2007-12-13 | The Brigham And Women's Hospital, Inc. | Abcb5 positive mesenchymal stem cells as immunomodulators |
LT2644205T (lt) | 2007-04-12 | 2018-12-10 | The Brigham And Women`S Hospital, Inc. | Nutaikymas į abcb5 vėžio terapijai |
US11542328B2 (en) | 2008-11-14 | 2023-01-03 | The Brigham And Women's Hospital, Inc. | Therapeutic and diagnostic methods relating to cancer stem cells |
PT3130923T (pt) | 2008-11-14 | 2020-06-17 | Brigham & Womens Hospital Inc | Métodos terapêuticos relacionados com células estaminais |
EP3865573A1 (en) | 2013-02-19 | 2021-08-18 | Children's Medical Center Corporation | Abcb5(+) stem cells for treating ocular disease |
JP6600299B2 (ja) * | 2013-05-10 | 2019-10-30 | ザ チルドレンズ メディカル センター コーポレーション | 創傷治癒および組織工学 |
EP4036228A1 (en) * | 2015-11-13 | 2022-08-03 | Avellino Lab USA, Inc. | Methods for the treatment of corneal dystrophies |
EP4054595A4 (en) * | 2019-11-07 | 2023-11-15 | Massachusetts Eye and Ear Infirmary | CULTURED AUTOLOGOUS LIMBAL EPITHELIAL CELLS (CALEC) TRANSPLANTATION |
EP3842079A1 (en) * | 2019-12-24 | 2021-06-30 | Universiteit Antwerpen | Ophthalmological device for the treatment of lscd and substrate for use in same |
WO2021202570A1 (en) * | 2020-03-30 | 2021-10-07 | Children's Medical Center Corporation | Use of stem cells for treatment of excessive inflammation |
WO2023014892A1 (en) * | 2021-08-04 | 2023-02-09 | Alpine Biotherapeutics Corporation | Sustainable ocular cell-mediated intraocular delivery of cellular therapeutics for treatment of ocular diseases or disorders |
KR20230129828A (ko) | 2022-03-02 | 2023-09-11 | 포항공과대학교 산학협력단 | 안구 후방 질환 또는 손상의 예방 또는 치료용 조성물 |
KR20230130479A (ko) | 2022-03-03 | 2023-09-12 | 서울대학교병원 | 안구건조증 또는 마이봄샘 기능장애의 예방, 개선, 또는 치료용 조성물 |
CN115074368B (zh) * | 2022-06-09 | 2023-08-08 | 澳门科技大学 | 一种耐药型类风湿性关节炎动物模型的构建及其应用 |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20080003206A1 (en) * | 2006-05-31 | 2008-01-03 | The Brigham And Women's Hospital, Inc. | ABCB5 positive mesenchymal stem cells as immunomodulators |
Family Cites Families (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5434075A (en) | 1992-03-20 | 1995-07-18 | Board Of Trustees Of The University Of Illinois | Monoclonal antibody to a human MDR1 multidrug resistance gene product, and uses |
US5837258A (en) | 1991-08-30 | 1998-11-17 | University Of South Florida | Induction of tissue, bone or cartilage formation using connective tissue growth factor |
US6231881B1 (en) | 1992-02-24 | 2001-05-15 | Anton-Lewis Usala | Medium and matrix for long-term proliferation of cells |
US5906934A (en) | 1995-03-14 | 1999-05-25 | Morphogen Pharmaceuticals, Inc. | Mesenchymal stem cells for cartilage repair |
JP2000508911A (ja) | 1996-04-19 | 2000-07-18 | オシリス セラピューティクス,インコーポレイテッド | 間葉幹細胞を用いる骨の再生および増強 |
US6152142A (en) | 1997-02-28 | 2000-11-28 | Tseng; Scheffer C. G. | Grafts made from amniotic membrane; methods of separating, preserving, and using such grafts in surgeries |
DE19722075C1 (de) | 1997-05-27 | 1998-10-01 | Wilhelm Dr Med Fleischmann | Vorrichtung zur Applikation von Wirkstoffen an einer Wundoberfläche |
ATE286118T1 (de) | 1998-03-13 | 2005-01-15 | Osiris Therapeutics Inc | Anwendungen für humane nicht autologe, mesenchymale stammzellen |
US6368636B1 (en) | 1998-03-18 | 2002-04-09 | Osiris Therapeutics, Inc. | Mesenchymal stem cells for prevention and treatment of immune responses in transplantation |
DE69910362T2 (de) | 1998-04-03 | 2004-06-24 | Osiris Therapeutics, Inc. | Anwendung der mesenchymalen stammzellen als immunsuppressiva |
DK1082410T3 (da) | 1998-05-29 | 2007-11-26 | Osiris Therapeutics Inc | Humane CD45 - og/eller fibroblast mesenchymale stamceller |
PL366290A1 (en) | 1999-11-29 | 2005-01-24 | Hill-Rom Services, Inc. | Wound treatment apparatus |
US6846883B2 (en) | 2000-06-05 | 2005-01-25 | The Brigham And Women's Hospital, Inc. | Gene encoding a multidrug resistance human P-glycoprotein homologue on chromosome 7p15-21 and uses thereof |
WO2002029106A2 (en) | 2000-10-03 | 2002-04-11 | California Institute Of Technology | Microfluidic devices and methods of use |
US6695824B2 (en) | 2001-04-16 | 2004-02-24 | The United States Of America As Represented By The Secretary Of The Army | Wound dressing system |
US6905678B2 (en) | 2001-07-07 | 2005-06-14 | Crucell Holland B.V. | Gene delivery vectors with cell type specificity for mesenchymal stem cells |
US8034904B2 (en) | 2002-06-14 | 2011-10-11 | Immunogen Inc. | Anti-IGF-I receptor antibody |
US20050186672A1 (en) * | 2004-01-27 | 2005-08-25 | Reliance Life Sciences Pvt. Ltd. | Tissue system with undifferentiated stem cells derived from corneal limbus |
WO2006103685A2 (en) | 2005-03-28 | 2006-10-05 | Vision Research Foundation | A method for cultivating cells derived from corneal limbal tissue and cells deived from corneal limbal tissue |
US8883507B2 (en) | 2005-10-18 | 2014-11-11 | The Regents Of The University Of Colorado | Conditionally immortalized long-term hematopoietic stem cells and methods of making and using such cells |
GB0610778D0 (en) | 2006-05-31 | 2006-07-12 | Het Nl Kanker I | Phosphatidylinositol phospahte and apoptosis |
LT2644205T (lt) | 2007-04-12 | 2018-12-10 | The Brigham And Women`S Hospital, Inc. | Nutaikymas į abcb5 vėžio terapijai |
US9011840B2 (en) | 2008-03-14 | 2015-04-21 | The Board Of Trustees Of The University Of Illinois | Activated mesenchymal stem cells for wound healing and impaired tissue regeneration |
PT3130923T (pt) | 2008-11-14 | 2020-06-17 | Brigham & Womens Hospital Inc | Métodos terapêuticos relacionados com células estaminais |
WO2010065711A1 (en) | 2008-12-04 | 2010-06-10 | Adimab, Inc. | An abcb5 epitope and antibodies thereto for the treatment of cancer |
GB0908927D0 (en) * | 2009-05-22 | 2009-07-01 | Univ Reading The | Synthetic graft |
WO2013002953A1 (en) | 2011-06-01 | 2013-01-03 | The Board Of Trustees Of The University Of Illinois | Membrane-scaffold composites for tissue engineering applications |
EP3865573A1 (en) | 2013-02-19 | 2021-08-18 | Children's Medical Center Corporation | Abcb5(+) stem cells for treating ocular disease |
JP6600299B2 (ja) | 2013-05-10 | 2019-10-30 | ザ チルドレンズ メディカル センター コーポレーション | 創傷治癒および組織工学 |
US20180134771A1 (en) | 2015-05-07 | 2018-05-17 | Bioxcel Corporation | Novel immunomodulatory therapeutic strategies targeting tumors in cancer |
-
2014
- 2014-02-19 EP EP21150996.3A patent/EP3865573A1/en active Pending
- 2014-02-19 DK DK14754427.4T patent/DK2964238T3/da active
- 2014-02-19 WO PCT/US2014/017076 patent/WO2014130518A1/en active Application Filing
- 2014-02-19 KR KR1020227011673A patent/KR102474489B1/ko active IP Right Grant
- 2014-02-19 JP JP2015558916A patent/JP7027026B2/ja active Active
- 2014-02-19 ES ES14754427T patent/ES2860573T3/es active Active
- 2014-02-19 KR KR1020157025733A patent/KR102385934B1/ko active IP Right Grant
- 2014-02-19 AU AU2014219026A patent/AU2014219026B2/en active Active
- 2014-02-19 US US14/768,885 patent/US9801912B2/en active Active
- 2014-02-19 CA CA2901931A patent/CA2901931C/en active Active
- 2014-02-19 EP EP14754427.4A patent/EP2964238B1/en active Active
-
2017
- 2017-10-30 US US15/796,920 patent/US11129854B2/en active Active
-
2019
- 2019-02-28 JP JP2019036040A patent/JP2019189600A/ja active Pending
-
2021
- 2021-09-27 US US17/486,855 patent/US20220118024A1/en active Pending
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20080003206A1 (en) * | 2006-05-31 | 2008-01-03 | The Brigham And Women's Hospital, Inc. | ABCB5 positive mesenchymal stem cells as immunomodulators |
Also Published As
Publication number | Publication date |
---|---|
KR20160033068A (ko) | 2016-03-25 |
JP7027026B2 (ja) | 2022-03-01 |
EP2964238A4 (en) | 2016-09-07 |
AU2014219026B2 (en) | 2018-11-29 |
EP2964238A1 (en) | 2016-01-13 |
EP2964238B1 (en) | 2021-01-13 |
ES2860573T3 (es) | 2021-10-05 |
US20150374756A1 (en) | 2015-12-31 |
KR20220048048A (ko) | 2022-04-19 |
CA2901931A1 (en) | 2014-08-28 |
EP3865573A1 (en) | 2021-08-18 |
KR102385934B1 (ko) | 2022-04-13 |
JP2019189600A (ja) | 2019-10-31 |
WO2014130518A1 (en) | 2014-08-28 |
US9801912B2 (en) | 2017-10-31 |
CA2901931C (en) | 2023-03-07 |
JP2016510727A (ja) | 2016-04-11 |
US11129854B2 (en) | 2021-09-28 |
AU2014219026A1 (en) | 2015-09-17 |
US20220118024A1 (en) | 2022-04-21 |
US20180064762A1 (en) | 2018-03-08 |
DK2964238T3 (da) | 2021-03-22 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US20220118024A1 (en) | Abcb5(+) stem cells for treating ocular disease | |
Gagliardi et al. | Photoreceptor cell replacement in macular degeneration and retinitis pigmentosa: a pluripotent stem cell-based approach | |
Ksander et al. | ABCB5 is a limbal stem cell gene required for corneal development and repair | |
Bull et al. | Human Muller stem cell (MIO-M1) transplantation in a rat model of glaucoma: survival, differentiation, and integration | |
ES2527444T5 (es) | Células del epitelio pigmentario de la retina derivadas de células madre | |
JP6920363B2 (ja) | 多機能未成熟歯髄幹細胞および療法適用 | |
Sun et al. | Retinal stem/progenitor properties of iris pigment epithelial cells | |
JP2007528703A (ja) | 分娩後由来細胞を使用する眼組織の修復および再生 | |
Rabesandratana et al. | Generation of a transplantable population of human iPSC-derived retinal ganglion cells | |
CN114245741A (zh) | 高功能性的制造的abcb5+间充质干细胞 | |
Thumann et al. | Phagocytosis of rod outer segments by human iris pigment epithelial cells in vitro | |
CN107249608A (zh) | 使用祖细胞治疗视网膜变性 | |
US9061017B2 (en) | Isolation and therapeutic application of adult retinal stem cells collected from extra-retinal tissues | |
Eveleth | Cell-based therapies for ocular disease | |
US10039790B2 (en) | Isolation and therapeutic application of adult retinal stem cells collected from extra-retinal tissues | |
KR20170093178A (ko) | 전구 세포를 사용한 안구 질환의 치료 | |
CN109414460A (zh) | 使用祖细胞治疗视网膜血管病 | |
CN108291199A (zh) | 使用祖细胞治疗视网膜变性 | |
US20240207483A1 (en) | Therapeutic Drug for Disease Accompanied by Disorders in Retinal Cells or Retinal Tissue | |
JP2022513736A (ja) | 多能性幹細胞由来の臨床グレードの角膜内皮細胞の作製および凍結保存 | |
Aweidah et al. | Survival of neural progenitors derived from human embryonic stem cells following subretinal transplantation in rodents | |
O'Malley et al. | Monoclonal antibody substrates facilitate long-term regenerative growth of adult primate retinal neurons | |
Penna | UNDERSTANDING AND PROMOTING THE FUNCTIONAL INTEGRATION OF NEURAL TRANSPLANTS IN PARKINSON’S | |
Del Priore et al. | Cellular transplantation for advanced age-related macular degeneration | |
Kawasaki et al. | JOS. April 2006, Vol. 47. No. 4 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A107 | Divisional application of patent | ||
E902 | Notification of reason for refusal | ||
E701 | Decision to grant or registration of patent right | ||
GRNT | Written decision to grant |