KR102419524B1 - 메닌-mll의 가교된 이환식 억제제 및 사용 방법 - Google Patents

메닌-mll의 가교된 이환식 억제제 및 사용 방법 Download PDF

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KR102419524B1
KR102419524B1 KR1020187029700A KR20187029700A KR102419524B1 KR 102419524 B1 KR102419524 B1 KR 102419524B1 KR 1020187029700 A KR1020187029700 A KR 1020187029700A KR 20187029700 A KR20187029700 A KR 20187029700A KR 102419524 B1 KR102419524 B1 KR 102419524B1
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KR20180127406A (ko
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타오 우
리안솅 리
이 왕
핑다 렌
졸란타 그렘벡카
토마즈 시에르픽키
시몬 클로소프스키
조나단 폴락
드미트리 보르킨
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쿠라 온콜로지, 인크.
더 리젠츠 오브 더 유니버시티 오브 미시간
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
KR1020187029700A 2016-03-16 2017-03-15 메닌-mll의 가교된 이환식 억제제 및 사용 방법 Active KR102419524B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662309362P 2016-03-16 2016-03-16
US62/309,362 2016-03-16
US201662431387P 2016-12-07 2016-12-07
US62/431,387 2016-12-07
PCT/US2017/022535 WO2017161002A1 (en) 2016-03-16 2017-03-15 Bridged bicyclic inhibitors of menin-mll and methods of use

Publications (2)

Publication Number Publication Date
KR20180127406A KR20180127406A (ko) 2018-11-28
KR102419524B1 true KR102419524B1 (ko) 2022-07-08

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US (3) US10752639B2 (enExample)
EP (1) EP3429585B1 (enExample)
JP (1) JP7000333B2 (enExample)
KR (1) KR102419524B1 (enExample)
CN (1) CN109640987B (enExample)
AU (1) AU2017235462B2 (enExample)
BR (1) BR112018068702A2 (enExample)
CA (1) CA3015845A1 (enExample)
IL (1) IL261625B (enExample)
MA (1) MA43823A (enExample)
MX (1) MX387806B (enExample)
MY (1) MY199965A (enExample)
PH (1) PH12018501955B1 (enExample)
SG (1) SG11201807834WA (enExample)
TW (1) TWI743096B (enExample)
WO (1) WO2017161002A1 (enExample)
ZA (1) ZA201805845B (enExample)

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