CA3015845A1 - Bridged bicyclic inhibitors of menin-mll and methods of use - Google Patents

Bridged bicyclic inhibitors of menin-mll and methods of use Download PDF

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Publication number
CA3015845A1
CA3015845A1 CA3015845A CA3015845A CA3015845A1 CA 3015845 A1 CA3015845 A1 CA 3015845A1 CA 3015845 A CA3015845 A CA 3015845A CA 3015845 A CA3015845 A CA 3015845A CA 3015845 A1 CA3015845 A1 CA 3015845A1
Authority
CA
Canada
Prior art keywords
compound
nr53r54
optionally substituted
nr52c
alkylene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3015845A
Other languages
English (en)
French (fr)
Inventor
Tao Wu
Liansheng Li
Yi Wang
Pingda Ren
Jolanta Grembecka
Tomasz Cierpicki
Szymon Klossowski
Jonathan Pollock
Dmitry Borkin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Michigan System
Kura Oncology Inc
Original Assignee
University of Michigan System
Kura Oncology Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Michigan System, Kura Oncology Inc filed Critical University of Michigan System
Publication of CA3015845A1 publication Critical patent/CA3015845A1/en
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
CA3015845A 2016-03-16 2017-03-15 Bridged bicyclic inhibitors of menin-mll and methods of use Pending CA3015845A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662309362P 2016-03-16 2016-03-16
US62/309,362 2016-03-16
US201662431387P 2016-12-07 2016-12-07
US62/431,387 2016-12-07
PCT/US2017/022535 WO2017161002A1 (en) 2016-03-16 2017-03-15 Bridged bicyclic inhibitors of menin-mll and methods of use

Publications (1)

Publication Number Publication Date
CA3015845A1 true CA3015845A1 (en) 2017-09-21

Family

ID=59851929

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3015845A Pending CA3015845A1 (en) 2016-03-16 2017-03-15 Bridged bicyclic inhibitors of menin-mll and methods of use

Country Status (17)

Country Link
US (3) US10752639B2 (enExample)
EP (1) EP3429585B1 (enExample)
JP (1) JP7000333B2 (enExample)
KR (1) KR102419524B1 (enExample)
CN (1) CN109640987B (enExample)
AU (1) AU2017235462B2 (enExample)
BR (1) BR112018068702A2 (enExample)
CA (1) CA3015845A1 (enExample)
IL (1) IL261625B (enExample)
MA (1) MA43823A (enExample)
MX (1) MX387806B (enExample)
MY (1) MY199965A (enExample)
PH (1) PH12018501955B1 (enExample)
SG (1) SG11201807834WA (enExample)
TW (1) TWI743096B (enExample)
WO (1) WO2017161002A1 (enExample)
ZA (1) ZA201805845B (enExample)

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TW202315636A (zh) 2021-06-17 2023-04-16 比利時商健生藥品公司 （ｒ）－ｎ－乙基－５－氟－ｎ－異丙基－２－（（５－（２－（６－（（２－甲氧基乙基）（甲基）胺基）－２－甲基己－３－基）－２，６－二氮雜螺［３．４］辛－６－基）－１，２，４－三𠯤－６－基）氧基）苯甲醯胺苯磺酸鹽
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