KR102411082B1 - 할로알킬 치환기를 지니는 비­방향족 고리에 의해 위치 3에서 치환된，ｈｉｖ 성숙화 억제 활성을 갖는 트리테르페노이드 - Google Patents

할로알킬 치환기를 지니는 비­방향족 고리에 의해 위치 3에서 치환된，ｈｉｖ 성숙화 억제 활성을 갖는 트리테르페노이드 Download PDF

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KR102411082B1
KR102411082B1 KR1020167031312A KR20167031312A KR102411082B1 KR 102411082 B1 KR102411082 B1 KR 102411082B1 KR 1020167031312 A KR1020167031312 A KR 1020167031312A KR 20167031312 A KR20167031312 A KR 20167031312A KR 102411082 B1 KR102411082 B1 KR 102411082B1
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mmol
fluoromethyl
mixture
cyclohex
octadecahydro
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KR20160147809A (ko
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싱-유엔 시트
얀 첸
지에 첸
제이콥 스위도르스키
브라이언 리 베나플레스
니 신
니콜라스 에이. 민웰
알리시아 게레이로-렌
리차드 에이. 하르트
리 수
쳉 리우
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비브 헬스케어 유케이 (넘버4) 리미티드
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63—Esters of sulfonic acids
    • C07C309/64—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms
    • C07C309/65—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms of a saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63—Esters of sulfonic acids
    • C07C309/64—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms
    • C07C309/65—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms of a saturated carbon skeleton
    • C07C309/66—Methanesulfonates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/06—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D239/08—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms directly attached in position 2
    • C07D239/12—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
    • C07D279/12—1,4-Thiazines; Hydrogenated 1,4-thiazines not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/04—Esters of boric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
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  • Epidemiology (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • AIDS & HIV (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
KR1020167031312A 2014-04-11 2015-04-09 할로알킬 치환기를 지니는 비­방향족 고리에 의해 위치 3에서 치환된，ｈｉｖ 성숙화 억제 활성을 갖는 트리테르페노이드 Expired - Fee Related KR102411082B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461978306P 2014-04-11 2014-04-11
US61/978,306 2014-04-11
PCT/US2015/025029 WO2015157483A1 (en) 2014-04-11 2015-04-09 Triterpenoids with hiv maturation inhibitory activity, substituted in position 3 by a non-aromatic ring carrying a haloalkyl substituent

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KR20160147809A KR20160147809A (ko) 2016-12-23
KR102411082B1 true KR102411082B1 (ko) 2022-06-17

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KR1020167031312A Expired - Fee Related KR102411082B1 (ko) 2014-04-11 2015-04-09 할로알킬 치환기를 지니는 비­방향족 고리에 의해 위치 3에서 치환된，ｈｉｖ 성숙화 억제 활성을 갖는 트리테르페노이드

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US (5) US9527882B2 (https=)
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KR (1) KR102411082B1 (https=)
CN (1) CN106604909B (https=)
AR (1) AR101077A1 (https=)
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UY36070A (es) 2014-04-11 2015-10-30 Bristol Myers Squibb Company Una Corporación Del Estado De Delaware Triterpenoides con actividad inhibidora de la maduración de hiv
EP3377177A2 (en) * 2015-11-20 2018-09-26 VIIV Healthcare UK(No.4) Limited Hiv maturation inhibitor formulations
AR107512A1 (es) * 2016-02-04 2018-05-09 VIIV HEALTHCARE UK Nº 5 LTD Triterpenoides modificados en c-3 y c-17 como inhibidores del vih-1
EP3506902A4 (en) * 2016-08-31 2020-04-22 VIIV Healthcare Company COMBINATIONS AND USES AND TREATMENTS THEREOF
ES2970042T3 (es) * 2018-04-24 2024-05-24 Viiv Healthcare Uk No 5 Ltd Compuestos con actividad inhibidora de la maduración del VIH
ES2938486T3 (es) * 2018-12-10 2023-04-11 Viiv Healthcare Uk No 4 Ltd Sal de mesilato de un compuesto de amino-lupano con actividad inhibidora de maduración del VIH
CN109705189B (zh) * 2018-12-29 2020-06-05 中国医学科学院药用植物研究所 具有式i所示结构的三萜衍生物及其制备方法和应用
CN110981765A (zh) * 2019-11-07 2020-04-10 肇庆巨元生化有限公司 一种25-羟基维生素d3中间体的制备方法
JP7703538B2 (ja) * 2019-12-09 2025-07-07 ヴィーブ、ヘルスケア、カンパニー カボテグラビルを含んでなる医薬組成物

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PT3129392T (pt) 2020-10-30
CA2944778A1 (en) 2015-10-15
BR112016023414A2 (https=) 2017-08-15
US20190151336A1 (en) 2019-05-23
US11464790B2 (en) 2022-10-11
CL2016002528A1 (es) 2017-06-23
SI3129392T1 (sl) 2020-11-30
EA030178B1 (ru) 2018-06-29
US10780102B2 (en) 2020-09-22
CN106604909A (zh) 2017-04-26
PH12016501951B1 (en) 2021-02-19
PL3129392T3 (pl) 2021-04-06
AR101077A1 (es) 2016-11-23
IL248053B (en) 2020-04-30
US10245275B2 (en) 2019-04-02
EP3129392B1 (en) 2020-08-05
TWI659964B (zh) 2019-05-21
HRP20201645T1 (hr) 2020-12-25
TW201623324A (zh) 2016-07-01
SMT202000581T1 (it) 2020-11-10
CN106604909B (zh) 2019-02-15
MA39374A1 (fr) 2018-06-29
ZA201606748B (en) 2018-05-30
AU2015243500A1 (en) 2016-10-27
MX2016013425A (es) 2017-05-02
IL248053A0 (en) 2016-11-30
NZ724644A (en) 2023-07-28
BR112016023414B1 (pt) 2022-09-13
DK3129392T3 (da) 2020-10-19
UY36070A (es) 2015-10-30
PH12016501951A1 (en) 2017-01-09
HUE051719T2 (hu) 2021-03-29
JP2017510659A (ja) 2017-04-13
DOP2016000277A (es) 2017-02-28
WO2015157483A1 (en) 2015-10-15
RS60959B1 (sr) 2020-11-30
CR20160472A (es) 2017-03-10
ES2828705T3 (es) 2021-05-27
US20150291655A1 (en) 2015-10-15
JP6568202B2 (ja) 2019-08-28
CY1123742T1 (el) 2022-03-24
LT3129392T (lt) 2020-11-10
PE20161391A1 (es) 2017-01-10
UA120927C2 (uk) 2020-03-10
EP3750910A1 (en) 2020-12-16
US20170056420A1 (en) 2017-03-02
CA2944778C (en) 2022-06-14
SG10201709017PA (en) 2017-11-29
AU2015243500B2 (en) 2017-03-30
US20200360404A1 (en) 2020-11-19
KR20160147809A (ko) 2016-12-23
MX374543B (es) 2025-03-06
SG11201608041QA (en) 2016-10-28
US20170340650A1 (en) 2017-11-30
EA201691760A1 (ru) 2017-02-28
EP3129392A1 (en) 2017-02-15
US9527882B2 (en) 2016-12-27

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