KR102408800B1 - 비시클릭 아릴 모노박탐 화합물 및 박테리아 감염의 치료를 위한 그의 사용 방법 - Google Patents
비시클릭 아릴 모노박탐 화합물 및 박테리아 감염의 치료를 위한 그의 사용 방법 Download PDFInfo
- Publication number
- KR102408800B1 KR102408800B1 KR1020187028417A KR20187028417A KR102408800B1 KR 102408800 B1 KR102408800 B1 KR 102408800B1 KR 1020187028417 A KR1020187028417 A KR 1020187028417A KR 20187028417 A KR20187028417 A KR 20187028417A KR 102408800 B1 KR102408800 B1 KR 102408800B1
- Authority
- KR
- South Korea
- Prior art keywords
- tert
- alkyl
- mmol
- amino
- pharmaceutically acceptable
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/429—Thiazoles condensed with heterocyclic ring systems
- A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
- A61K31/431—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems containing further heterocyclic rings, e.g. ticarcillin, azlocillin, oxacillin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C53/00—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen
- C07C53/15—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen containing halogen
- C07C53/16—Halogenated acetic acids
- C07C53/18—Halogenated acetic acids containing fluorine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/424—Oxazoles condensed with heterocyclic ring systems, e.g. clavulanic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662304447P | 2016-03-07 | 2016-03-07 | |
| US62/304,447 | 2016-03-07 | ||
| PCT/US2017/020303 WO2017155765A1 (en) | 2016-03-07 | 2017-03-02 | Bicyclic aryl monobactam compounds and methods of use thereof for the treatment of bacterial infections |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20180121948A KR20180121948A (ko) | 2018-11-09 |
| KR102408800B1 true KR102408800B1 (ko) | 2022-06-13 |
Family
ID=59789685
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020187028417A Active KR102408800B1 (ko) | 2016-03-07 | 2017-03-02 | 비시클릭 아릴 모노박탐 화합물 및 박테리아 감염의 치료를 위한 그의 사용 방법 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US10407421B2 (enExample) |
| EP (1) | EP3426248B1 (enExample) |
| JP (1) | JP7034929B2 (enExample) |
| KR (1) | KR102408800B1 (enExample) |
| CN (1) | CN108778273B (enExample) |
| AU (1) | AU2017228870B2 (enExample) |
| BR (1) | BR112018067930B1 (enExample) |
| CA (1) | CA3016341A1 (enExample) |
| MA (1) | MA43811A (enExample) |
| MX (1) | MX2018010878A (enExample) |
| RU (1) | RU2733402C2 (enExample) |
| WO (1) | WO2017155765A1 (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP7034929B2 (ja) | 2016-03-07 | 2022-03-14 | メルク・シャープ・アンド・ドーム・コーポレーション | 二環式アリールモノバクタム化合物及び細菌感染症を治療するためにそれらを使用する方法 |
| MA48994A (fr) | 2017-03-30 | 2020-02-05 | Hoffmann La Roche | Isoquinoléines utilisées en tant qu'inhibiteurs de hpk1 |
| GEP20227406B (en) * | 2017-10-02 | 2022-08-25 | Merck Sharp & Dohme | Chromane monobactam compounds for the treatment of bacterial infections |
| WO2019144969A1 (zh) * | 2018-01-29 | 2019-08-01 | 南京明德新药研发股份有限公司 | 用于治疗细菌感染的单环β-内酰胺化合物 |
| EP3826722A1 (en) | 2018-07-24 | 2021-06-02 | F. Hoffmann-La Roche AG | Isoquinoline compounds and uses thereof |
| TW202024053A (zh) | 2018-10-02 | 2020-07-01 | 美商建南德克公司 | 異喹啉化合物及其用途 |
| US11612606B2 (en) | 2018-10-03 | 2023-03-28 | Genentech, Inc. | 8-aminoisoquinoline compounds and uses thereof |
| WO2020098635A1 (zh) * | 2018-11-13 | 2020-05-22 | 南京圣和药业股份有限公司 | 单环内酰胺化合物及其应用 |
| EP3901150B1 (en) * | 2018-12-18 | 2025-12-03 | Shenzhen Optimum Biological Technology Co., Ltd | Monocyclic beta-lactam compound for use in the treatment of pneumonia |
| CN110963967B (zh) * | 2019-11-25 | 2021-02-12 | 武汉智顿科技发展有限公司 | 一种2-甲基-4-氨基喹啉的制备方法 |
| CN111018777B (zh) * | 2019-11-25 | 2021-02-12 | 武汉智顿科技发展有限公司 | 一种地喹氯铵的制备方法 |
| CN111303144B (zh) * | 2019-12-13 | 2020-11-27 | 苏州信诺维医药科技有限公司 | 一种治疗细菌感染的化合物 |
| WO2021121387A1 (zh) * | 2019-12-19 | 2021-06-24 | 南京明德新药研发有限公司 | 化合物在制药中的应用 |
| EP4146650A4 (en) | 2020-09-01 | 2024-01-17 | Ningxia Academy of Agriculture and Forestry Sciences | BETA-LACTAMASE INHIBITORS AND THEIR PRODUCTION |
| MX2023011616A (es) | 2021-03-31 | 2023-10-30 | Fedora Pharmaceuticals Inc | Compuestos de lactivicina, su preparacion y uso como agentes antibacterianos. |
| EP4146651A4 (en) | 2021-05-07 | 2024-06-05 | Ningxia Academy of Agriculture and Forestry Sciences | SULFONYLAMIDINE SUBSTITUTED COMPOUNDS AND THEIR USE AS BETA-LACTAMASE INHIBITORS |
| AU2021473165B2 (en) * | 2021-11-09 | 2025-05-22 | Guangzhou HC New Drug Research Co., Ltd. | PHARMACEUTICAL COMPOSITION CONTAINING β-LACTAM COMPOUND AND USE THEREOF |
| JPWO2024101337A1 (enExample) * | 2022-11-07 | 2024-05-16 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2010530372A (ja) | 2007-06-12 | 2010-09-09 | アカオゲン，インコーポレーテッド | 抗菌剤 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4684722A (en) | 1986-01-06 | 1987-08-04 | E. R. Squibb & Sons, Inc. | Monosulfactams |
| US5250691A (en) * | 1991-09-09 | 1993-10-05 | E. R. Squibb & Sons, Inc. | Heteroaryl derivatives of monocyclic beta-lactam antibiotics |
| MY127641A (en) | 1995-10-12 | 2006-12-29 | Essential Therapeutics Inc | Cephalosporin antibiotics |
| RU2269525C2 (ru) * | 2000-08-10 | 2006-02-10 | Бритиш Биотех Фармасьютикалс Лимитед | Антибактериальные агенты |
| CA2783572C (en) | 2005-12-07 | 2016-08-09 | Basilea Pharmaceutica Ag | Useful combinations of monobactam antibiotics with beta-lactamase inhibitors |
| CA2815821C (en) | 2010-11-29 | 2015-07-07 | Pfizer Inc. | Monobactams useful for treating bacterial infections |
| UY34585A (es) | 2012-01-24 | 2013-09-02 | Aicuris Gmbh & Co Kg | Compuestos b-lactámicos sustituidos con amidina, su preparación y uso |
| US20140275007A1 (en) | 2013-03-14 | 2014-09-18 | Rempex Pharmaceuticals, Inc. | Oxamazin antibiotics |
| PT3122745T (pt) | 2014-03-24 | 2019-04-30 | Novartis Ag | Compostos orgânicos de monobactama para o tratamento de infeções bacterianas |
| JP7034929B2 (ja) | 2016-03-07 | 2022-03-14 | メルク・シャープ・アンド・ドーム・コーポレーション | 二環式アリールモノバクタム化合物及び細菌感染症を治療するためにそれらを使用する方法 |
-
2017
- 2017-03-02 JP JP2018546678A patent/JP7034929B2/ja active Active
- 2017-03-02 US US16/076,781 patent/US10407421B2/en active Active
- 2017-03-02 BR BR112018067930-5A patent/BR112018067930B1/pt active IP Right Grant
- 2017-03-02 WO PCT/US2017/020303 patent/WO2017155765A1/en not_active Ceased
- 2017-03-02 CN CN201780015430.2A patent/CN108778273B/zh active Active
- 2017-03-02 CA CA3016341A patent/CA3016341A1/en active Pending
- 2017-03-02 KR KR1020187028417A patent/KR102408800B1/ko active Active
- 2017-03-02 EP EP17763763.4A patent/EP3426248B1/en active Active
- 2017-03-02 MX MX2018010878A patent/MX2018010878A/es unknown
- 2017-03-02 RU RU2018134948A patent/RU2733402C2/ru active
- 2017-03-02 AU AU2017228870A patent/AU2017228870B2/en active Active
- 2017-03-02 MA MA043811A patent/MA43811A/fr unknown
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2010530372A (ja) | 2007-06-12 | 2010-09-09 | アカオゲン，インコーポレーテッド | 抗菌剤 |
Non-Patent Citations (1)
| Title |
|---|
| JP 2015-504907 A.* |
Also Published As
| Publication number | Publication date |
|---|---|
| BR112018067930A2 (pt) | 2019-01-22 |
| EP3426248A4 (en) | 2019-07-10 |
| RU2018134948A3 (enExample) | 2020-04-08 |
| BR112018067930B1 (pt) | 2024-02-15 |
| EP3426248B1 (en) | 2023-11-15 |
| JP2019507768A (ja) | 2019-03-22 |
| RU2018134948A (ru) | 2020-04-08 |
| WO2017155765A1 (en) | 2017-09-14 |
| MA43811A (fr) | 2018-11-28 |
| KR20180121948A (ko) | 2018-11-09 |
| CA3016341A1 (en) | 2017-09-14 |
| AU2017228870A1 (en) | 2018-09-06 |
| AU2017228870B2 (en) | 2021-02-18 |
| BR112018067930A8 (pt) | 2023-04-11 |
| CN108778273A (zh) | 2018-11-09 |
| CN108778273B (zh) | 2022-06-17 |
| US10407421B2 (en) | 2019-09-10 |
| EP3426248A1 (en) | 2019-01-16 |
| US20190071436A1 (en) | 2019-03-07 |
| JP7034929B2 (ja) | 2022-03-14 |
| MX2018010878A (es) | 2018-11-09 |
| RU2733402C2 (ru) | 2020-10-01 |
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Patent event code: PX09011S01I Patent event date: 20220314 Comment text: Decision to Refuse Application Patent event code: PX09012R01I Patent event date: 20211116 Comment text: Amendment to Specification, etc. Patent event code: PX09012R01I Patent event date: 20200227 Comment text: Amendment to Specification, etc. |
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Patent event date: 20220602 Comment text: Decision to Grant Registration Patent event code: PX07013S01D Patent event date: 20220513 Comment text: Amendment to Specification, etc. Patent event code: PX07012R01I Patent event date: 20220314 Comment text: Decision to Refuse Application Patent event code: PX07011S01I Patent event date: 20211116 Comment text: Amendment to Specification, etc. Patent event code: PX07012R01I Patent event date: 20200227 Comment text: Amendment to Specification, etc. Patent event code: PX07012R01I |
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