JP7034929B2 - 二環式アリールモノバクタム化合物及び細菌感染症を治療するためにそれらを使用する方法 - Google Patents
二環式アリールモノバクタム化合物及び細菌感染症を治療するためにそれらを使用する方法 Download PDFInfo
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- JP7034929B2 JP7034929B2 JP2018546678A JP2018546678A JP7034929B2 JP 7034929 B2 JP7034929 B2 JP 7034929B2 JP 2018546678 A JP2018546678 A JP 2018546678A JP 2018546678 A JP2018546678 A JP 2018546678A JP 7034929 B2 JP7034929 B2 JP 7034929B2
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- Prior art keywords
- alkyl
- alkylene
- heta
- tert
- cycloalkyl
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- 0 *C(*)([C@](CNC(C(C1=NC(N)=S*1)=NO***IICCN)=O)C1=O)N1NCCS(O)(=O)=O Chemical compound *C(*)([C@](CNC(C(C1=NC(N)=S*1)=NO***IICCN)=O)C1=O)N1NCCS(O)(=O)=O 0.000 description 17
- DTQVDTLACAAQTR-UHFFFAOYSA-M [O-]C(C(F)(F)F)=O Chemical compound [O-]C(C(F)(F)F)=O DTQVDTLACAAQTR-UHFFFAOYSA-M 0.000 description 3
- AJMDMNYTTSGFEL-UHFFFAOYSA-N CC1CNC(C)(C)C1 Chemical compound CC1CNC(C)(C)C1 AJMDMNYTTSGFEL-UHFFFAOYSA-N 0.000 description 2
- STTAXGNNBZAZRU-GXBUFBABSA-N CC(C)(C(C1=O)NC(/C(/c2c[s]c(N)n2)=N\OC(COc(cc2)cc(c(N)c3)c2nc3NCC2CNC2)C(O)=O)=O)N1OS(O)(=O)=O Chemical compound CC(C)(C(C1=O)NC(/C(/c2c[s]c(N)n2)=N\OC(COc(cc2)cc(c(N)c3)c2nc3NCC2CNC2)C(O)=O)=O)N1OS(O)(=O)=O STTAXGNNBZAZRU-GXBUFBABSA-N 0.000 description 1
- STMLGZKRANMWMR-BOXJOGJDSA-N CC(C)(C(C1=O)NC(/C(/c2c[s]c(N)n2)=N\O[C@@H](COc2cc3ccc(N(CCCN)CC4CNC4)nc3cc2)C(O)=O)=O)N1OS(O)(=O)=O Chemical compound CC(C)(C(C1=O)NC(/C(/c2c[s]c(N)n2)=N\O[C@@H](COc2cc3ccc(N(CCCN)CC4CNC4)nc3cc2)C(O)=O)=O)N1OS(O)(=O)=O STMLGZKRANMWMR-BOXJOGJDSA-N 0.000 description 1
- PLWFLAWXUJNXJD-OIJGQNCOSA-N CC(C)(C(C1=O)NC(/C(/c2c[s]c(N)n2)=N\O[C@@H](COc2cc3ccc(NCCCN(CC4CNC4)CC4CNC4)nc3cc2)C(O)=O)=O)N1OS(O)(=O)=O Chemical compound CC(C)(C(C1=O)NC(/C(/c2c[s]c(N)n2)=N\O[C@@H](COc2cc3ccc(NCCCN(CC4CNC4)CC4CNC4)nc3cc2)C(O)=O)=O)N1OS(O)(=O)=O PLWFLAWXUJNXJD-OIJGQNCOSA-N 0.000 description 1
- IOKGWQZQCNXXLD-UHFFFAOYSA-N CC(C)(C)OC(NCCCBr)=O Chemical compound CC(C)(C)OC(NCCCBr)=O IOKGWQZQCNXXLD-UHFFFAOYSA-N 0.000 description 1
- KFRGFSJMQYPDRO-UHFFFAOYSA-N CC(C)(C)OC(NCCCNCC(C1)CN1C(OC(C)(C)C)=O)=O Chemical compound CC(C)(C)OC(NCCCNCC(C1)CN1C(OC(C)(C)C)=O)=O KFRGFSJMQYPDRO-UHFFFAOYSA-N 0.000 description 1
- XKTIXTLCIPJGSM-UHFFFAOYSA-N CC(C)(C)OC(NCCC[n](cc1)nc1N)=O Chemical compound CC(C)(C)OC(NCCC[n](cc1)nc1N)=O XKTIXTLCIPJGSM-UHFFFAOYSA-N 0.000 description 1
- LDTMNHIZDFDFFY-UHFFFAOYSA-N CC(C)(C)OC(Nc1nc(C(C(O)=O)=O)c[s]1)=O Chemical compound CC(C)(C)OC(Nc1nc(C(C(O)=O)=O)c[s]1)=O LDTMNHIZDFDFFY-UHFFFAOYSA-N 0.000 description 1
- JPQCZOUBLNGLCZ-UHFFFAOYSA-N CC(C)(C)OC(Nc1nc(C(C(O)=O)=O)n[s]1)=O Chemical compound CC(C)(C)OC(Nc1nc(C(C(O)=O)=O)n[s]1)=O JPQCZOUBLNGLCZ-UHFFFAOYSA-N 0.000 description 1
- UIPWOQFEUXUECH-UHFFFAOYSA-N CC(C)(C)OC(Nc1nc(C)n[s]1)=O Chemical compound CC(C)(C)OC(Nc1nc(C)n[s]1)=O UIPWOQFEUXUECH-UHFFFAOYSA-N 0.000 description 1
- QWJLAKXKMDRERJ-VWLOTQADSA-N CC(C)(C)OC([C@H](COc(cc1)cc2c1c(NC(C1)CN1C(OC(C)(C)C)=O)ncc2)ON(C(c1c2cccc1)=O)C2=O)=O Chemical compound CC(C)(C)OC([C@H](COc(cc1)cc2c1c(NC(C1)CN1C(OC(C)(C)C)=O)ncc2)ON(C(c1c2cccc1)=O)C2=O)=O QWJLAKXKMDRERJ-VWLOTQADSA-N 0.000 description 1
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- LKSKITFMSMRGHW-KTXNWRNMSA-N CC(C)([C@@H](C1=O)NC(/C(/c2c[s]c(N)n2)=N\O[C@@H](COc2cc3ccc(NCCCNCC4CNC4)nc3cc2)C(O)=O)=O)N1OS(O)(=O)=O Chemical compound CC(C)([C@@H](C1=O)NC(/C(/c2c[s]c(N)n2)=N\O[C@@H](COc2cc3ccc(NCCCNCC4CNC4)nc3cc2)C(O)=O)=O)N1OS(O)(=O)=O LKSKITFMSMRGHW-KTXNWRNMSA-N 0.000 description 1
- UKXSDSAVZFLVDE-KWABXKTDSA-N CC(C)([C@@H](C1=O)NC(/C(/c2c[s]c(N)n2)=N\O[C@H](COc(cc2)cc(cc3)c2nc3NC2CNC2)c2n[nH]nn2)=O)N1OS(O)(=O)=O Chemical compound CC(C)([C@@H](C1=O)NC(/C(/c2c[s]c(N)n2)=N\O[C@H](COc(cc2)cc(cc3)c2nc3NC2CNC2)c2n[nH]nn2)=O)N1OS(O)(=O)=O UKXSDSAVZFLVDE-KWABXKTDSA-N 0.000 description 1
- OLQXKZHSXLLYHN-GXGYXBNZSA-N CC(C)([C@@H](C1O)NC(/C(/c2c[s]c(N)n2)=N\OC(COc(cc2)cc(c(N)c3)c2nc3NCC2CNC2)C(O)=O)=O)N1OS(O)(=O)=O Chemical compound CC(C)([C@@H](C1O)NC(/C(/c2c[s]c(N)n2)=N\OC(COc(cc2)cc(c(N)c3)c2nc3NCC2CNC2)C(O)=O)=O)N1OS(O)(=O)=O OLQXKZHSXLLYHN-GXGYXBNZSA-N 0.000 description 1
- AXXBKXZGJNPDDV-MXWOKKETSA-N CC(C)([C@@H](C1O)NC(/C(/c2c[s]c(N)n2)=N\OC(COc(cc2)cc(cc3)c2nc3NC2CNC2)c2n[nH]nn2)=O)N1OS(O)(=O)=O Chemical compound CC(C)([C@@H](C1O)NC(/C(/c2c[s]c(N)n2)=N\OC(COc(cc2)cc(cc3)c2nc3NC2CNC2)c2n[nH]nn2)=O)N1OS(O)(=O)=O AXXBKXZGJNPDDV-MXWOKKETSA-N 0.000 description 1
- CDODDZJCEADUQQ-UHFFFAOYSA-N CC1(C)CNCCC1 Chemical compound CC1(C)CNCCC1 CDODDZJCEADUQQ-UHFFFAOYSA-N 0.000 description 1
- UZOFELREXGAFOI-UHFFFAOYSA-N CC1CCNCC1 Chemical compound CC1CCNCC1 UZOFELREXGAFOI-UHFFFAOYSA-N 0.000 description 1
- SBJJYYYROWTLCA-UHFFFAOYSA-N CCCC(C=N)S Chemical compound CCCC(C=N)S SBJJYYYROWTLCA-UHFFFAOYSA-N 0.000 description 1
- XNVRKLCQBZTGNA-UHFFFAOYSA-N CCOC(C(c1c[s]c(N)n1)=O)=O Chemical compound CCOC(C(c1c[s]c(N)n1)=O)=O XNVRKLCQBZTGNA-UHFFFAOYSA-N 0.000 description 1
- VMVNZNXAVJHNDJ-UHFFFAOYSA-N COC(C(F)(F)F)=O Chemical compound COC(C(F)(F)F)=O VMVNZNXAVJHNDJ-UHFFFAOYSA-N 0.000 description 1
- DJKUIGPCSNRFRK-UHFFFAOYSA-N Cc1n[s]c(N)n1 Chemical compound Cc1n[s]c(N)n1 DJKUIGPCSNRFRK-UHFFFAOYSA-N 0.000 description 1
- HLUOWZVVIRLAQL-UHFFFAOYSA-N Cc1nc(CC(O)=O)n[s]1 Chemical compound Cc1nc(CC(O)=O)n[s]1 HLUOWZVVIRLAQL-UHFFFAOYSA-N 0.000 description 1
- JPNFAEKTXXGPCO-UHFFFAOYSA-N NC(C(O)=O)(N)N Chemical compound NC(C(O)=O)(N)N JPNFAEKTXXGPCO-UHFFFAOYSA-N 0.000 description 1
- JVVRJMXHNUAPHW-UHFFFAOYSA-N Nc1n[nH]cc1 Chemical compound Nc1n[nH]cc1 JVVRJMXHNUAPHW-UHFFFAOYSA-N 0.000 description 1
- BTNAZHHYONIOIV-UHFFFAOYSA-N O=S1(N=Cc2c1cccc2)=O Chemical compound O=S1(N=Cc2c1cccc2)=O BTNAZHHYONIOIV-UHFFFAOYSA-N 0.000 description 1
- XZNOAVNRSFURIR-UHFFFAOYSA-N OC(C(F)(F)F)(C(F)(F)F)C(F)(F)F Chemical compound OC(C(F)(F)F)(C(F)(F)F)C(F)(F)F XZNOAVNRSFURIR-UHFFFAOYSA-N 0.000 description 1
- AWJUIBRHMBBTKR-UHFFFAOYSA-N c1cc2ccncc2cc1 Chemical compound c1cc2ccncc2cc1 AWJUIBRHMBBTKR-UHFFFAOYSA-N 0.000 description 1
- KTZQTRPPVKQPFO-UHFFFAOYSA-N c1n[o]c2c1cccc2 Chemical compound c1n[o]c2c1cccc2 KTZQTRPPVKQPFO-UHFFFAOYSA-N 0.000 description 1
- CSNIZNHTOVFARY-UHFFFAOYSA-N c1n[s]c2c1cccc2 Chemical compound c1n[s]c2c1cccc2 CSNIZNHTOVFARY-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/424—Oxazoles condensed with heterocyclic ring systems, e.g. clavulanic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C53/00—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen
- C07C53/15—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen containing halogen
- C07C53/16—Halogenated acetic acids
- C07C53/18—Halogenated acetic acids containing fluorine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/429—Thiazoles condensed with heterocyclic ring systems
- A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
- A61K31/431—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems containing further heterocyclic rings, e.g. ticarcillin, azlocillin, oxacillin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662304447P | 2016-03-07 | 2016-03-07 | |
| US62/304,447 | 2016-03-07 | ||
| PCT/US2017/020303 WO2017155765A1 (en) | 2016-03-07 | 2017-03-02 | Bicyclic aryl monobactam compounds and methods of use thereof for the treatment of bacterial infections |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019507768A JP2019507768A (ja) | 2019-03-22 |
| JP2019507768A5 JP2019507768A5 (enExample) | 2020-04-02 |
| JP7034929B2 true JP7034929B2 (ja) | 2022-03-14 |
Family
ID=59789685
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018546678A Active JP7034929B2 (ja) | 2016-03-07 | 2017-03-02 | 二環式アリールモノバクタム化合物及び細菌感染症を治療するためにそれらを使用する方法 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US10407421B2 (enExample) |
| EP (1) | EP3426248B1 (enExample) |
| JP (1) | JP7034929B2 (enExample) |
| KR (1) | KR102408800B1 (enExample) |
| CN (1) | CN108778273B (enExample) |
| AU (1) | AU2017228870B2 (enExample) |
| BR (1) | BR112018067930B1 (enExample) |
| CA (1) | CA3016341A1 (enExample) |
| MA (1) | MA43811A (enExample) |
| MX (1) | MX2018010878A (enExample) |
| RU (1) | RU2733402C2 (enExample) |
| WO (1) | WO2017155765A1 (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2018010878A (es) | 2016-03-07 | 2018-11-09 | Merck Sharp & Dohme | Compuestos de aril-monobactam biciclicos y metodos de uso de los mismos para el tratamiento de infecciones bacterianas. |
| MA48994A (fr) | 2017-03-30 | 2020-02-05 | Hoffmann La Roche | Isoquinoléines utilisées en tant qu'inhibiteurs de hpk1 |
| MA50629A (fr) * | 2017-10-02 | 2021-03-31 | Merck Sharp & Dohme | Composés monobactames de chromane pour le traitement d'infections bactériennes |
| US11459323B2 (en) | 2018-01-29 | 2022-10-04 | Medshine Discovery Inc. | Monocyclic β-lactam compound for treating bacterial infection |
| JP7386841B2 (ja) | 2018-07-24 | 2023-11-27 | エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト | イソキノリン化合物及びその使用 |
| TW202024053A (zh) | 2018-10-02 | 2020-07-01 | 美商建南德克公司 | 異喹啉化合物及其用途 |
| US11612606B2 (en) | 2018-10-03 | 2023-03-28 | Genentech, Inc. | 8-aminoisoquinoline compounds and uses thereof |
| KR20210083285A (ko) * | 2018-11-13 | 2021-07-06 | 난징 산홈 팔마세우티칼 컴퍼니 리미티드 | 모노박탐 화합물 및 그의 사용 |
| WO2020125670A1 (zh) * | 2018-12-18 | 2020-06-25 | 南京明德新药研发有限公司 | 单环β-内酰胺化合物在制药中的应用 |
| CN111018777B (zh) * | 2019-11-25 | 2021-02-12 | 武汉智顿科技发展有限公司 | 一种地喹氯铵的制备方法 |
| CN110963967B (zh) * | 2019-11-25 | 2021-02-12 | 武汉智顿科技发展有限公司 | 一种2-甲基-4-氨基喹啉的制备方法 |
| CN111303144B (zh) * | 2019-12-13 | 2020-11-27 | 苏州信诺维医药科技有限公司 | 一种治疗细菌感染的化合物 |
| CN114828850B (zh) * | 2019-12-19 | 2024-08-13 | 深圳嘉科生物科技有限公司 | 化合物在制药中的应用 |
| EP4146650A4 (en) | 2020-09-01 | 2024-01-17 | Ningxia Academy of Agriculture and Forestry Sciences | BETA-LACTAMASE INHIBITORS AND THEIR PRODUCTION |
| WO2022208356A1 (en) | 2021-03-31 | 2022-10-06 | Fedora Pharmaceuticals Inc. | Lactivicin compounds, their preparation and use as antibacterial agents |
| EP4146651A4 (en) | 2021-05-07 | 2024-06-05 | Ningxia Academy of Agriculture and Forestry Sciences | SULFONYLAMIDINE SUBSTITUTED COMPOUNDS AND THEIR USE AS BETA-LACTAMASE INHIBITORS |
| EP4431113A4 (en) * | 2021-11-09 | 2025-10-22 | Inst Med Biotechnology Cams | PHARMACEUTICAL COMPOSITION CONTAINING A ß-LACTAM COMPOUND AND USE THEREOF |
| IL320644A (en) * | 2022-11-07 | 2025-07-01 | Univ Kyoto | Quinazoline derivatives |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2015504907A (ja) | 2012-01-24 | 2015-02-16 | アイクリス ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディトゲゼルシャフト | アミジン置換β−ラクタム化合物類、それらの調製及び抗菌剤 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4684722A (en) | 1986-01-06 | 1987-08-04 | E. R. Squibb & Sons, Inc. | Monosulfactams |
| US5250691A (en) * | 1991-09-09 | 1993-10-05 | E. R. Squibb & Sons, Inc. | Heteroaryl derivatives of monocyclic beta-lactam antibiotics |
| MY127641A (en) * | 1995-10-12 | 2006-12-29 | Essential Therapeutics Inc | Cephalosporin antibiotics |
| RU2269525C2 (ru) * | 2000-08-10 | 2006-02-10 | Бритиш Биотех Фармасьютикалс Лимитед | Антибактериальные агенты |
| SI1965798T1 (sl) | 2005-12-07 | 2012-01-31 | Basilea Pharmaceutica Ag | Uporabni monobaktamski antibiotiki |
| CA2691987C (en) * | 2007-06-12 | 2016-08-16 | Achaogen, Inc. | Antibacterial agents |
| DK2646436T3 (en) | 2010-11-29 | 2015-06-29 | Pfizer | monobactams |
| US20140275007A1 (en) | 2013-03-14 | 2014-09-18 | Rempex Pharmaceuticals, Inc. | Oxamazin antibiotics |
| ES2719136T3 (es) | 2014-03-24 | 2019-07-08 | Novartis Ag | Compuestos orgánicos de monobactam para el tratamiento de infecciones bacterianas |
| MX2018010878A (es) | 2016-03-07 | 2018-11-09 | Merck Sharp & Dohme | Compuestos de aril-monobactam biciclicos y metodos de uso de los mismos para el tratamiento de infecciones bacterianas. |
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| JP2015504907A (ja) | 2012-01-24 | 2015-02-16 | アイクリス ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディトゲゼルシャフト | アミジン置換β−ラクタム化合物類、それらの調製及び抗菌剤 |
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| AU2017228870A1 (en) | 2018-09-06 |
| RU2018134948A3 (enExample) | 2020-04-08 |
| CN108778273A (zh) | 2018-11-09 |
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| RU2018134948A (ru) | 2020-04-08 |
| AU2017228870B2 (en) | 2021-02-18 |
| KR20180121948A (ko) | 2018-11-09 |
| EP3426248A1 (en) | 2019-01-16 |
| MA43811A (fr) | 2018-11-28 |
| RU2733402C2 (ru) | 2020-10-01 |
| BR112018067930A2 (pt) | 2019-01-22 |
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| CA3016341A1 (en) | 2017-09-14 |
| BR112018067930A8 (pt) | 2023-04-11 |
| MX2018010878A (es) | 2018-11-09 |
| EP3426248B1 (en) | 2023-11-15 |
| JP2019507768A (ja) | 2019-03-22 |
| BR112018067930B1 (pt) | 2024-02-15 |
| US20190071436A1 (en) | 2019-03-07 |
| WO2017155765A1 (en) | 2017-09-14 |
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