KR102395543B1 - 기능화된 벤조피란 화합물 및 이의 용도 - Google Patents

기능화된 벤조피란 화합물 및 이의 용도 Download PDF

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KR102395543B1
KR102395543B1 KR1020167021722A KR20167021722A KR102395543B1 KR 102395543 B1 KR102395543 B1 KR 102395543B1 KR 1020167021722 A KR1020167021722 A KR 1020167021722A KR 20167021722 A KR20167021722 A KR 20167021722A KR 102395543 B1 KR102395543 B1 KR 102395543B1
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compound
cancer
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KR20160110427A (ko
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앤드루 히튼
데이비드 브라운
그레이엄 켈리
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카지아 테라퓨틱스 리미티드
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
    • C07D311/08—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring
    • C07D311/16—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring substituted in position 7
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing aromatic rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1020167021722A 2014-02-07 2015-02-05 기능화된 벤조피란 화합물 및 이의 용도 Active KR102395543B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201461937368P 2014-02-07 2014-02-07
US61/937,368 2014-02-07
US201461987323P 2014-05-01 2014-05-01
US61/987,323 2014-05-01
PCT/AU2015/050040 WO2015117202A1 (en) 2014-02-07 2015-02-05 Functionalised benzopyran compounds and use thereof

Publications (2)

Publication Number Publication Date
KR20160110427A KR20160110427A (ko) 2016-09-21
KR102395543B1 true KR102395543B1 (ko) 2022-05-09

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US (2) US9701655B2 (enExample)
EP (1) EP2953938B1 (enExample)
JP (1) JP6570042B2 (enExample)
KR (1) KR102395543B1 (enExample)
CN (2) CN108484559A (enExample)
AU (1) AU2015213484B2 (enExample)
BR (1) BR112016018099B8 (enExample)
CA (1) CA2936012C (enExample)
CL (1) CL2016001937A1 (enExample)
DK (1) DK2953938T3 (enExample)
ES (1) ES2643407T3 (enExample)
IL (1) IL241515B (enExample)
LT (1) LT2953938T (enExample)
MX (1) MX368063B (enExample)
MY (1) MY195739A (enExample)
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PH (1) PH12016501422B1 (enExample)
PL (1) PL2953938T3 (enExample)
PT (1) PT2953938T (enExample)
RU (1) RU2676766C2 (enExample)
SA (1) SA516371583B1 (enExample)
SG (2) SG11201506988TA (enExample)
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WO (1) WO2015117202A1 (enExample)

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MY195739A (en) * 2014-02-07 2023-02-08 Novogen ltd Functionalised Benzopyran Compounds and use Thereof
EP3253208B1 (en) 2015-02-02 2021-05-05 MEI Pharma, Inc. Combination therapies for use in the treatment of breast cancer
US10265294B2 (en) 2016-03-31 2019-04-23 Yale University Compositions and methods for treating epithelial cancer
CA3058492A1 (en) * 2016-04-06 2017-10-12 Noxopharm Limited Radiotherapy improvements
WO2017173498A1 (en) 2016-04-06 2017-10-12 Noxopharm Limited Isoflavonoid composition with improved pharmacokinetics
CN109730996B (zh) * 2017-03-01 2021-08-24 浙江大学 喹啉结构类型雄激素受体拮抗剂及其应用
AU2021247415A1 (en) 2020-03-30 2022-09-29 Noxopharm Limited Methods for the treatment of inflammation associated with infection
CA3181730A1 (en) * 2020-06-11 2021-12-16 Daniel P. Gold Combination therapies
WO2023235929A1 (en) * 2022-06-08 2023-12-14 Noxopharm Limited Functionalised benzopyran compounds and uses thereof
CN118005594B (zh) * 2023-05-24 2024-10-29 内蒙古大学 3-羟基苯并二氢吡喃衍生物的合成及其抗肿瘤活性

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PL2953938T3 (pl) 2017-12-29
PH12016501422B1 (en) 2022-02-16
PH12016501422A1 (en) 2016-08-31
BR112016018099B8 (pt) 2023-01-17
MX2016010137A (es) 2017-02-15
AU2015213484A1 (en) 2015-09-17
CA2936012C (en) 2023-03-07
CL2016001937A1 (es) 2017-01-20
CN105980372A (zh) 2016-09-28
EP2953938B1 (en) 2017-08-02
LT2953938T (lt) 2017-10-10
BR112016018099B1 (pt) 2022-10-11
PT2953938T (pt) 2017-10-09
NZ711603A (en) 2017-05-26
US9701655B2 (en) 2017-07-11
IL241515B (en) 2019-06-30
US10370349B2 (en) 2019-08-06
WO2015117202A1 (en) 2015-08-13
SG11201604490SA (en) 2016-07-28
EP2953938A4 (en) 2016-08-10
DK2953938T3 (en) 2017-10-02
BR112016018099A2 (pt) 2017-08-08
US20160340329A1 (en) 2016-11-24
JP2017507175A (ja) 2017-03-16
JP6570042B2 (ja) 2019-09-04
CA2936012A1 (en) 2015-08-13
US20180141925A1 (en) 2018-05-24
SI2953938T1 (en) 2018-01-31
CN105980372B (zh) 2018-05-08
IL241515A0 (en) 2015-11-30
RU2016133731A (ru) 2018-03-12
HK1218914A1 (en) 2017-03-17
RU2676766C2 (ru) 2019-01-11
CN108484559A (zh) 2018-09-04
MX368063B (es) 2019-09-18
ES2643407T3 (es) 2017-11-22
EP2953938A1 (en) 2015-12-16
SA516371583B1 (ar) 2019-04-18
RU2016133731A3 (enExample) 2018-08-08
AU2015213484B2 (en) 2015-11-05
SG11201506988TA (en) 2015-10-29
MY195739A (en) 2023-02-08
KR20160110427A (ko) 2016-09-21

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