KR102376248B1 - 삼환성 스피로 화합물 - Google Patents

삼환성 스피로 화합물 Download PDF

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KR102376248B1
KR102376248B1 KR1020177018905A KR20177018905A KR102376248B1 KR 102376248 B1 KR102376248 B1 KR 102376248B1 KR 1020177018905 A KR1020177018905 A KR 1020177018905A KR 20177018905 A KR20177018905 A KR 20177018905A KR 102376248 B1 KR102376248 B1 KR 102376248B1
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cyclopropane
amino
carbonyl
phenyl
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KR20170102885A (ko
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마사키 아사다
고스케 다니
마사야 히로베
사토노리 히구치
가즈히로 후치베
료 오이카와
도루 고타니
히로츠구 다카노
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오노 야꾸힝 고교 가부시키가이샤
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Priority to KR1020227007889A priority Critical patent/KR102559499B1/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/63—Carboxylic acid nitriles containing cyano groups and nitrogen atoms further bound to other hetero atoms, other than oxygen atoms of nitro or nitroso groups, bound to the same carbon skeleton
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    • A61K31/275—Nitriles; Isonitriles
    • A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
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    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
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    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
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    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
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Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ733575A (en) * 2015-01-09 2022-10-28 Ono Pharmaceutical Co Tricyclic spiro compound
CR20180323A (es) 2015-11-20 2018-08-06 Idorsia Pharmaceuticals Ltd Derivados de indol n-sustituídos como moduladores de los receptores de pge2
HUE057799T2 (hu) 2016-07-07 2022-06-28 Ono Pharmaceutical Co EP4 antagonistát és immunellenõrzõpont gátlót tartalmazó kombináció
CN110621667A (zh) 2017-05-18 2019-12-27 爱杜西亚药品有限公司 嘧啶衍生物
PL3625228T3 (pl) 2017-05-18 2021-12-20 Idorsia Pharmaceuticals Ltd Pochodne pirymidyny jako modulatory receptora pge2
EA201992676A1 (ru) 2017-05-18 2020-05-06 Идорсия Фармасьютиклз Лтд Фенильные производные в качестве модуляторов pge2 рецепторов
CN110621671A (zh) 2017-05-18 2019-12-27 爱杜西亚药品有限公司 作为pge2受体调节剂的苯并呋喃及苯并噻吩衍生物
EP3625224B1 (en) 2017-05-18 2021-08-04 Idorsia Pharmaceuticals Ltd N-substituted indole derivatives
WO2018216640A1 (ja) 2017-05-22 2018-11-29 小野薬品工業株式会社 Ｅｐ４アンタゴニスト
JP7159007B2 (ja) * 2017-11-01 2022-10-24 小野薬品工業株式会社 脳腫瘍の治療のための医薬
CN112300019A (zh) * 2019-07-31 2021-02-02 华东师范大学 一种邻乙酰氨基苯丁酸类化合物的制备方法
US20230390303A1 (en) 2020-11-13 2023-12-07 Ono Pharmaceutical Co., Ltd. Cancer treatment by combination of ep4 antagonist and immune checkpoint inhibitor
JP2024016314A (ja) * 2020-12-24 2024-02-07 小野薬品工業株式会社 一般式（ｉ－ａ）で示される化合物、その薬学的に許容される塩、またはそれらの水和物と免疫チェックポイント阻害薬および／またはｅｐ４受容体拮抗薬との組み合わせ
CN117377656A (zh) * 2021-05-28 2024-01-09 南京明德新药研发有限公司 苯并螺杂环衍生物及其应用
US20250092008A1 (en) 2021-08-10 2025-03-20 Ono Pharmaceutical Co., Ltd. Process for making an ep4 antagonist
WO2025135108A1 (ja) * 2023-12-22 2025-06-26 Ａｇｃ株式会社 新規なｅｐ４アンタゴニスト
WO2025212569A1 (en) 2024-04-05 2025-10-09 Park City Bio, LLC Selective serotonin receptor modultors and methods of making and using the same

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002016311A1 (en) 2000-08-22 2002-02-28 Ono Pharmaceutical Co., Ltd. Carboxylic acid derivatives, process for producing the same and drugs containing the same as the active ingredient
JP2002506851A (ja) 1998-03-13 2002-03-05 メルク フロスト カナダ アンド カンパニー カルボン酸類およびアシルスルホンアミド類、そのような化合物を含む組成物ならびに治療方法
JP2002526517A (ja) 1998-10-07 2002-08-20 メルク フロスト カナダ アンド カンパニー プロスタグランジン受容体リガンド
WO2003016254A1 (en) 2001-08-09 2003-02-27 Ono Pharmaceutical Co., Ltd. Carboxylic acid derivative compounds and drugs comprising these compounds as the active ingredient
WO2004037247A1 (en) 2002-10-21 2004-05-06 Irm Llc Oxindoles with anti-hiv activity
JP2004517099A (ja) 2000-12-21 2004-06-10 グラクソ グループ リミテッド Ｅｐ４受容体に結合するナフタレン誘導体

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2081679A1 (en) 1991-11-27 1993-05-28 Raj N. Misra Gem-dialkyl-7-oxabicycloheptyl substituted heterocyclic amide prostaglandin analogs useful in the treatment of thrombotic and vasospastic disease
EP1071648A2 (en) * 1998-03-13 2001-01-31 Merck Frosst Canada & Co. Carboxylic acids and acylsulfonamides, compositions containing such compounds and methods of treatment
US6242493B1 (en) * 1998-03-13 2001-06-05 Merck Frosst Canada & Co. Carboxylic acids and acylsulfonamides, compositions containing such compounds and methods of treatment
AU2003211574A1 (en) 2002-03-05 2003-09-16 Ono Pharmaceutical Co., Ltd. 8-azaprostaglandin derivative compounds and drugs containing the compounds as the active ingredient
UA80474C2 (en) * 2003-02-26 2007-09-25 Sugen Inc Aminoheteroaryl compounds as inhibitors of protein kinase
AP2006003769A0 (en) 2004-05-04 2006-10-31 Pfizer Ortho substituted aryl or heteroaryl amide compounds
GB0808282D0 (en) 2008-05-07 2008-06-11 Medical Res Council Compounds for use in stabilizing p53 mutants
WO2012071458A1 (en) * 2010-11-22 2012-05-31 Array Biopharma Inc. Heterocyclic inhibitors of beta - secretase for the treatment of neurodegenerative diseases
EP2729445B1 (en) * 2011-07-04 2015-10-21 Rottapharm Biotech S.r.l. Cyclic amine derivatives as ep4 receptor antagonists
US20150004175A1 (en) 2011-12-13 2015-01-01 Yale University Compositions and Methods for Reducing CTL Exhaustion
RU2016101548A (ru) * 2013-07-03 2017-08-08 Ф. Хоффманн-Ля Рош Аг Соединения амидов гетероарилпиридона и азапиридона
NZ733575A (en) * 2015-01-09 2022-10-28 Ono Pharmaceutical Co Tricyclic spiro compound
HUE057799T2 (hu) * 2016-07-07 2022-06-28 Ono Pharmaceutical Co EP4 antagonistát és immunellenõrzõpont gátlót tartalmazó kombináció

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002506851A (ja) 1998-03-13 2002-03-05 メルク フロスト カナダ アンド カンパニー カルボン酸類およびアシルスルホンアミド類、そのような化合物を含む組成物ならびに治療方法
JP2002526517A (ja) 1998-10-07 2002-08-20 メルク フロスト カナダ アンド カンパニー プロスタグランジン受容体リガンド
WO2002016311A1 (en) 2000-08-22 2002-02-28 Ono Pharmaceutical Co., Ltd. Carboxylic acid derivatives, process for producing the same and drugs containing the same as the active ingredient
JP2004517099A (ja) 2000-12-21 2004-06-10 グラクソ グループ リミテッド Ｅｐ４受容体に結合するナフタレン誘導体
WO2003016254A1 (en) 2001-08-09 2003-02-27 Ono Pharmaceutical Co., Ltd. Carboxylic acid derivative compounds and drugs comprising these compounds as the active ingredient
WO2004037247A1 (en) 2002-10-21 2004-05-06 Irm Llc Oxindoles with anti-hiv activity

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