BR112017014740A2 - composto espiro tricíclico - Google Patents
composto espiro tricíclicoInfo
- Publication number
- BR112017014740A2 BR112017014740A2 BR112017014740-8A BR112017014740A BR112017014740A2 BR 112017014740 A2 BR112017014740 A2 BR 112017014740A2 BR 112017014740 A BR112017014740 A BR 112017014740A BR 112017014740 A2 BR112017014740 A2 BR 112017014740A2
- Authority
- BR
- Brazil
- Prior art keywords
- receptor
- spiro compound
- prevention
- treatment
- activity against
- Prior art date
Links
- 150000003413 spiro compounds Chemical class 0.000 title 1
- 101150109738 Ptger4 gene Proteins 0.000 abstract 4
- 230000004913 activation Effects 0.000 abstract 2
- 230000003042 antagnostic effect Effects 0.000 abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 230000002265 prevention Effects 0.000 abstract 2
- 239000004480 active ingredient Substances 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/275—Nitriles; Isonitriles
- A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
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- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
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- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
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- A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
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- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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Abstract
é fornecido aqui um agente medicinal para a prevenção e/ou tratamento de doenças causadas por ativação do receptor ep4. um composto tendo atividade antagonista contra o receptor ep4 está contido como um ingrediente ativo no agente medicinal. o composto representado pela seguinte fórmula geral (i), um sal, um n-óxido ou um solvato deste, ou um pró-fármaco deste é útil como um componente medicinal tendo atividade antagonista contra o receptor ep4 para a prevenção e/ou tratamento de doenças causadas por ativação do receptor ep4. na fórmula, todos os símbolos são como definidos na especificação.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2015002712 | 2015-01-09 | ||
JP2015-002712 | 2015-01-09 | ||
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CR20180323A (es) | 2015-11-20 | 2018-08-06 | Idorsia Pharmaceuticals Ltd | Derivados de indol n-sustituídos como moduladores de los receptores de pge2 |
MY197673A (en) | 2016-07-07 | 2023-07-03 | Ono Pharmaceutical Co | Combination comprising ep4 antagonist and immune checkpoint inhibitor |
MA49127B1 (fr) | 2017-05-18 | 2022-05-31 | Idorsia Pharmaceuticals Ltd | Dérivés d'indole n-substitués |
SG11201908729UA (en) | 2017-05-18 | 2019-10-30 | Idorsia Pharmaceuticals Ltd | Phenyl derivatives as pge2 receptor modulators |
AR111807A1 (es) | 2017-05-18 | 2019-08-21 | Idorsia Pharmaceuticals Ltd | Derivados de benzofurano y benzotiofeno como moduladores del receptor pge2 |
CA3063788A1 (en) | 2017-05-18 | 2018-11-22 | Idorsia Pharmaceuticals Ltd | Pyrimidine derivatives |
AU2018268311B2 (en) | 2017-05-18 | 2022-02-10 | Idorsia Pharmaceuticals Ltd | Pyrimidine derivatives as PGE2 receptor modulators |
WO2018216640A1 (ja) | 2017-05-22 | 2018-11-29 | 小野薬品工業株式会社 | Ep4アンタゴニスト |
JP7159007B2 (ja) * | 2017-11-01 | 2022-10-24 | 小野薬品工業株式会社 | 脳腫瘍の治療のための医薬 |
CN112300019A (zh) * | 2019-07-31 | 2021-02-02 | 华东师范大学 | 一种邻乙酰氨基苯丁酸类化合物的制备方法 |
JPWO2022102731A1 (pt) | 2020-11-13 | 2022-05-19 | ||
JP2024016314A (ja) * | 2020-12-24 | 2024-02-07 | 小野薬品工業株式会社 | 一般式(i-a)で示される化合物、その薬学的に許容される塩、またはそれらの水和物と免疫チェックポイント阻害薬および/またはep4受容体拮抗薬との組み合わせ |
WO2022247862A1 (zh) * | 2021-05-28 | 2022-12-01 | 南京明德新药研发有限公司 | 苯并螺杂环衍生物及其应用 |
JP7205657B1 (ja) | 2021-08-10 | 2023-01-17 | 小野薬品工業株式会社 | Ep4アンタゴニストの製造方法 |
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CA2081679A1 (en) * | 1991-11-27 | 1993-05-28 | Raj N. Misra | Gem-dialkyl-7-oxabicycloheptyl substituted heterocyclic amide prostaglandin analogs useful in the treatment of thrombotic and vasospastic disease |
CA2322742A1 (en) * | 1998-03-13 | 1999-09-23 | Merck Frosst Canada & Co./Merck Frosst Canada & Cie | Carboxylic acids and acylsulfonamides, compositions containing such compounds and methods of treatment |
EP1071648A2 (en) * | 1998-03-13 | 2001-01-31 | Merck Frosst Canada & Co. | Carboxylic acids and acylsulfonamides, compositions containing such compounds and methods of treatment |
US6242493B1 (en) | 1998-03-13 | 2001-06-05 | Merck Frosst Canada & Co. | Carboxylic acids and acylsulfonamides, compositions containing such compounds and methods of treatment |
US6211197B1 (en) * | 1998-10-07 | 2001-04-03 | Merck Frosst Canada & Co. | Prostaglandin receptor ligands |
EP1312601A4 (en) * | 2000-08-22 | 2005-09-21 | Ono Pharmaceutical Co | CARBOXYLENE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, AND MEDICAMENTS CONTAINING THEM AS AN ACTIVE SUBSTANCE |
GB0031302D0 (en) * | 2000-12-21 | 2001-01-31 | Glaxo Group Ltd | Napthalene derivatives |
IL160253A0 (en) * | 2001-08-09 | 2004-07-25 | Ono Pharmaceutical Co | Carboxylic acid derivative compounds and drugs comprising these compounds as the active ingredient |
JP4547912B2 (ja) * | 2002-03-05 | 2010-09-22 | 小野薬品工業株式会社 | 8−アザプロスタグランジン誘導体化合物およびその化合物を有効成分として含有する薬剤 |
AU2003286604A1 (en) | 2002-10-21 | 2004-05-13 | Irm Llc | Oxindoles with anti-hiv activity |
SI1603570T1 (sl) * | 2003-02-26 | 2013-03-29 | Sugen, Inc. | Spojine aminoheteroarila kot zaviralci proteinkinaze |
CN1950334A (zh) | 2004-05-04 | 2007-04-18 | 辉瑞有限公司 | 邻位取代的芳基或杂芳基酰胺化合物 |
GB0808282D0 (en) * | 2008-05-07 | 2008-06-11 | Medical Res Council | Compounds for use in stabilizing p53 mutants |
US20120157448A1 (en) * | 2010-11-22 | 2012-06-21 | Adam Cook | Compounds for treating neurodegenerative diseases |
KR101760164B1 (ko) * | 2011-07-04 | 2017-07-20 | 로타팜 바이오테크 에스.알.엘 | Ep4 수용체 길항제로서 사이클릭 아민 유도체 |
WO2013090552A1 (en) | 2011-12-13 | 2013-06-20 | Yale University | Compositions and methods for reducing ctl exhaustion |
CN110698481B (zh) * | 2013-07-03 | 2023-02-28 | 豪夫迈·罗氏有限公司 | 杂芳基吡啶酮和氮杂-吡啶酮酰胺化合物 |
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