KR102362341B1 - 세포 투과성 펩티드, 그를 포함한 컨쥬게이트 및 그를 포함한 조성물 - Google Patents

세포 투과성 펩티드, 그를 포함한 컨쥬게이트 및 그를 포함한 조성물 Download PDF

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KR102362341B1
KR102362341B1 KR1020157009509A KR20157009509A KR102362341B1 KR 102362341 B1 KR102362341 B1 KR 102362341B1 KR 1020157009509 A KR1020157009509 A KR 1020157009509A KR 20157009509 A KR20157009509 A KR 20157009509A KR 102362341 B1 KR102362341 B1 KR 102362341B1
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김상재
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주식회사 젬백스앤카엘
김상재
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
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KR1020157009509A 2012-09-19 2013-09-17 세포 투과성 펩티드, 그를 포함한 컨쥬게이트 및 그를 포함한 조성물 Active KR102362341B1 (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1020227004140A KR102544207B1 (ko) 2012-09-19 2013-09-17 세포 투과성 펩티드, 그를 포함한 컨쥬게이트 및 그를 포함한 조성물

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
KR1020120104144 2012-09-19
KR20120104144 2012-09-19
KR1020120104173 2012-09-19
KR20120104173 2012-09-19
KR1020120109216 2012-09-28
KR20120109207 2012-09-28
KR1020120109207 2012-09-28
KR20120109216 2012-09-28
KR1020130017169 2013-02-18
KR20130017169 2013-02-18
PCT/KR2013/008438 WO2014046478A1 (ko) 2012-09-19 2013-09-17 세포 투과성 펩티드, 그를 포함한 컨쥬게이트 및 그를 포함한 조성물

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KR1020227004140A Division KR102544207B1 (ko) 2012-09-19 2013-09-17 세포 투과성 펩티드, 그를 포함한 컨쥬게이트 및 그를 포함한 조성물

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KR20150065725A KR20150065725A (ko) 2015-06-15
KR102362341B1 true KR102362341B1 (ko) 2022-02-14

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KR1020157009509A Active KR102362341B1 (ko) 2012-09-19 2013-09-17 세포 투과성 펩티드, 그를 포함한 컨쥬게이트 및 그를 포함한 조성물
KR1020237019231A Active KR102578890B1 (ko) 2012-09-19 2013-09-17 세포 투과성 펩티드, 그를 포함한 컨쥬게이트 및 그를 포함한 조성물
KR1020227004140A Active KR102544207B1 (ko) 2012-09-19 2013-09-17 세포 투과성 펩티드, 그를 포함한 컨쥬게이트 및 그를 포함한 조성물

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KR1020237019231A Active KR102578890B1 (ko) 2012-09-19 2013-09-17 세포 투과성 펩티드, 그를 포함한 컨쥬게이트 및 그를 포함한 조성물
KR1020227004140A Active KR102544207B1 (ko) 2012-09-19 2013-09-17 세포 투과성 펩티드, 그를 포함한 컨쥬게이트 및 그를 포함한 조성물

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US (4) US9902945B2 (enExample)
EP (3) EP3736282B1 (enExample)
JP (5) JP6352923B2 (enExample)
KR (3) KR102362341B1 (enExample)
CN (3) CN110074997B (enExample)
ES (2) ES2802253T3 (enExample)
TW (3) TWI655204B (enExample)
WO (1) WO2014046478A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
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KR102541402B1 (ko) * 2022-02-18 2023-06-14 주식회사 레메디 아토피 피부염 예방 또는 치료 활성을 가지는 펩타이드

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* Cited by examiner, † Cited by third party
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JP6262721B2 (ja) 2012-05-11 2018-01-17 ジェムバックス アンド カエル カンパニー，リミティド 敗血症の予防用または治療用の組成物
CN116694597A (zh) 2012-05-11 2023-09-05 珍白斯凯尔有限公司 具有抗炎活性的肽及其在制备抗炎组合物中的应用
KR101799904B1 (ko) 2012-07-11 2017-11-22 주식회사 젬백스앤카엘 세포 투과성 펩티드, 그를 포함한 컨쥬게이트 및 그를 포함한 조성물
US20150125438A1 (en) 2012-07-20 2015-05-07 Sang Jae Kim Anti-Inflammatory Peptides and Composition Comprising the Same
ES2758451T3 (es) 2012-09-19 2020-05-05 Gemvax & Kael Co Ltd Péptido de penetración celular, conjugado que comprende el mismo y composición que comprende el conjugado
EP3736282B1 (en) 2012-09-19 2023-06-21 Gemvax & Kael Co., Ltd. Cell penetrating peptide, conjugate comprising same, and composition comprising conjugate
TWI616530B (zh) * 2012-09-19 2018-03-01 傑姆維克斯＆凱爾有限公司 穿膜胜肽以及包含該胜肽之共軛物及組成物（一）
US9631184B2 (en) 2012-09-19 2017-04-25 Gemvax & Kael Co., Ltd. Cell penetrating peptide, conjugate comprising same, and composition comprising conjugate
WO2014171792A1 (ko) 2013-04-19 2014-10-23 주식회사 카엘젬백스 허혈성 손상 치료 및 예방용 조성물
US10383926B2 (en) 2013-06-07 2019-08-20 Gemvax & Kael Co., Ltd. Biological markers useful in cancer immunotherapy
ES2808076T3 (es) 2013-06-21 2021-02-25 Gemvax & Kael Co Ltd Regulador de la secreción hormonal, composición que lo contiene y procedimiento para controlar la secreción hormonal mediante su uso
CA2926183C (en) 2013-10-23 2018-07-03 Gemvax & Kael Co., Ltd. Composition for treating and preventing benign prostatic hyperplasia
EP3072519B1 (en) 2013-11-22 2020-08-19 Gemvax & Kael Co., Ltd. Peptide having angiogenesis inhibitory activity and composition containing same
EP3085380B1 (en) 2013-12-17 2020-06-17 Gemvax & Kael Co., Ltd. Composition for treating prostate cancer
KR102373603B1 (ko) * 2014-04-11 2022-03-14 주식회사 젬백스앤카엘 섬유증 억제 활성을 가지는 펩티드 및 이를 포함하는 조성물
EP3138399B1 (en) 2014-04-30 2023-09-06 Gemvax & Kael Co., Ltd. Composition for organ, tissue, or cell transplantation, kit, and transplantation method
KR102413243B1 (ko) 2014-12-23 2022-06-27 주식회사 젬백스앤카엘 안질환 치료 펩티드 및 이를 포함하는 안질환 치료용 조성물
JP6751097B2 (ja) 2015-02-27 2020-09-02 ジェムバックス アンド カエル カンパニー，リミティド 聴力損傷予防用ペプチド及びそれを含む組成物
CN107667112B (zh) 2015-05-26 2021-12-07 珍白斯凯尔有限公司 新型肽和含有其的组合物
KR101647804B1 (ko) * 2015-06-24 2016-08-11 한국과학기술연구원 신규 세포투과 펩타이드 및 이의 용도
EP3318265B1 (en) 2015-07-02 2021-08-18 Gemvax & Kael Co., Ltd. Peptide having anti-viral effect and composition containing same
EP3341389B1 (en) * 2015-08-28 2021-10-06 The Medical College of Wisconsin, Inc. Peptide inhibitors of telomerase translocation and therapeutic uses thereof
WO2017176087A1 (ko) 2016-04-07 2017-10-12 주식회사 젬백스앤카엘 텔로머라제 활성 증가 및 텔로미어 연장 효능을 가지는 펩티드 및 이를 포함하는 조성물
KR101710186B1 (ko) * 2016-09-01 2017-03-10 (주)에이씨티 6-아미노헥사노산 유도체 및 그 유도체를 함유하는 광반응성 화장료 조성물
KR101843830B1 (ko) * 2016-09-27 2018-04-02 (주)라온크리에이트 피부 상태 개선 장치 및 그의 사용 방법
CN107168012A (zh) * 2017-07-11 2017-09-15 深圳市华星光电技术有限公司 一种彩色光刻胶及其制备方法
JP7262105B2 (ja) 2019-03-29 2023-04-21 国立研究開発法人理化学研究所 細胞透過性配列を有するポリペプチド及びそれを含む組成物
CN114213508B (zh) * 2020-09-03 2024-06-04 深圳厚存纳米药业有限公司 一种多肽及其多肽复合物纳米粒、核酸疫苗和应用
AU2022257908A1 (en) 2021-04-15 2023-11-30 Icure Bnp Co., Ltd. Cell-penetrating peptide, anti-cancer peptide, and pharmaceutical composition for preventing or treating cancer, comprising same
KR102713418B1 (ko) * 2021-07-27 2024-10-07 ㈜에빅스젠 세포막 투과 펩티드 및 이를 포함하는 세포내 전달체
KR102415717B1 (ko) * 2021-12-29 2022-07-05 주식회사 펩스젠 혈액뇌장벽 투과능을 가지는 신규한 펩타이드 및 이의 용도
WO2023128122A1 (ko) * 2021-12-29 2023-07-06 주식회사 펩스젠 혈액뇌장벽 투과능을 가지는 펩타이드 및 이의 용도
WO2024117321A1 (ko) * 2022-12-01 2024-06-06 ㈜에빅스젠 세포막 투과 펩티드 및 이를 포함하는 세포내 전달체
CN119552212B (zh) * 2025-01-26 2025-04-25 杭州康源食品科技有限公司 一种具有降尿酸活性的三肽lfp及其应用

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000002581A1 (en) * 1998-07-08 2000-01-20 Norsk Hydro Asa Antigenic peptides derived from telomerase
US20070190561A1 (en) 1996-10-01 2007-08-16 Geron Corporation Segments of the Human Gene for Telomerase Reverse Transcriptase
US20100003229A1 (en) * 2008-06-19 2010-01-07 Santos Janine H Nuclear telomerase reverse transcriptase variant
WO2011101173A1 (en) * 2010-02-16 2011-08-25 Oslo University Hospital Hf Polypeptides

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3869092B2 (ja) * 1996-10-01 2007-01-17 ジェロン・コーポレーション ヒトテロメラーゼ触媒性サブユニット
US6093809A (en) * 1996-10-01 2000-07-25 University Technology Corporation Telomerase
US6475789B1 (en) * 1996-10-01 2002-11-05 University Technology Corporation Human telomerase catalytic subunit: diagnostic and therapeutic methods
US7585622B1 (en) * 1996-10-01 2009-09-08 Geron Corporation Increasing the proliferative capacity of cells using telomerase reverse transcriptase
US7078491B1 (en) 2000-09-21 2006-07-18 Amgen Inc. Selective binding agents of telomerase
US7294708B2 (en) * 2002-05-31 2007-11-13 Beijing Institute Of Biotechnology Telomerase reverse transcriptase fragments and uses thereof
US8128908B2 (en) 2004-04-30 2012-03-06 University Of Florida Research Foundation, Inc. Nanoparticles and their use for multifunctional bioimaging
EP1994942A1 (en) * 2007-05-25 2008-11-26 INSERM (Institut National de la Santé et de la Recherche Médicale) Pharmaceutical compositions comprising telomerase, and uses thereof
US8362209B2 (en) 2007-08-23 2013-01-29 University Of Medicine And Dentistry Of New Jersey Telomerase reverse transcriptase variant
NZ745324A (en) * 2007-09-25 2023-02-24 Pastoral Greenhouse Gas Res Ltd Vaccines and vaccine components for inhibition of microbial cells
ES2602453T3 (es) * 2008-06-16 2017-02-21 Mediolanum Farmaceutici S.P.A. Inmunoterapia antitumoral
IT1393509B1 (it) * 2008-07-08 2012-04-27 Advanced Accelerator Applications S A Peptidi e loro uso come carrier in cellule cancerose
US20110318380A1 (en) 2008-10-01 2011-12-29 Dako Denmark A/S MHC Multimers in Cancer Vaccines and Immune Monitoring
KR101169030B1 (ko) 2009-01-21 2012-07-26 애니젠 주식회사 신규한 세포막 투과 도메인 및 이를 포함하는 세포내 전달 시스템
CN116694597A (zh) 2012-05-11 2023-09-05 珍白斯凯尔有限公司 具有抗炎活性的肽及其在制备抗炎组合物中的应用
US20150125438A1 (en) 2012-07-20 2015-05-07 Sang Jae Kim Anti-Inflammatory Peptides and Composition Comprising the Same
US20170327802A1 (en) 2012-07-20 2017-11-16 Gemvax & Kael Co., Ltd. Anti-Inflammatory Peptides and Composition Comprising the Same
EP3736282B1 (en) 2012-09-19 2023-06-21 Gemvax & Kael Co., Ltd. Cell penetrating peptide, conjugate comprising same, and composition comprising conjugate
ES2758451T3 (es) 2012-09-19 2020-05-05 Gemvax & Kael Co Ltd Péptido de penetración celular, conjugado que comprende el mismo y composición que comprende el conjugado
US9631184B2 (en) 2012-09-19 2017-04-25 Gemvax & Kael Co., Ltd. Cell penetrating peptide, conjugate comprising same, and composition comprising conjugate
US10383926B2 (en) 2013-06-07 2019-08-20 Gemvax & Kael Co., Ltd. Biological markers useful in cancer immunotherapy
WO2015005723A1 (ko) 2013-07-12 2015-01-15 주식회사 카엘젬백스 세포 투과성 펩티드 및 이를 포함하는 컨쥬게이트
US20170112941A1 (en) 2015-10-13 2017-04-27 Symic Ip, Llc Ve-cadherin binding bioconjugate
CN106749537A (zh) * 2017-02-04 2017-05-31 北京大学第医院 一种多肽及其作为siRNA递送载体的应用

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070190561A1 (en) 1996-10-01 2007-08-16 Geron Corporation Segments of the Human Gene for Telomerase Reverse Transcriptase
WO2000002581A1 (en) * 1998-07-08 2000-01-20 Norsk Hydro Asa Antigenic peptides derived from telomerase
US20100003229A1 (en) * 2008-06-19 2010-01-07 Santos Janine H Nuclear telomerase reverse transcriptase variant
WO2011101173A1 (en) * 2010-02-16 2011-08-25 Oslo University Hospital Hf Polypeptides

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102541402B1 (ko) * 2022-02-18 2023-06-14 주식회사 레메디 아토피 피부염 예방 또는 치료 활성을 가지는 펩타이드
WO2023158051A1 (ko) * 2022-02-18 2023-08-24 주식회사 레메디 아토피 피부염 예방 또는 치료 활성을 가지는 펩타이드

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