KR102335535B1 - 18f-표지된 화합물의 합성을 위한 이중 실행 카세트 - Google Patents

18f-표지된 화합물의 합성을 위한 이중 실행 카세트 Download PDF

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KR102335535B1
KR102335535B1 KR1020167012207A KR20167012207A KR102335535B1 KR 102335535 B1 KR102335535 B1 KR 102335535B1 KR 1020167012207 A KR1020167012207 A KR 1020167012207A KR 20167012207 A KR20167012207 A KR 20167012207A KR 102335535 B1 KR102335535 B1 KR 102335535B1
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reaction vessel
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KR20160085769A (ko
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자비에 프란시
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지이 헬쓰케어 리미티드
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/005—Sugars; Derivatives thereof; Nucleosides; Nucleotides; Nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0491—Sugars, nucleosides, nucleotides, oligonucleotides, nucleic acids, e.g. DNA, RNA, nucleic acid aptamers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00495—Means for heating or cooling the reaction vessels
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00709—Type of synthesis
    • B01J2219/00716—Heat activated synthesis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/00731—Saccharides

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
KR1020167012207A 2013-11-13 2014-11-12 18f-표지된 화합물의 합성을 위한 이중 실행 카세트 Active KR102335535B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361903486P 2013-11-13 2013-11-13
US61/903,486 2013-11-13
PCT/EP2014/074330 WO2015071288A1 (en) 2013-11-13 2014-11-12 Dual run cassette for the synthesis of 18f-labelled compounds

Publications (2)

Publication Number Publication Date
KR20160085769A KR20160085769A (ko) 2016-07-18
KR102335535B1 true KR102335535B1 (ko) 2021-12-08

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KR1020167012207A Active KR102335535B1 (ko) 2013-11-13 2014-11-12 18f-표지된 화합물의 합성을 위한 이중 실행 카세트

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Country Link
US (1) US10584078B2 (enExample)
EP (1) EP3068747B1 (enExample)
JP (1) JP6496726B2 (enExample)
KR (1) KR102335535B1 (enExample)
CN (2) CN104762666A (enExample)
BE (1) BE1022357A9 (enExample)
CA (1) CA2930479C (enExample)
DE (2) DE202014010612U1 (enExample)
DK (1) DK3068747T3 (enExample)
ES (1) ES3005832T3 (enExample)
FI (1) FI3068747T3 (enExample)
HR (1) HRP20250050T1 (enExample)
HU (1) HUE069777T2 (enExample)
IL (1) IL235650B (enExample)
PL (1) PL3068747T3 (enExample)
PT (1) PT3068747T (enExample)
RS (1) RS66442B1 (enExample)
WO (1) WO2015071288A1 (enExample)

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GB201420094D0 (en) * 2014-11-12 2014-12-24 Ge Healthcare Ltd Flouride trapping arrangement
US10109385B2 (en) 2009-09-23 2018-10-23 Abt Molecular Imaging, Inc. Dose synthesis card for use with automated biomarker production system
FI3068747T3 (fi) * 2013-11-13 2024-12-30 Ge Healthcare Ltd Kaksoisajettava kasetti 18f-leimattujen yhdisteiden synteesiä varten
GB201420093D0 (en) 2014-11-12 2014-12-24 Ge Healthcare Ltd Pet tracer purification system
WO2016130449A1 (en) * 2015-02-10 2016-08-18 Abt Molecular Imaging, Inc. Dose synthesis card for use with automated biomarker production system
GB201504287D0 (en) 2015-03-13 2015-04-29 Ge Healthcare Ltd Piercing device
NL2014828B1 (en) 2015-05-20 2017-01-31 Out And Out Chemistry S P R L Method of performing a plurality of synthesis processes of preparing a radiopharmaceutical in series, a device and cassette for performing this method.
WO2018236115A1 (ko) 2017-06-19 2018-12-27 (주)퓨쳐켐 전립선암 진단을 위한 18f-표지된 화합물 및 그의 용도
LT3643707T (lt) 2017-06-19 2022-05-25 Futurechem Co., Ltd. 18f žymėtas junginys, skirtas prostatos vėžio diagnostikai ir jo panaudojimas
JP6954361B2 (ja) * 2017-09-19 2021-10-27 株式会社村田製作所 濾過装置及び濾過方法
WO2019058865A1 (ja) 2017-09-25 2019-03-28 株式会社村田製作所 濾過装置
CN108126648A (zh) * 2018-01-04 2018-06-08 江苏华益科技有限公司 一种放射性药物的自动传输装置及方法
CN113413840A (zh) * 2021-06-04 2021-09-21 四川玖谊源粒子科技有限公司 一种用于制备多核素放射性药物的合成系统
BE1032491B1 (fr) 2024-03-27 2025-10-27 Trasis S A Synthèse de traceurs à plusieurs passages sur cassette

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US20120108858A1 (en) * 2010-10-28 2012-05-03 Maxim Kiselev Method and device for manufacturing of radiopharmaceuticals

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US7413714B1 (en) 2000-07-16 2008-08-19 Ymc Co. Ltd. Sequential reaction system
CN100374453C (zh) * 2005-11-18 2008-03-12 南方医科大学南方医院 2－18f－2－脱氧－d－葡萄糖的合成工艺
CN101346391A (zh) * 2005-12-02 2009-01-14 日本医事物理股份有限公司 放射性氟标记化合物的制备方法
JP4926546B2 (ja) 2006-05-30 2012-05-09 住友重機械工業株式会社 放射性薬液合成装置の使用方法、及び放射性薬液合成装置
KR20110106895A (ko) * 2008-12-22 2011-09-29 바이엘 파마 악티엔게젤샤프트 교환 수지를 사용하여 방사성핵종-표지된 화합물을 합성하는 방법
CN101830937B (zh) * 2009-03-12 2012-06-06 张锦明 可视化、双反应管氟-18多功能自动化合成模块
JP2012532164A (ja) * 2009-07-10 2012-12-13 バイエル ファーマ アクチエンゲゼルシャフト 放射性トレーサーの精製のための低‐中圧液体クロマトグラフィーの使用
US10639608B2 (en) * 2010-04-08 2020-05-05 Siemens Medical Solutions Usa, Inc. System, device and method for preparing tracers and transferring materials during radiosynthesis
DE102010036356A1 (de) 2010-07-12 2012-01-12 Abx Advanced Biochemical Compounds Gmbh Vorrichtung zur Synthese radioaktiv markierter Verbindungen
CN103270004A (zh) 2010-12-29 2013-08-28 通用电气健康护理有限公司 洗脱溶液
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GB201117785D0 (en) 2011-10-14 2011-11-30 Ge Healthcare Ltd Improved radiosynthesis method
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FI3068747T3 (fi) * 2013-11-13 2024-12-30 Ge Healthcare Ltd Kaksoisajettava kasetti 18f-leimattujen yhdisteiden synteesiä varten

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Publication number Priority date Publication date Assignee Title
US20120108858A1 (en) * 2010-10-28 2012-05-03 Maxim Kiselev Method and device for manufacturing of radiopharmaceuticals

Also Published As

Publication number Publication date
BE1022357B1 (fr) 2016-03-24
WO2015071288A1 (en) 2015-05-21
KR20160085769A (ko) 2016-07-18
CN113564722A (zh) 2021-10-29
PL3068747T3 (pl) 2025-03-10
DE202014010612U1 (de) 2016-04-19
BE1022357A9 (fr) 2017-02-02
IL235650A0 (en) 2015-02-26
US20160257622A1 (en) 2016-09-08
HUE069777T2 (hu) 2025-04-28
US10584078B2 (en) 2020-03-10
PT3068747T (pt) 2025-01-24
EP3068747A1 (en) 2016-09-21
ES3005832T3 (en) 2025-03-17
DK3068747T3 (da) 2025-01-13
FI3068747T3 (fi) 2024-12-30
RS66442B1 (sr) 2025-02-28
IL235650B (en) 2019-10-31
HRP20250050T1 (hr) 2025-04-11
JP6496726B2 (ja) 2019-04-03
CA2930479C (en) 2023-03-28
DE202015007501U1 (de) 2015-12-17
EP3068747B1 (en) 2024-10-30
JP2017503752A (ja) 2017-02-02
CN104762666A (zh) 2015-07-08
CA2930479A1 (en) 2015-05-21

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