KR102317698B1 - 수면 장애 및 다른 장애를 치료하기 위한 방법 및 조성물 - Google Patents
수면 장애 및 다른 장애를 치료하기 위한 방법 및 조성물 Download PDFInfo
- Publication number
- KR102317698B1 KR102317698B1 KR1020207033595A KR20207033595A KR102317698B1 KR 102317698 B1 KR102317698 B1 KR 102317698B1 KR 1020207033595 A KR1020207033595 A KR 1020207033595A KR 20207033595 A KR20207033595 A KR 20207033595A KR 102317698 B1 KR102317698 B1 KR 102317698B1
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- South Korea
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- YXBPEKXZDLPJMM-FPOVZHCZSA-N Fc(cc1)ccc1OCCCN1C[C@H]2c3cccc(NCC4)c3N4[C@H]2CC1 Chemical compound Fc(cc1)ccc1OCCCN1C[C@H]2c3cccc(NCC4)c3N4[C@H]2CC1 YXBPEKXZDLPJMM-FPOVZHCZSA-N 0.000 description 2
- YVZRLGPZGPETSM-PMACEKPBSA-N Fc(cc1)ccc1OCCCN1C[C@H]2c3cccc(OCC4)c3N4[C@H]2CC1 Chemical compound Fc(cc1)ccc1OCCCN1C[C@H]2c3cccc(OCC4)c3N4[C@H]2CC1 YVZRLGPZGPETSM-PMACEKPBSA-N 0.000 description 2
- HOIIHACBCFLJET-SFTDATJTSA-N CN(CC1)c2c3N1[C@@H](CCN(CCCC(c(cc1)ccc1F)=O)C1)[C@@H]1c3ccc2 Chemical compound CN(CC1)c2c3N1[C@@H](CCN(CCCC(c(cc1)ccc1F)=O)C1)[C@@H]1c3ccc2 HOIIHACBCFLJET-SFTDATJTSA-N 0.000 description 1
- HQQJXCPFCHRCKP-SFTDATJTSA-N CN(CC1)c2c3N1[C@@H](CCN(CCCOc(cc1)ccc1F)C1)[C@@H]1c3ccc2 Chemical compound CN(CC1)c2c3N1[C@@H](CCN(CCCOc(cc1)ccc1F)C1)[C@@H]1c3ccc2 HQQJXCPFCHRCKP-SFTDATJTSA-N 0.000 description 1
- DLXKEWOEEPMPHX-PMACEKPBSA-N O=C(CCCN1C[C@H]2c(cccc3OCC4)c3N4[C@H]2CC1)c(cc1)ccc1F Chemical compound O=C(CCCN1C[C@H]2c(cccc3OCC4)c3N4[C@H]2CC1)c(cc1)ccc1F DLXKEWOEEPMPHX-PMACEKPBSA-N 0.000 description 1
- WPJSNLWFVMFFSG-FPOVZHCZSA-N O=C(CCCN1C[C@H]2c3cccc(NCC4)c3N4[C@H]2CC1)c(cc1)ccc1F Chemical compound O=C(CCCN1C[C@H]2c3cccc(NCC4)c3N4[C@H]2CC1)c(cc1)ccc1F WPJSNLWFVMFFSG-FPOVZHCZSA-N 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/34—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
- A01N43/40—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings
- A01N43/42—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings condensed with carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/14—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychology (AREA)
- Psychiatry (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Dentistry (AREA)
- Wood Science & Technology (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicinal Preparation (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US5643308P | 2008-05-27 | 2008-05-27 | |
| US61/056,433 | 2008-05-27 | ||
| US15503209P | 2009-02-24 | 2009-02-24 | |
| US61/155,032 | 2009-02-24 | ||
| PCT/US2009/003261 WO2009145900A1 (en) | 2008-05-27 | 2009-05-27 | Methods and compositions for sleep disorders and other disorders |
| KR1020197000911A KR102184038B1 (ko) | 2008-05-27 | 2009-05-27 | 수면 장애 및 다른 장애를 치료하기 위한 방법 및 조성물 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020197000911A Division KR102184038B1 (ko) | 2008-05-27 | 2009-05-27 | 수면 장애 및 다른 장애를 치료하기 위한 방법 및 조성물 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20200134341A KR20200134341A (ko) | 2020-12-01 |
| KR102317698B1 true KR102317698B1 (ko) | 2021-10-25 |
Family
ID=41377435
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020207033595A Active KR102317698B1 (ko) | 2008-05-27 | 2009-05-27 | 수면 장애 및 다른 장애를 치료하기 위한 방법 및 조성물 |
| KR1020167032085A Active KR102133073B1 (ko) | 2008-05-27 | 2009-05-27 | 수면 장애 및 다른 장애를 치료하기 위한 방법 및 조성물 |
| KR1020107029327A Ceased KR20110022631A (ko) | 2008-05-27 | 2009-05-27 | 수면 장애 및 다른 장애를 치료하기 위한 방법 및 조성물 |
| KR1020197000911A Active KR102184038B1 (ko) | 2008-05-27 | 2009-05-27 | 수면 장애 및 다른 장애를 치료하기 위한 방법 및 조성물 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020167032085A Active KR102133073B1 (ko) | 2008-05-27 | 2009-05-27 | 수면 장애 및 다른 장애를 치료하기 위한 방법 및 조성물 |
| KR1020107029327A Ceased KR20110022631A (ko) | 2008-05-27 | 2009-05-27 | 수면 장애 및 다른 장애를 치료하기 위한 방법 및 조성물 |
| KR1020197000911A Active KR102184038B1 (ko) | 2008-05-27 | 2009-05-27 | 수면 장애 및 다른 장애를 치료하기 위한 방법 및 조성물 |
Country Status (9)
| Country | Link |
|---|---|
| US (10) | USRE48839E1 (enExample) |
| EP (2) | EP2320731A4 (enExample) |
| JP (2) | JP6106361B2 (enExample) |
| KR (4) | KR102317698B1 (enExample) |
| CN (2) | CN105168219B (enExample) |
| AU (1) | AU2009251816B2 (enExample) |
| CA (1) | CA2725342C (enExample) |
| MX (3) | MX377802B (enExample) |
| WO (1) | WO2009145900A1 (enExample) |
Families Citing this family (72)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008052139A2 (en) | 2006-10-25 | 2008-05-02 | Somaxon Pharmaceuticals, Inc. | Ultra low dose doxepin and methods of using the same to treat sleep disorders |
| WO2008070795A2 (en) * | 2006-12-06 | 2008-06-12 | Somaxon Pharmaceuticals, Inc. | Combination therapy using low-dose doxepin for the improvement of sleep |
| KR102238390B1 (ko) | 2007-03-12 | 2021-04-08 | 인트라-셀룰라 써래피스, 인코퍼레이티드. | 치환된 헤테로환 융합 감마-카르볼린 합성 |
| DK2262505T3 (en) | 2008-03-12 | 2015-01-05 | Intra Cellular Therapies Inc | Substituted heterocyclic-CONCENTRATED GAMMA -carboline-SOLID |
| MX377802B (es) | 2008-05-27 | 2025-03-11 | Intra Cellular Therapies Inc | Metodos y composiciones para trastornos del sueño y otros trastornos. |
| US8653263B2 (en) | 2009-10-23 | 2014-02-18 | Janssen Pharmaceutica | Disubstituted octahydropyrrolo[3,4-c]pyrroles as orexin receptor modulators |
| US8993572B2 (en) * | 2010-04-22 | 2015-03-31 | Intra-Cellular Therapies, Inc. | Pyrido[3′,4′:4,5]pyrrolo[1,2,3-de]quinoxalines derivatives and [1,4]oxazino[2,3,4-hi]pyrido[4,3-b]indole derivatives |
| WO2012064349A1 (en) * | 2010-11-09 | 2012-05-18 | Forest Carl A | Sleep aid composition and method |
| JP6050813B2 (ja) * | 2011-07-08 | 2016-12-21 | イーライ リリー アンド カンパニー | 二重作用Ｈ１インバースアゴニスト／５−ＨＴ２Ａアンタゴニストとしての（チエノ［２，３−ｂ］［１，５］ベンゾオキサゼピン−４−イル）ピペラジン−１−イル化合物 |
| RU2014145682A (ru) * | 2012-04-14 | 2016-06-10 | Интра-Селлулар Терапиз, Инк | Органические соединения |
| CN103175973B (zh) * | 2013-02-26 | 2015-05-13 | 首都医科大学 | 甘丙肽在制备女性抑郁症检测工具中的应用 |
| US11235020B2 (en) * | 2013-03-13 | 2022-02-01 | Abraham Palmer | Methods and compositions for inhibiting glyoxalase 1 (GLO1) |
| WO2014152804A1 (en) * | 2013-03-14 | 2014-09-25 | Hyperion Biotechnology | Methods and compositions for biomarkers of fatigue, fitness and physical performance capacity |
| US9708322B2 (en) | 2013-03-15 | 2017-07-18 | Intra-Cellular Therapies, Inc. | Substituted pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxalines for inhibiting serotonin reuptake transporter activity |
| CA3205777A1 (en) * | 2013-12-03 | 2015-06-11 | Intra-Cellular Therapies, Inc. | Heterocycle fused gamma-carboline compounds for use in treatment of schizophrenia |
| US10077267B2 (en) | 2014-04-04 | 2018-09-18 | Intra-Cellular Therapies, Inc. | Organic compounds |
| WO2015154030A1 (en) | 2014-04-04 | 2015-10-08 | Intra-Cellular Therapies, Inc. | Organic compounds |
| DK3251699T3 (da) * | 2015-01-28 | 2024-05-21 | Univ Duke | Sammensætning omfattende methylphenidat og ondansetron til anvendelse i stofrelaterede forstyrrelser |
| WO2017117514A1 (en) * | 2015-12-31 | 2017-07-06 | Tung Roger D | Deuterated iti-007 |
| PL3838274T3 (pl) | 2016-01-26 | 2024-04-02 | Intra-Cellular Therapies, Inc. | Pochodna pirydo[3',4':4,5]pirolo[1,2,3-DE]chinoksaliny do zastosowania w leczeniu zaburzeń OUN |
| BR112018067906A2 (pt) | 2016-03-10 | 2019-01-29 | Janssen Pharmaceutica Nv | métodos de tratamento de depressão usando antagonistas do receptor de orexina-2 |
| CA3016353C (en) | 2016-03-25 | 2021-04-27 | Intra-Cellular Therapies, Inc. | Deuterated fused heterocycle gamma-carbolines and compositions thereof useful in the treatment of nervous system disorders |
| WO2017172784A1 (en) * | 2016-03-28 | 2017-10-05 | Intra-Cellular Therapies, Inc. | Novel salts and crystals |
| WO2017172811A1 (en) * | 2016-03-28 | 2017-10-05 | Intra-Cellular Therapies, Inc. | Novel co-crystals |
| EP3436083A4 (en) * | 2016-03-28 | 2019-11-27 | Intra-Cellular Therapies, Inc. | NOVEL COMPOSITIONS AND METHOD |
| EP3525763B1 (en) | 2016-10-12 | 2025-03-05 | Intra-Cellular Therapies, Inc. | Amorphous solid dispersions |
| US10961245B2 (en) | 2016-12-29 | 2021-03-30 | Intra-Cellular Therapies, Inc. | Substituted heterocycle fused gamma-carbolines for treatment of central nervous system disorders |
| JP6987868B2 (ja) | 2016-12-29 | 2022-01-05 | イントラ−セルラー・セラピーズ・インコーポレイテッドIntra−Cellular Therapies, Inc. | 有機化合物 |
| KR102398194B1 (ko) | 2017-03-24 | 2022-05-18 | 인트라-셀룰라 써래피스, 인코퍼레이티드. | 신규한 조성물 및 방법 |
| CN110636845A (zh) * | 2017-04-10 | 2019-12-31 | 雷迪博士实验室有限公司 | 卢美哌隆对甲苯磺酸盐的无定形形式和固体分散体 |
| US9993486B1 (en) | 2017-06-19 | 2018-06-12 | Tlc Therapeutics, Llc | Oral quetiapine suspension formulations with extended shelf life and enhanced bioavailability |
| BR112020001666A2 (pt) | 2017-07-26 | 2020-07-21 | Intra-Cellular Therapies, Inc. | compostos orgânicos |
| KR102667268B1 (ko) | 2017-07-26 | 2024-05-17 | 인트라-셀룰라 써래피스, 인코퍼레이티드. | 유기 화합물 |
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