JP6106361B2 - 睡眠障害および他の障害のための方法および組成物 - Google Patents

睡眠障害および他の障害のための方法および組成物 Download PDF

Info

Publication number
JP6106361B2
JP6106361B2 JP2011511638A JP2011511638A JP6106361B2 JP 6106361 B2 JP6106361 B2 JP 6106361B2 JP 2011511638 A JP2011511638 A JP 2011511638A JP 2011511638 A JP2011511638 A JP 2011511638A JP 6106361 B2 JP6106361 B2 JP 6106361B2
Authority
JP
Japan
Prior art keywords
pharmaceutical composition
compound
composition according
disorders
sleep
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2011511638A
Other languages
English (en)
Japanese (ja)
Other versions
JP2011523949A5 (enExample
JP2011523949A (ja
Inventor
シャロン・メイツ
アレン・エイ・フィーンバーグ
ローレンス・ピー・ウェノグル
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Intra Cellular Therapies Inc
Original Assignee
Intra Cellular Therapies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41377435&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JP6106361(B2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Intra Cellular Therapies Inc filed Critical Intra Cellular Therapies Inc
Publication of JP2011523949A publication Critical patent/JP2011523949A/ja
Publication of JP2011523949A5 publication Critical patent/JP2011523949A5/ja
Application granted granted Critical
Publication of JP6106361B2 publication Critical patent/JP6106361B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/34Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
    • A01N43/40Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings
    • A01N43/42Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings condensed with carbocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/195Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/53751,4-Oxazines, e.g. morpholine
    • A61K31/53831,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/20Hypnotics; Sedatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/06Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D498/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/14Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2011511638A 2008-05-27 2009-05-27 睡眠障害および他の障害のための方法および組成物 Active JP6106361B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US5643308P 2008-05-27 2008-05-27
US61/056,433 2008-05-27
US15503209P 2009-02-24 2009-02-24
US61/155,032 2009-02-24
PCT/US2009/003261 WO2009145900A1 (en) 2008-05-27 2009-05-27 Methods and compositions for sleep disorders and other disorders

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2015076230A Division JP2015157828A (ja) 2008-05-27 2015-04-02 睡眠障害および他の障害のための方法および組成物

Publications (3)

Publication Number Publication Date
JP2011523949A JP2011523949A (ja) 2011-08-25
JP2011523949A5 JP2011523949A5 (enExample) 2012-06-28
JP6106361B2 true JP6106361B2 (ja) 2017-03-29

Family

ID=41377435

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2011511638A Active JP6106361B2 (ja) 2008-05-27 2009-05-27 睡眠障害および他の障害のための方法および組成物
JP2015076230A Pending JP2015157828A (ja) 2008-05-27 2015-04-02 睡眠障害および他の障害のための方法および組成物

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2015076230A Pending JP2015157828A (ja) 2008-05-27 2015-04-02 睡眠障害および他の障害のための方法および組成物

Country Status (9)

Country Link
US (10) USRE48839E1 (enExample)
EP (2) EP3085231A1 (enExample)
JP (2) JP6106361B2 (enExample)
KR (4) KR102317698B1 (enExample)
CN (2) CN102105059B (enExample)
AU (1) AU2009251816B2 (enExample)
CA (1) CA2725342C (enExample)
MX (3) MX377802B (enExample)
WO (1) WO2009145900A1 (enExample)

Families Citing this family (74)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008052139A2 (en) 2006-10-25 2008-05-02 Somaxon Pharmaceuticals, Inc. Ultra low dose doxepin and methods of using the same to treat sleep disorders
WO2008070795A2 (en) * 2006-12-06 2008-06-12 Somaxon Pharmaceuticals, Inc. Combination therapy using low-dose doxepin for the improvement of sleep
ES2776889T3 (es) 2007-03-12 2020-08-03 Intra Cellular Therapies Inc Síntesis de gamma-carbolinas condensadas a heterociclo sustituido
CN102046175B (zh) 2008-03-12 2015-08-12 细胞内治疗公司 取代的杂环稠合的γ-咔啉固体
CN102105059B (zh) 2008-05-27 2015-09-30 细胞内治疗公司 用于睡眠障碍和其他疾病的方法和组合物
HUE043962T2 (hu) 2009-10-23 2019-09-30 Janssen Pharmaceutica Nv Diszubsztituált oktahidro-pirrolo[3,4-C]pirrolok mint orexin receptor modulátorok
JP5894574B2 (ja) * 2010-04-22 2016-03-30 イントラ−セルラー・セラピーズ・インコーポレイテッドIntra−Cellular Therapies, Inc. 有機化合物
US8741888B2 (en) * 2010-11-09 2014-06-03 Carl A. Forest Sleep aid composition and method
WO2013009517A1 (en) * 2011-07-08 2013-01-17 Eli Lilly And Company (THIENO[2,3-b][1,5]BENZOXAZEPIN-4-YL)PIPERAZIN-1-YL COMPOUNDS AS DUAL ACTIVITY H1 INVERSE AGONISTS/5-HT2A ANTAGONISTS
CN104519886B (zh) * 2012-04-14 2017-09-12 细胞内治疗公司 有机化合物
CN103175973B (zh) * 2013-02-26 2015-05-13 首都医科大学 甘丙肽在制备女性抑郁症检测工具中的应用
WO2014159720A1 (en) * 2013-03-13 2014-10-02 The University Of Chicago Methods and compositions for inhibiting glyoxalase 1 (glo1)
WO2014152804A1 (en) * 2013-03-14 2014-09-25 Hyperion Biotechnology Methods and compositions for biomarkers of fatigue, fitness and physical performance capacity
DK2968320T3 (da) 2013-03-15 2021-02-01 Intra Cellular Therapies Inc Organiske forbindelser
CN114366741A (zh) * 2013-12-03 2022-04-19 细胞内治疗公司 新方法
CA2944755A1 (en) 2014-04-04 2015-10-08 Intra-Cellular Therapies, Inc. Organic compounds
KR20170012210A (ko) * 2014-04-04 2017-02-02 인트라-셀룰라 써래피스, 인코퍼레이티드. 유기 화합물
KR20200032759A (ko) * 2015-01-28 2020-03-26 주식회사 제네리스코리아 신경정신계 장애의 치료를 위한 조성물 및 방법
WO2017117514A1 (en) * 2015-12-31 2017-07-06 Tung Roger D Deuterated iti-007
KR102735964B1 (ko) 2016-01-26 2024-11-28 인트라-셀룰라 써래피스, 인코퍼레이티드. 유기 화합물
CA3016706A1 (en) 2016-03-10 2017-09-14 Janssen Pharmaceutica Nv Methods of treating depression using orexin-2 receptor antagonists
HUE055334T2 (hu) 2016-03-25 2021-11-29 Intra Cellular Therapies Inc Szerves vegyületek és azok alkalmazása központi idegrendszeri betegségek kezelésében vagy megelõzésében
JP2019510039A (ja) 2016-03-28 2019-04-11 イントラ−セルラー・セラピーズ・インコーポレイテッドIntra−Cellular Therapies, Inc. 新規組成物および方法
US10654854B2 (en) 2016-03-28 2020-05-19 Intra-Cellular Therapies, Inc. Salts and crystals of ITI-007
JP6997718B2 (ja) * 2016-03-28 2022-01-18 イントラ-セルラー・セラピーズ・インコーポレイテッド 新規共結晶
WO2018071233A1 (en) 2016-10-12 2018-04-19 Intra-Cellular Therapies, Inc. Amorphous solid dispersions
EP3562484B1 (en) 2016-12-29 2021-08-25 Intra-Cellular Therapies, Inc. Pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxaline derivatives useful in the treatment of cns disorders
WO2018126140A1 (en) 2016-12-29 2018-07-05 Intra-Cellular Therapies, Inc. Organic compounds
BR112019019875A2 (pt) 2017-03-24 2020-04-22 Intra Cellular Therapies Inc novas composições e métodos
WO2018189646A1 (en) 2017-04-10 2018-10-18 Dr. Reddy's Laboratories Limited AMORPHOUS FORM AND SOLID DISPERSIONS OF LUMATEPERONE p-TOSYLATE
US9993486B1 (en) 2017-06-19 2018-06-12 Tlc Therapeutics, Llc Oral quetiapine suspension formulations with extended shelf life and enhanced bioavailability
IL272249B2 (en) 2017-07-26 2023-11-01 Intra Cellular Therapies Inc organic compounds
IL272252B2 (en) 2017-07-26 2024-03-01 Intra Cellular Therapies Inc Derivatives of substituted heterocycle fused gamma-carbolines, pharmaceutical compositions comnprising them and their use in treatment
MX2020007271A (es) * 2017-09-26 2020-08-17 Intra Cellular Therapies Inc Sales y cristales novedosos.
KR102036909B1 (ko) * 2017-11-28 2019-10-25 한국과학기술원 신규 디스토니아 치료용 약학적 조성물
WO2019178484A1 (en) 2018-03-16 2019-09-19 Intra-Cellular Therapies, Inc. Novel methods
JP2021519271A (ja) 2018-03-23 2021-08-10 イントラ−セルラー・セラピーズ・インコーポレイテッドIntra−Cellular Therapies, Inc. 有機化合物
US12364694B2 (en) 2018-03-23 2025-07-22 Intra-Cellular Therapies, Inc. Organic compounds
MX2020013116A (es) 2018-06-06 2021-05-12 Intra Cellular Therapies Inc Sales y cristales novedosos.
WO2019237037A1 (en) 2018-06-08 2019-12-12 Intra-Cellular Therapies, Inc. Novel methods
CA3106447A1 (en) 2018-06-11 2019-12-19 Intra-Cellular Therapies, Inc. Substituted heterocycle fused gamma-carbolines synthesis
CN112585690B (zh) 2018-06-21 2025-04-15 阿奎斯蒂弗医疗股份有限公司 用于制作含有药物活性物质的个性化个体单位剂量的系统和方法
US12144808B2 (en) 2018-08-29 2024-11-19 Intra-Cellular Therapies, Inc. Compositions and methods
EP3843738A4 (en) 2018-08-31 2022-06-01 Intra-Cellular Therapies, Inc. NEW METHODS
KR20210052472A (ko) 2018-08-31 2021-05-10 인트라-셀룰라 써래피스, 인코퍼레이티드. 신규한 방법
CN120789028A (zh) 2018-09-07 2025-10-17 阿奎蒂夫疗法公司 具有精确的活性物溶出谱的口腔膜组合物和剂型
US20210393621A1 (en) 2018-10-26 2021-12-23 The Research Foundation For The State University Of New York Combination serotonin specific reuptake inhibitor and serotonin 1a receptor partial agonist for reducing l-dopa-induced dyskinesia
WO2020131911A1 (en) 2018-12-17 2020-06-25 Intra-Cellular Therapies, Inc. Substituted heterocycle fused gamma-carbolines synthesis
US12195462B2 (en) 2018-12-17 2025-01-14 Intra-Cellular Therapies, Inc. Organic compound
MX2021007141A (es) 2018-12-17 2021-08-11 Intra Cellular Therapies Inc Sintesis de gamma-carbolinas fusionadas con heterociclo sustituido.
EP3897643B1 (en) 2018-12-21 2023-11-15 Intra-Cellular Therapies, Inc. A pyridopyrroloquinoxaline compound and its medical use
JP7649743B2 (ja) * 2018-12-21 2025-03-21 イントラ-セルラー・セラピーズ・インコーポレイテッド 有機化合物
MX2022000143A (es) 2019-07-07 2022-02-17 Intra Cellular Therapies Inc Metodos novedosos.
US12478623B2 (en) 2019-09-25 2025-11-25 Intra-Cellular Therapies, Inc. Methods of treating central nervous system disorders comprising administering lumateperone and a nitric oxide donor
KR102227268B1 (ko) * 2019-10-07 2021-03-12 한국과학기술원 디스토니아 치료 후보 약물의 신규 스크리닝 방법
BR112022008294A2 (pt) 2019-11-01 2022-07-26 Aquestive Therapeutics Inc Composições de profármaco e métodos de tratamento
BR112022008784A2 (pt) 2019-11-14 2022-07-26 Aquestive Therapeutics Inc Composições multimodais e métodos de tratamento
JP7261942B2 (ja) * 2019-12-11 2023-04-20 イントラ-セルラー・セラピーズ・インコーポレイテッド 有機化合物
EP4076461A4 (en) 2019-12-19 2024-01-03 Intra-Cellular Therapies, Inc. METHODS OF TREATMENT OF SCHIZOPHRENIA
US20230339949A1 (en) * 2020-10-09 2023-10-26 Shujing Biopharma Co., Ltd HETEROCYCLIC SUBSTITUTED FUSED y-CARBOLINE DERIVATIVE, PREPARATION METHOD THEREFOR, INTERMEDIATE THEREOF AND USE THEREOF
KR20230134136A (ko) 2021-01-15 2023-09-20 어퀘스티브 테라퓨틱스, 아이엔씨. 전구약물 조성물 및 치료 방법
WO2022192476A1 (en) 2021-03-09 2022-09-15 Aquestive Therapeutics, Inc. Dosage forms having equivalent biocomparable profiles
EP4441209A4 (en) * 2021-11-29 2025-12-17 Editas Medicine Inc MANIPULATED CRISPR/Cas12A EFFECT PROTEINS AND USES THEM
US12414948B2 (en) 2022-05-18 2025-09-16 Intra-Cellular Therapies, Inc. Methods
KR20250012110A (ko) 2022-05-18 2025-01-23 인트라-셀룰라 써래피스, 인코퍼레이티드. 신규 방법
CN115067220B (zh) * 2022-06-16 2023-04-25 中国人民解放军军事科学院军事医学研究院 一种双通道小动物恐惧共情行为检测系统
WO2024088285A1 (zh) * 2022-10-26 2024-05-02 上海枢境生物科技有限公司 一种杂环取代的稠合γ-咔啉类衍生物的甲磺酸盐、晶型及其制备方法和应用
CN120417904A (zh) 2022-12-30 2025-08-01 细胞内治疗公司 作用于血清素5-HT2A受体的杂环稠合γ-咔啉
EP4665344A1 (en) * 2023-02-17 2025-12-24 Intra-Cellular Therapies, Inc. Lumateperone and derivatives thereof for modulating the nervous system
WO2025111568A1 (en) 2023-11-22 2025-05-30 Intra-Cellular Therapies, Inc. Lumateperone and analogues, as 5-ht2a or 5-ht2a/d2 receptor modulators, for use in the treatment of psychiatric disorders caused by viral, bacterial, or autoimmune encephalitis, and of psychiatric symptoms thereof
KR20250129554A (ko) 2024-02-22 2025-08-29 단국대학교 천안캠퍼스 산학협력단 드로페리돌을 유효성분으로 포함하는 신경 질환 예방 또는 치료용 약학 조성물
WO2025240804A1 (en) 2024-05-16 2025-11-20 Intra-Cellular Therapies, Inc. Novel compositions, devices and methods
WO2026011136A1 (en) 2024-07-03 2026-01-08 Intra-Cellular Therapies, Inc. Organic compounds
WO2026011166A1 (en) 2024-07-03 2026-01-08 Intra-Cellular Therapies, Inc. Substituted heterocycles for use in the treatment of diseases involving the 5-ht2a receptor

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4162318A (en) * 1976-05-05 1979-07-24 Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.P.A. Use of trazodone and etoperidone in Parkinsonism and in other extrapyramidal syndromes characterized by tremors
HU208484B (en) 1988-08-17 1993-11-29 Chinoin Gyogyszer Es Vegyeszet Process for producing pharmaceutical composition containing acid additional salt of selegilin as active component for treating schisofrenia
US5114976A (en) 1989-01-06 1992-05-19 Norden Michael J Method for treating certain psychiatric disorders and certain psychiatric symptoms
US6713471B1 (en) 1999-06-15 2004-03-30 Bristol-Myers Squibb Pharma Company Substituted heterocycle fused gamma-carbolines
CN1370176A (zh) * 1999-06-15 2002-09-18 布里斯托尔-迈尔斯斯奎布药品公司 取代的杂环稠合γ-咔啉
US7071186B2 (en) 1999-06-15 2006-07-04 Bristol-Myers Squibb Pharma Co. Substituted heterocycle fused gamma-carbolines
US20050222209A1 (en) 2004-04-01 2005-10-06 Zeldis Jerome B Methods and compositions for the treatment, prevention or management of dysfunctional sleep and dysfunctional sleep associated with disease
CN101141960A (zh) 2005-01-25 2008-03-12 细胞基因公司 使用4-氨基-2-(3-甲基-2,6-二氧代哌啶-3-基)-异吲哚-1,3-二酮的方法和组合物
WO2007025103A2 (en) 2005-08-23 2007-03-01 Intra-Cellular Therapies, Inc. Organic compounds for treating reduced dopamine receptor signalling activity
EP1973876A2 (en) 2006-01-13 2008-10-01 Wyeth Sulfonyl substituted 1h-indoles as ligands for the 5-hydroxytryptamine receptors
JP2010502722A (ja) 2006-09-08 2010-01-28 ブレインセルス,インコーポレイティド 4−アシルアミノピリジン誘導体を含む組み合わせ
ES2776889T3 (es) 2007-03-12 2020-08-03 Intra Cellular Therapies Inc Síntesis de gamma-carbolinas condensadas a heterociclo sustituido
CN101842010A (zh) 2007-08-01 2010-09-22 梅迪维新神经学公司 使用抗精神病的组合治疗产品来治疗精神分裂症的方法和组合物
JP2011511638A (ja) * 2008-02-07 2011-04-14 シェーリング コーポレイション 抗tslpr抗体の設計製作
CN102046175B (zh) 2008-03-12 2015-08-12 细胞内治疗公司 取代的杂环稠合的γ-咔啉固体
CN102105059B (zh) * 2008-05-27 2015-09-30 细胞内治疗公司 用于睡眠障碍和其他疾病的方法和组合物
JP5894574B2 (ja) 2010-04-22 2016-03-30 イントラ−セルラー・セラピーズ・インコーポレイテッドIntra−Cellular Therapies, Inc. 有機化合物
CN104519886B (zh) 2012-04-14 2017-09-12 细胞内治疗公司 有机化合物
DK2968320T3 (da) * 2013-03-15 2021-02-01 Intra Cellular Therapies Inc Organiske forbindelser
CN114366741A (zh) * 2013-12-03 2022-04-19 细胞内治疗公司 新方法
KR20170012210A (ko) * 2014-04-04 2017-02-02 인트라-셀룰라 써래피스, 인코퍼레이티드. 유기 화합물
CA2944755A1 (en) * 2014-04-04 2015-10-08 Intra-Cellular Therapies, Inc. Organic compounds
KR102735964B1 (ko) * 2016-01-26 2024-11-28 인트라-셀룰라 써래피스, 인코퍼레이티드. 유기 화합물
JP6997718B2 (ja) * 2016-03-28 2022-01-18 イントラ-セルラー・セラピーズ・インコーポレイテッド 新規共結晶
US10654854B2 (en) * 2016-03-28 2020-05-19 Intra-Cellular Therapies, Inc. Salts and crystals of ITI-007
WO2018071233A1 (en) * 2016-10-12 2018-04-19 Intra-Cellular Therapies, Inc. Amorphous solid dispersions
IL272252B2 (en) * 2017-07-26 2024-03-01 Intra Cellular Therapies Inc Derivatives of substituted heterocycle fused gamma-carbolines, pharmaceutical compositions comnprising them and their use in treatment
KR20210052472A (ko) * 2018-08-31 2021-05-10 인트라-셀룰라 써래피스, 인코퍼레이티드. 신규한 방법

Also Published As

Publication number Publication date
US8598119B2 (en) 2013-12-03
WO2009145900A1 (en) 2009-12-03
CA2725342A1 (en) 2009-12-03
US10702522B2 (en) 2020-07-07
CN105168219A (zh) 2015-12-23
US20140050783A1 (en) 2014-02-20
US20110071080A1 (en) 2011-03-24
KR20190006606A (ko) 2019-01-18
EP2320731A1 (en) 2011-05-18
US20230355616A1 (en) 2023-11-09
US9168258B2 (en) 2015-10-27
MX377802B (es) 2025-03-11
CN105168219B (zh) 2018-11-20
US20190183888A1 (en) 2019-06-20
CN102105059A (zh) 2011-06-22
CN102105059B (zh) 2015-09-30
CA2725342C (en) 2024-02-20
US20170189398A1 (en) 2017-07-06
US20240041871A1 (en) 2024-02-08
KR20110022631A (ko) 2011-03-07
KR102133073B1 (ko) 2020-07-10
JP2011523949A (ja) 2011-08-25
KR102184038B1 (ko) 2020-11-27
US9616061B2 (en) 2017-04-11
AU2009251816A1 (en) 2009-12-03
EP3085231A1 (en) 2016-10-26
MX2010013020A (es) 2011-03-21
KR102317698B1 (ko) 2021-10-25
AU2009251816B2 (en) 2015-12-10
KR20200134341A (ko) 2020-12-01
EP2320731A4 (en) 2012-09-26
JP2015157828A (ja) 2015-09-03
USRE48839E1 (en) 2021-12-07
US20160030425A1 (en) 2016-02-04
HK1219306A1 (zh) 2017-03-31
US20200405713A1 (en) 2020-12-31
US10117867B2 (en) 2018-11-06
US20250332164A1 (en) 2025-10-30
MX2020012868A (es) 2022-06-14
KR20160135371A (ko) 2016-11-25

Similar Documents

Publication Publication Date Title
JP6106361B2 (ja) 睡眠障害および他の障害のための方法および組成物
US11142529B2 (en) Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
JP7514534B2 (ja) 認知障害を処置するためのベンゾジアゼピン誘導体、組成物および方法
JP2010116412A (ja) 精神分裂病を治療するための方法および組成物
JP2018008981A (ja) パーキンソン病におけるジスキネジアを治療するための新規d3ドーパミン受容体アゴニスト
TWI335329B (en) 7-[2-[4-(6-fluoro-3-methyl-1,2-benzisoxazol-5-yl)-1-piperazinyl]ethyl]-2-(1-propynyl)-7h-pyrazolo-[4,3-e]-[1,2,4]-triazolo-[1,5-c]-pyrimidin-5-amine
AU2015218433B2 (en) Methods and compositions for sleep disorders and other disorders
HK1219306B (zh) 用於睡眠障碍和其他疾病的方法和组合物
HK1230864A1 (en) Method and compositions for sleep disorders and other disorders

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20120509

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20120509

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20131217

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20140317

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20140325

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20140417

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20141202

RD04 Notification of resignation of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7424

Effective date: 20141215

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20150402

A911 Transfer to examiner for re-examination before appeal (zenchi)

Free format text: JAPANESE INTERMEDIATE CODE: A911

Effective date: 20150519

A912 Re-examination (zenchi) completed and case transferred to appeal board

Free format text: JAPANESE INTERMEDIATE CODE: A912

Effective date: 20150703

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20161025

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20161122

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20161208

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20170306

R150 Certificate of patent or registration of utility model

Ref document number: 6106361

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250