KR102317166B1 - 뇌암의 치료 - Google Patents

뇌암의 치료 Download PDF

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Publication number
KR102317166B1
KR102317166B1 KR1020207027176A KR20207027176A KR102317166B1 KR 102317166 B1 KR102317166 B1 KR 102317166B1 KR 1020207027176 A KR1020207027176 A KR 1020207027176A KR 20207027176 A KR20207027176 A KR 20207027176A KR 102317166 B1 KR102317166 B1 KR 102317166B1
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South Korea
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certain embodiments
yloxy
methylphenyl
pyridin
dihydrooxazol
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KR1020207027176A
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English (en)
Korean (ko)
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KR20200115656A (ko
Inventor
파트리스 에이. 리
새넌 엘. 윈스키
케빈 코치
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어레이 바이오파마 인크.
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48048296&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=KR102317166(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by 어레이 바이오파마 인크. filed Critical 어레이 바이오파마 인크.
Priority to KR1020217033686A priority Critical patent/KR102490961B1/ko
Publication of KR20200115656A publication Critical patent/KR20200115656A/ko
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
KR1020207027176A 2012-03-23 2013-03-25 뇌암의 치료 Active KR102317166B1 (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1020217033686A KR102490961B1 (ko) 2012-03-23 2013-03-25 뇌암의 치료

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201261615082P 2012-03-23 2012-03-23
US61/615,082 2012-03-23
KR1020147029340A KR102160462B1 (ko) 2012-03-23 2013-03-25 뇌암의 치료
PCT/US2013/033751 WO2013142875A1 (en) 2012-03-23 2013-03-25 Treatment of brain cancer

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR1020147029340A Division KR102160462B1 (ko) 2012-03-23 2013-03-25 뇌암의 치료

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020217033686A Division KR102490961B1 (ko) 2012-03-23 2013-03-25 뇌암의 치료

Publications (2)

Publication Number Publication Date
KR20200115656A KR20200115656A (ko) 2020-10-07
KR102317166B1 true KR102317166B1 (ko) 2021-10-26

Family

ID=48048296

Family Applications (3)

Application Number Title Priority Date Filing Date
KR1020207027176A Active KR102317166B1 (ko) 2012-03-23 2013-03-25 뇌암의 치료
KR1020147029340A Active KR102160462B1 (ko) 2012-03-23 2013-03-25 뇌암의 치료
KR1020217033686A Active KR102490961B1 (ko) 2012-03-23 2013-03-25 뇌암의 치료

Family Applications After (2)

Application Number Title Priority Date Filing Date
KR1020147029340A Active KR102160462B1 (ko) 2012-03-23 2013-03-25 뇌암의 치료
KR1020217033686A Active KR102490961B1 (ko) 2012-03-23 2013-03-25 뇌암의 치료

Country Status (30)

Country Link
US (3) US20150110780A1 (https=)
EP (4) EP3400943B1 (https=)
JP (6) JP2015514075A (https=)
KR (3) KR102317166B1 (https=)
CN (2) CN109223791A (https=)
AU (4) AU2013234921A1 (https=)
CA (1) CA2867723C (https=)
CL (1) CL2014002497A1 (https=)
CO (1) CO7071139A2 (https=)
CY (2) CY1120204T1 (https=)
DK (2) DK3400943T3 (https=)
ES (2) ES2855142T3 (https=)
HR (1) HRP20180659T1 (https=)
HU (2) HUE037966T2 (https=)
IL (3) IL234627B (https=)
LT (1) LT2827900T (https=)
MX (1) MX354024B (https=)
MY (2) MY202114A (https=)
NZ (4) NZ756264A (https=)
PH (2) PH12021550360A1 (https=)
PL (2) PL3400943T3 (https=)
PT (2) PT3400943T (https=)
RS (1) RS57140B1 (https=)
RU (2) RU2018138976A (https=)
SG (1) SG11201405954YA (https=)
SI (2) SI2827900T1 (https=)
SM (1) SMT201800251T1 (https=)
TR (1) TR201808450T4 (https=)
UA (1) UA122044C2 (https=)
WO (1) WO2013142875A1 (https=)

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WO2013056108A2 (en) 2011-10-14 2013-04-18 Array Biopharma Inc. Solid dispersion
EP3400943B1 (en) 2012-03-23 2020-12-02 Array Biopharma, Inc. Compounds for use in the treatment of brain metastases in a patient with erbb2+ breast cancer
WO2018165015A1 (en) * 2017-03-09 2018-09-13 The Board Of Trustees Of The Leland Stanford Junior University Treatment of pediatric brain tumors with targeting of cd47 pathway
BR112019022280A2 (pt) 2017-04-28 2020-05-19 Seattle Genetics Inc tratamento de cânceres de her2 positivo
IL276398B2 (en) 2018-01-31 2026-03-01 Deciphera Pharmaceuticals Llc Combination therapy for mastocytosis
CN118416236A (zh) 2018-01-31 2024-08-02 德西费拉制药有限责任公司 治疗胃肠道间质瘤的组合疗法
JP7139448B2 (ja) * 2018-04-09 2022-09-20 ノボキュア ゲーエムベーハー ＴＴＦｉｅｌｄｓ及びオーロラキナーゼ阻害剤による腫瘍の治療
CN109942576B (zh) * 2019-03-07 2020-09-11 上海工程技术大学 Irbinitinib及中间体的制备方法
WO2020185812A1 (en) 2019-03-11 2020-09-17 Teva Pharmaceuticals International Gmbh Solid state forms of ripretinib
CN111825604A (zh) * 2019-04-16 2020-10-27 宁波药腾医药科技有限公司 一种图卡替尼及其中间产物的合成方法
EP4013412B1 (en) 2019-08-12 2026-01-28 Deciphera Pharmaceuticals, LLC Ripretinib for treating gastrointestinal stromal tumors
MX2022008103A (es) * 2019-12-30 2022-09-19 Deciphera Pharmaceuticals Llc Formulaciones de inhibidores de la cinasa amorfa y metodos de estas.
EP4084779B1 (en) 2019-12-30 2024-10-09 Deciphera Pharmaceuticals, LLC Compositions of 1-(4-bromo-5-(1-ethyl-7-(methylamino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2-fluorophenyl)-3-phenylurea

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EP3400943B1 (en) 2012-03-23 2020-12-02 Array Biopharma, Inc. Compounds for use in the treatment of brain metastases in a patient with erbb2+ breast cancer

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PT3400943T (pt) 2021-02-02
JP2015514075A (ja) 2015-05-18
HUE053156T2 (hu) 2021-06-28
PT2827900T (pt) 2018-06-14
CO7071139A2 (es) 2014-09-30
PL2827900T3 (pl) 2018-08-31
CN104203279B (zh) 2018-10-30
EP2827900A1 (en) 2015-01-28
JP2019081792A (ja) 2019-05-30
RU2018138976A (ru) 2018-12-06
CA2867723A1 (en) 2013-09-26
PL3400943T3 (pl) 2021-06-14
JP2022190126A (ja) 2022-12-22
EP3400943A1 (en) 2018-11-14
NZ630843A (en) 2017-01-27
CL2014002497A1 (es) 2014-11-14
MX354024B (es) 2018-02-08
LT2827900T (lt) 2018-05-10
WO2013142875A1 (en) 2013-09-26
US11504370B2 (en) 2022-11-22
AU2021261849A1 (en) 2021-12-02
HK1206276A1 (en) 2016-01-08
CN109223791A (zh) 2019-01-18
KR20210131426A (ko) 2021-11-02
DK2827900T3 (en) 2018-05-07
IL234627B (en) 2018-10-31
IL261659A (en) 2018-10-31
HRP20180659T1 (hr) 2018-06-01
ES2673165T3 (es) 2018-06-20
DK3400943T3 (da) 2021-02-08
AU2017272232C1 (en) 2019-08-15
CA2867723C (en) 2022-11-08
JP2017141302A (ja) 2017-08-17
KR20200115656A (ko) 2020-10-07
RU2672575C2 (ru) 2018-11-16
US20230190749A1 (en) 2023-06-22
UA122044C2 (uk) 2020-09-10
RU2018138976A3 (https=) 2022-04-08
AU2019203618B2 (en) 2021-08-05
SG11201405954YA (en) 2014-10-30
RU2014142700A (ru) 2016-05-20
AU2013234921A1 (en) 2014-10-02
EP3400943B1 (en) 2020-12-02
CY1123837T1 (el) 2022-05-27
HUE037966T2 (hu) 2018-09-28
PH12014502032A1 (en) 2014-11-24
SI3400943T1 (sl) 2021-03-31
JP2024019526A (ja) 2024-02-09
SI2827900T1 (en) 2018-06-29
MY202114A (en) 2024-04-04
CY1120204T1 (el) 2018-12-12
EP4252855A3 (en) 2023-11-15
IL269205A (en) 2019-11-28
EP2827900B1 (en) 2018-03-21
JP6898960B2 (ja) 2021-07-07
JP2021178820A (ja) 2021-11-18
CN104203279A (zh) 2014-12-10
PH12021550360A1 (en) 2023-04-03
AU2017272232A1 (en) 2018-01-04
NZ756264A (en) 2022-09-30
TR201808450T4 (tr) 2018-07-23
EP4252855A2 (en) 2023-10-04
KR102490961B1 (ko) 2023-01-19
ES2855142T3 (es) 2021-09-23
US20190255051A1 (en) 2019-08-22
IL269205B (en) 2020-06-30
AU2017272232B2 (en) 2019-02-28
JP7404485B2 (ja) 2023-12-25
KR102160462B1 (ko) 2020-09-28
MX2014011437A (es) 2014-11-10
NZ741615A (en) 2019-10-25
MY174883A (en) 2020-05-20
SMT201800251T1 (it) 2018-07-17
AU2019203618A1 (en) 2019-06-13
KR20140139009A (ko) 2014-12-04
US20150110780A1 (en) 2015-04-23
NZ724544A (en) 2018-05-25
RS57140B1 (sr) 2018-07-31
EP3842044A1 (en) 2021-06-30

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