KR102263812B1 - a-syn/IGF1R에 대한 이중 특이 항체 및 그 용도 - Google Patents

a-syn/IGF1R에 대한 이중 특이 항체 및 그 용도 Download PDF

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KR102263812B1
KR102263812B1 KR1020207009513A KR20207009513A KR102263812B1 KR 102263812 B1 KR102263812 B1 KR 102263812B1 KR 1020207009513 A KR1020207009513 A KR 1020207009513A KR 20207009513 A KR20207009513 A KR 20207009513A KR 102263812 B1 KR102263812 B1 KR 102263812B1
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antibody
cdr2
cdr3
cdr1
heavy chain
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KR20200067838A (ko
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안진형
안성원
김동인
성은실
엄재현
이상훈
유원규
김주희
박경진
정혜진
정진원
이보라
성병제
김연주
손용규
안세원
송대해
유지선
박영돈
염동훈
이요섭
정재호
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에이비엘바이오 주식회사
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    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C07K2317/00—Immunoglobulins specific features
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    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
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    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
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    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
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    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

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KR1020207009513A 2017-12-14 2018-12-14 a-syn/IGF1R에 대한 이중 특이 항체 및 그 용도 Active KR102263812B1 (ko)

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KR1020170172205 2017-12-14
KR20170172205 2017-12-14
US201862693474P 2018-07-03 2018-07-03
US62/693,474 2018-07-03
US201862734391P 2018-09-21 2018-09-21
US201862734388P 2018-09-21 2018-09-21
US62/734,391 2018-09-21
US62/734,388 2018-09-21
PCT/KR2018/015953 WO2019117684A1 (ko) 2017-12-14 2018-12-14 a-syn/IGF1R에 대한 이중 특이 항체 및 그 용도

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CN (2) CN116731173A (https=)
AU (2) AU2018385230B2 (https=)
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