KR102228921B1 - Pdgf 및 vegf 결합 부분을 포함하는 융합 단백질 및 이의 이용방법 - Google Patents

Pdgf 및 vegf 결합 부분을 포함하는 융합 단백질 및 이의 이용방법 Download PDF

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KR102228921B1
KR102228921B1 KR1020157027849A KR20157027849A KR102228921B1 KR 102228921 B1 KR102228921 B1 KR 102228921B1 KR 1020157027849 A KR1020157027849 A KR 1020157027849A KR 20157027849 A KR20157027849 A KR 20157027849A KR 102228921 B1 KR102228921 B1 KR 102228921B1
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피터 퍼찬
제프리 아딩거
힐라드 루빈
새뮤얼 워즈워쓰
에이브러햄 스카리아
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젠자임 코포레이션
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1858—Platelet-derived growth factor [PDGF]
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
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    • A61K38/18—Growth factors; Growth regulators
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    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
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    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
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    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
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KR1020157027849A 2013-03-13 2014-03-13 Pdgf 및 vegf 결합 부분을 포함하는 융합 단백질 및 이의 이용방법 Expired - Fee Related KR102228921B1 (ko)

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US201361780914P 2013-03-13 2013-03-13
US61/780,914 2013-03-13
PCT/US2014/026872 WO2014160507A1 (en) 2013-03-13 2014-03-13 Fusion proteins comprising pdgf and vegf binding portions and methods of using thereof

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KR20150126923A KR20150126923A (ko) 2015-11-13
KR102228921B1 true KR102228921B1 (ko) 2021-03-16

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US (4) US9637534B2 (https=)
EP (1) EP2968461B1 (https=)
JP (2) JP6561042B2 (https=)
KR (1) KR102228921B1 (https=)
CN (1) CN105188733B (https=)
AR (1) AR095437A1 (https=)
AU (2) AU2014243712B2 (https=)
BR (1) BR112015022208A8 (https=)
CA (1) CA2904623A1 (https=)
DK (1) DK2968461T3 (https=)
ES (1) ES2933558T3 (https=)
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IL (2) IL240950B (https=)
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PL (1) PL2968461T3 (https=)
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RS (1) RS63820B1 (https=)
RU (1) RU2692652C2 (https=)
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WO2024029876A1 (ko) 2022-08-02 2024-02-08 주식회사 파노로스바이오사이언스 변형된 융합 단백질 및 이의 용도
WO2025033876A1 (ko) 2023-08-04 2025-02-13 주식회사 파노로스바이오사이언스 변형된 융합 단백질과 scFv의 결합체 및 이의 용도

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KR102205830B1 (ko) * 2017-10-26 2021-01-21 주식회사 큐로진생명과학 솔루블 VEGFR-1 변이체 cDNA를 함유하는 rAAV를 포함하는 황반변성 치료용 조성물
US11548931B2 (en) 2017-11-16 2023-01-10 Xl-Protein Gmbh PASylated VEGFR/PDGFR fusion proteins and their use in therapy
CN111406071B (zh) * 2017-11-16 2024-01-16 成都硕德药业有限公司 Pas化的vegfr/pdgfr融合蛋白及其在治疗中的用途
AU2019212622B2 (en) 2018-01-26 2024-05-23 The Regents Of The University Of California Methods and compositions for treatment of angiogenic disorders using anti-VEGF agents
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BR112022010113A2 (pt) 2019-11-25 2022-09-06 Univ California Inibidores de vegf de longa ação para neovascularização intraocular
AU2020396699B2 (en) * 2019-12-04 2024-07-18 Cdmogen Co., Ltd Composition for treating diabetic retinopathy, comprising rAAV containing soluble VEGFR-1 variant cDNA
CN111826400A (zh) * 2020-07-21 2020-10-27 中科宝承生物医学科技有限公司 一种双特异性抗体nk细胞制备方法及其细胞和应用
CN112961250B (zh) * 2021-03-01 2023-06-06 长春金赛药业有限责任公司 抗体融合蛋白及其应用
CN113105558A (zh) * 2021-04-01 2021-07-13 芜湖英特菲尔生物制品产业研究院有限公司 一种酿酒酵母表达人rPDGF-HSA融合蛋白及其标准品的制备方法
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WO2023199951A1 (ja) * 2022-04-13 2023-10-19 株式会社セルージョン 抗ｖｅｇｆ機能を有する多能性幹細胞及びその分化細胞
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