SG11201506802SA - Fusion proteins comprising pdgf and vegf binding portions and methods of using thereof - Google Patents
Fusion proteins comprising pdgf and vegf binding portions and methods of using thereofInfo
- Publication number
- SG11201506802SA SG11201506802SA SG11201506802SA SG11201506802SA SG11201506802SA SG 11201506802S A SG11201506802S A SG 11201506802SA SG 11201506802S A SG11201506802S A SG 11201506802SA SG 11201506802S A SG11201506802S A SG 11201506802SA SG 11201506802S A SG11201506802S A SG 11201506802SA
- Authority
- SG
- Singapore
- Prior art keywords
- pdgf
- methods
- fusion proteins
- binding portions
- vegf binding
- Prior art date
Links
- 101100372758 Danio rerio vegfaa gene Proteins 0.000 title 1
- 101150030763 Vegfa gene Proteins 0.000 title 1
- 102000037865 fusion proteins Human genes 0.000 title 1
- 108020001507 fusion proteins Proteins 0.000 title 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1858—Platelet-derived growth factor [PDGF]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1858—Platelet-derived growth factor [PDGF]
- A61K38/1866—Vascular endothelial growth factor [VEGF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
- C12N2510/02—Cells for production
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14141—Use of virus, viral particle or viral elements as a vector
- C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Cell Biology (AREA)
- Toxicology (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pulmonology (AREA)
- Vascular Medicine (AREA)
- Rheumatology (AREA)
- Biotechnology (AREA)
- Endocrinology (AREA)
- Ophthalmology & Optometry (AREA)
- Pain & Pain Management (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361780914P | 2013-03-13 | 2013-03-13 | |
| PCT/US2014/026872 WO2014160507A1 (en) | 2013-03-13 | 2014-03-13 | Fusion proteins comprising pdgf and vegf binding portions and methods of using thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201506802SA true SG11201506802SA (en) | 2015-09-29 |
Family
ID=50680144
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG10201707501TA SG10201707501TA (en) | 2013-03-13 | 2014-03-13 | Fusion proteins comprising pdgf and vegf binding portions and methods of using thereof |
| SG10201912956YA SG10201912956YA (en) | 2013-03-13 | 2014-03-13 | Fusion proteins comprising pdgf and vegf binding portions and methods of using thereof |
| SG11201506802SA SG11201506802SA (en) | 2013-03-13 | 2014-03-13 | Fusion proteins comprising pdgf and vegf binding portions and methods of using thereof |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG10201707501TA SG10201707501TA (en) | 2013-03-13 | 2014-03-13 | Fusion proteins comprising pdgf and vegf binding portions and methods of using thereof |
| SG10201912956YA SG10201912956YA (en) | 2013-03-13 | 2014-03-13 | Fusion proteins comprising pdgf and vegf binding portions and methods of using thereof |
Country Status (27)
| Country | Link |
|---|---|
| US (4) | US9637534B2 (en) |
| EP (1) | EP2968461B1 (en) |
| JP (2) | JP6561042B2 (en) |
| KR (1) | KR102228921B1 (en) |
| CN (1) | CN105188733B (en) |
| AR (1) | AR095437A1 (en) |
| AU (2) | AU2014243712B2 (en) |
| BR (1) | BR112015022208A8 (en) |
| CA (1) | CA2904623A1 (en) |
| DK (1) | DK2968461T3 (en) |
| ES (1) | ES2933558T3 (en) |
| FI (1) | FI2968461T3 (en) |
| HK (1) | HK1220618A1 (en) |
| HR (1) | HRP20221447T1 (en) |
| HU (1) | HUE060464T2 (en) |
| IL (2) | IL240950B (en) |
| LT (1) | LT2968461T (en) |
| MX (1) | MX363533B (en) |
| PL (1) | PL2968461T3 (en) |
| PT (1) | PT2968461T (en) |
| RS (1) | RS63820B1 (en) |
| RU (1) | RU2692652C2 (en) |
| SG (3) | SG10201707501TA (en) |
| SI (1) | SI2968461T1 (en) |
| TW (1) | TWI631133B (en) |
| UY (1) | UY35407A (en) |
| WO (1) | WO2014160507A1 (en) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8765432B2 (en) | 2009-12-18 | 2014-07-01 | Oligasis, Llc | Targeted drug phosphorylcholine polymer conjugates |
| ES2933558T3 (en) | 2013-03-13 | 2023-02-10 | Genzyme Corp | Fusion proteins comprising PDGF and VEGF binding portions and methods of using the same |
| EP3010525A1 (en) * | 2013-06-20 | 2016-04-27 | Novartis AG | Use of a vegf antagonist in treating choroidal neovascularisation |
| HUE052447T2 (en) | 2013-09-08 | 2021-04-28 | Kodiak Sciences Inc | Factor viii zwitterionic polymer conjugates |
| KR101844596B1 (en) | 2014-03-18 | 2018-04-05 | 한국과학기술원 | Compositions for Treating Eye Disease comprising Glycosylated VEGF Decoy Receptor Fusion Protein |
| CA2953698A1 (en) * | 2014-06-28 | 2015-12-30 | Kodiak Sciences Inc. | Dual pdgf/vegf antagonists |
| US9840553B2 (en) | 2014-06-28 | 2017-12-12 | Kodiak Sciences Inc. | Dual PDGF/VEGF antagonists |
| CN107208076A (en) | 2014-10-17 | 2017-09-26 | 科达制药 | Butyrylcholine esterase amphoteric ion polymer conjugate |
| AU2016229053B2 (en) | 2015-03-11 | 2018-07-12 | Ap Biosciences, Inc. | Fusion protein comprising a ligand binding domain of VEGF and PDGF |
| EP3313426B1 (en) * | 2015-06-28 | 2020-04-29 | Allgenesis Biotherapeutics Inc. | Fusion proteins for inhibiting angiogenesis |
| WO2017084616A1 (en) * | 2015-11-19 | 2017-05-26 | Zhuhai Tairuishang Biopharm Ltd. | Methods and compositions for binding vegf |
| AU2016381964B2 (en) | 2015-12-30 | 2024-02-15 | Kodiak Sciences Inc. | Antibodies and conjugates thereof |
| AU2017245143B2 (en) | 2016-03-30 | 2024-01-11 | Ab Biosciences, Inc. | Recombinant intravenous immunoglobulin (rIVIG) compositions and methods for their production and use |
| KR101685532B1 (en) * | 2016-04-26 | 2016-12-13 | 한국프라임제약주식회사 | A VEGFR fusion protein |
| JP6849390B2 (en) * | 2016-10-28 | 2021-03-24 | 花王株式会社 | Joint stiffness improving agent |
| KR102205830B1 (en) * | 2017-10-26 | 2021-01-21 | 주식회사 큐로진생명과학 | Pharmaceutical Composition for Treating Macular Degeneration Containing AAV Including cDNA of Soluble VEGFR Variant |
| WO2019083171A2 (en) * | 2017-10-26 | 2019-05-02 | 주식회사 큐로진생명과학 | Composition comprising raav containing soluble vegfr-1 derivative cdna for treatment of macular degeneration |
| EP3710483A4 (en) * | 2017-11-16 | 2021-10-20 | XL-protein GmbH | Pasylated vegfr/pdgfr fusion proteins and their use in therapy |
| CN111406071B (en) * | 2017-11-16 | 2024-01-16 | 成都硕德药业有限公司 | PAS-like VEGFR/PDGFR fusion proteins and their use in therapy |
| CN111741761B (en) * | 2018-01-26 | 2023-04-18 | 加利福尼亚大学董事会 | Methods and compositions for treating angiogenic disorders using anti-VEGF agents |
| CN112203679A (en) | 2018-03-02 | 2021-01-08 | 科达制药股份有限公司 | IL-6 antibodies and fusion constructs and conjugates thereof |
| CN114786731A (en) | 2019-10-10 | 2022-07-22 | 科达制药股份有限公司 | Methods of treating ocular disorders |
| JP2023502501A (en) | 2019-11-25 | 2023-01-24 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | Long-acting VEGF inhibitors for intraocular angiogenesis |
| KR102505262B1 (en) * | 2019-12-04 | 2023-03-03 | (주) 씨드모젠 | Pharmaceutical Composition for Treating Macular Degeneration Containing AAV Including cDNA of Soluble VEGFR-1 Variant |
| CN111826400A (en) * | 2020-07-21 | 2020-10-27 | 中科宝承生物医学科技有限公司 | Preparation method of bispecific antibody NK cell, cell and application thereof |
| CN112961250B (en) * | 2021-03-01 | 2023-06-06 | 长春金赛药业有限责任公司 | Antibody fusion proteins and uses thereof |
| CN113105558A (en) * | 2021-04-01 | 2021-07-13 | 芜湖英特菲尔生物制品产业研究院有限公司 | Saccharomyces cerevisiae expression human rPDGF-HSA fusion protein and preparation method of standard substance thereof |
| CA3222464A1 (en) * | 2021-06-18 | 2022-12-22 | Ikarovec Limited | Retinal disorders |
| WO2023199951A1 (en) * | 2022-04-13 | 2023-10-19 | 株式会社セルージョン | Multipotent stem cell having anti-vegf function and differentiated cell thereof |
| US11723955B1 (en) | 2022-05-13 | 2023-08-15 | Allgenesis Biotherapeutics Inc. | VEGFR fusion protein pharmaceutical composition |
| KR20240019034A (en) * | 2022-08-02 | 2024-02-14 | 주식회사 파노로스바이오사이언스 | Modified fusion protein and the use thereof |
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| ES2933558T3 (en) | 2013-03-13 | 2023-02-10 | Genzyme Corp | Fusion proteins comprising PDGF and VEGF binding portions and methods of using the same |
-
2014
- 2014-03-13 ES ES14722439T patent/ES2933558T3/en active Active
- 2014-03-13 RU RU2015142999A patent/RU2692652C2/en active
- 2014-03-13 CN CN201480026585.2A patent/CN105188733B/en active Active
- 2014-03-13 HU HUE14722439A patent/HUE060464T2/en unknown
- 2014-03-13 SI SI201432005T patent/SI2968461T1/en unknown
- 2014-03-13 WO PCT/US2014/026872 patent/WO2014160507A1/en active Application Filing
- 2014-03-13 JP JP2016502268A patent/JP6561042B2/en active Active
- 2014-03-13 EP EP14722439.8A patent/EP2968461B1/en active Active
- 2014-03-13 AU AU2014243712A patent/AU2014243712B2/en active Active
- 2014-03-13 US US14/210,354 patent/US9637534B2/en active Active
- 2014-03-13 SG SG10201707501TA patent/SG10201707501TA/en unknown
- 2014-03-13 FI FIEP14722439.8T patent/FI2968461T3/en active
- 2014-03-13 DK DK14722439.8T patent/DK2968461T3/en active
- 2014-03-13 MX MX2015011951A patent/MX363533B/en unknown
- 2014-03-13 PT PT147224398T patent/PT2968461T/en unknown
- 2014-03-13 TW TW103109211A patent/TWI631133B/en not_active IP Right Cessation
- 2014-03-13 PL PL14722439.8T patent/PL2968461T3/en unknown
- 2014-03-13 UY UY0001035407A patent/UY35407A/en not_active Application Discontinuation
- 2014-03-13 BR BR112015022208A patent/BR112015022208A8/en not_active IP Right Cessation
- 2014-03-13 HR HRP20221447TT patent/HRP20221447T1/en unknown
- 2014-03-13 AR ARP140100983A patent/AR095437A1/en unknown
- 2014-03-13 SG SG10201912956YA patent/SG10201912956YA/en unknown
- 2014-03-13 RS RS20221155A patent/RS63820B1/en unknown
- 2014-03-13 KR KR1020157027849A patent/KR102228921B1/en active IP Right Grant
- 2014-03-13 CA CA2904623A patent/CA2904623A1/en not_active Abandoned
- 2014-03-13 SG SG11201506802SA patent/SG11201506802SA/en unknown
- 2014-03-13 LT LTEPPCT/US2014/026872T patent/LT2968461T/en unknown
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2015
- 2015-08-31 IL IL240950A patent/IL240950B/en active IP Right Grant
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2016
- 2016-07-20 HK HK16108675.7A patent/HK1220618A1/en unknown
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2017
- 2017-03-28 US US15/471,725 patent/US10183983B2/en active Active
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2018
- 2018-11-20 US US16/197,194 patent/US11084864B2/en active Active
- 2018-12-12 AU AU2018278902A patent/AU2018278902A1/en not_active Abandoned
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2019
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- 2019-05-19 IL IL266715A patent/IL266715A/en unknown
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2021
- 2021-07-02 US US17/367,027 patent/US20220064262A1/en active Pending
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