KR102177225B1 - 촉매-무함유 표면 작용화 및 중합체 그라프팅 - Google Patents

촉매-무함유 표면 작용화 및 중합체 그라프팅 Download PDF

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KR102177225B1
KR102177225B1 KR1020207001606A KR20207001606A KR102177225B1 KR 102177225 B1 KR102177225 B1 KR 102177225B1 KR 1020207001606 A KR1020207001606 A KR 1020207001606A KR 20207001606 A KR20207001606 A KR 20207001606A KR 102177225 B1 KR102177225 B1 KR 102177225B1
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KR20200009136A (ko
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로렌조 베르티
앤드류 에이. 브라운
웨인 엔. 조지
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일루미나, 인코포레이티드
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    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J7/00—Chemical treatment or coating of shaped articles made of macromolecular substances
    • C08J7/12—Chemical modification
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B27/00—Layered products comprising a layer of synthetic resin
    • B32B27/28—Layered products comprising a layer of synthetic resin comprising synthetic resins not wholly covered by any one of the sub-groups B32B27/30 - B32B27/42
    • B32B27/283—Layered products comprising a layer of synthetic resin comprising synthetic resins not wholly covered by any one of the sub-groups B32B27/30 - B32B27/42 comprising polysiloxanes
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    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B7/00—Layered products characterised by the relation between layers; Layered products characterised by the relative orientation of features between layers, or by the relative values of a measurable parameter between layers, i.e. products comprising layers having different physical, chemical or physicochemical properties; Layered products characterised by the interconnection of layers
    • B32B7/04—Interconnection of layers
    • B32B7/10—Interconnection of layers at least one layer having inter-reactive properties
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    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
    • C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
    • C08F220/52—Amides or imides
    • C08F220/54—Amides, e.g. N,N-dimethylacrylamide or N-isopropylacrylamide
    • C08F220/60—Amides, e.g. N,N-dimethylacrylamide or N-isopropylacrylamide containing nitrogen in addition to the carbonamido nitrogen
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    • C09D133/00—Coating compositions based on homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides, or nitriles thereof; Coating compositions based on derivatives of such polymers
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    • C09D133/26—Homopolymers or copolymers of acrylamide or methacrylamide
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00614—Delimitation of the attachment areas
    • B01J2219/00617—Delimitation of the attachment areas by chemical means
    • B01J2219/00619—Delimitation of the attachment areas by chemical means using hydrophilic or hydrophobic regions
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    • B01J2219/00623—Immobilisation or binding
    • B01J2219/00626—Covalent
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    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00632—Introduction of reactive groups to the surface
    • B01J2219/00637—Introduction of reactive groups to the surface by coating it with another layer
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    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Laminated Bodies (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
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  • Surface Treatment Of Glass (AREA)
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  • Peptides Or Proteins (AREA)
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KR1020207001606A 2013-07-01 2014-06-26 촉매-무함유 표면 작용화 및 중합체 그라프팅 Active KR102177225B1 (ko)

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KR1020207031892A KR102266002B1 (ko) 2013-07-01 2014-06-26 촉매-무함유 표면 작용화 및 중합체 그라프팅

Applications Claiming Priority (5)

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US201361841647P 2013-07-01 2013-07-01
US61/841,647 2013-07-01
US201461971381P 2014-03-27 2014-03-27
US61/971,381 2014-03-27
PCT/US2014/044356 WO2015002813A1 (en) 2013-07-01 2014-06-26 Catalyst-free surface functionalization and polymer grafting

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KR1020167002434A Division KR102070483B1 (ko) 2013-07-01 2014-06-26 촉매-무함유 표면 작용화 및 중합체 그라프팅

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KR102177225B1 true KR102177225B1 (ko) 2020-11-10

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KR1020207031892A Active KR102266002B1 (ko) 2013-07-01 2014-06-26 촉매-무함유 표면 작용화 및 중합체 그라프팅
KR1020167002434A Active KR102070483B1 (ko) 2013-07-01 2014-06-26 촉매-무함유 표면 작용화 및 중합체 그라프팅

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KR1020167002434A Active KR102070483B1 (ko) 2013-07-01 2014-06-26 촉매-무함유 표면 작용화 및 중합체 그라프팅

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JP (3) JP6511046B2 (enExample)
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Families Citing this family (107)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI2556171T1 (sl) 2010-04-05 2016-03-31 Prognosys Biosciences, Inc. Prostorsko kodirane biološke analize
US10787701B2 (en) 2010-04-05 2020-09-29 Prognosys Biosciences, Inc. Spatially encoded biological assays
GB201106254D0 (en) 2011-04-13 2011-05-25 Frisen Jonas Method and product
EP4592400A3 (en) 2012-10-17 2025-10-29 10x Genomics Sweden AB Methods and product for optimising localised or spatial detection of gene expression in a tissue sample
EP4219745B1 (en) 2013-06-25 2025-09-03 Prognosys Biosciences, Inc. Spatially encoded biological assays using a microfluidic device
KR102177225B1 (ko) 2013-07-01 2020-11-10 일루미나, 인코포레이티드 촉매-무함유 표면 작용화 및 중합체 그라프팅
AU2014364898B2 (en) 2013-12-19 2018-07-26 Illumina, Inc. Substrates comprising nano-patterning surfaces and methods of preparing thereof
SG10201809900PA (en) 2014-07-31 2018-12-28 Illumina Inc Hybrid Nanopore Sensors
US9982250B2 (en) 2014-08-21 2018-05-29 Illumina Cambridge Limited Reversible surface functionalization
LT3212684T (lt) * 2014-10-31 2020-04-10 Illumina Cambridge Limited Polimerai ir dnr kopolimero dangos
DK3901281T4 (da) 2015-04-10 2025-10-20 Illumina Inc Rumligt adskilt, multipleks nukleinsyreanalyse af biologiske prøver
CA3160383A1 (en) 2015-05-11 2016-11-17 Illumina, Inc. Platform for discovery and analysis of therapeutic agents
EP3320399A1 (en) 2015-07-07 2018-05-16 Illumina, Inc. Selective surface patterning via nanoimprinting
ES2945607T3 (es) 2015-07-17 2023-07-04 Illumina Inc Láminas de polímero para aplicaciones de secuenciación
AU2016330924A1 (en) * 2015-10-02 2018-04-26 PixarBio Corporation Compositions for an injectable, in situ forming neuroscaffold and methods of using the same
AU2017267653B2 (en) 2016-05-18 2021-05-13 Illumina, Inc. Self assembled patterning using patterned Hydrophobic surfaces
DK3488002T3 (da) 2016-07-22 2021-06-21 Univ Oregon Health & Science Enkeltcelle-helgenombiblioteker og kombinatoriske indekseringsfremgangsmåder til fremstilling deraf
CA3046374A1 (en) 2016-12-22 2018-06-28 Illumina, Inc. Imprinting apparatus
RU2754808C2 (ru) * 2016-12-22 2021-09-07 Иллюмина, Инк. Модуль проточной ячейки и способ его получения
CA3046379A1 (en) * 2016-12-22 2018-06-28 Illumina, Inc Arrays with quality control tracers
PL3558510T3 (pl) 2016-12-22 2023-03-13 Illumina, Inc. Macierz zawierająca starter sekwencjonujący i jednostkę niesekwencjonującą
JP7123928B2 (ja) 2016-12-22 2022-08-23 イラミーナ インコーポレーテッド 樹脂膜とパターン化ポリマー層を含むアレイ
KR102370056B1 (ko) * 2017-02-24 2022-03-03 일루미나, 인코포레이티드 탄산칼슘 슬러리
EP3913053A1 (en) 2017-04-23 2021-11-24 Illumina Cambridge Limited Compositions and methods for improving sample identification in indexed nucleic acid libraries
WO2018200386A1 (en) 2017-04-23 2018-11-01 Illumina, Inc. Compositions and methods for improving sample identification in indexed nucleic acid libraries
CA3060979C (en) 2017-04-23 2023-07-11 Illumina Cambridge Limited Compositions and methods for improving sample identification in indexed nucleic acid libraries
NL2019044B1 (en) * 2017-05-11 2018-11-15 Illumina Inc Protective surface coatings for flow cells
SG11201911730XA (en) 2017-06-07 2020-01-30 Univ Oregon Health & Science Single cell whole genome libraries for methylation sequencing
US11987780B2 (en) 2017-07-14 2024-05-21 Cedars-Sinai Medical Center L-glass: a novel functionalization method for covalently attaching ECM protein to optical glass
US20200202977A1 (en) 2017-07-31 2020-06-25 Illumina, Inc. Sequencing system with multiplexed biological sample aggregation
CN111108219B (zh) 2017-08-01 2024-12-27 伊鲁米纳公司 使用的水凝胶珠和流动池的遗传物质的空间索引和文库制备
MY203405A (en) * 2017-12-21 2024-06-26 Illumina Inc Flow cells with hydrogel coating
BR112019027630B1 (pt) 2017-12-22 2023-03-21 Illumina, Inc Substâncias cataliticamente ativas
NL2020625B1 (en) 2017-12-22 2019-07-02 Illumina Inc Two-filter light detection devices and methods of manufacturing same
AU2019248635B2 (en) 2018-04-02 2022-01-27 Illumina, Inc. Compositions and methods for making controls for sequence-based genetic testing
AU2019257320B2 (en) 2018-04-20 2022-04-07 Illumina, Inc. Methods of encapsulating single cells, the encapsulated cells and uses thereof
JP7100069B2 (ja) 2018-05-15 2022-07-12 イルミナ インコーポレイテッド 表面結合オリゴヌクレオチドを化学開裂および脱保護するための組成物および方法
CN119955902A (zh) 2018-05-17 2025-05-09 伊鲁米纳公司 具有减少的扩增偏倚的高通量单细胞测序
CN111247248A (zh) 2018-06-04 2020-06-05 伊鲁米纳公司 高通量单细胞转录组文库及制备和使用方法
JP7437161B2 (ja) 2018-06-29 2024-02-22 イラミーナ インコーポレーテッド フローセル
CN112739856B (zh) * 2018-07-18 2024-10-15 上海科技大学 有机化合物功能性独立的标记
TW202019989A (zh) * 2018-08-06 2020-06-01 美商康寧公司 具有穩定聚合物塗層之流動槽及其用於基因定序之用途
WO2020076976A1 (en) 2018-10-10 2020-04-16 Readcoor, Inc. Three-dimensional spatial molecular indexing
CN111100785B (zh) * 2018-10-25 2023-08-11 深圳市真迈生物科技有限公司 固相基底、其处理方法和确定处理条件的方法
WO2020086843A1 (en) * 2018-10-26 2020-04-30 Illumina, Inc. Modulating polymer beads for dna processing
WO2020123320A2 (en) 2018-12-10 2020-06-18 10X Genomics, Inc. Imaging system hardware
AU2019406313A1 (en) * 2018-12-17 2021-01-07 Illumina, Inc. Flow cells and sequencing kits
BR112021006044A2 (pt) * 2018-12-21 2021-06-29 Illumina, Inc. depleção de rna baseada em nuclease
US11649485B2 (en) 2019-01-06 2023-05-16 10X Genomics, Inc. Generating capture probes for spatial analysis
US11926867B2 (en) 2019-01-06 2024-03-12 10X Genomics, Inc. Generating capture probes for spatial analysis
BR112021006234A2 (pt) 2019-03-01 2021-09-28 Illumina, Inc. Bibliotecas de células únicas e núcleos únicos de alto rendimento e métodos de preparo e uso
NL2023316B1 (en) 2019-03-21 2020-09-28 Illumina Inc Artificial intelligence-based sequencing
NL2023310B1 (en) 2019-03-21 2020-09-28 Illumina Inc Training data generation for artificial intelligence-based sequencing
NL2023311B9 (en) 2019-03-21 2021-03-12 Illumina Inc Artificial intelligence-based generation of sequencing metadata
US11210554B2 (en) 2019-03-21 2021-12-28 Illumina, Inc. Artificial intelligence-based generation of sequencing metadata
WO2020191389A1 (en) 2019-03-21 2020-09-24 Illumina, Inc. Training data generation for artificial intelligence-based sequencing
NL2023679B1 (en) 2019-08-09 2021-04-13 Illumina Inc System and method for patterning flow cell substrates
WO2021028815A1 (en) 2019-08-09 2021-02-18 Illumina Inc. System and method for patterning flow cell substrates
SG11202109486QA (en) 2019-12-19 2021-09-29 Illumina Inc High-throughput single-cell libraries and methods of making and of using
US12085499B2 (en) 2019-12-20 2024-09-10 Illumina, Inc. Flow cells
US11821035B1 (en) 2020-01-29 2023-11-21 10X Genomics, Inc. Compositions and methods of making gene expression libraries
US12076701B2 (en) 2020-01-31 2024-09-03 10X Genomics, Inc. Capturing oligonucleotides in spatial transcriptomics
EP4106913A1 (en) * 2020-02-21 2022-12-28 10X Genomics, Inc. Compositions, methods and systems for sample processing
CA3145159A1 (en) * 2020-04-24 2021-10-28 Illumina Cambridge Limited Flow cells
US11188778B1 (en) 2020-05-05 2021-11-30 Illumina, Inc. Equalization-based image processing and spatial crosstalk attenuator
US12209266B2 (en) 2020-05-12 2025-01-28 Illumina, Inc. Generating nucleic acids with modified bases using recombinant terminal deoxynucleotidyl transferase
WO2021252617A1 (en) 2020-06-09 2021-12-16 Illumina, Inc. Methods for increasing yield of sequencing libraries
AU2021299216A1 (en) 2020-06-30 2022-12-08 Illumina, Inc. Catalytically controlled sequencing by synthesis to produce scarless DNA
CN116018412A (zh) 2020-07-08 2023-04-25 Illumina公司 作为转座体载体的小珠
CN111743857A (zh) * 2020-07-30 2020-10-09 瑞希(重庆)生物科技有限公司 一种壳聚糖水凝胶及其制备方法
US20220049303A1 (en) 2020-08-17 2022-02-17 Readcoor, Llc Methods and systems for spatial mapping of genetic variants
WO2022058845A1 (en) * 2020-09-15 2022-03-24 3M Innovative Properties Company Nanopatterned films with patterned surface chemistry
IL299441A (en) * 2020-10-20 2023-02-01 Illumina Inc Flow Cells
US11361194B2 (en) 2020-10-27 2022-06-14 Illumina, Inc. Systems and methods for per-cluster intensity correction and base calling
CN114573764B (zh) * 2020-11-30 2023-08-29 深圳市真迈生物科技有限公司 聚合物、芯片及其制备方法和应用
AU2021416526A1 (en) * 2021-01-05 2023-06-22 Illumina Cambridge Limited Compositions including functional groups coupled to substrates, and methods of making the same
CA3206511A1 (en) 2021-01-29 2022-08-04 Yir-Shyuan WU Methods, compositions and kits to improve seeding efficiency of flow cells with polynucleotides
US12296333B2 (en) 2021-02-22 2025-05-13 Illumina, Inc. Hybrid glass plastic flow cell and fabrication methods
CN117043354A (zh) 2021-03-09 2023-11-10 伊鲁米纳公司 聚合物、制备聚合物的方法以及使寡核苷酸与聚合物偶联的方法
KR102488382B1 (ko) * 2021-04-19 2023-01-17 한국화학연구원 클릭반응을 이용한 고밀도 및 고안정성 cnt 필름 코팅 기판 및 이의 제조방법
JP2024518882A (ja) * 2021-04-30 2024-05-08 イルミナ ケンブリッジ リミテッド フローセル及び方法
EP4355476A1 (en) 2021-06-15 2024-04-24 Illumina, Inc. Hydrogel-free surface functionalization for sequencing
US11455487B1 (en) 2021-10-26 2022-09-27 Illumina Software, Inc. Intensity extraction and crosstalk attenuation using interpolation and adaptation for base calling
WO2023003757A1 (en) 2021-07-19 2023-01-26 Illumina Software, Inc. Intensity extraction with interpolation and adaptation for base calling
EP4373958A1 (en) 2021-07-23 2024-05-29 Illumina, Inc. Methods for preparing substrate surface for dna sequencing
WO2023069927A1 (en) 2021-10-20 2023-04-27 Illumina, Inc. Methods for capturing library dna for sequencing
CN118525028A (zh) * 2021-11-01 2024-08-20 特韦斯特生物科学公司 用于合成的装置和方法
CN114231401B (zh) * 2022-02-21 2022-05-03 北京芯迈微生物技术有限公司 一种核酸检测试剂盒及检测方法
WO2023183764A1 (en) 2022-03-22 2023-09-28 Illumina Cambridge Limited Substrate with orthogonally functional nanodomains
JP2025512975A (ja) 2022-04-07 2025-04-22 イルミナ インコーポレイテッド 改変シチジンデアミナーゼ及び使用方法
CN115010852B (zh) * 2022-06-01 2023-10-10 郑州玛特瑞斯生物科技有限公司 一种测序芯片表面修饰用聚合物、测序芯片及其表面修饰方法
CN119317964A (zh) 2022-06-09 2025-01-14 因美纳有限公司 碱基检出对流通池倾斜的依赖
EP4594343A1 (en) 2022-09-30 2025-08-06 Illumina, Inc. Methods of using cpg binding proteins in mapping modified cytosine nucleotides
EP4594482A1 (en) 2022-09-30 2025-08-06 Illumina, Inc. Cytidine deaminases and methods of use in mapping modified cytosine nucleotides
CN120153070A (zh) 2022-09-30 2025-06-13 因美纳有限公司 解旋酶-胞苷脱氨酶复合物及其使用方法
US20240199659A1 (en) * 2022-12-01 2024-06-20 Gelest, Inc. Cycloalkylnorbornene compounds with heterocyclic functionality for voc-free crosslinking and surface functionalization
EP4630153A1 (en) 2022-12-07 2025-10-15 Illumina, Inc. Etch-free photoresist patterning in multi-depth nanowells
WO2024251960A1 (en) 2023-06-08 2024-12-12 Illumina, Inc. Capturing and amplifying polynucleotides, and reusing flowcells, using silica particles
WO2025006431A1 (en) 2023-06-28 2025-01-02 Illumina, Inc. Photoresist patterning in multi-depth nanowells
WO2025006441A1 (en) 2023-06-28 2025-01-02 Illumina, Inc. Capturing and amplifying polynucleotides using particles
WO2025006484A1 (en) 2023-06-29 2025-01-02 Illumina, Inc. Methods of functionalizing magnetic particles and methods of generating amplicons using magnetic particles
WO2025072793A1 (en) 2023-09-28 2025-04-03 Illumina, Inc. Altered cytidine deaminases and methods of use
WO2025081064A2 (en) 2023-10-11 2025-04-17 Illumina, Inc. Thermophilic deaminase and methods for identifying modified cytosine
CN117486500A (zh) * 2023-11-03 2024-02-02 郑州玛特瑞斯生物科技有限公司 一种玻片量产工艺、玻片加工用装置
EP4567128A1 (en) 2023-12-07 2025-06-11 Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft Improved method and means for spatial nucleic acid detection in-situ
WO2025137222A1 (en) 2023-12-19 2025-06-26 Illumina, Inc. Methylation detection assay
WO2025240905A1 (en) 2024-05-17 2025-11-20 The Broad Institute, Inc. Imaging-free high-resolution spatial macromolecule abundance reconstruction

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120095203A1 (en) 2009-03-18 2012-04-19 Commissariat A L'energie Atomique Et Aux Ene Alt Novel silane compounds having a cyclic carbon chain including an alkyne function for functionalising solid substrates and immobilising biological molecules on said substrates

Family Cites Families (107)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8810400D0 (en) 1988-05-03 1988-06-08 Southern E Analysing polynucleotide sequences
US5130238A (en) 1988-06-24 1992-07-14 Cangene Corporation Enhanced nucleic acid amplification process
GB8822228D0 (en) 1988-09-21 1988-10-26 Southern E M Support-bound oligonucleotides
US6346413B1 (en) 1989-06-07 2002-02-12 Affymetrix, Inc. Polymer arrays
US5800992A (en) 1989-06-07 1998-09-01 Fodor; Stephen P.A. Method of detecting nucleic acids
DE3924454A1 (de) 1989-07-24 1991-02-07 Cornelis P Prof Dr Hollenberg Die anwendung von dna und dna-technologie fuer die konstruktion von netzwerken zur verwendung in der chip-konstruktion und chip-produktion (dna chips)
WO1991006678A1 (en) 1989-10-26 1991-05-16 Sri International Dna sequencing
US5455166A (en) 1991-01-31 1995-10-03 Becton, Dickinson And Company Strand displacement amplification
ES2097925T3 (es) 1991-09-18 1997-04-16 Affymax Tech Nv Metodo para sintetizar diversas colecciones de oligomeros.
WO1993009668A1 (en) 1991-11-22 1993-05-27 Affymax Technology N.V. Combinatorial strategies for polymer synthesis
DE69333650T2 (de) 1992-02-19 2006-01-12 The Public Health Research Institute Of The City Of New York, Inc. Neue anordnungn von oligonukleotiden und ihr nutzen zum sortieren, isolieren, sequenzieren und manipulieren von nukleinsäuren
US5583211A (en) 1992-10-29 1996-12-10 Beckman Instruments, Inc. Surface activated organic polymers useful for location - specific attachment of nucleic acids, peptides, proteins and oligosaccharides
US5472672A (en) 1993-10-22 1995-12-05 The Board Of Trustees Of The Leland Stanford Junior University Apparatus and method for polymer synthesis using arrays
US6156501A (en) 1993-10-26 2000-12-05 Affymetrix, Inc. Arrays of modified nucleic acid probes and methods of use
JPH09507121A (ja) 1993-10-26 1997-07-22 アフィマックス テクノロジーズ ナームロゼ ベノートスハップ 生物学的チップ上の核酸プローブアレー
US5429807A (en) 1993-10-28 1995-07-04 Beckman Instruments, Inc. Method and apparatus for creating biopolymer arrays on a solid support surface
CA2185239C (en) 1994-03-16 2002-12-17 Nanibhushan Dattagupta Isothermal strand displacement nucleic acid amplification
US5552278A (en) 1994-04-04 1996-09-03 Spectragen, Inc. DNA sequencing by stepwise ligation and cleavage
US5807522A (en) 1994-06-17 1998-09-15 The Board Of Trustees Of The Leland Stanford Junior University Methods for fabricating microarrays of biological samples
US5641658A (en) 1994-08-03 1997-06-24 Mosaic Technologies, Inc. Method for performing amplification of nucleic acid with two primers bound to a single solid support
US5556752A (en) 1994-10-24 1996-09-17 Affymetrix, Inc. Surface-bound, unimolecular, double-stranded DNA
US5750341A (en) 1995-04-17 1998-05-12 Lynx Therapeutics, Inc. DNA sequencing by parallel oligonucleotide extensions
US5624711A (en) 1995-04-27 1997-04-29 Affymax Technologies, N.V. Derivatization of solid supports and methods for oligomer synthesis
US5545531A (en) 1995-06-07 1996-08-13 Affymax Technologies N.V. Methods for making a device for concurrently processing multiple biological chip assays
DE69638321D1 (de) 1995-10-11 2011-03-03 Luminex Corp Gleichzeitige mehrfachanalyse klinischer proben
US5658734A (en) 1995-10-17 1997-08-19 International Business Machines Corporation Process for synthesizing chemical compounds
US6458530B1 (en) 1996-04-04 2002-10-01 Affymetrix Inc. Selecting tag nucleic acids
KR20000011069A (ko) 1996-05-09 2000-02-25 스리-디멘셔널 파마슈티컬스 인코포레이티드 리간드 개발 및 다변수 단백질 화학의 최적화를 위한미량이식판 열 이동 분석 및 그 장치
GB9620209D0 (en) 1996-09-27 1996-11-13 Cemu Bioteknik Ab Method of sequencing DNA
GB9626815D0 (en) 1996-12-23 1997-02-12 Cemu Bioteknik Ab Method of sequencing DNA
US6297006B1 (en) 1997-01-16 2001-10-02 Hyseq, Inc. Methods for sequencing repetitive sequences and for determining the order of sequence subfragments
US7622294B2 (en) 1997-03-14 2009-11-24 Trustees Of Tufts College Methods for detecting target analytes and enzymatic reactions
EP0975802B1 (en) 1997-04-01 2004-06-23 Manteia S.A. Method of nucleic acid sequencing
US6465178B2 (en) 1997-09-30 2002-10-15 Surmodics, Inc. Target molecule attachment to surfaces
US6485944B1 (en) 1997-10-10 2002-11-26 President And Fellows Of Harvard College Replica amplification of nucleic acid arrays
US6087102A (en) 1998-01-07 2000-07-11 Clontech Laboratories, Inc. Polymeric arrays and methods for their use in binding assays
US6287776B1 (en) 1998-02-02 2001-09-11 Signature Bioscience, Inc. Method for detecting and classifying nucleic acid hybridization
JP3944996B2 (ja) 1998-03-05 2007-07-18 株式会社日立製作所 Ｄｎａプローブアレー
US6031078A (en) 1998-06-16 2000-02-29 Millennium Pharmaceuticals, Inc. MTbx protein and nucleic acid molecules and uses therefor
AR021833A1 (es) 1998-09-30 2002-08-07 Applied Research Systems Metodos de amplificacion y secuenciacion de acido nucleico
US6277628B1 (en) 1998-10-02 2001-08-21 Incyte Genomics, Inc. Linear microarrays
US6391937B1 (en) 1998-11-25 2002-05-21 Motorola, Inc. Polyacrylamide hydrogels and hydrogel arrays made from polyacrylamide reactive prepolymers
US6355431B1 (en) 1999-04-20 2002-03-12 Illumina, Inc. Detection of nucleic acid amplification reactions using bead arrays
ATE413467T1 (de) 1999-04-20 2008-11-15 Illumina Inc Detektion von nukleinsäurereaktionen auf kügelchen-arrays
US20050191698A1 (en) 1999-04-20 2005-09-01 Illumina, Inc. Nucleic acid sequencing using microsphere arrays
US20060275782A1 (en) 1999-04-20 2006-12-07 Illumina, Inc. Detection of nucleic acid reactions on bead arrays
FR2792631B1 (fr) * 1999-04-21 2004-03-19 Pasteur Institut Support solide fonctionnalise pour la synthese de composes comportant au moins une fonction alpha oxoaldehyde et ses applications.
US6372813B1 (en) 1999-06-25 2002-04-16 Motorola Methods and compositions for attachment of biomolecules to solid supports, hydrogels, and hydrogel arrays
US6664061B2 (en) 1999-06-25 2003-12-16 Amersham Biosciences Ab Use and evaluation of a [2+2] photoaddition in immobilization of oligonucleotides on a three-dimensional hydrogel matrix
US6274320B1 (en) 1999-09-16 2001-08-14 Curagen Corporation Method of sequencing a nucleic acid
US7244559B2 (en) 1999-09-16 2007-07-17 454 Life Sciences Corporation Method of sequencing a nucleic acid
US7582420B2 (en) 2001-07-12 2009-09-01 Illumina, Inc. Multiplex nucleic acid reactions
EP1990428B1 (en) 2000-02-07 2010-12-22 Illumina, Inc. Nucleic acid detection methods using universal priming
US6913884B2 (en) 2001-08-16 2005-07-05 Illumina, Inc. Compositions and methods for repetitive use of genomic DNA
US6770441B2 (en) 2000-02-10 2004-08-03 Illumina, Inc. Array compositions and methods of making same
WO2001059432A2 (en) 2000-02-10 2001-08-16 Illumina, Inc. Array of individual arrays as substrate for bead-based simultaneous processing of samples and manufacturing method therefor
WO2001062982A2 (en) 2000-02-25 2001-08-30 Mosaic Technologies, Inc. Methods for multi-stage solid phase amplification of nucleic acids
JP2003535317A (ja) 2000-05-01 2003-11-25 プロリゴ・エルエルシー 付加環化バイオコンジュゲーション法を利用してオリゴヌクレオチドを固定化する方法
AU8288101A (en) 2000-07-07 2002-01-21 Visigen Biotechnologies Inc Real-time sequence determination
EP1307414A2 (en) 2000-08-09 2003-05-07 Amersham Biosciences AB The use and evaluation of a 2+2] photocycloaddition in immobilization of oligonucleotides on a three-dimensional hydrogel matrix
US7211414B2 (en) 2000-12-01 2007-05-01 Visigen Biotechnologies, Inc. Enzymatic nucleic acid synthesis: compositions and methods for altering monomer incorporation fidelity
AR031640A1 (es) 2000-12-08 2003-09-24 Applied Research Systems Amplificacion isotermica de acidos nucleicos en un soporte solido
US20030027226A1 (en) 2001-05-10 2003-02-06 Cory Abate-Shen Monoclonal antibody for NKX3.1 and method for detecting same
GB0127564D0 (en) 2001-11-16 2002-01-09 Medical Res Council Emulsion compositions
US7057026B2 (en) 2001-12-04 2006-06-06 Solexa Limited Labelled nucleotides
US20040002090A1 (en) 2002-03-05 2004-01-01 Pascal Mayer Methods for detecting genome-wide sequence variations associated with a phenotype
JP2004085556A (ja) * 2002-06-28 2004-03-18 Canon Inc プローブ担体の製造方法、製造装置及び品質保証方法
ES2550513T3 (es) 2002-08-23 2015-11-10 Illumina Cambridge Limited Nucleótidos modificados para secuenciación de polinucleótidos
US7595883B1 (en) 2002-09-16 2009-09-29 The Board Of Trustees Of The Leland Stanford Junior University Biological analysis arrangement and approach therefor
EP1594950A4 (en) 2003-01-29 2007-07-25 454 Corp PRODUCT FOR THE PREPARATION OF SIMPLE STRANDED DNA BANKS
CA2528577C (en) 2003-06-20 2012-08-07 Illumina, Inc. Methods and compositions for whole genome amplification and genotyping
CA2531105C (en) 2003-07-05 2015-03-17 The Johns Hopkins University Method and compositions for detection and enumeration of genetic variations
EP2789383B1 (en) 2004-01-07 2023-05-03 Illumina Cambridge Limited Molecular arrays
WO2006044078A2 (en) 2004-09-17 2006-04-27 Pacific Biosciences Of California, Inc. Apparatus and method for analysis of molecules
CA2611671C (en) 2005-06-15 2013-10-08 Callida Genomics, Inc. Single molecule arrays for genetic and chemical analysis
US7892737B2 (en) * 2005-06-30 2011-02-22 Life Technologies Corporation Compositions, kits and methods pertaining to stability modulation of PNA oligomer/nucleic acid complexes
GB0514936D0 (en) * 2005-07-20 2005-08-24 Solexa Ltd Preparation of templates for nucleic acid sequencing
GB0514909D0 (en) * 2005-07-20 2005-08-24 Solexa Ltd Methods of nucleic acid amplification and sequencing
US7405281B2 (en) 2005-09-29 2008-07-29 Pacific Biosciences Of California, Inc. Fluorescent nucleotide analogs and uses therefor
US7955837B2 (en) * 2005-10-29 2011-06-07 Bayer Technology Services Gmbh Process for determining one or more analytes in samples of biological origin having complex composition, and use thereof
GB0522310D0 (en) 2005-11-01 2005-12-07 Solexa Ltd Methods of preparing libraries of template polynucleotides
CA2641851A1 (en) * 2006-02-08 2007-08-16 Eric Hans Vermaas Method for sequencing a polynucleotide template
EP2021503A1 (en) 2006-03-17 2009-02-11 Solexa Ltd. Isothermal methods for creating clonal single molecule arrays
EP4105644A3 (en) 2006-03-31 2022-12-28 Illumina, Inc. Systems and devices for sequence by synthesis analysis
US7754429B2 (en) * 2006-10-06 2010-07-13 Illumina Cambridge Limited Method for pair-wise sequencing a plurity of target polynucleotides
WO2008051530A2 (en) 2006-10-23 2008-05-02 Pacific Biosciences Of California, Inc. Polymerase enzymes and reagents for enhanced nucleic acid sequencing
US8262900B2 (en) 2006-12-14 2012-09-11 Life Technologies Corporation Methods and apparatus for measuring analytes using large scale FET arrays
US8349167B2 (en) 2006-12-14 2013-01-08 Life Technologies Corporation Methods and apparatus for detecting molecular interactions using FET arrays
AU2007334393A1 (en) 2006-12-14 2008-06-26 Life Technologies Corporation Methods and apparatus for measuring analytes using large scale FET arrays
JP5532648B2 (ja) 2008-04-03 2014-06-25 信越化学工業株式会社 カルボキシル基を有するオルガノポリシロキサンで表面処理された粉体、該粉体の分散物および該粉体を含む化粧料
JP5285949B2 (ja) * 2008-04-16 2013-09-11 Ｒｉｍｔｅｃ株式会社 複合成形体
US20100137143A1 (en) 2008-10-22 2010-06-03 Ion Torrent Systems Incorporated Methods and apparatus for measuring analytes
US20110143966A1 (en) * 2009-12-15 2011-06-16 Affymetrix, Inc. Surface Modifications and Methods for their Synthesis and Use
US8496997B2 (en) * 2010-03-10 2013-07-30 The University Of Melbourne Process for the preparation of a cross-linked multilayer film
US9096899B2 (en) 2010-10-27 2015-08-04 Illumina, Inc. Microdevices and biosensor cartridges for biological or chemical analysis and systems and methods for the same
WO2012079030A2 (en) 2010-12-10 2012-06-14 The Regents Of The University Of California Bioconjugation using bifunctional linkers
US8951781B2 (en) 2011-01-10 2015-02-10 Illumina, Inc. Systems, methods, and apparatuses to image a sample for biological or chemical analysis
EP2532639A1 (en) 2011-06-09 2012-12-12 ModiQuest B.V. Method for preparing a reactive coating
EP2718465B1 (en) * 2011-06-09 2022-04-13 Illumina, Inc. Method of making an analyte array
WO2013036748A1 (en) 2011-09-09 2013-03-14 Berry, Lana, L. Bicyclo[6.1.0]non-4-yne reagents for chemical modification of oligonucleotides
US8778849B2 (en) 2011-10-28 2014-07-15 Illumina, Inc. Microarray fabrication system and method
JP2013151468A (ja) * 2011-11-30 2013-08-08 Agilent Technologies Inc オリゴマーの合成及び精製の新規方法
EP2793949B1 (en) * 2011-12-23 2018-08-22 Innate Pharma Enzymatic conjugation of antibodies
US9012022B2 (en) 2012-06-08 2015-04-21 Illumina, Inc. Polymer coatings
US9512422B2 (en) 2013-02-26 2016-12-06 Illumina, Inc. Gel patterned surfaces
KR102177225B1 (ko) * 2013-07-01 2020-11-10 일루미나, 인코포레이티드 촉매-무함유 표면 작용화 및 중합체 그라프팅
US9982250B2 (en) * 2014-08-21 2018-05-29 Illumina Cambridge Limited Reversible surface functionalization

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120095203A1 (en) 2009-03-18 2012-04-19 Commissariat A L'energie Atomique Et Aux Ene Alt Novel silane compounds having a cyclic carbon chain including an alkyne function for functionalising solid substrates and immobilising biological molecules on said substrates

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