KR102165122B1 - 암 치료에 대한 감수성을 예측하기 위한 바이오마커 - Google Patents
암 치료에 대한 감수성을 예측하기 위한 바이오마커 Download PDFInfo
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- KR102165122B1 KR102165122B1 KR1020197001837A KR20197001837A KR102165122B1 KR 102165122 B1 KR102165122 B1 KR 102165122B1 KR 1020197001837 A KR1020197001837 A KR 1020197001837A KR 20197001837 A KR20197001837 A KR 20197001837A KR 102165122 B1 KR102165122 B1 KR 102165122B1
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- Prior art keywords
- cancer
- methyl
- dihydro
- hydroxy
- cyclopenta
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- 0 C*1CC*CC1 Chemical compound C*1CC*CC1 0.000 description 7
- PYEHNKXDXBNHQQ-UHFFFAOYSA-N CN(c(cccc1)c1N1)C1=O Chemical compound CN(c(cccc1)c1N1)C1=O PYEHNKXDXBNHQQ-UHFFFAOYSA-N 0.000 description 1
- SUXHSNPVCLGQFE-UHFFFAOYSA-N N/C(/c1ccccn1)=N\C(C1CCN(Cc(cc2)ccc2-c(nc(C=CNC2=[IH])c2c2)c2-c2ccccc2)CC1)=N Chemical compound N/C(/c1ccccn1)=N\C(C1CCN(Cc(cc2)ccc2-c(nc(C=CNC2=[IH])c2c2)c2-c2ccccc2)CC1)=N SUXHSNPVCLGQFE-UHFFFAOYSA-N 0.000 description 1
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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- A—HUMAN NECESSITIES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
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- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
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- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Analytical Chemistry (AREA)
- Pathology (AREA)
- Epidemiology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biophysics (AREA)
- Hospice & Palliative Care (AREA)
- General Engineering & Computer Science (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Cell Biology (AREA)
- General Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161471036P | 2011-04-01 | 2011-04-01 | |
| US61/471,036 | 2011-04-01 | ||
| PCT/US2012/031662 WO2012135749A2 (en) | 2011-04-01 | 2012-03-30 | Biomarkers for predicting sensitivity to cancer treatments |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020137029129A Division KR102016182B1 (ko) | 2011-04-01 | 2012-03-30 | 암 치료에 대한 감수성을 예측하기 위한 바이오마커 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20190011813A KR20190011813A (ko) | 2019-02-07 |
| KR102165122B1 true KR102165122B1 (ko) | 2020-10-13 |
Family
ID=46932419
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020197001837A Expired - Fee Related KR102165122B1 (ko) | 2011-04-01 | 2012-03-30 | 암 치료에 대한 감수성을 예측하기 위한 바이오마커 |
| KR1020137029129A Expired - Fee Related KR102016182B1 (ko) | 2011-04-01 | 2012-03-30 | 암 치료에 대한 감수성을 예측하기 위한 바이오마커 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020137029129A Expired - Fee Related KR102016182B1 (ko) | 2011-04-01 | 2012-03-30 | 암 치료에 대한 감수성을 예측하기 위한 바이오마커 |
Country Status (15)
| Country | Link |
|---|---|
| US (4) | US20140031259A1 (https=) |
| EP (2) | EP2694959B8 (https=) |
| JP (4) | JP6293655B2 (https=) |
| KR (2) | KR102165122B1 (https=) |
| CN (1) | CN103858007B (https=) |
| AU (1) | AU2012236134A1 (https=) |
| BR (1) | BR112013025356B1 (https=) |
| CA (1) | CA2850175C (https=) |
| ES (1) | ES2768081T3 (https=) |
| IL (1) | IL228636A0 (https=) |
| MX (1) | MX348655B (https=) |
| PL (1) | PL2694959T3 (https=) |
| RU (1) | RU2635193C2 (https=) |
| SG (2) | SG10201507582VA (https=) |
| WO (1) | WO2012135749A2 (https=) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012135781A1 (en) * | 2011-04-01 | 2012-10-04 | Genentech, Inc. | Combinations of akt inhibitor compounds and chemotherapeutic agents, and methods of use |
| PL2694959T3 (pl) * | 2011-04-01 | 2020-05-18 | Genentech, Inc. | Biomarkery do przewidywania wrażliwości w leczeniu nowotworu złośliwego |
| EP2959014B1 (en) | 2013-02-25 | 2019-11-13 | Genentech, Inc. | Methods and compositions for detecting and treating drug resistant akt mutant |
| US20170290849A1 (en) * | 2014-09-05 | 2017-10-12 | The Trustees Of Columbia University In The City Of New York | AKT and SHH Pathway Inhibitor Combination Therapy for Treating Basal Cell Carcinomas |
| BR112017007962A2 (pt) * | 2014-10-24 | 2018-01-23 | Koninklijke Philips Nv | método implementado por computador, aparelho, mídia de armazenamento, programa de computador, kit, e, uso do kit |
| CN106783976A (zh) * | 2016-12-12 | 2017-05-31 | 东莞市广信知识产权服务有限公司 | 一种GaN沟道MOS界面结构 |
| KR102129532B1 (ko) * | 2018-07-19 | 2020-07-02 | 조성은 | Pten 억제제에 대한 췌장암 치료 반응성 예측용 바이오마커 및 이의 용도 |
| WO2020252455A1 (en) * | 2019-06-13 | 2020-12-17 | The General Hospital Corporation | Engineered human-endogenous virus-like particles and methods of use thereof for delivery to cells |
| CA3189601A1 (en) | 2020-07-24 | 2022-01-27 | The General Hospital Corporation | Enhanced virus-like particles and methods of use thereof for delivery to cells |
| CN113025713B (zh) * | 2021-02-23 | 2022-11-22 | 浙江东睿生物科技有限公司 | 用于预测肿瘤患者对特定抗肿瘤药物的敏感性的生物标志物的应用 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008006040A1 (en) * | 2006-07-06 | 2008-01-10 | Array Biopharma Inc. | Hydroxylated and methoxylated cyclopenta [d] pyrimidines as akt protein kinase inhibitors |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4683203A (en) | 1984-04-14 | 1987-07-28 | Redco N.V. | Immobilized enzymes, processes for preparing same, and use thereof |
| US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| IE61148B1 (en) | 1988-03-10 | 1994-10-05 | Ici Plc | Method of detecting nucleotide sequences |
| WO1995011995A1 (en) * | 1993-10-26 | 1995-05-04 | Affymax Technologies N.V. | Arrays of nucleic acid probes on biological chips |
| EP2369007B1 (en) | 1996-05-29 | 2015-07-29 | Cornell Research Foundation, Inc. | Detection of nucleic acid sequence differences using coupled ligase detection and polymerase chain reactions |
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