JP6293655B2 - 癌治療に対する感受性を予測するためのバイオマーカー - Google Patents

癌治療に対する感受性を予測するためのバイオマーカー Download PDF

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JP6293655B2
JP6293655B2 JP2014502870A JP2014502870A JP6293655B2 JP 6293655 B2 JP6293655 B2 JP 6293655B2 JP 2014502870 A JP2014502870 A JP 2014502870A JP 2014502870 A JP2014502870 A JP 2014502870A JP 6293655 B2 JP6293655 B2 JP 6293655B2
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hydroxy
methyl
cyclopenta
dihydro
piperazin
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JP2014524009A5 (https=
JP2014524009A (ja
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クイ リン，
クイ リン，
エリザベス パンヌース，
エリザベス パンヌース，
ソマセカー セシャギリ，
ソマセカー セシャギリ，
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Genentech Inc
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Genentech Inc
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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  • Health & Medical Sciences (AREA)
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  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
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  • General Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
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  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
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JP2014502870A 2011-04-01 2012-03-30 癌治療に対する感受性を予測するためのバイオマーカー Active JP6293655B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161471036P 2011-04-01 2011-04-01
US61/471,036 2011-04-01
PCT/US2012/031662 WO2012135749A2 (en) 2011-04-01 2012-03-30 Biomarkers for predicting sensitivity to cancer treatments

Related Child Applications (1)

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JP2017201976A Division JP2018050625A (ja) 2011-04-01 2017-10-18 癌治療に対する感受性を予測するためのバイオマーカー

Publications (3)

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JP2014524009A JP2014524009A (ja) 2014-09-18
JP2014524009A5 JP2014524009A5 (https=) 2017-11-30
JP6293655B2 true JP6293655B2 (ja) 2018-03-14

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JP2014502870A Active JP6293655B2 (ja) 2011-04-01 2012-03-30 癌治療に対する感受性を予測するためのバイオマーカー
JP2017201976A Pending JP2018050625A (ja) 2011-04-01 2017-10-18 癌治療に対する感受性を予測するためのバイオマーカー
JP2019165545A Active JP7044746B2 (ja) 2011-04-01 2019-09-11 癌治療に対する感受性を予測するためのバイオマーカー
JP2022042069A Withdrawn JP2022095670A (ja) 2011-04-01 2022-03-17 癌治療に対する感受性を予測するためのバイオマーカー

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JP2017201976A Pending JP2018050625A (ja) 2011-04-01 2017-10-18 癌治療に対する感受性を予測するためのバイオマーカー
JP2019165545A Active JP7044746B2 (ja) 2011-04-01 2019-09-11 癌治療に対する感受性を予測するためのバイオマーカー
JP2022042069A Withdrawn JP2022095670A (ja) 2011-04-01 2022-03-17 癌治療に対する感受性を予測するためのバイオマーカー

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US (4) US20140031259A1 (https=)
EP (2) EP2694959B8 (https=)
JP (4) JP6293655B2 (https=)
KR (2) KR102165122B1 (https=)
CN (1) CN103858007B (https=)
AU (1) AU2012236134A1 (https=)
BR (1) BR112013025356B1 (https=)
CA (1) CA2850175C (https=)
ES (1) ES2768081T3 (https=)
IL (1) IL228636A0 (https=)
MX (1) MX348655B (https=)
PL (1) PL2694959T3 (https=)
RU (1) RU2635193C2 (https=)
SG (2) SG10201507582VA (https=)
WO (1) WO2012135749A2 (https=)

Cited By (1)

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Publication number Priority date Publication date Assignee Title
JP2020022457A (ja) * 2011-04-01 2020-02-13 ジェネンテック， インコーポレイテッド 癌治療に対する感受性を予測するためのバイオマーカー

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012135781A1 (en) * 2011-04-01 2012-10-04 Genentech, Inc. Combinations of akt inhibitor compounds and chemotherapeutic agents, and methods of use
EP2959014B1 (en) 2013-02-25 2019-11-13 Genentech, Inc. Methods and compositions for detecting and treating drug resistant akt mutant
US20170290849A1 (en) * 2014-09-05 2017-10-12 The Trustees Of Columbia University In The City Of New York AKT and SHH Pathway Inhibitor Combination Therapy for Treating Basal Cell Carcinomas
BR112017007962A2 (pt) * 2014-10-24 2018-01-23 Koninklijke Philips Nv método implementado por computador, aparelho, mídia de armazenamento, programa de computador, kit, e, uso do kit
CN106783976A (zh) * 2016-12-12 2017-05-31 东莞市广信知识产权服务有限公司 一种GaN沟道MOS界面结构
KR102129532B1 (ko) * 2018-07-19 2020-07-02 조성은 Pten 억제제에 대한 췌장암 치료 반응성 예측용 바이오마커 및 이의 용도
WO2020252455A1 (en) * 2019-06-13 2020-12-17 The General Hospital Corporation Engineered human-endogenous virus-like particles and methods of use thereof for delivery to cells
CA3189601A1 (en) 2020-07-24 2022-01-27 The General Hospital Corporation Enhanced virus-like particles and methods of use thereof for delivery to cells
CN113025713B (zh) * 2021-02-23 2022-11-22 浙江东睿生物科技有限公司 用于预测肿瘤患者对特定抗肿瘤药物的敏感性的生物标志物的应用

Family Cites Families (16)

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Publication number Priority date Publication date Assignee Title
US4683203A (en) 1984-04-14 1987-07-28 Redco N.V. Immobilized enzymes, processes for preparing same, and use thereof
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
IE61148B1 (en) 1988-03-10 1994-10-05 Ici Plc Method of detecting nucleotide sequences
WO1995011995A1 (en) * 1993-10-26 1995-05-04 Affymax Technologies N.V. Arrays of nucleic acid probes on biological chips
EP2369007B1 (en) 1996-05-29 2015-07-29 Cornell Research Foundation, Inc. Detection of nucleic acid sequence differences using coupled ligase detection and polymerase chain reactions
AU2001265121A1 (en) 2000-05-30 2001-12-11 Applera Corporation Methods for detecting target nucleic acids using coupled ligation and amplification
US20030119004A1 (en) 2001-12-05 2003-06-26 Wenz H. Michael Methods for quantitating nucleic acids using coupled ligation and amplification
EP1496981A2 (en) * 2002-04-08 2005-01-19 Merck & Co., Inc. Method of treating cancer
WO2004110356A2 (en) * 2003-05-15 2004-12-23 Cbr Institute For Biomedical Research, Inc. Methods for modulating cell-to-cell adhesion using an agonist of c1inh-type protein activity
US8063050B2 (en) 2006-07-06 2011-11-22 Array Biopharma Inc. Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors
UA95641C2 (xx) * 2006-07-06 2011-08-25 Эррей Биофарма Инк. Гідроксильовані піримідильні циклопентани як інгібітори акт протеїнкінази$гидроксилированные пиримидильные циклопентаны как ингибиторы акт протеинкиназы
WO2008049022A2 (en) 2006-10-18 2008-04-24 Translational Genomics Research Institute Methods for detection of cancer
WO2009006567A2 (en) 2007-07-05 2009-01-08 Array Biopharma Inc. Pyrimidyl cyclopentanes as akt protein kinase inhibitors
CA2695330C (en) * 2007-07-12 2017-06-13 University Of South Florida Inhibitors of akt/pkb with anti-tumor activity
WO2009103790A2 (en) * 2008-02-21 2009-08-27 Universite Libre De Bruxelles Method and kit for the detection of genes associated with pik3ca mutation and involved in pi3k/akt pathway activation in the er-positive and her2-positive subtypes with clinical implications
PL2694959T3 (pl) * 2011-04-01 2020-05-18 Genentech, Inc. Biomarkery do przewidywania wrażliwości w leczeniu nowotworu złośliwego

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2020022457A (ja) * 2011-04-01 2020-02-13 ジェネンテック， インコーポレイテッド 癌治療に対する感受性を予測するためのバイオマーカー
JP7044746B2 (ja) 2011-04-01 2022-03-30 ジェネンテック， インコーポレイテッド 癌治療に対する感受性を予測するためのバイオマーカー

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