KR102163936B1 - 장기-활성 싱글-체인 인슐린 유사체 - Google Patents

장기-활성 싱글-체인 인슐린 유사체 Download PDF

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Publication number
KR102163936B1
KR102163936B1 KR1020157014591A KR20157014591A KR102163936B1 KR 102163936 B1 KR102163936 B1 KR 102163936B1 KR 1020157014591 A KR1020157014591 A KR 1020157014591A KR 20157014591 A KR20157014591 A KR 20157014591A KR 102163936 B1 KR102163936 B1 KR 102163936B1
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South Korea
Prior art keywords
insulin
gly
leu
arg
cys
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Expired - Fee Related
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KR1020157014591A
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English (en)
Korean (ko)
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KR20150096387A (ko
Inventor
마이클 웨이쓰
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케이스 웨스턴 리저브 유니버시티
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
KR1020157014591A 2012-11-05 2013-11-05 장기-활성 싱글-체인 인슐린 유사체 Expired - Fee Related KR102163936B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261722350P 2012-11-05 2012-11-05
US61/722,350 2012-11-05
PCT/US2013/068585 WO2014071405A2 (en) 2012-11-05 2013-11-05 Long-acting single-chain insulin analogues

Publications (2)

Publication Number Publication Date
KR20150096387A KR20150096387A (ko) 2015-08-24
KR102163936B1 true KR102163936B1 (ko) 2020-10-13

Family

ID=50628271

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020157014591A Expired - Fee Related KR102163936B1 (ko) 2012-11-05 2013-11-05 장기-활성 싱글-체인 인슐린 유사체

Country Status (15)

Country Link
US (2) US9499600B2 (https=)
EP (1) EP2914620B1 (https=)
JP (1) JP6584953B2 (https=)
KR (1) KR102163936B1 (https=)
CN (2) CN112266414A (https=)
AU (1) AU2013337250B2 (https=)
BR (1) BR112015010194B1 (https=)
CA (1) CA2890719C (https=)
EA (1) EA201590882A1 (https=)
ES (1) ES2694418T3 (https=)
IL (1) IL238651B (https=)
MX (1) MX2015005662A (https=)
PH (1) PH12015500989A1 (https=)
SG (1) SG11201503522RA (https=)
WO (1) WO2014071405A2 (https=)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014015078A1 (en) * 2012-07-17 2014-01-23 Michael Weiss O-linked carbohydrate-modified insulin analogues
US9624287B2 (en) 2012-07-17 2017-04-18 Case Western Reserve University O-linked carbohydrate-modified insulin analogues
WO2015106269A2 (en) 2014-01-13 2015-07-16 Thermalin Diabetes, Llc Rapid action insulin formulations and pharmaceutical delivery systems
CZ308383B6 (cs) * 2014-06-30 2020-07-15 Ústav Organické Chemie A Biochemie Akademie Věd Čr, V.V.I. Derivát inzulinu s cyklickou strukturou v C-konci B-řetězce
AU2015328222B9 (en) * 2014-10-06 2020-12-24 Case Western Reserve University Biphasic single-chain insulin analogues
AR105616A1 (es) 2015-05-07 2017-10-25 Lilly Co Eli Proteínas de fusión
JP7203415B2 (ja) 2015-12-23 2023-01-13 ケース ウェスタン リザーブ ユニバーシティ ポリマー溶融物内の超安定型インスリン類似体のカプセル化
EP3883957A4 (en) * 2018-11-19 2022-08-17 Case Western Reserve University SINGLE-CHAIN INSULIN ANALOGS WITH POLYALANINE C-DOMAIN SUBSEGMENTS
SG11202106167XA (en) 2018-12-11 2021-07-29 Sanofi Sa Insulin conjugates
TWI844709B (zh) 2019-07-31 2024-06-11 美商美國禮來大藥廠 鬆弛素(relaxin)類似物及其使用方法
KR20220112817A (ko) * 2019-12-10 2022-08-11 사노피 설폰아미드 및 폴리펩티드의 콘주게이트를 형성하는 방법
EP4405384A1 (en) 2021-09-20 2024-07-31 Kyon Biotech AG Arginase-insulin fusion protein

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6630348B1 (en) 2000-10-02 2003-10-07 Univ Yonsei Seoul Single-chain insulin analog and a polynucleotide sequence encoding the analog
US20070129284A1 (en) 2003-12-03 2007-06-07 Novo Nordisk A/S Single-chain insulin
US20110195896A1 (en) 2008-04-22 2011-08-11 Case Western Reserve University Isoform-specific insulin analogues

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1193272B1 (en) * 2000-10-02 2004-06-30 Yonsei University Single-chain insulin analogs
US20060217290A1 (en) * 2003-04-29 2006-09-28 Kohn Wayne D Insulin analogs having protracted time action
KR100508616B1 (ko) * 2003-06-20 2005-08-17 신항철 염기성 아미노산 첨가를 통한 활성이 증가된 단일사슬 인슐린 아날로그
EP2074140B8 (en) * 2006-10-04 2015-10-28 Case Western Reserve University Fibrillation-resistant insulin and insulin analogues
WO2011003820A1 (de) * 2009-07-06 2011-01-13 Sanofi-Aventis Deutschland Gmbh Hitze- und schüttelstabile insulinzubereitungen
PL2451437T3 (pl) * 2009-07-06 2017-05-31 Sanofi-Aventis Deutschland Gmbh Wodne preparaty insuliny zawierające metioninę
US8399407B2 (en) 2009-09-17 2013-03-19 Case Western Reserve University Non-standard insulin analogues
JP2014533241A (ja) * 2011-10-27 2014-12-11 ケース ウェスタン リザーブ ユニバーシティＣａｓｅ Ｗｅｓｔｅｒｎｒｅｓｅｒｖｅ Ｕｎｉｖｅｒｓｉｔｙ 超濃縮速効型インスリン類似体製剤
CA2898730A1 (en) * 2012-01-20 2013-07-25 Case Western Reserve University Glutamic acid-stabilized insulin analogues
AU2013323669B2 (en) * 2012-09-26 2018-03-01 Indiana University Research And Technology Corporation Insulin analog dimers

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6630348B1 (en) 2000-10-02 2003-10-07 Univ Yonsei Seoul Single-chain insulin analog and a polynucleotide sequence encoding the analog
US20070129284A1 (en) 2003-12-03 2007-06-07 Novo Nordisk A/S Single-chain insulin
US20110195896A1 (en) 2008-04-22 2011-08-11 Case Western Reserve University Isoform-specific insulin analogues

Also Published As

Publication number Publication date
JP2016506366A (ja) 2016-03-03
IL238651B (en) 2020-03-31
AU2013337250B2 (en) 2017-06-22
US20150274803A1 (en) 2015-10-01
US9975940B2 (en) 2018-05-22
EA201590882A1 (ru) 2015-09-30
KR20150096387A (ko) 2015-08-24
BR112015010194A2 (pt) 2017-12-12
US20170137488A1 (en) 2017-05-18
CA2890719A1 (en) 2014-05-08
WO2014071405A2 (en) 2014-05-08
EP2914620B1 (en) 2018-08-08
EP2914620A2 (en) 2015-09-09
EP2914620A4 (en) 2016-05-25
JP6584953B2 (ja) 2019-10-02
CN105008395B (zh) 2020-12-29
CA2890719C (en) 2023-02-14
MX2015005662A (es) 2015-08-20
CN105008395A (zh) 2015-10-28
SG11201503522RA (en) 2015-06-29
CN112266414A (zh) 2021-01-26
WO2014071405A3 (en) 2014-08-21
BR112015010194B1 (pt) 2022-03-22
ES2694418T3 (es) 2018-12-20
IL238651A0 (en) 2015-06-30
PH12015500989A1 (en) 2015-07-13
US9499600B2 (en) 2016-11-22

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