CN112266414A - 长效单链胰岛素类似物 - Google Patents
长效单链胰岛素类似物 Download PDFInfo
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- CN112266414A CN112266414A CN202010947063.3A CN202010947063A CN112266414A CN 112266414 A CN112266414 A CN 112266414A CN 202010947063 A CN202010947063 A CN 202010947063A CN 112266414 A CN112266414 A CN 112266414A
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- insulin
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- gly
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- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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| JP (1) | JP6584953B2 (https=) |
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| WO2014015078A1 (en) * | 2012-07-17 | 2014-01-23 | Michael Weiss | O-linked carbohydrate-modified insulin analogues |
| US9624287B2 (en) | 2012-07-17 | 2017-04-18 | Case Western Reserve University | O-linked carbohydrate-modified insulin analogues |
| WO2015106269A2 (en) | 2014-01-13 | 2015-07-16 | Thermalin Diabetes, Llc | Rapid action insulin formulations and pharmaceutical delivery systems |
| CZ308383B6 (cs) * | 2014-06-30 | 2020-07-15 | Ústav Organické Chemie A Biochemie Akademie Věd Čr, V.V.I. | Derivát inzulinu s cyklickou strukturou v C-konci B-řetězce |
| AU2015328222B9 (en) * | 2014-10-06 | 2020-12-24 | Case Western Reserve University | Biphasic single-chain insulin analogues |
| AR105616A1 (es) | 2015-05-07 | 2017-10-25 | Lilly Co Eli | Proteínas de fusión |
| JP7203415B2 (ja) | 2015-12-23 | 2023-01-13 | ケース ウェスタン リザーブ ユニバーシティ | ポリマー溶融物内の超安定型インスリン類似体のカプセル化 |
| EP3883957A4 (en) * | 2018-11-19 | 2022-08-17 | Case Western Reserve University | SINGLE-CHAIN INSULIN ANALOGS WITH POLYALANINE C-DOMAIN SUBSEGMENTS |
| SG11202106167XA (en) | 2018-12-11 | 2021-07-29 | Sanofi Sa | Insulin conjugates |
| TWI844709B (zh) | 2019-07-31 | 2024-06-11 | 美商美國禮來大藥廠 | 鬆弛素(relaxin)類似物及其使用方法 |
| KR20220112817A (ko) * | 2019-12-10 | 2022-08-11 | 사노피 | 설폰아미드 및 폴리펩티드의 콘주게이트를 형성하는 방법 |
| EP4405384A1 (en) | 2021-09-20 | 2024-07-31 | Kyon Biotech AG | Arginase-insulin fusion protein |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1902226A (zh) * | 2003-12-03 | 2007-01-24 | 诺和诺德公司 | 单链胰岛素 |
| CN102065885A (zh) * | 2008-04-22 | 2011-05-18 | 卡斯西部储备大学 | 同种型特异性的胰岛素类似物 |
| US8192957B2 (en) * | 2006-10-04 | 2012-06-05 | Case Western Reserve University | Fibrillation-resistant insulin and insulin analogues |
| US20120252724A1 (en) * | 2009-07-06 | 2012-10-04 | Sanofi-Aventis | Insulin preparations containing methionine |
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| KR100449454B1 (ko) * | 2000-10-02 | 2004-09-21 | 이현철 | 단일사슬 인슐린 유도체의 유전자를 포함하는 당뇨병치료용 벡터 |
| EP1193272B1 (en) * | 2000-10-02 | 2004-06-30 | Yonsei University | Single-chain insulin analogs |
| US20060217290A1 (en) * | 2003-04-29 | 2006-09-28 | Kohn Wayne D | Insulin analogs having protracted time action |
| KR100508616B1 (ko) * | 2003-06-20 | 2005-08-17 | 신항철 | 염기성 아미노산 첨가를 통한 활성이 증가된 단일사슬 인슐린 아날로그 |
| WO2011003820A1 (de) * | 2009-07-06 | 2011-01-13 | Sanofi-Aventis Deutschland Gmbh | Hitze- und schüttelstabile insulinzubereitungen |
| US8399407B2 (en) | 2009-09-17 | 2013-03-19 | Case Western Reserve University | Non-standard insulin analogues |
| JP2014533241A (ja) * | 2011-10-27 | 2014-12-11 | ケース ウェスタン リザーブ ユニバーシティＣａｓｅ Ｗｅｓｔｅｒｎｒｅｓｅｒｖｅ Ｕｎｉｖｅｒｓｉｔｙ | 超濃縮速効型インスリン類似体製剤 |
| CA2898730A1 (en) * | 2012-01-20 | 2013-07-25 | Case Western Reserve University | Glutamic acid-stabilized insulin analogues |
| AU2013323669B2 (en) * | 2012-09-26 | 2018-03-01 | Indiana University Research And Technology Corporation | Insulin analog dimers |
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Patent Citations (4)
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| CN1902226A (zh) * | 2003-12-03 | 2007-01-24 | 诺和诺德公司 | 单链胰岛素 |
| US8192957B2 (en) * | 2006-10-04 | 2012-06-05 | Case Western Reserve University | Fibrillation-resistant insulin and insulin analogues |
| CN102065885A (zh) * | 2008-04-22 | 2011-05-18 | 卡斯西部储备大学 | 同种型特异性的胰岛素类似物 |
| US20120252724A1 (en) * | 2009-07-06 | 2012-10-04 | Sanofi-Aventis | Insulin preparations containing methionine |
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| JP2016506366A (ja) | 2016-03-03 |
| IL238651B (en) | 2020-03-31 |
| AU2013337250B2 (en) | 2017-06-22 |
| US20150274803A1 (en) | 2015-10-01 |
| US9975940B2 (en) | 2018-05-22 |
| EA201590882A1 (ru) | 2015-09-30 |
| KR20150096387A (ko) | 2015-08-24 |
| BR112015010194A2 (pt) | 2017-12-12 |
| US20170137488A1 (en) | 2017-05-18 |
| CA2890719A1 (en) | 2014-05-08 |
| WO2014071405A2 (en) | 2014-05-08 |
| EP2914620B1 (en) | 2018-08-08 |
| EP2914620A2 (en) | 2015-09-09 |
| EP2914620A4 (en) | 2016-05-25 |
| JP6584953B2 (ja) | 2019-10-02 |
| CN105008395B (zh) | 2020-12-29 |
| CA2890719C (en) | 2023-02-14 |
| MX2015005662A (es) | 2015-08-20 |
| CN105008395A (zh) | 2015-10-28 |
| SG11201503522RA (en) | 2015-06-29 |
| WO2014071405A3 (en) | 2014-08-21 |
| BR112015010194B1 (pt) | 2022-03-22 |
| ES2694418T3 (es) | 2018-12-20 |
| KR102163936B1 (ko) | 2020-10-13 |
| IL238651A0 (en) | 2015-06-30 |
| PH12015500989A1 (en) | 2015-07-13 |
| US9499600B2 (en) | 2016-11-22 |
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