KR102154382B1 - 위장 통증을 조절하는 제제의 선택 - Google Patents

위장 통증을 조절하는 제제의 선택 Download PDF

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KR102154382B1
KR102154382B1 KR1020167022947A KR20167022947A KR102154382B1 KR 102154382 B1 KR102154382 B1 KR 102154382B1 KR 1020167022947 A KR1020167022947 A KR 1020167022947A KR 20167022947 A KR20167022947 A KR 20167022947A KR 102154382 B1 KR102154382 B1 KR 102154382B1
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bacterial strain
induced
trpv1
pain
gastrointestinal
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KR1020167022947A
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Korean (ko)
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KR20160111992A (ko
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이아몬 코놀리
볼프강 쿤제
존 비에넨스톡
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바이오가이아 에이비
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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G01N33/5041Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects involving analysis of members of signalling pathways
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66Microorganisms or materials therefrom
    • A61K35/74Bacteria
    • A61K35/741Probiotics
    • A61K35/744Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
    • A61K35/747Lactobacilli, e.g. L. acidophilus or L. brevis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66Microorganisms or materials therefrom
    • A61K35/74Bacteria
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6872Intracellular protein regulatory factors and their receptors, e.g. including ion channels
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K2035/11Medicinal preparations comprising living procariotic cells
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705Assays involving receptors, cell surface antigens or cell surface determinants
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00Screening for compounds of potential therapeutic value
    • G01N2500/10Screening for compounds of potential therapeutic value involving cells
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/06Gastro-intestinal diseases

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Toxicology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
KR1020167022947A 2014-01-23 2015-01-23 위장 통증을 조절하는 제제의 선택 KR102154382B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
SE1450065-6 2014-01-23
SE1450065 2014-01-23
SE1450813-9 2014-07-01
SE1450813 2014-07-01
PCT/SE2015/050064 WO2015112083A1 (en) 2014-01-23 2015-01-23 Selection of agents modulating gastrointestinal pain

Publications (2)

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KR20160111992A KR20160111992A (ko) 2016-09-27
KR102154382B1 true KR102154382B1 (ko) 2020-09-10

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US (3) US20160334391A1 (es)
EP (2) EP3629026B1 (es)
JP (1) JP6635925B2 (es)
KR (1) KR102154382B1 (es)
CN (1) CN106164674B (es)
AU (1) AU2015209763B2 (es)
BR (1) BR122023013786B1 (es)
CA (1) CA2936560C (es)
CL (1) CL2016001878A1 (es)
DK (1) DK3629026T3 (es)
ES (2) ES2767060T3 (es)
IL (1) IL246563B (es)
MX (1) MX369105B (es)
NZ (1) NZ721882A (es)
PL (1) PL3629026T3 (es)
RU (1) RU2692671C2 (es)
SG (1) SG11201605378TA (es)
UA (1) UA120846C2 (es)
WO (1) WO2015112083A1 (es)

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Publication number Priority date Publication date Assignee Title
US11179427B2 (en) 2013-01-21 2021-11-23 Eth Zurich Baby food composition comprising viable propionic acid-producing bacteria
US11376287B2 (en) 2016-10-20 2022-07-05 Biofermin Pharmaceutical Co., Ltd. Agent acting on transcellular ion transporter in intestinal tract, agent for activating chloride channel, agent for preventing or treating renal disease, or agent for promoting defecation
HUE059963T2 (hu) 2018-07-24 2023-01-28 Biogaia Ab Melatonintámogató baktériumok szelektálása és felhasználása az infantilis kólika csökkentésére
CN112739814B (zh) * 2018-07-24 2023-12-08 生命大地女神有限公司 使用能够增加腺苷水平的细菌菌株的治疗方法
CN111484982A (zh) * 2020-05-14 2020-08-04 西南民族大学 一种人结直肠腺癌细胞trpv1基因敲除细胞株及应用

Citations (1)

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JP2012188409A (ja) 2011-03-14 2012-10-04 Biofuerumin Seiyaku Kk 消化管痛の予防又は軽減剤

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IT1289984B1 (it) 1997-02-27 1998-10-19 Proge Farm Srl Ceppi di lattobacilli utili nel trattamento di disfunzioni del sistema gastrointestinale
US8506881B2 (en) * 2005-04-01 2013-08-13 Board of Trustees at the Southern Illinois University Intermetallic bonded diamond composite composition and methods of forming articles from same
US7344867B2 (en) * 2005-04-15 2008-03-18 Eamonn Connolly Selection and use of lactic acid bacteria for reducing inflammation in mammals
US20080051454A1 (en) 2006-04-21 2008-02-28 The Board Of Trustees Operating Michigan State University Compositions and methods for transient receptor potential vanilloid (TRPV) channel mediated treatments
US7374924B2 (en) * 2006-06-05 2008-05-20 Biogaia Ab Use of selected lactic acid bacteria for reducing infantile colic
WO2008090434A1 (en) 2007-01-25 2008-07-31 Pfizer Japan Inc. Substituted n-bicyclicalkyl bicyclic carboxyamide compounds
ES2464459T3 (es) * 2008-06-25 2014-06-02 H. Lundbeck A/S Modulación del sistema receptor Trpv:receptor de dominio Vps 10p para el tratamiento del dolor
KR101091810B1 (ko) 2009-09-11 2011-12-12 고려대학교 산학협력단 신규 활성제를 이용한 trpv1 활성화 방법
CN104010635A (zh) * 2011-09-09 2014-08-27 Api起源有限责任公司 包含trpv1选择性激动剂的止痛组合物及其制备和应用
JPWO2013141202A1 (ja) 2012-03-21 2015-08-03 独立行政法人国立精神・神経医療研究センター 筋増加剤、及び筋増加物質のスクリーニング方法

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JP2012188409A (ja) 2011-03-14 2012-10-04 Biofuerumin Seiyaku Kk 消化管痛の予防又は軽減剤

Non-Patent Citations (2)

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Also Published As

Publication number Publication date
CA2936560A1 (en) 2015-07-30
IL246563A0 (en) 2016-08-31
EP3097423B1 (en) 2019-12-04
US11371985B2 (en) 2022-06-28
CN106164674A (zh) 2016-11-23
US20160334391A1 (en) 2016-11-17
AU2015209763B2 (en) 2020-12-24
CN106164674B (zh) 2018-10-09
EP3629026B1 (en) 2021-02-24
MX369105B (es) 2019-10-29
UA120846C2 (uk) 2020-02-25
RU2016134215A3 (es) 2018-09-28
CL2016001878A1 (es) 2017-10-20
WO2015112083A1 (en) 2015-07-30
US20200225214A1 (en) 2020-07-16
BR122023013786B1 (pt) 2023-12-12
PL3629026T3 (pl) 2021-08-02
MX2016009613A (es) 2016-11-08
JP2017507651A (ja) 2017-03-23
US20180259503A1 (en) 2018-09-13
KR20160111992A (ko) 2016-09-27
NZ721882A (en) 2019-02-22
RU2692671C2 (ru) 2019-06-26
AU2015209763A1 (en) 2016-07-21
DK3629026T3 (da) 2021-05-17
SG11201605378TA (en) 2016-08-30
ES2874479T3 (es) 2021-11-05
IL246563B (en) 2019-11-28
BR112016016969A2 (pt) 2020-09-24
JP6635925B2 (ja) 2020-01-29
US10656141B2 (en) 2020-05-19
CA2936560C (en) 2021-06-01
ES2767060T3 (es) 2020-06-16
EP3097423A1 (en) 2016-11-30
EP3629026A1 (en) 2020-04-01
RU2016134215A (ru) 2018-03-01

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