KR102151842B1 - 토파시티닙 경구용 지속 방출 투여 형태 - Google Patents

토파시티닙 경구용 지속 방출 투여 형태 Download PDF

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Publication number
KR102151842B1
KR102151842B1 KR1020177030720A KR20177030720A KR102151842B1 KR 102151842 B1 KR102151842 B1 KR 102151842B1 KR 1020177030720 A KR1020177030720 A KR 1020177030720A KR 20177030720 A KR20177030720 A KR 20177030720A KR 102151842 B1 KR102151842 B1 KR 102151842B1
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South Korea
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tofacitinib
coating
dosage form
water
pharmaceutical dosage
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Korean (ko)
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KR20170121332A (ko
Inventor
스콧 맥스 헤르비그
스리람 크리쉬나스와미
조셉 쿠쉬너 이브
마니샤 람바
토마스 씨. 스톡
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화이자 인코포레이티드
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pulmonology (AREA)
  • Endocrinology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Dermatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Transplantation (AREA)
  • Emergency Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Oncology (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
KR1020177030720A 2013-03-16 2014-03-12 토파시티닙 경구용 지속 방출 투여 형태 Active KR102151842B1 (ko)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201361802479P 2013-03-16 2013-03-16
US61/802,479 2013-03-16
US201361864059P 2013-08-09 2013-08-09
US61/864,059 2013-08-09
US201461934428P 2014-01-31 2014-01-31
US61/934,428 2014-01-31
PCT/IB2014/059689 WO2014147526A1 (en) 2013-03-16 2014-03-12 Tofacitinib oral sustained release dosage forms

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR1020157029051A Division KR20150131238A (ko) 2013-03-16 2014-03-12 토파시티닙 경구용 지속 방출 투여 형태

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020207024740A Division KR102213616B1 (ko) 2013-03-16 2014-03-12 토파시티닙 경구용 지속 방출 투여 형태

Publications (2)

Publication Number Publication Date
KR20170121332A KR20170121332A (ko) 2017-11-01
KR102151842B1 true KR102151842B1 (ko) 2020-09-03

Family

ID=50819757

Family Applications (5)

Application Number Title Priority Date Filing Date
KR1020217003195A Ceased KR20210014763A (ko) 2013-03-16 2014-03-12 토파시티닙 경구용 지속 방출 투여 형태
KR1020157029051A Ceased KR20150131238A (ko) 2013-03-16 2014-03-12 토파시티닙 경구용 지속 방출 투여 형태
KR1020227037608A Ceased KR20220151016A (ko) 2013-03-16 2014-03-12 토파시티닙 경구용 지속 방출 투여 형태
KR1020177030720A Active KR102151842B1 (ko) 2013-03-16 2014-03-12 토파시티닙 경구용 지속 방출 투여 형태
KR1020207024740A Active KR102213616B1 (ko) 2013-03-16 2014-03-12 토파시티닙 경구용 지속 방출 투여 형태

Family Applications Before (3)

Application Number Title Priority Date Filing Date
KR1020217003195A Ceased KR20210014763A (ko) 2013-03-16 2014-03-12 토파시티닙 경구용 지속 방출 투여 형태
KR1020157029051A Ceased KR20150131238A (ko) 2013-03-16 2014-03-12 토파시티닙 경구용 지속 방출 투여 형태
KR1020227037608A Ceased KR20220151016A (ko) 2013-03-16 2014-03-12 토파시티닙 경구용 지속 방출 투여 형태

Family Applications After (1)

Application Number Title Priority Date Filing Date
KR1020207024740A Active KR102213616B1 (ko) 2013-03-16 2014-03-12 토파시티닙 경구용 지속 방출 투여 형태

Country Status (22)

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US (4) US9937181B2 (enExample)
EP (3) EP4249055A3 (enExample)
JP (3) JP6041823B2 (enExample)
KR (5) KR20210014763A (enExample)
CN (2) CN105101952B (enExample)
AU (2) AU2014233850B2 (enExample)
BR (1) BR112015020453B1 (enExample)
CA (2) CA3037328C (enExample)
CY (1) CY1124007T1 (enExample)
DK (1) DK2968155T3 (enExample)
ES (1) ES2865134T3 (enExample)
HU (1) HUE053911T2 (enExample)
IL (3) IL241400B (enExample)
MX (1) MX2021000550A (enExample)
NZ (2) NZ710792A (enExample)
PL (1) PL2968155T3 (enExample)
PT (1) PT2968155T (enExample)
SG (2) SG10201810985XA (enExample)
SI (1) SI2968155T1 (enExample)
TW (1) TWI619516B (enExample)
WO (1) WO2014147526A1 (enExample)
ZA (2) ZA201505468B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023090720A1 (ko) * 2021-11-16 2023-05-25 오즈온바이오 주식회사 산 민감성 성분을 포함하는 삼투성 제제 조성물

Families Citing this family (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2759924B2 (ja) 1995-08-11 1998-05-28 株式会社ゼクセル 燃料噴射装置の噴射時期検出装置
JP6041823B2 (ja) 2013-03-16 2016-12-14 ファイザー・インク トファシチニブの経口持続放出剤形
GB201402070D0 (en) * 2014-02-07 2014-03-26 Galapagos Nv Pharmaceutical compositions for the treatment of inflammatory disorders
US20170151244A1 (en) * 2014-06-23 2017-06-01 Sun Pharmaceutical Industries Limited Oral pharmaceutical composition of tofacitinib
AR101476A1 (es) 2014-08-07 2016-12-21 Acerta Pharma Bv Métodos para tratar cánceres, enfermedades inmunes y autoinmunes, y enfermedades inflamatorias en base a la tasa de ocupación de la tirosin quinasa de bruton (btk) y a la tasa de resíntesis de la tirosin quinasa de bruton (btk)
CN104622827A (zh) * 2015-03-05 2015-05-20 重庆华邦制药有限公司 托法替布片剂及其制备方法
WO2016192680A1 (en) * 2015-06-03 2016-12-08 Triastek, Inc. Dosage forms and use thereof
JP6796083B2 (ja) * 2015-06-09 2020-12-02 カプスゲル・ベルギウム・ナムローゼ・フェンノートシャップＣａｐｓｕｇｅｌ Ｂｅｌｇｉｕｍ ＮＶ カプセル中の薬剤の噴霧乾燥ディスパーションからの迅速な溶解を達成するための製剤
WO2017010938A1 (en) * 2015-07-16 2017-01-19 National University Of Singapore Printing drug tablets with fully customizable release profiles for personalized medicine
WO2017017542A1 (en) * 2015-07-27 2017-02-02 Unichem Laboratories Limited Tofacitinib orally disintegrating tablets
WO2017029587A1 (en) * 2015-08-19 2017-02-23 Sun Pharmaceutical Industries Limited Sustained release oral pharmaceutical compositions of tofacitinib
US20180311247A1 (en) * 2015-10-02 2018-11-01 Gilead Sciences, Inc. Combination therapies for treating cancers
CN120289468A (zh) 2015-10-16 2025-07-11 艾伯维公司 制备咪唑并[1,2-a]吡咯并[2,3-e]吡嗪类化合物及其固态形式的方法
US11780848B2 (en) 2015-10-16 2023-10-10 Abbvie Inc. Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-n-(2,2,2-trifluoroethyl)pyrrolidine-1- carboxamide and solid state forms thereof
US11524964B2 (en) 2015-10-16 2022-12-13 Abbvie Inc. Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-n-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof
US11365198B2 (en) 2015-10-16 2022-06-21 Abbvie Inc. Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof
US12365689B2 (en) 2015-10-16 2025-07-22 Abbvie Inc. Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-n-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof
US11512092B2 (en) 2015-10-16 2022-11-29 Abbvie Inc. Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-n-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof
US10550126B2 (en) 2015-10-16 2020-02-04 Abbvie Inc. Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-A]pyrrolo[2,3-e]-pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof
JP6983868B2 (ja) 2016-04-22 2021-12-17 レセプター・ホールディングス・インコーポレイテッド 即効性の植物由来医薬化合物及び栄養補給剤
CN108066319B (zh) * 2016-11-10 2022-01-14 江苏先声药业有限公司 一种枸橼酸托法替布肠溶缓释微丸及其制备方法
CN106420648A (zh) * 2016-11-22 2017-02-22 山东淄博新达制药有限公司 枸橼酸托法替布片剂及其制备方法
EA201892396A1 (ru) 2016-12-02 2019-04-30 Ресептор Лайф Сайенсиз, Инк. Быстродействующие растительные лекарственные соединения и биологически активные добавки
KR20180066296A (ko) * 2016-12-07 2018-06-19 서울대학교산학협력단 토파시티닙을 포함하는 고염증 증상의 예방 또는 치료용 약학적 조성물 및 토파시티닙을 포함하는 고염증 증상의 예방 또는 개선용 건강기능식품 조성물
EP3573602A4 (en) 2017-01-26 2020-09-16 Triastek, Inc. DOSAGE FORMS OF CONTROLLED RELEASE AT SPECIFIC GASTROINTESTINAL SITES
CN110418796A (zh) * 2017-03-08 2019-11-05 施万生物制药研发Ip有限责任公司 托法替尼(tofacitinib)的葡萄糖苷酸前药
US11564922B2 (en) 2017-03-09 2023-01-31 Abbvie Inc. Methods of treating crohn's disease and ulcerative colitis
MX2019010733A (es) 2017-03-09 2019-11-01 Abbvie Inc Metodos para tratar la enfermedad de crohn y la colitis ulcerosa.
US10759865B2 (en) 2017-08-22 2020-09-01 Eyal Levit Treatment of diabetes mellitus
KR102078805B1 (ko) * 2017-11-30 2020-02-19 보령제약 주식회사 토파시티닙을 포함하는 약제학적 조성물
EP3810096A1 (en) 2018-05-24 2021-04-28 Synthon B.V. Controlled release tofacitinib compositions
US20190381046A1 (en) * 2018-06-14 2019-12-19 Andrew HANNA Tofacitinib and baclofen compositions and applications
CN108992454B (zh) * 2018-06-20 2020-06-02 合肥医工医药股份有限公司 一种治疗皮肤炎症性疾病的复方药物组合物
CN110946834B (zh) * 2018-09-27 2023-03-31 四川科伦药物研究院有限公司 枸橼酸托法替布片及其制备工艺
CN111150711B (zh) * 2018-11-07 2023-04-07 上海博志研新药物技术有限公司 托法替布控释片、制备方法及其应用
AU2019385420A1 (en) 2018-11-19 2021-07-08 Spoke Sciences, Inc. N-acylated fatty amino acids to reduce absorption variability in cannabinoid based compositions
CN111358795A (zh) * 2018-12-26 2020-07-03 浙江万晟药业有限公司 一种枸橼酸托法替布制剂及其制备方法
KR20200082006A (ko) * 2018-12-28 2020-07-08 주식회사 대웅제약 토파시티닙 또는 그의 약제학적으로 허용되는 염을 함유한 서방성 제제 및 그의 제조방법
US20220249385A1 (en) * 2019-03-27 2022-08-11 Unichem Laboratories Limited Extended release composition of tofacitinib
US20220401446A1 (en) 2019-08-29 2022-12-22 Synthon B.V. Controlled release tofacitinib compositions
BR112022007826A2 (pt) * 2019-11-14 2022-07-05 Pfizer Combinações de 1-(((2s,3s,4s)-3-etil-4-fluoro-5-oxopirrolidin-2-il)metóxi)-7-metóxi-isoquino¬lina-6-carboxamida e formas de dosagem oral
CN110787145B (zh) * 2019-12-17 2022-03-29 南京康川济医药科技有限公司 一种枸橼酸托法替布缓释片及其制备方法
CN113018273B (zh) * 2019-12-25 2024-08-09 上海宣泰医药科技股份有限公司 一种固体制剂及其制备方法和用途
WO2021169724A1 (zh) * 2020-02-26 2021-09-02 上海博志研新药物技术有限公司 托法替尼缓释剂型、其制备方法及应用
JP7442347B2 (ja) * 2020-03-06 2024-03-04 東京エレクトロン株式会社 基板処理装置及び基板処理方法
US11766438B2 (en) 2020-04-24 2023-09-26 Slayback Pharma Llc Pharmaceutical compositions of tofacitinib for oral administration
US20230172934A1 (en) * 2020-05-18 2023-06-08 Zim Laboratories Limited Novel extended release composition of tofacitinib, its derivatives and salts
CN113712932A (zh) * 2020-05-25 2021-11-30 南京帝昌医药科技有限公司 一种枸橼酸托法替布渗透泵片及其制备方法
BR112023001529A2 (pt) * 2020-07-28 2023-04-11 Novelstar Pharmaceuticals Inc Nova forma de dosagem de liberação estendida gastroretentiva
CN111728953B (zh) * 2020-07-29 2023-08-08 中国科学院上海药物研究所 一种托法替布或其盐的缓释制剂及其制备方法
CN114099499A (zh) * 2020-08-26 2022-03-01 上海博志研新药物技术有限公司 依达拉奉口服持续释放组合物、制备方法及应用
CN112755000A (zh) * 2021-01-21 2021-05-07 石药集团欧意药业有限公司 一种枸橼酸托法替布缓释片
CN113069434A (zh) * 2021-03-11 2021-07-06 绍兴文理学院元培学院 一种枸橼酸托法替布控释胶囊及其制备方法
US20240285633A1 (en) 2021-06-04 2024-08-29 Synthon B.V. Prolonged release tofacitinib compositions
US20230240998A1 (en) * 2021-12-22 2023-08-03 Hikma Pharmaceuticals Usa Inc. Tofacitinib extended release formulations
AU2023329168A1 (en) 2022-08-26 2025-03-20 Synthon B.V. Prolonged release tofacitinib compositions without functional coating
CN116115580A (zh) * 2023-02-17 2023-05-16 北大医药股份有限公司 一种枸橼酸托法替布缓释片及其制备方法
WO2024206200A1 (en) * 2023-03-29 2024-10-03 Merck Sharp & Dohme Llc Controlled release pde10a formulations
KR102793673B1 (ko) * 2025-02-04 2025-04-11 삼익제약주식회사 바리시티닙을 포함하는 장기지속형 미립구의 제조 방법 및 이의 제조 방법으로 제조된 바리시티닙을 포함하는 장기지속형 미립구

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012100949A1 (en) * 2011-01-27 2012-08-02 Ratiopharm Gmbh Oral dosage forms for modified release comprising tasocitinib

Family Cites Families (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2322793A (en) 1939-08-21 1943-06-29 Robert S Drummond Gear finishing tool
US3247066A (en) 1962-09-12 1966-04-19 Parke Davis & Co Controlled release dosage form containing water-swellable beadlet
US3845770A (en) 1972-06-05 1974-11-05 Alza Corp Osmatic dispensing device for releasing beneficial agent
US3952741A (en) 1975-01-09 1976-04-27 Bend Research Inc. Controlled release delivery system by an osmotic bursting mechanism
US4519801A (en) 1982-07-12 1985-05-28 Alza Corporation Osmotic device with wall comprising cellulose ether and permeability enhancer
US5612059A (en) 1988-08-30 1997-03-18 Pfizer Inc. Use of asymmetric membranes in delivery devices
IL91398A (en) 1988-08-30 1994-05-30 Pfizer Pharmaceutical delivery device comprising active substance surrounded by asymmetric membrane
US5358502A (en) 1993-02-25 1994-10-25 Pfizer Inc PH-triggered osmotic bursting delivery devices
DE69425453T2 (de) * 1993-04-23 2001-04-12 Novartis Ag, Basel Wirkstoffabgabevorrichtung mit gesteuerter Freigabe
PT758244E (pt) 1994-05-06 2002-04-29 Pfizer Formas de dosagem libertacao controlada de azitromicina
US5945125A (en) 1995-02-28 1999-08-31 Temple University Controlled release tablet
US5736159A (en) 1995-04-28 1998-04-07 Andrx Pharmaceuticals, Inc. Controlled release formulation for water insoluble drugs in which a passageway is formed in situ
US5837379A (en) 1997-01-31 1998-11-17 Andrx Pharmaceuticals, Inc. Once daily pharmaceutical tablet having a unitary core
ID23503A (id) 1997-07-01 2000-04-27 Pfizer Garam-garam sertralina dan bentuk-bentuk sediaan lepas-lambat dari sertralina
FR2766708B1 (fr) 1997-07-30 2000-05-05 Galenix Dev Composition contenant de l'hydroxypropylcellulose, de l'hydroxypropylmethylcellulose et/ou de l'ethylcellullose a titre d'agents desintegrants, et procede d'obtention
US6706283B1 (en) 1999-02-10 2004-03-16 Pfizer Inc Controlled release by extrusion of solid amorphous dispersions of drugs
GEP20053479B (en) * 1999-12-10 2005-03-25 Pfizer Prod Inc Pyrrolo[2,3-d]Pyrimidine Compounds, Pharmaceutical Composition Containing the Same and Use
IN190699B (enExample) 2001-02-02 2003-08-16 Sun Pharmaceutical Ind Ltd
US7301023B2 (en) 2001-05-31 2007-11-27 Pfizer Inc. Chiral salt resolution
CA2466657C (en) * 2001-11-13 2011-02-01 Yamanouchi Pharma Technologies, Inc. Soluble drug extended release system
GB0127423D0 (en) 2001-11-15 2002-01-09 Glaxo Group Ltd Process
GT200200234A (es) 2001-12-06 2003-06-27 Compuestos cristalinos novedosos
US20030175346A1 (en) 2002-02-01 2003-09-18 Anne Billotte Osmotic delivery system
CN1874761A (zh) * 2003-09-02 2006-12-06 辉瑞产品公司 齐拉西酮的持续释放剂型
US7825106B2 (en) 2003-09-03 2010-11-02 Agi Therapeutics Ltd. Modified release formulations and methods of treating inflammatory bowel disease
CA2547597A1 (en) 2003-12-04 2005-06-16 Pfizer Products Inc. Multiparticulate compositions with improved stability
WO2005053652A1 (en) 2003-12-04 2005-06-16 Pfizer Products Inc. Multiparticulate crystalline drug compositions containing a poloxamer and a glyceride
KR20080064209A (ko) 2003-12-04 2008-07-08 화이자 프로덕츠 인코포레이티드 바람직하게는 폴록사머와 글리세라이드를 함유하는다미립자 아지트로마이신 조성물의 제조를 위해 압출기를사용하는 분무응결 방법
US20080199527A1 (en) 2004-12-21 2008-08-21 Pfizer Inc. Enteric Coated Azithromycin Multiparticulates
CA2596029A1 (en) * 2005-01-27 2006-08-03 David E. Edgren Oral osmotic dosage form having a high flux membrane
US20070031496A1 (en) * 2005-08-04 2007-02-08 Edgren David E Osmotic dosage forms comprising semipermeable membranes with polymer blends providing improved properties
WO2007057762A2 (en) 2005-11-16 2007-05-24 Pfizer Limited Osmotic bi-layer tablet
MX2008013606A (es) 2006-04-24 2008-10-30 Pfizer Prod Inc Membranas asimetricas para dispositivos de administracion de farmacos.
JP2009542646A (ja) * 2006-06-30 2009-12-03 ボード オブ トラステーズ オブ ザ ユニバーシティ オブ アルカンザス 徐放型穿孔錠剤
EP3026052A1 (en) 2009-04-20 2016-06-01 Auspex Pharmaceuticals, Inc. Preparation of deuterated piperidine inhibitors of janus kinase 3
WO2011039686A1 (en) 2009-09-30 2011-04-07 Pfizer Inc. Latrepirdine oral sustained release dosage forms
US8519970B2 (en) 2010-07-16 2013-08-27 Perceptive Pixel Inc. Capacitive touch sensor having correlation with a receiver
EP2481397A1 (en) * 2011-01-27 2012-08-01 Ratiopharm GmbH Pharmaceutical compositions comprising tasocitinib
JP6041823B2 (ja) 2013-03-16 2016-12-14 ファイザー・インク トファシチニブの経口持続放出剤形
WO2014174073A1 (en) 2013-04-26 2014-10-30 Sandoz Ag Sustained release formulations of tofacitinib

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012100949A1 (en) * 2011-01-27 2012-08-02 Ratiopharm Gmbh Oral dosage forms for modified release comprising tasocitinib

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023090720A1 (ko) * 2021-11-16 2023-05-25 오즈온바이오 주식회사 산 민감성 성분을 포함하는 삼투성 제제 조성물
WO2023090719A1 (ko) * 2021-11-16 2023-05-25 오즈온바이오 주식회사 산 민감성 성분을 포함하는 삼투성 제제 조성물

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