KR102151082B1 - 항진균 화합물 제조방법 - Google Patents

항진균 화합물 제조방법 Download PDF

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KR102151082B1
KR102151082B1 KR1020167025607A KR20167025607A KR102151082B1 KR 102151082 B1 KR102151082 B1 KR 102151082B1 KR 1020167025607 A KR1020167025607 A KR 1020167025607A KR 20167025607 A KR20167025607 A KR 20167025607A KR 102151082 B1 KR102151082 B1 KR 102151082B1
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KR20160138012A (ko
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윌리엄 제이. 훅스트라
크리스토퍼 엠. 예이츠
마크 벵케
아사프 아리마다노브
스콧 에이. 데이비드
더글라스 프랭클린 프라이
Original Assignee
더 유나이티드 스테이츠 오브 어메리카, 애즈 리프리젠티드 바이 더 시크리터리, 디파트먼트 오브 헬쓰 앤드 휴먼 서비시스
마이코비아 파마슈티컬즈, 인코포레이티드
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Application filed by 더 유나이티드 스테이츠 오브 어메리카, 애즈 리프리젠티드 바이 더 시크리터리, 디파트먼트 오브 헬쓰 앤드 휴먼 서비시스, 마이코비아 파마슈티컬즈, 인코포레이티드 filed Critical 더 유나이티드 스테이츠 오브 어메리카, 애즈 리프리젠티드 바이 더 시크리터리, 디파트먼트 오브 헬쓰 앤드 휴먼 서비시스
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/26—Radicals substituted by halogen atoms or nitro radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Artificial Filaments (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
KR1020167025607A 2014-03-19 2015-03-19 항진균 화합물 제조방법 Active KR102151082B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461955615P 2014-03-19 2014-03-19
US61/955,615 2014-03-19
PCT/US2015/021491 WO2015143172A1 (en) 2014-03-19 2015-03-19 Antifungal compound process

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KR20160138012A KR20160138012A (ko) 2016-12-02
KR102151082B1 true KR102151082B1 (ko) 2020-09-03

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US (2) US10173998B2 (enrdf_load_stackoverflow)
EP (1) EP3119745B1 (enrdf_load_stackoverflow)
JP (1) JP6509897B2 (enrdf_load_stackoverflow)
KR (1) KR102151082B1 (enrdf_load_stackoverflow)
CN (2) CN106458900B (enrdf_load_stackoverflow)
AU (1) AU2015231226B2 (enrdf_load_stackoverflow)
BR (1) BR112016020937B1 (enrdf_load_stackoverflow)
CA (1) CA2942968C (enrdf_load_stackoverflow)
EA (1) EA037587B1 (enrdf_load_stackoverflow)
ES (1) ES2815373T3 (enrdf_load_stackoverflow)
HU (1) HUE052446T2 (enrdf_load_stackoverflow)
MX (1) MX365494B (enrdf_load_stackoverflow)
PL (1) PL3119745T3 (enrdf_load_stackoverflow)
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WO2015143166A1 (en) 2014-03-19 2015-09-24 Viamet Pharmaceuticals, Inc. Antifungal compound process
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US10196375B2 (en) 2014-03-19 2019-02-05 Mycovia Pharmaceuticals, Inc. Antifungal compound process
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WO2015143180A1 (en) 2014-03-19 2015-09-24 Viamet Pharmaceuticals, Inc. Antifungal compound process
JP2017514790A (ja) 2014-03-19 2017-06-08 ヴィアメット ファーマスーティカルズ，インコーポレイテッド 抗真菌化合物の調製方法
BR112016021257B1 (pt) 2014-03-19 2021-03-02 Viamet Pharmaceuticals (NC), Inc. 2-(2,4- difluorofenil-1,1-diflúor-1-(5-substituído-piridin-2-il)-3- (1h-tetrazol-1-il)propan-2-óis e processos para preparação e uso dos mesmos
KR20160138013A (ko) * 2014-03-19 2016-12-02 비아멧 파마슈티컬즈, 인코포레이티드 항진균 화합물 제조방법
BR112017018823A2 (pt) * 2015-03-19 2018-04-24 Viamet Pharmaceuticals, Inc. compostos antifúngicos e processos para a fabricação
US10308632B2 (en) * 2015-09-18 2019-06-04 Vps-3, Inc. Antifungal compounds and processes for making
JP2021502402A (ja) 2017-11-13 2021-01-28 バイエル アクチェンゲゼルシャフトＢａｙｅｒ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ テトラゾリルプロピル誘導体および殺真菌剤としてのそれらの使用
AU2019325436B2 (en) * 2018-08-18 2023-10-26 5Metis, Inc. Solid forms of substituted benzoxaborole and compositions thereof
CN114573557B (zh) * 2022-03-28 2024-03-08 浙江天宇药业股份有限公司 一种奥特康唑的制备方法
CN116621816B (zh) * 2022-09-23 2025-07-04 北京莱瑞森医药科技有限公司 一种伏立康唑对映异构对b的拆分方法
CN116675672B (zh) * 2023-06-05 2025-04-25 北京康立生医药技术开发有限公司 一种抗真菌药物的制备方法
CN119798219B (zh) * 2025-01-13 2025-07-18 长治医学院 一种奥特康唑的制备方法

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AU2015231226A1 (en) 2016-10-06
EP3119745B1 (en) 2020-08-05
US20190161469A1 (en) 2019-05-30
CA2942968A1 (en) 2015-09-24
CA2942968C (en) 2022-03-15
EA037587B1 (ru) 2021-04-19
CN109970629B (zh) 2023-04-11
JP2017509644A (ja) 2017-04-06
WO2015143172A1 (en) 2015-09-24
CN106458900A (zh) 2017-02-22
ES2815373T3 (es) 2021-03-29
US20170088539A1 (en) 2017-03-30
EA201691649A1 (ru) 2016-12-30
CN106458900B (zh) 2019-01-01
MX365494B (es) 2019-06-05
JP6509897B2 (ja) 2019-05-08
PL3119745T3 (pl) 2021-01-25
BR112016020937B1 (pt) 2022-09-20
AU2015231226B2 (en) 2019-04-04
MX2016012056A (es) 2017-04-27
CN109970629A (zh) 2019-07-05
HUE052446T2 (hu) 2021-04-28
US10173998B2 (en) 2019-01-08
BR112016020937A2 (enrdf_load_stackoverflow) 2017-08-15
EP3119745A4 (en) 2017-08-23
EP3119745A1 (en) 2017-01-25
KR20160138012A (ko) 2016-12-02
US10392365B2 (en) 2019-08-27

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