KR102140031B1 - A cosmetic and a bath composition containing the active ingredient of Buddha's hand - Google Patents
A cosmetic and a bath composition containing the active ingredient of Buddha's hand Download PDFInfo
- Publication number
- KR102140031B1 KR102140031B1 KR1020180151902A KR20180151902A KR102140031B1 KR 102140031 B1 KR102140031 B1 KR 102140031B1 KR 1020180151902 A KR1020180151902 A KR 1020180151902A KR 20180151902 A KR20180151902 A KR 20180151902A KR 102140031 B1 KR102140031 B1 KR 102140031B1
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- South Korea
- Prior art keywords
- extract
- water
- insoluble
- cosmetic composition
- skin
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Dermatology (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Cosmetics (AREA)
Abstract
본 발명은 불수감 추출물이 포함하는 화장료 조성물을 제조하여, 불수감 특유의 향이 존재하며, 색소 침착을 막아 피부톤을 환하고 밝게 해주는 미백 효과 및 항산화 효과가 우수한 기능성 화장품을 제공하고자 한다.
또한, 불수감에서 불수감 추출물을 추출한 후 남은 잔여액인 불수감 중탕수을 입욕제 조성물로 제조하여여 불수감 중탕수를 포함하여 항산화 효과 및 피부 미백 효과가 있는 입욕제를 제공하고자 한다.The present invention is intended to provide a functional cosmetic product having a whitening effect and an antioxidant effect that prepares a cosmetic composition included in an insensitivity extract, has a peculiar fragrance, and prevents pigmentation and brightens and brightens skin tone.
In addition, it is intended to provide a bathing agent having an antioxidant effect and a skin whitening effect, including water-insoluble water by preparing a water-insoluble bath water composition, which is the remaining liquid after extracting the water-in-water extract from the water-insoluble feeling.
Description
본 발명은 기능성 화장료 조성물 및 입욕제 조성물에 관한 것으로서, 보다 상세하게는, 식물성 소재인 불수감의 유효성분을 포함하는 항산화효과 및 피부미백효과가 뛰어난 기능성 화장료 조성물 및 입욕제 조성물에 관한 것이다.The present invention relates to a functional cosmetic composition and a bath composition, and more particularly, to a functional cosmetic composition and a bath composition having excellent antioxidant and skin whitening effects, including an active ingredient of insensibility as a vegetable material.
화장품 시장은 단순 미용 산업이라는 패러다임을 넘어 최근 기술과 효능을 결합한 하이테크 산업으로 인식되고 있다. 고성장 중인 화장품 산업은 과거 유행 중심의 경쟁 산업이었는데, 최근 다양한 첨단기술과 접목되면서 기술효능 중심의 산업으로 변화하고 있다. 그동안 국내 화장품 시장은 2006년, 5조 6,000억 원에서, 2011년, 8조 9,000억 원으로, 연평균 10.4% 성장하며, 고성장세를 유지했다. 특히, 사회 전반에 걸쳐 웰빙안티에이징 열풍이 불면서 화장품 산업의 성장은 당분간 지속할 것으로 전망되고 있다.The cosmetics market is recognized as a high-tech industry that combines technology and efficacy in recent years beyond the paradigm of the simple beauty industry. The cosmetics industry, which is growing rapidly, was a competitive industry centered on fashion in the past, but recently, it is changing to a technology-oriented industry as it is combined with various advanced technologies. In the meantime, the domestic cosmetics market has grown from 1,5% in 2006 to 5,900 billion won in 2011 and 8,900 billion won in 2011, maintaining a high growth rate. In particular, the growth of the cosmetics industry is expected to continue for the time being as the well-being anti-aging fever is blowing across society.
피부노화는 자연히 발생하는 내인성 노화와 외부 요인에 의해 일어나는 외인성 노화로 구분된다. 내인성 노화의 요인은 주로 유전적인 요인을 말하며 피부 세포 및 조직의 구조와 변화를 결정한다. 외인성 노화의 요인은 외부에서 유래된 요인으로 영양부족, 햇빛, 환경오염 등이 속하며 얼마든지 예방 가능하고 피할 수 있는 요인이다.Skin aging is divided into naturally occurring endogenous aging and exogenous aging caused by external factors. Factors of endogenous aging are mainly genetic factors and determine the structure and changes of skin cells and tissues. The factors of exogenous aging are factors derived from the outside, such as malnutrition, sunlight, and environmental pollution, which are preventable and avoidable.
이러한 요인으로 인해 피부 노화가 진행됨으로서 피부가 건조해지고 거칠어지며 주름 생성, 색소 침착 및 수분 부족 현상 등이 일어나게 된다. 따라서 피부 미용에 대한 관심이 높아지며 특히 피부 노화에 대한 관심과 노화를 늦추기 위한 시도들이 행하여지고 있다.Due to these factors, skin aging progresses, skin becomes dry and rough, wrinkles, pigmentation, and lack of moisture occur. Therefore, interest in skin beauty is increasing, and particularly, interest in skin aging and attempts to slow aging are being made.
또한, 피부 미백이 멜라닌 색소와 직접적으로 관련되어 있다는 것은 널리 알려진 사실이다. 멜라닌은 자외선을 차단하여 진피 이하의 피부 기관을 보호해주는 동시에, 피부 생체 내에 생겨난 자유 라디칼 등에 의한 피부 내 단백질과 유전자들의 손상을 보호해주는 유용한 역할을 하지만, 멜라닌이 필요 이상으로 많이 생기게 되면 피부 노화를 가져오며 기미나 주근깨 등과 같은 과색소침착증을 유발한다. 미백 작용은 멜라닌의 생성을 억제하거나, 멜라노좀의 이동을 저해함으로써 가능해진다. 이러한 메커니즘으로 식약처에 의해 미백 성분으로 등록된 물질은 닥나무 추출물, 알부틴, 에칠아스코빌에텔, 유용성감초추출물, 아스코빌글루코사이드, 나이아신아마이드, 알파-비사볼올, 아스코빌테트라이소팔미테이트 등인데, 일반적으로 멜라닌의 생성을 억제함으로써 그 효과를 나타낸다. It is also well known that skin whitening is directly related to melanin pigments. Melanin protects the skin organs below the dermis by blocking ultraviolet rays, and at the same time, plays a useful role in protecting proteins and genes in the skin by free radicals generated in the skin.However, if more melanin is produced than necessary, it causes skin aging. It causes hyperpigmentation such as freckles and freckles. The whitening action becomes possible by inhibiting the production of melanin or inhibiting the migration of melanosomes. Substances registered as whitening ingredients by the Ministry of Food and Drug Safety through this mechanism are mulberry extract, arbutin, ethyl ascorbyl ether, oil-soluble licorice extract, ascorbyl glucoside, niacinamide, alpha-bisabolol, ascorbyltetraisopalmitate, etc. By suppressing the production of melanin, it shows the effect.
그러나, 대부분의 알려진 주름 개선 또는 미백 효과를 가진 피부 개선을 위한 물질들은 피부 적용시 자극, 발적 등의 안전성 문제로 사용량의 제한이 있거나, 효과가 미미하여 실질적으로 피부기능 개선 또는 상처 치유의 효과를 기대할 수 없었다. 따라서, 기존의 피부 개선용 화장료 조성물보다 생체에 안전하고 효과가 높은 새로운 피부 개선용 화장료 조성물의 개발이 절실히 요구되고 있다.However, most of the known substances for skin improvement with wrinkle improvement or whitening effect have limitations in use due to safety problems such as irritation and redness when applying the skin, or the effect is insignificant to substantially improve the skin function or the effect of wound healing. Could not. Accordingly, there is an urgent need for the development of a new cosmetic composition for skin improvement that is safer and more effective in living body than an existing cosmetic composition for skin improvement.
본 발명은 불수감 추출물 및 불수감 중탕수를 포함하는 조성물을 포함하여 부작용이 적고, 안정성이 확보된 항산화 효과 또는 피부 미백 효과를 나타내는 화장품 및 입욕제를 제공하는 것이다. The present invention is to provide a cosmetic and bathing agent that exhibits an anti-oxidant effect or skin whitening effect with little side effects and stability, including a composition comprising a water-insoluble extract and a water-insoluble heavy water.
그러나 본 발명의 목적들은 상기에 언급된 목적으로 제한되지 않으며, 언급되지 않은 또 다른 목적들은 아래의 기재로부터 당업자에게 명확하게 이해될 수 있을 것이다.However, the objects of the present invention are not limited to those mentioned above, and other objects not mentioned will be clearly understood by those skilled in the art from the following description.
불수감 추출물을 유효성분으로 포함하는 화장료 조성물로 불수감을 물에 넣고 끓인 후 끓여 나온 증기를 냉각시켜 증기를 액체 상태로 응축하여 액상의 상기 불수감 추출물을 추출하고, 상기 불수감 추출물은 지용성의 불수감 오일 및 수용성의 불수감 추출수를 포함하는 것을 특징으로 한다.A cosmetic composition comprising an insensibility extract as an active ingredient, boils the insensibility in water, boils, cools the boiled steam to condense the steam to extract the liquid insensibility extract, and the insensibility extract is fat-soluble insoluble oil and water-soluble Characterized in that it comprises a water extract of the incompatibility.
상기 화장료 조성물은 항산화효과 및 피부미백효과 기능을 포함하는 것을 특징으로 한다.The cosmetic composition is characterized by including an antioxidant effect and a skin whitening effect function.
상기 불수감 추출물은 상기 화장료 조성물 총 중량에 대하여 5~20중량%의 양으로 함유됨을 특징으로 한다.The water-insoluble extract is characterized in that it is contained in an amount of 5 to 20% by weight relative to the total weight of the cosmetic composition.
상기 불수감 추출물은 추가로 발효될 수 있는 것을 특징으로 한다.The insensibility extract is characterized in that it can be further fermented.
상기 화장료 조성물은 상기 불수감 추출물 외에 겨우살이 추출물 및 인동초 추출물에서 선택되는 1종 이상을 더 포함할 수 있는 것을 특징한다.The cosmetic composition is characterized in that it may further include at least one selected from mistletoe extract and indongcho extract in addition to the incombustible extract.
상기 화장료 조성물은 화장품, 디퓨저, 향수, 방향제, 비누, 클렌저로 구성된 군으로부터 선택된 제품에 적용하는 것을 특징으로 한다.The cosmetic composition is characterized in that it is applied to products selected from the group consisting of cosmetics, diffusers, perfumes, fragrances, soaps, cleansers.
불수감에서 불수감 추출물을 추출한 후 남아있는 잔여액을 유효성분으로 포함하는 입욕제 조성물로 상기 잔여액은 불수감 중탕수를 포함하는 것을 특징으로 한다.After extracting the extract of insensibility from the insensibility, the remaining solution is a bath composition containing the remaining liquid as an active ingredient, wherein the residual solution comprises insoluble water.
본 발명은 불수감 추출물이 포함하는 화장료 조성물로서, 불수감 특유의 향이 존재하며, 색소 침착을 막아 피부톤을 환하고 밝게 해주는 미백 효과가 우수하여 미백 개선 기능성 화장품에 사용될 수 있다. The present invention is a cosmetic composition included in the insensitivity extract, has a peculiar flavor of insensitivity, and has excellent whitening effect to brighten and brighten the skin tone by preventing pigmentation, and thus can be used in functional cosmetics for improving whitening.
더욱 구체적으로 본 발명에 따른 불수감 추출물을 포함하여, 지성, 건성 및 복합성 피부 등 피부 타입에 상관없이 트러블이 전혀 나타나지 않고, 오히려 문제성 피부가 개선되는 효과를 나타내며, 주름, 미백 개선 및 리프팅 효과에 대한 만족도가 우수한 화장품을 제공할 수 있다. More specifically, including the insensibility extract according to the present invention, regardless of the skin type, such as oily, dry and complex skin, no trouble appears at all, rather, it shows the effect of improving the problematic skin, and improves wrinkles, whitening and lifting effects. Cosmetics with excellent satisfaction can be provided.
또한, 본 발명은 불수감 중탕수를 포함하는 입욕제 조성물로서, 불수감을 물에 넣고 끓인 후 끓여 나온 증기를 냉각시켜 추출물을 수득하고 남아있는 불수감 잔여액인 불수감 중탕수를 입욕제 조성물로 재활용하여 사용할 수 있다.In addition, the present invention is a bath composition containing insoluble water, and the boiled water is put in water and boiled, and then the boiled steam is cooled to obtain an extract, and the remaining water-insoluble water, which is the remaining water-insoluble water, can be reused as a bath composition. .
이하에 본 발명을 상세하게 설명하기에 앞서, 본 명세서에 사용된 용어는 특정의 실시예를 기술하기 위한 것일 뿐 첨부하는 특허청구의 범위에 의해서만 한정되는 본 발명의 범위를 한정하려는 것은 아님을 이해하여야 한다. 본 명세서에 사용되는 모든 기술용어 및 과학용어는 다른 언급이 없는 한은 기술적으로 통상의 기술을 가진 자에게 일반적으로 이해되는 것과 동일한 의미를 가진다.Before describing the present invention in detail below, it is understood that the terms used herein are only for describing specific embodiments and are not intended to limit the scope of the present invention, which is limited only by the scope of the appended claims. shall. All technical and scientific terms used in this specification have the same meaning as commonly understood by those skilled in the art unless otherwise stated.
본 명세서 및 청구범위의 전반에 걸쳐, 다른 언급이 없는 한 포함(comprise, comprises, comprising)이라는 용어는 언급된 물건, 단계 또는 일군의 물건, 및 단계를 포함하는 것을 의미하고, 임의의 어떤 다른 물건, 단계 또는 일군의 물건 또는 일군의 단계를 배제하는 의미로 사용된 것은 아니다.Throughout this specification and claims, the term "comprise, comprises, comprising," unless otherwise stated, means including the recited article, step or group of articles, and steps, and any any other article. It is not meant to exclude a step or group of things or a group of steps.
한편, 본 발명의 여러 가지 실시예들은 명확한 반대의 지적이 없는 한 그 외의 어떤 다른 실시예들과 결합될 수 있다. 특히 바람직하거나 유리하다고 지시하는 어떤 특징도 바람직하거나 유리하다고 지시한 그 외의 어떤 특징 및 특징들과 결합될 수 있다. 이하, 첨부된 도면을 참조하여 본 발명의 실시예 및 이에 따른 효과를 설명하기로 한다.On the other hand, various embodiments of the present invention can be combined with any other embodiments, unless otherwise indicated. Any feature indicated as particularly preferred or advantageous may be combined with any other feature or features indicated as preferred or advantageous. Hereinafter, embodiments and effects according to the present invention will be described with reference to the accompanying drawings.
본 발명에 따른 항산화 효과 및 피부 미백 효과 기능성을 가진 화장료 조성물 및 입욕제 조성물은 정제수 및 불수감 추출물 또는 불수감 중탕수를 포함하여, 가공된 식물의 유효성분을 포함함으로써 항산화 효과 및 색소 침착을 막아 피부톤을 환하고 밝게 해주는 미백 개선 기능성 화장품에 사용될 수 있다. The cosmetic composition and the bath composition having the antioxidant effect and skin whitening effect function according to the present invention include purified water and insoluble water extract or insoluble water, and contain active ingredients of processed plants to prevent antioxidant effects and pigmentation to reduce skin tone It can be used in brightening whitening functional cosmetics.
본 명세서에서, 상기 "유효성분"의 의미는 단독으로 목적하는 활성을 나타내거나 또는 그 자체는 활성이 없는 담체와 함께 활성을 나타낼 수 있는 성분을 의미한다. 또한 본 명세서에서, 상기 “불수감 추출물” 또는 “불수감 중탕수”는 본 발명에 따른 특정 식물로부터 유효성분을 적어도 1종 이상 포함하는 것을 의미한다. 기타 본 명세서에서 특별히 정의되지 아니한 용어에 대해서는 국어사전적 의미나 당업계에서 통상 받아들여지고 있는 의미를 따른다.In the present specification, the meaning of the "active ingredient" refers to a component that can exhibit the desired activity alone or itself can exhibit activity with an inactive carrier. In addition, in the present specification, the “incapacitated extract” or “incapacitated heavy water” means that at least one active ingredient is included from a specific plant according to the present invention. Other terms that are not specifically defined in the present specification follow the meaning of the Korean dictionary or the meaning commonly accepted in the art.
본 발명의 화장료 조성물은 불수감 추출물을 유효성분으로 함유함으로써 불수감 특유의 향이 존재하고 항산화 효과 및 피부미백 효과가 뛰어나다. The cosmetic composition of the present invention contains a water-insoluble extract as an active ingredient, and thus has a peculiar flavor of water-insensitive feeling and has excellent antioxidant and skin whitening effects.
또한, 본 발명의 입욕제 조성물은 불수감에서 불수감 추출물을 추출한 후 남아있는 잔여액을 유효성분으로 함유함으로써 불수감 특유의 향이 존재하고 항산화 효과 및 피부미백 효과가 뛰어나다.In addition, the bath composition of the present invention extracts the incombustibility extract from the incombustibility, and contains the remaining liquid as an active ingredient, thereby having a peculiar flavor of the incombustibility and excellent antioxidant and skin whitening effects.
본 발명에 사용하는 불수감(Citrus medica L. var. sarcodactylis Swingle)은 상록 저목으로 가지에 가시가 있고 잎은 호생하며 길이 10~18㎝, 폭 4~5㎝ 정도로 크며 잎 가장자리에 거치가 있다. 엽병은 천천히 발달하며 꽃은 흰색이 있으며 담자색을 띤 것도 많고 엽액에서 나와 총상화서로 붙는다. 화관은 4~5열로 다수의 암술로 하나의 수술이 있다. 과실은 향기가 많으며 색은 선황색으로 겨울에 열매를 맺으며 모양은 부처의 손가락을 닮아서 ‘불수감’이라고 불리게 되었다. 불수감 과실은 또한 과실주, 천연방향제, 웰빙차로 쓰이며 식용. 약용. 관상용으로 모두 가능하다. 불수감의 대표적인 효능은 간기능 개선이며, 위장기관에 좋으며 폐와 기관지를 진정시켜 오랜 기침과 가래를 삭히는데 좋다. 비타민c가 풍부하고, 항산화 작용이 탁월하여 면역력증강 정균. 항균작용과 식욕을 억제해주며 구역, 소화불량, 배에 까스가 차는 증상에 좋으며 남성의 하체강화에도 그 효능이 탁월하며, 피부미백에도 효과가 있음이 확인되었다.The imperceptibility used in the present invention (Citrus medica L. var. sarcodactylis Swingle) is an evergreen shrub with thorns on the branches, leaves are coarse, 10-18 cm long, 4-5 cm wide, and mounted on the edge of the leaves. The leaf disease develops slowly, the flower has a white color, and there are many purple-colored flowers, and it comes out of the axillary fluid and attaches as a gunshot wound. Corolla is a 4-5 row, with multiple pistils, with one operation. The fruit has a lot of scent, and its color is yellow, and it bears fruit in winter, and the shape resembles the Buddha's finger, so it is called ‘unsatisfactory’. Impervious fruits are also used as fruit wines, natural fragrances, and wellness tea and are edible. Medicinal. All for ornamental use. The typical efficacy of insensitivity is improvement of liver function, good for the gastrointestinal tract, and it is good for calming the lungs and bronchi and cutting long cough and sputum. It is rich in vitamin c and has excellent antioxidant activity, improving immunity. It has been confirmed that it has antibacterial action and suppresses appetite, is good for nausea, indigestion, and stomach tingling symptoms. It is also effective in strengthening the lower body of men and has an effect on skin whitening.
본 발명에 사용하는 불수감 추출물은 열매 외에 줄기, 뿌리, 잎, 꽃을 모두 사용하여 증류 추출법, 압착법, 용매 추출법을 이용하여 얻은 추출액 뿐 아니라 추출액을 다시 일부 또는 전부 농축하여 얻은 농축물 또는 상기의 농축물을 다시 건조시켜 제조한 침체, 전제, 정기, 유동엑기스 및 상기 불수감 중에 함유되어 주 효과를 발휘하는 화학 물질은 물론 식물 그 자체를 모두 포함한다.The water-insoluble extract used in the present invention is a concentrate obtained by partially or fully concentrating the extract as well as the extract obtained using a distillation extraction method, a compression method, a solvent extraction method using all of stems, roots, leaves, and flowers in addition to fruits, or the above. It contains all of the plants themselves, as well as the chemicals contained in the stagnation, premise, periodic, fluidized extract, and the above-mentioned insensitivity, which were produced by drying the concentrate again, and exhibiting the main effect.
또한, 불수감에서 불수감 추출물을 추출한 후 남은 잔여액은 불수감 중탕수라 하여 여과 분리하여 사용하는 것을 포함한다.In addition, the residual liquid remaining after extracting the incommunity extract from the incomprehension includes using the filtrate separation as the incombustible hot water.
본 발명에 따른 화장료 조성물은 상기 불수감 추출물을 조성물 총 중량에 대하여 0.01∼90 중량%, 보다 바람직하게는 1∼50 중량%, 더욱 바람직하게는 5~20중량%의 양으로 함유한다. 이는 0.01 중량% 미만에서는 항산화 효과 및 피부 미백 효과를 기대할 수 없고, 90 중량% 초과에서는 피부 안정성 및 제형상의 문제가 있기 때문이다.The cosmetic composition according to the present invention contains the insoluble extract in an amount of 0.01 to 90% by weight, more preferably 1 to 50% by weight, and more preferably 5 to 20% by weight relative to the total weight of the composition. This is because the antioxidant effect and skin whitening effect cannot be expected at less than 0.01% by weight, and there is a problem in skin stability and formulation when it exceeds 90% by weight.
또한, 본 발명에 따른 입욕제 조성물은 상기 불수감 중탕수를 조성물 총 중량에 대하여 0.01∼90 중량%, 보다 바람직하게는 1∼50 중량%, 더욱 바람직하게는 5~20중량%의 양으로 함유한다. 이는 0.01 중량% 미만에서는 항산화 효과 및 피부 미백 효과를 기대할 수 없고, 90 중량% 초과에서는 피부 안정성 및 제형상의 문제가 있기 때문이다.In addition, the bath composition according to the present invention contains the insoluble water in the amount of 0.01 to 90% by weight, more preferably 1 to 50% by weight, more preferably 5 to 20% by weight relative to the total weight of the composition. This is because the antioxidant effect and skin whitening effect cannot be expected at less than 0.01% by weight, and there is a problem in skin stability and formulation when it exceeds 90% by weight.
본 발명에 따른 화장료 조성물 및 입욕제 조성물에는 불수감 추출물 및 불수감 중탕수 외에 추가로 꽈리열매(Physalis Alkekengi Fruit), 귤껍질(Citrus Unshiu Peel), 녹두(Phaseolus Radiatus Seed), 콩(Phellinus Linteus), 병풀(Centella Asiatica), 녹차(Camellia Sinensis Leaf), 어성초(Houttuynia Cordata), 황금(Perilla Frutescens Leaf), 상황버섯(Phellinus Linteus) 및 자소엽(Perilla Frutescens Leaf), 겨우살이(Viscum album var. coloratum), 인동초(Lonicera japonica) 로 구성되는 군에서 선택되는 어느 1종 이상의 식물 추출물을 포함할 수 있다. 바람직하게는 겨우살, 인동초 군에서 선택되는 어느 1종 이상의 식물 추출물을 포함할 수 있다. 추가로 포함되는 식물 추출물은 조성물 총 중량에 대하여 0.01∼90 중량%, 보다 바람직하게는 1∼50 중량%, 더욱 바람직하게는 5~20중량%의 양으로 함유한다. 이는 0.01 중량% 미만에서는 항산화 효과 및 미백 효과를 기대할 수 없고, 90 중량% 초과에서는 피부 안정성 및 제형상의 문제가 있기 때문이다.The cosmetic composition and the bath composition according to the present invention include in addition to insensibility extracts and insensibility heavy water, Physalis Alkekengi Fruit, Citrus Unshiu Peel, Phaseolus Radiatus Seed, Soybean (Phellinus Linteus), Centella ( Centella Asiatica, Green Tea (Camellia Sinensis Leaf), Houttuynia Cordata, Golden (Perilla Frutescens Leaf), Phellinus Linteus and Perilla Frutescens Leaf, Mistletoe (Viscum album var. coloratum) Lonicera japonica) may include any one or more plant extracts selected from the group consisting of. Preferably it may include any one or more plant extracts selected from the mistletoe, Indongcho group. The additionally included plant extract is contained in an amount of 0.01 to 90% by weight, more preferably 1 to 50% by weight, and even more preferably 5 to 20% by weight based on the total weight of the composition. This is because an antioxidant effect and a whitening effect cannot be expected at less than 0.01% by weight, and there is a problem in skin stability and formulation when it exceeds 90% by weight.
상기 불수감 추출물은 증류수에 잠긴 불수감을 가열하여 발생한 증기를 냉각 응축한 것이고, 상기 불수감 중탕수는 증류수에 잠긴 불수감에서 불수감 추출물을 추출하고 남은 잔여액인 것을 특징으로 한다. 구체적인 추출 방법에 대해서는 후술한다.The insensibility extract is a condensation of the steam generated by heating the insensitivity immersed in distilled water, and the insensitized hot water is a residual liquid remaining after extracting the insensitivity extract from the insensitivity immersed in distilled water. The specific extraction method will be described later.
본 발명에 따른 화장료 조성물 및 입욕제 조성물은 화장품학 또는 피부과학적으로 허용 가능한 매질 또는 기제를 함유하여 제형화될 수 있다. 이는 국소적용에 적합한 모든 제형으로서, 예를 들면, 용액, 겔, 고체, 반죽 무수 생성물, 수상에 유상을 분산시켜 얻은 에멀젼, 현탁액, 마이크로에멀젼, 마이크로캡슐, 미세과립구 또는 이온형(리포좀) 및 비이온형의 소낭 분산제의 형태로, 또는 크림, 스킨, 로션, 파우더, 연고, 스프레이 또는 콘실 스틱의 형태로 제공될 수 있다. 또한 포말(foam)의 형태로 또는 압축된 추진제를 더 함유한 에어로졸 조성물의 형태로도 사용될 수 있다. 이들 조성물은 당해 분야의 통상적인 방법에 따라 제조될 수 있다.The cosmetic composition and the bath composition according to the present invention may be formulated by containing a cosmetic or dermatologically acceptable medium or base. These are all formulations suitable for topical application, for example solutions, gels, solids, dough anhydrous products, emulsions, suspensions, microemulsions, microcapsules, microgranules or ionic (liposomes) and ratios obtained by dispersing an oil phase in an aqueous phase. It can be provided in the form of an ionic vesicle dispersant, or in the form of a cream, skin, lotion, powder, ointment, spray or conceal stick. It can also be used in the form of a foam or in the form of an aerosol composition further containing a compressed propellant. These compositions can be prepared according to conventional methods in the art.
화장료 조성물은 불수감 추출물 이외에 화장품 제제에 있어서 수용가능한 담체를 포함할 수 있다. 상기 담체로서는 알콜, 오일, 계면활성제, 지방산, 실리콘 오일, 방부제, 습윤제, 보습제, 점성 변형제, 유제, 안정제, 자외선 차단제, 발색제, 향료, 희석제 등이 예시될 수 있다.The cosmetic composition may include an acceptable carrier in cosmetic preparations in addition to the insoluble extract. Examples of the carrier include alcohols, oils, surfactants, fatty acids, silicone oils, preservatives, wetting agents, moisturizers, viscous modifiers, emulsions, stabilizers, sunscreens, colorants, fragrances, diluents, and the like.
상기 알코올, 오일, 계면활성제, 지방산, 실리콘 오일, 방부제, 습윤제, 보습제, 점성 변형제, 유제, 안정제, 자외선 차단제, 발색제, 향료, 희석제 등으로 사용될 수 있는 구체적인 화합물 또는 조성물은 이미 당업계에 공지되어 있기 때문에 당업자라면 적절한 해당 화합물 또는 조성물을 선택하여 사용할 수 있다.Specific compounds or compositions that can be used as the alcohol, oil, surfactant, fatty acid, silicone oil, preservative, wetting agent, moisturizer, viscous modifier, emulsion, stabilizer, sunscreen, colorant, fragrance, diluent, etc. are already known in the art As it is, those skilled in the art can select and use the appropriate compound or composition.
여기서 몇 가지를 예시하여 보면, 알콜로서는 고급 알콜, 프로필렌 글리콜, 1,3-부틸렌 글리콜, 글리세린, 소르비톨, 폴리에틸렌글리콜 등의 수용성 다가 알콜 등을 들 수 있고, 오일로서는 아보가드유, 팜유, 우지, 호호바유 등을 들 수 있고, 방부제로서는 에틸파라벤, 부틸파라벤 등을 들 수 있으며, 보습제로서는 히알론산, 황산콘드로이친(chondroitin sulfate), 피롤리돈카복실산염 등을 들 수 있으며, 희석제로서는 에탄올, 이소프로판올 등을 들 수 있다.Some examples here include alcohols such as higher alcohols, propylene glycol, 1,3-butylene glycol, glycerin, sorbitol, polyethylene glycol, and other water-soluble polyhydric alcohols. Examples of oils include avocado oil, palm oil, and tallow, Jojoba oil, and examples of the preservatives include ethyl paraben and butyl paraben. Hydrating agents include hyaluronic acid, chondroitin sulfate, pyrrolidone carboxylate, and ethanol and isopropanol as diluents. Can be heard.
더욱 구체적으로 피부용 화장품의 제형이 페이스트, 크림 또는 겔인 경우에는 담체 성분으로서 동물섬유, 식물섬유, 왁스, 파라핀, 전분, 트라칸트, 셀룰로오스 유도체, 폴리에틸렌 글리콜, 실리콘, 벤토나이트, 실리카, 탈크 또는 산화아연 등이 이용될 수 있다.More specifically, when the cosmetic formulation for skin is a paste, cream, or gel, animal fibers, plant fibers, wax, paraffin, starch, tracant, cellulose derivatives, polyethylene glycol, silicone, bentonite, silica, talc or zinc oxide, etc. are used as carrier components. This can be used.
또한 제형이 파우더 또는 스프레이인 경우에는 담체 성분으로서 락토스, 탈크, 실리카, 알루미늄 히드록시드, 칼슘 실리케이트 또는 폴리아미드 파우더가 이용될 수 있고, 특히 스프레이인 경우에는 추가적으로 클로로플루오로히드로카본, 프로판/부탄 또는 디메틸 에테르와 같은 추진체를 포함할 수 있다.In addition, when the formulation is a powder or a spray, lactose, talc, silica, aluminum hydroxide, calcium silicate or polyamide powder may be used as a carrier component. In particular, in the case of a spray, additionally chlorofluorohydrocarbon, propane/butane Or propellants such as dimethyl ether.
또한 제형이 용액 또는 유탁액의 경우에는 담체 성분으로서 용매, 용매화제 또는 유탁화제가 이용되고, 예컨대 물, 에탄올, 이소프로판올, 에틸 카보네이트, 에틸 아세테이트, 벤질 알코올, 벤질 벤조에이트, 프로필렌 글리콜, 1,3-부틸글리콜 오일, 글리세롤 지방족 에스테르, 폴리에틸렌 글리콜 또는 소르비탄의 지방산에스테르가 있다.Further, when the formulation is a solution or an emulsion, a solvent, solvating agent or emulsifying agent is used as a carrier component, such as water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, propylene glycol, 1,3 -Fatty acid esters of butyl glycol oil, glycerol aliphatic esters, polyethylene glycol or sorbitan.
또한 제형이 현탁액인 경우에는 담체 성분으로서 물, 에탄올 또는 프로필렌 글리콜과 같은 액상 희석제, 에톡실화 이소스테아릴 알코올, 폴리옥시에틸렌 소르비톨 에스테르 및 폴리옥시에틸렌 소르비탄 에스테르와 같은 현탁제, 미소결정성 셀룰로오스, 알루미늄 메타히드록시드, 벤토나이트, 아가 또는 트라칸트 등이 이용될 수 있다.Also, when the formulation is a suspension, liquid diluents such as water, ethanol or propylene glycol as carrier components, ethoxylated isostearyl alcohol, suspensions such as polyoxyethylene sorbitol esters and polyoxyethylene sorbitan esters, microcrystalline cellulose, Aluminum metahydroxide, bentonite, agar or trakant, etc. can be used.
또한 제형이 계면-활성제 함유 클린징인 경우에는 담체 성분으로서 지방족 알코올 설페이트, 지방족 알코올 에테르 설페이트, 설포숙신산 모노에스테르, 이세티오네이트, 이미다졸리늄 유도체, 메틸타우레이트, 사르코시네이트, 지방산 아미드 에테르 설페이트, 알킬아미도베타인, 지방족 알코올, 지방산 글리세리드, 지방산 디에탄올아미드, 식물성 유, 리놀린 유도체 또는 에톡실화 글리세롤 지방산 에스테르 등이 이용될 수 있다Also, when the formulation is a surfactant-containing cleansing agent, aliphatic alcohol sulfate, aliphatic alcohol ether sulfate, sulfosuccinic acid monoester, isethionate, imidazolinium derivatives, methyltaurate, sarcosinate, fatty acid amide ether sulfate as carrier components , Alkylamidobetaine, aliphatic alcohols, fatty acid glycerides, fatty acid diethanolamides, vegetable oils, linoline derivatives or ethoxylated glycerol fatty acid esters and the like can be used.
또한 본 발명에 따른 불수감 추출물을 포함하는 비누의 경우, 비누 기재에 불수감 추출물을 포함하여 제조될 수 있으며, 첨가제로서 피부 보습제, 유화제, 경수 연화제 등을 포함하여 제조될 수 있다.In addition, in the case of a soap containing the water-insoluble extract according to the present invention, it may be prepared by including the water-insoluble extract on the soap base, and may be prepared by including a skin moisturizer, emulsifier, hard water softener, etc. as an additive.
상기 비누 기재로서는 야자유, 팜유, 대두유, 파마자유, 올리브유, 팜핵류 등의 식물유지 또는 우지, 돈지, 양지, 어유 등의 동물유지 등이 사용될 수 있고, 상기 피부 보습제로서는 글리세린, 에리트리톨, 폴리에틸렌글리콜, 프로필렌글리콜, 부틸렌글리콜, 펜틸렌글리콜, 헥실글리콜, 이소프로필미리스테이트, 실리콘 유도체, 알로에베라, 솔비톨 등이 사용될 수 있으며, 상기 유화제로서는 천연오일, 왁스 지방알콜, 탄화수소류, 천연식물 추출물 등이 사용될 수 있고, 상기 경수연화제로서는 테트라소듐 이디티에이 등이 사용될 수 있다.As the soap base, plant oils such as palm oil, palm oil, soybean oil, perm oil, olive oil, and palm kernels, or animal oils such as tallow, pork, sun, and fish oil may be used. As the skin moisturizer, glycerin, erythritol, and polyethylene glycol , Propylene glycol, butylene glycol, pentylene glycol, hexyl glycol, isopropyl myristate, silicone derivatives, aloe vera, sorbitol, etc. can be used, and as the emulsifier, natural oil, wax fat alcohol, hydrocarbons, natural plant extracts, etc. This can be used, and as the water softener, tetrasodium IDT or the like can be used.
본 발명의 비누 조성물은 또한 첨가제로서 항균제, 분산제, 거품억제제, 용매, 물때 방지제, 부식 방지제, 향료, 색소, 금속이온 봉쇄제, 산화방지제, 방부제 등을 추가적으로 포함할 수 있다.The soap composition of the present invention may also additionally include antibacterial agents, dispersants, antifoaming agents, solvents, descaling agents, corrosion inhibitors, fragrances, pigments, metal ion blockers, antioxidants, preservatives and the like as additives.
본 발명에 따른 불수감 중탕수를 포함하는 입욕제의 경우, 입욕제 기재에 불수감 중탕수를 첨가하여 제조될 수 있다. In the case of a bathing agent containing insensible heavy water according to the present invention, it may be prepared by adding insoluble water to the bathing agent base material.
본 발명에 따른 항산화 효과 및 피부 미백 효과 화장료 조성물에 포함되는 불수감 추출물의 제조방법은 불수감을 세척 및 건조하는 준비단계(S10), 준비된 불수감이 잠기도록 증류수를 넣고 가열하는 가열단계(S20) 및 가열되어 발생된 증기를 냉각 응축하여 불수감 추출을 얻는 응축단계(S30)를 포함한다.Antioxidant effect and skin whitening effect according to the present invention is a method for preparing an insensitivity extract contained in a cosmetic composition, a preparation step (S10) for washing and drying the insensitivity feeling, a heating step (S20) in which distilled water is added and heated to lock the prepared insensitivity feeling, and heating And a condensation step (S30) in which condensed steam is cooled and condensed to obtain an insensibility.
본 발명에 따른 준비단계(S10)는 불수감에서 유효성분을 추출하기 전에 불수감 재료를 준비하는 단계로서, 불수감의 줄기, 뿌리, 잎, 꽃 또는 열매를 준비하고, 각각 세척, 건조 및 분쇄한다.The preparation step (S10) according to the present invention is a step of preparing an insensitivity material before extracting the active ingredient from the insensitivity, preparing the stem, root, leaf, flower or fruit of the incommunity, and washing, drying and crushing, respectively.
본 발명에 따른 가열단계(S20)는 준비된 불수감 재료에서 유효성분을 증기로 추출하는 단계로서, 준비단계(S10)에서 준비된 불수감 재료에 증류수를 불수감이 잠길 수 있도록 넣고 증류수가 끓을 때까지 가열한다. 이 때 발생한 증기는 한 곳으로 모이도록 한다. The heating step (S20) according to the present invention is a step of extracting the active ingredient from the prepared non-sensitizing material as steam, and distilled water is added to the non-sensitizing material prepared in the preparation step (S10) so that the non-sensitization is submerged and heated until the distilled water boils. The steam generated at this time should be gathered in one place.
본 발명에 따른 응축단계(S30)은 가열단계(S20)에서 발생한 증기를 응축하여 불수감 추출물을 수득하는 단계로, 가열단계(S20)에서 발생된 증기를 냉각시켜 다시 액체로 응축하여 액상의 불수감 추출물을 수득한다. 불수감 추출물에는 지용성의 불수감 오일 및 수용성의 불수감 추출수가 포함되어 있으며, 불수감 오일 및 불수감 추출수는 밀도차이에 의해 가벼운 불수감 오일 성분은 위로 무거운 불수감 추출수 성분은 아래로 분리되므로 불수감 오일과 불수감 추출수 성분의 분리가 용이하다. 응축방법은 냉각파이프 등의 다양한 공지된 방법을 사용할 수 있다. The condensation step (S30) according to the present invention is a step of condensing the steam generated in the heating step (S20) to obtain an insensibility extract, and cooling the steam generated in the heating step (S20) to condense it into a liquid again to extract the liquid insensibility. To obtain The oil-insoluble oil-insoluble oil and water-insoluble oil-insoluble extract water include the oil-insoluble oil-insoluble oil and water-insoluble oil-insoluble extract water. Easy separation of components. As the condensation method, various known methods such as a cooling pipe can be used.
본 발명에 따른 불수감 추출물 제조방법에서 가열단계(S20) 및 응축단계(S30)를 거쳐 불수감 추출물이 모두 추출된 후 가열 후 남아있는 불수감 잔여액인 불수감 중탕수는 일반적으로 버려져왔다. 그러나 불수감 중탕수에도 여전히 불수감의 기능성 성분이 남아있다. 가열단계(S20)에서 증류수를 사용했으므로 별도의 용매 교환 단계없이 불수감 중탕수를 여과 분리하여 입욕제 조성물로 사용할 수 있다. 불수감 중탕수는 이미 불수감 추출물의 추출 단계에서 가열되어 농축된 상태이므로 별도의 농축단계는 필요하지 않다.In the method of manufacturing an insensitivity extract according to the present invention, after the heating step (S20) and the condensation step (S30), all of the insensitivity extracts are extracted, and the insensitivity heavy water, which is the remaining insensitivity after heating, has been generally discarded. However, the functional component of the insensitivity still remains in the intangible hot water. Since distilled water was used in the heating step (S20), it is possible to use the bath composition as a filter by separating the water-insoluble sodium bicarbonate water without a separate solvent exchange step. Since the insoluble water is already heated and concentrated in the extraction step of the insoluble water extract, a separate concentration step is not necessary.
본 발명에 따른 불수감 추출물 및 불수감 중탕수는 추가로 발효단계(S40)을 수행할 수 있다. 발효단계(S40)는 배양단계(S41), 불수감 추출물 및 불수감 중탕수를 배양된 미생물로 발효시켜 불수감 발효추출물 및 불수감 발효중탕수를 얻는 발효단계(S42)를 포함한다. The insensibility extract and the insensibility heavy water according to the present invention may further perform a fermentation step (S40). The fermentation step (S40) includes a fermentation step (S42) in which a fermentation extract (S41), an inferior persimmon extract, and an inferior persimmon hot water are fermented with cultured microorganisms to obtain an inferior fermented extract and inferior fermented heavy water.
본 발명에 따른 배양단계(S41)는 배지에 바실러스(Bacillus) 및 복합김치유산균을 포함하는 미생물을 접종하고 종균 배양하는 단계로서 후술할 식물 추출물의 발효단계(S42)에 사용될 미생물을 배양하는 단계이다. The culturing step according to the present invention (S41) is a step of inoculating microorganisms containing Bacillus (Bacillus) and complex kimchi lactic acid bacteria in a medium and culturing spawns, and culturing microorganisms to be used in the fermentation step (S42) of the plant extract to be described later. .
더욱 구체적으로 바실러스 서브틸러스(Bacillus subtillis) 및 복합김치유산균을 가열 멸균된 배지에 접종하고 37 내지 46℃에서 15 내지 45일 동안 배양한다. 배양된 미생물을 동결 건조 후 분말화하여 후술할 발효단계(S42)에 사용할 수 있도록 한다. More specifically, Bacillus subtilus (Bacillus subtillis) and complex kimchi lactic acid bacteria were inoculated in a heat sterilized medium and cultured at 37 to 46°C for 15 to 45 days. The cultured microorganism is freeze-dried and powdered to be used in a fermentation step (S42) to be described later.
본 발명에 따른 발효단계(S42)는 불수감 추출물 및 불수감 중탕수를 배양단계(S41)에서 얻어진 배양 미생물을 이용하여 발효(pH 5.0 내지 7.5)시켜 식물의 발효추출물을 얻는 단계로서, 불수감 추출물 및 불수감 중탕수에 당류 및 탄소원을 투입하고 호기 발효시키는 1차 발효단계(S43) 및 1차 발효물에 배양 미생물을 투입하고 혐기 발효시키는 2차 발효단계(S44)를 포함한다. The fermentation step (S42) according to the present invention is a step of obtaining fermentation extracts of plants by fermenting (pH 5.0 to 7.5) fermentation extracts and non-sensitized heavy water using cultured microorganisms obtained in the culturing step (S41). It includes a primary fermentation step (S43) in which sugars and a carbon source are added to the hot water and aerobic fermentation and a secondary fermentation step (S44) in which culture microorganisms are added to the primary fermentation product and anaerobic fermentation is performed.
발효(fermentation)란 미생물이 분비하는 효소에 의해 유기물을 분해하는 과정으로서, 미생물이 에너지를 얻는 과정에서 유용한 물질을 내는 것을 포함하는 의미이다. 본 발명에 따른 발효단계(S42)에 사용되는 배양 미생물은 포도당 또는 유당과 같은 당을 분해하여 젖산이나 초산과 같은 유기산을 생성하며, 부산물로 아밀라아제, 셀룰라아제, 리파아제, 프로테아제와 같은 효소를 생성하여 상기 식물 추출물 내의 거대분자의 저분자화를 통하여 피부침투를 용이하게 해준다. 발효 과정을 통해 피부 침투가 잘 이루어지게 하면서도 피부 자극이 적은 화장료 조성물 및 입욕제 조성물을 제공할 수 있다.Fermentation is a process of decomposing organic substances by enzymes secreted by microorganisms, which means that microorganisms emit useful substances in the process of obtaining energy. The cultured microorganism used in the fermentation step (S42) according to the present invention decomposes sugars such as glucose or lactose to produce organic acids such as lactic acid or acetic acid, and generates enzymes such as amylase, cellulase, lipase, and protease as by-products. It facilitates skin penetration through the reduction of macromolecules in plant extracts. Through the fermentation process, it is possible to provide a cosmetic composition and a bath composition having little skin irritation while allowing skin to penetrate well.
본 발명에 따른 1차 발효단계(S43)는 불수감 추출물 및 불수감 중탕수에 당류 및 탄소원을 투입하고 자연 호기 발효시키는 단계로서, 더욱 구체적으로는 발효기에 멸균된 불수감 추출물 및 불수감 중탕수을 투입하고, 투입한 불수감 추출물 및 불수감 중탕수 질량 대비 당류 및 탄소원을 0.003 내지 0.7 wt% 투입한 후 17 내지 32℃ 온도에서 12 내지 36시간 자연 호기 발효시키는 단계이다. 1차 발효 이후 압력을 가하여 진공상태로 만들어 후술할 2차 발효를 진행시킬 수 있다. The first fermentation step (S43) according to the present invention is a step of injecting sugar and carbon sources into the insensibility extract and insensibility heavy water, and more specifically, injecting sterilized insensibility extract and insensibility heavy water into the fermenter It is a step of natural aerobic fermentation for 12 to 36 hours at a temperature of 17 to 32° C. after adding 0.003 to 0.7 wt% of a sugar and carbon source relative to the mass of a water-insoluble extract and water-insoluble heavy water. After the first fermentation, pressure may be applied to make the vacuum to proceed with the second fermentation, which will be described later.
본 발명에 따른 2차 발효단계(S44)는 1차 발효단계(S43)의해 발효된 1차 발효물에 상기 배양 미생물을 투입하고 혐기 발효시키는 단계로서, 더욱 구체적으로는 1차 발효물에 배양된 바실러스 서브틸러스 및 복합김치유산균을 1차 발효물 질량 대비 0.05 내지 6 wt% 투입하고, 32 내지 54℃ 온도에서 72 내지 120 시간 진공 저온 발효시켜 상기 불수감 발효추출물 및 불수감 발효중탕수를 얻는 단계이다.The second fermentation step (S44) according to the present invention is a step of injecting the culture microorganism into the first fermentation product fermented by the first fermentation step (S43) and fermenting it anaerobicly, and more specifically, it is cultured in the first fermentation product. Bacillus subtilus and complex kimchi lactobacillus is a step of obtaining 0.05 to 6 wt% based on the mass of the primary fermentation product, and vacuum-lowering fermentation at a temperature of 32 to 54°C for 72 to 120 hours to obtain the inferior fermented extract and inferior fermented hot water. .
본 발명에 따른 발효단계(S40)는 2차 발효단계(S44) 이후에 불수감 발효추출물 및 불수감 발효중탕수를 숙성시키는 숙성단계(S50)를 더 포함할 수 있다. 더욱 구체적으로 상기 숙성단계(S50)는 2차 발효단계(S40)에서 얻어진 불수감 발효추출물 및 불수감 발효중탕수에서 부유물을 여과 분리한 후 1개월 이상 숙성시키는 단계로서 숙성된 불수감 발효추출물 및 불수감 발효중탕수를 제조할 수 있다. The fermentation step (S40) according to the present invention may further include an aging step (S50) of aging the inferior fermented extract and the inferior fermented hot water after the second fermentation step (S44). More specifically, the aging step (S50) is a step of filtering and separating the suspended solids from the inferior fermented extract and the inferior fermented hot water obtained in the second fermentation step (S40) and aging for at least 1 month to mature the inferior fermented extract and inferior fermented fermented water Water can be prepared.
본 발명에 따른 항산화 효과 및 피부 미백 효과를 가진 화장료 조성물은 정제수에 여러 단계를 거쳐 제조된 불수감 추출물 및 불수감 발효추출물을 특정 비율로 혼합하는 혼합단계(S60)를 포함하여 제조할 수 있다. The cosmetic composition having an antioxidant effect and a skin whitening effect according to the present invention can be prepared by including a mixing step (S60) of mixing a water-insoluble extract and a water-insoluble fermentation extract prepared through various steps in purified water.
본 발명에 따른 화장료 조성물은 상기 불수감 추출물 및 불수감 발효추출물은 조성물 총 중량에 대하여 0.01∼90 중량%, 보다 바람직하게는 1∼50 중량%, 더욱 바람직하게는 5~20중량%의 양으로 함유한다. 이는 0.01 중량% 미만에서는 미백 효과를 기대할 수 없고, 90 중량% 초과에서는 피부 안정성 및 제형상의 문제가 있기 때문이다.The cosmetic composition according to the present invention contains the water-insoluble extract and the water-insoluble fermentation extract in an amount of 0.01 to 90% by weight, more preferably 1 to 50% by weight, and more preferably 5 to 20% by weight based on the total weight of the composition. . This is because the whitening effect cannot be expected at less than 0.01% by weight, and there is a problem in skin stability and formulation when it exceeds 90% by weight.
또한, 본 발명에 따른 항산화 효과 및 피부 미백 효과를 가진 입욕제 조성물은 정제수에 여러 단계를 거쳐 제조된 불수감 중탕수 및 불수감 발효중탕수를 특정 비율로 혼합하는 혼합단계(S60)를 포함하여 제조할 수 있다. In addition, the bath composition having an antioxidant effect and a skin whitening effect according to the present invention can be prepared by including a mixing step (S60) of mixing the water-insoluble medium water and the water-insoluble fermented medium water prepared through various steps in purified water at a specific ratio. have.
또한, 본 발명에 따른 입욕제 조성물은 상기 불수감 중탕수 및 불수감 발효중탕수를 조성물 총 중량에 대하여 0.01∼90 중량%, 보다 바람직하게는 1∼50 중량%, 더욱 바람직하게는 5~20중량%의 양으로 함유한다. 이는 0.01 중량% 미만에서는 미백 효과를 기대할 수 없고, 90 중량% 초과에서는 피부 안정성 및 제형상의 문제가 있기 때문이다.In addition, the bath composition according to the present invention is 0.01 to 90% by weight, more preferably 1 to 50% by weight, and more preferably 5 to 20% by weight of the total weight of the composition, Contains in quantity. This is because the whitening effect cannot be expected at less than 0.01% by weight, and there is a problem in skin stability and formulation when it exceeds 90% by weight.
본 발명에 따른 항산화 효과 및 피부 미백 효과를 가진 화장품은 상기 준비단계(S10), 가열단계(S20) 및 응축단계(S30)를 통해 불수감 추출물을 얻은 후, 정제수와 혼합하는 혼합단계(S60)를 통해 화장료 조성물을 얻고, 기타 화장품을 구성하는 성분과 혼합하여 원하는 제형의 화장품으로 제조하는 제형화단계(S70)를 포함하여 제조된다.Cosmetics having an antioxidant effect and skin whitening effect according to the present invention is obtained through the preparation step (S10), the heating step (S20) and the condensation step (S30), after obtaining the insoluble extract, mixing step (S60) to mix with purified water It is prepared by including a cosmetic composition step (S70) to obtain a cosmetic composition through mixing with other components constituting the cosmetic product to prepare a cosmetic of the desired formulation.
본 발명에 따른 제형화단계(S70)는 제조된 화장료 조성물 및 기타 화장품 성분을 혼합하여 에센스, 로션, 크림, 앰플 등의 화장품으로 제조하는 단계이다. 또한 상기 응축단계(S30)에서 수득된 불수감 추출물 대신 발효단계(S40)를 통해 발효된 불수감 발효추출물을 사용할 수 있다. 이때, 불수감 발효추출물은 멸균필터(0.45 내지 0.2μm)로 멸균처리한 것을 사용하여 제형화될 수 있다. The formulation step (S70) according to the present invention is a step of mixing the prepared cosmetic composition and other cosmetic ingredients to produce cosmetics such as essences, lotions, creams, and ampoules. In addition, it is possible to use the inferior fermentation extract fermented through the fermentation step (S40) instead of the insensitivity extract obtained in the condensation step (S30). At this time, the inferior fermentation extract may be formulated using a sterilized filter (0.45 to 0.2 μm).
또한, 본 발명에 따른 항산화 효과 및 피부 미백 효과를 가진 입욕제는 상기 가열단계(S10) 및 응축단계(S20)를 통해 불수감 추출물을 얻은 후 남아있는 불수감 잔여액인 불수감 중탕수를 정제수와 혼합하는 혼합단계(S60)를 통해 입욕제 조성물을 얻고, 기타 입욕제를 구성하는 성분과 혼합하여 원하는 제형의 입욕제로 제조하는 제형화단계(S70)를 포함하여 제조된다. In addition, the bathing agent having an antioxidant effect and a skin whitening effect according to the present invention is mixed with purified water, which is a residual liquid of insensitivity remaining after obtaining the insensitivity extract through the heating step (S10) and the condensation step (S20). The bath composition is obtained through the step (S60), and is prepared by including a formulation step (S70) of mixing with other components constituting the bath agent to prepare a bath formulation of a desired formulation.
본 발명에 따른 제형화단계(S70)는 상기 불수감 중탕수 대신 발효단계(S40)를 통해 발효된 불수감 발효중탕수를 사용할 수 있다. 이때, 불수감 발효중탕수는 멸균필터(0.45 내지 0.2μm)로 멸균처리한 것을 사용하여 제형화될 수 있다. In the formulation step (S70) according to the present invention, the non-sensitized fermented middle water fermented through the fermentation step (S40) may be used instead of the non-sensitized middle water. At this time, the inferior fermented middle water can be formulated using a sterilized filter (0.45 to 0.2 μm).
(1) 관능평가- 피부 타입별 주름 및 미백 개선 테스트(1) Sensory evaluation-test for improving wrinkles and whitening by skin type
본 발명에 따라 제조된 화장료 조성물을 함유하는 미백 크림을 제조하여 지성 피부, 건성 피부, 복합성 피부 별로 3개월 동안 임상테스트를 진행하였다. 상기 제조된 미백 크림 6 내지 12g을 1일 1회 얼굴, 목 및 임파선에 도포한 후 피부 개선 효과를 관찰하였다. 임상테스트는 40대 내지 70대 여성 15명, 남성 5명, 총 20명을 대상으로 진행되었다. 평가항목은 리프팅, 주름, 미백 효과로 평가하였으며, 육안 및 체감을 기준으로 아주 만족/만족/보통/미흡/아주 미흡 5단계로 평가하여 평균값을 하기 표 1에 나타내었다. A whitening cream containing the cosmetic composition prepared in accordance with the present invention was prepared to conduct a clinical test for 3 months for oily skin, dry skin, and complex skin. After applying the prepared whitening cream 6 to 12g once a day to the face, neck and lymph nodes, the skin improvement effect was observed. The clinical test was conducted on 15 women in their 40s and 70s, 5 men, and a total of 20 people. The evaluation items were evaluated by lifting, wrinkle, and whitening effects, and the average value was shown in Table 1 below by evaluating in 5 stages: very satisfactory/satisfactory/normal/insufficient/very poor based on the naked eye and bodily sensation.
(5)Very satisfied
(5)
(4)Satisfaction
(4)
(3)usually
(3)
(2)Inadequate
(2)
(1)Very poor
(One)
상기 제조된 미백 크림을 3개월 사용 후 피부 상태를 확인한 결과, 지성, 건성 및 복합성 피부 등 피부 타입에 상관없이 트러블이 전혀 나타나지 않았고, 오히려 문제성 피부가 개선되는 효과를 나타냈으며, 주름, 미백 개선 및 리프팅 효과에 대한 만족도가 우수한 효과를 나타내었다.As a result of confirming the skin condition after using the prepared whitening cream for 3 months, no trouble appeared at all regardless of skin type such as oily, dry and complex skin, and rather, it showed an effect of improving problematic skin, improving wrinkles, whitening and Satisfaction with the lifting effect showed an excellent effect.
또한, 미백 크림을 사용 시 불수감 특유의 향이 시간이 지나도 은은하게 남아있어 사용자들의 만족도가 우수하였다. In addition, when using the whitening cream, the unique scent of the incombustibility remained subdued over time, so users' satisfaction was excellent.
(2) 미백 개선 평가(2) Whitening improvement evaluation
본 발명에 따른 불수감 추출물, 불수감 중탕수 및 이들의 발효물의 미백효과를 확인하기 위하여 멜라민을 형성하는데 효소로 쓰이는 티로시나아제(Tyrosinase) 저해활성 측정 및 멜라닌 생합성 저해 활성 측정을 실시하였다.In order to confirm the whitening effect of insensibility extracts, insensitized hot water and fermentation products according to the present invention, tyrosinase inhibitory activity and melanin biosynthesis inhibitory activity, which are used as enzymes to form melamine, were measured.
불수감 추출물 1 내지 50 중량%, 5 내지 20 중량%; 불수감 중탕수 5 내지 20 중량%; 불수감 발효추출물을 5 내지 20중량%; 범위 내로 다양한 함량으로 포함하는 4개 군을 불수감 추출물, 불수감 중탕수 및 발효물을 포함하는 조성물로서 제조하였다. (실시예 1 내지 4)1 to 50% by weight, 5 to 20% by weight of insensibility extract; 5-20% by weight of insoluble water; 5 to 20% by weight of the insensitivity fermentation extract; Four groups containing various contents within a range were prepared as a composition comprising an insensitivity extract, an insensitivity heavy water, and a fermented product. (Examples 1 to 4)
불수감 추출물 5 내지 20 중량%에 겨우살이 추출물 5 내지 20 중량% 및 인동초 추출물 5 내지 20 중량% 범위의 추출물을 추가로 포함하는 조성물을 제조하였다. (실시예 5 내지 6)A composition was further prepared comprising 5-20% by weight of mistletoe extract and 5-20% by weight of mistletoe extract and 5-20% by weight of Indongcho extract. (Examples 5 to 6)
불수감 추출물, 불수감 중탕수 및 발효물 대신에 닥나무 추출물 5 내지 20중량%, 꾸지나무 추출물 5 내지 20중량% 범위 내로 포함되는 2개 군을 포함하는 조성물을 제조하였다. (비교예 1 내지 2)A composition comprising two groups included in the range of 5 to 20% by weight of mulberry extract and 5 to 20% by weight of koji tree extract instead of insensibility extract, insensitized dehydrated water and fermentation was prepared. (Comparative Examples 1 to 2)
또한, 불수감 추출물이 0.01 중량% 미만, 90 중량% 초과로 포함되는 조성물을 제조하였다. (비교예 3)In addition, a composition containing less than 0.01% by weight and more than 90% by weight of the water-insoluble extract was prepared. (Comparative Example 3)
티로시나아제 저해활성 측정은 0.175M sodium phosphate buffer(pH 6.8) 0.5mL 반응구에 10mM L-DOPA를 녹인 기질액 0.2mL 및 시료용액 0.1mL의 혼합액에 mushroom tyrosinase(110U/mL, Sigma Co, Mo, USA) 0.2mL을 첨가하여 25℃에서 2분간 반응시켜 반응액 중에 생성된 DOPA chrome을 475nm에서 측정하였다. 티록시나아제 저해활성은 하기 식 1을 이용하여 시료용액의 첨가구와 무첨가구의 흡광도를 이용하여 저해율(%)을 측정하였으며 그 결과를 표 1에 나타내었다.To measure tyrosinase inhibitory activity, mushroom tyrosinase (110 U/mL, Sigma Co, Mo) was added to a mixture of 0.2 mL of a substrate solution in which 10 mM L-DOPA was dissolved in 0.5 mL of 0.175 M sodium phosphate buffer (pH 6.8) and 0.1 mL of sample solution. , USA) 0.2 mL was added and reacted at 25° C. for 2 minutes to measure DOPA chrome generated in the reaction solution at 475 nm. The inhibitory activity of thyroxinase was measured by using the following formula 1, and the inhibition rate (%) was measured using the absorbance of the sample solution with and without additives, and the results are shown in Table 1.
[식 1][Equation 1]
저해율(%) = ( 1 - 시료첨가군의 흡광도 / 무첨가군의 흡광도 ) × 100Inhibition rate (%) = (1-absorbance of the sample-added group / absorbance of the non-added group) × 100
1Comparative example
One
2Comparative example
2
3Comparative example
3
티로시나아제 저해 활성 측정 결과 실시예 1 내지 6의 경우 1000μg/mL에서 50% 이상의 높은 저해율을 나타내었다. 불수감 추출물의 함량 범위가 5 내지 20 중량%인 실시예 2가 가장 저해 활성이 우수하였고, 불수감 추출물 및 불수감 중탕수를 발효했을 때 저해율이 향상된 것을 확인할 수 있었다.As a result of measuring tyrosinase inhibitory activity, Examples 1 to 6 exhibited a high inhibition rate of 50% or more at 1000 μg/mL. It was confirmed that Example 2, which had a content range of 5-20% by weight of the insensitivity extract, had the best inhibitory activity, and the inhibition rate was improved when the insensitivity extract and the insensitivity heavy water were fermented.
한편, 멜라민 생합성 저해 측정은 DMEM 배지로 배양된 멜라노마 세포를 100mm culture dish에 2×106 cell/dish가 되게 분주하고 24시간 배양 후 시료를 농도별로 조제하여 2mL 첨가하고, 48시간 후에 인산완충액(pH 7.4)으로 세척하였다. 그 다음 0.25M trypsin EDTA 용액으로 세포를 탈착한 후 수확한 세포를 1×106 세포 당 1mL의 5% TCA로 처리하고, 2,500rpm으로 2회 원심분리한 후 분리된 melanin을 인산완충액으로 세척한 뒤 ether:ethanol(1:3) 1mL를 가하여 2회 원심분리한 후 ether 1mL로 세척 건조시켰다. 건조된 melanin에 1N NaOH를 1mL 가하여 80℃에서 1시간 반응시킨 후 분광 광도계 405nm에서 흡광도를 측정하였다. 멜라민 생합성 저해는 상기 수학식 1을 이용하여 시료 용액의 첨가구와 무첨가구의 흡광도를 이용하여 저해율(%)을 측정하였으며 그 결과를 표 5에 나타내었다.On the other hand, in the measurement of the inhibition of melamine biosynthesis, melanoma cells cultured with DMEM medium were dispensed into 2 x 106 cells/dish in a 100 mm culture dish, and after 24 hours of incubation, samples were prepared by concentration and added to 2 mL, and after 48 hours, phosphate buffer solution ( pH 7.4). After detaching the cells with 0.25 M trypsin EDTA solution, the harvested cells were treated with 1 mL of 5% TCA per 1×106 cells, centrifuged twice at 2,500 rpm, and the separated melanin was washed with a phosphate buffer solution. 1 mL of ether:ethanol (1:3) was added and centrifuged twice, followed by washing and drying with 1 mL of ether. 1 mL of 1N NaOH was added to the dried melanin and reacted at 80° C. for 1 hour, and absorbance was measured at a spectrophotometer at 405 nm. Inhibition of melamine biosynthesis was measured by using the Equation 1 above, the inhibition rate (%) was measured using the absorbance of the sample solution with and without additives, and the results are shown in Table 5.
1Comparative example
One
2Comparative example
2
3Comparative example
3
멜라민 생합성 저해 활성 측정 결과 실시예 1 내지 6의 경우 100μg/mL에서 60% 이상의 높은 저해율을 나타내었다. 불수감 추출물의 함량 범위가 5 내지 20 중량%인 실시예 2가 가장 저해 활성이 우수하였고, 불수감 추출물 및 불수감 중탕수를 발효했을 때 저해율이 향상된 것을 확인할 수 있었다.As a result of measuring the activity of inhibiting melamine biosynthesis, Examples 1 to 6 exhibited a high inhibition rate of 60% or more at 100 μg/mL. It was confirmed that Example 2, which had a content range of 5-20% by weight of the insensitivity extract, had the best inhibitory activity, and the inhibition rate was improved when the insensitivity extract and the insensitivity heavy water were fermented.
(3) DPPH 라디칼 소거 활성 평가(3) Evaluation of DPPH radical scavenging activity
본 발명에 따른 본 발명에 따른 불수감 추출물, 불수감 중탕수 및 이들의 발효물의 항산화 활성 여부를 평가하기 위하여 DPPH(α,α-diphenyl-β-picrylhydrazyl) radical 소거 활성을 검색하는 Blois 방법을 이용하였다. The Blois method was used to detect the radical scavenging activity of DPPH (α,α-diphenyl-β-picrylhydrazyl) radicals in order to evaluate the antioxidant activity of insensibility extracts, insensibility heavy water and fermentation products according to the present invention according to the present invention.
미백개선 평가 시 사용한 시료와 동일한 시료를 사용한다. The same sample as that used for whitening improvement evaluation is used.
먼저 DPPH 2mg에 15 mL의 에탄올을 가하여 녹인 DPPH(1,1-Diphenyl-2-picrylhydrazyl) 원액을 1200 μL 취하고 DMSO 500 μL와 에탄올 3000 μL를 혼합하여 최종으로 초기 흡광도(B)를 측정하기 위한 DPPH 용액을 제조하였다. 준비된 DPPH 용액 450 μL를 석영 cuvette안에 넣고 518 nm에서 초기 흡광도(B)를 측정하였으며, 초기 흡광도가 0.97 초과인 경우 에탄올을 더 넣어 희석하여 측정하고, 0.94 미만인 경우 DPPH 원액을 더 넣어 초기 흡광도가 0.94에서 0.97 사이의 값을 갖도록 조절하였다. 메탄올에 녹인 시료 50μL를 흡광도 값이 맞춰진 DPPH 용액이 들어있는 cuvette에 넣고 518 nm에서 10초 간격으로 10분 동안 흡광도(C)를 측정하였다. 이때의 항산화 활성은 reduction %로 표기하며 하기 식 2를 통해 산출하였다.First, DPPH to measure the initial absorbance (B) by taking 1200 μL of DPPH (1,1-Diphenyl-2-picrylhydrazyl) stock solution dissolved by adding 15 mL of ethanol to 2 mg of DPPH, and mixing 500 μL of DMSO with 3000 μL of ethanol The solution was prepared. 450 μL of the prepared DPPH solution was placed in a quartz cuvette, and the initial absorbance (B) was measured at 518 nm.If the initial absorbance was greater than 0.97, dilution was performed by adding more ethanol, and if it was less than 0.94, the initial absorbance was further added by adding DPPH stock solution. It was adjusted to have a value between 0.97. 50 μL of the sample dissolved in methanol was placed in a cuvette containing a DPPH solution with an adjusted absorbance value, and absorbance (C) was measured at 518 nm for 10 minutes at 10 second intervals. The antioxidant activity at this time is expressed as reduction% and was calculated through Equation 2 below.
[식 2][Equation 2]
항산화 활성(ΔA) = B(초기 흡광도) ― C(시료를 넣은 용액의 흡광도)Antioxidant activity (ΔA) = B (initial absorbance) ― C (absorbance of solution with sample)
여기서 B는 초기 흡광도인 0.94~0.97 이며, C는 10분 동안 측정한 가장 낮은 흡광도를 의미한다. 산출된 항산화 활성 ΔA는 하기 식 3을 통해 reduction(%)로 변환하였다. 측정된 reduction(%) 값을 하기 표 4에 나타내었다.(단위 : %, 농도 : 0.1mg/ml)Here, B is the initial absorbance of 0.94~0.97, and C is the lowest absorbance measured for 10 minutes. The calculated antioxidant activity ΔA was converted to reduction (%) through Equation 3 below. The measured reduction (%) values are shown in Table 4 below (unit: %, concentration: 0.1 mg/ml).
[식 3][Equation 3]
Reduction (%) = (ΔA ÷ B) × 100Reduction (%) = (ΔA ÷ B) × 100
1Comparative example
One
2Comparative example
2
3Comparative example
3
(standard)Vitamin C
(standard)
소거 활성
(%)DPPH
Scavenging activity
(%)
본 발명의 실시예에 따른 불수감 추출물의 경우 비교예와 비교하여 높은 DPPH 라디칼 소거 활성을 나타내었으며, 불수감 추출물 및 불수감 중탕수를 발효했을 때 항산화 활성이 향상된 것을 확인할 수 있었다.In the case of the insensitivity extract according to the embodiment of the present invention, it exhibited a high DPPH radical scavenging activity compared to the comparative example, and it was confirmed that the antioxidant activity was improved when the insensitivity extract and the insensitivity hot water were fermented.
Claims (7)
상기 불수감 추출물은,
불수감을 증류수에 넣고 끓여 나온 증기를 냉각시켜 응축된 액상의 불수감 추출물을 얻는 단계;
추출된 추출물을 17~32℃ 온도에서 12~36시간 자연 호기 발효되는 1차 발효 단계; 및
32~54℃ 온도에서 72~120시간 진공 혐기 발효되는 2차 발효 단계를 통해 얻어지고,
상기 액상 추출물은 지용성의 불수감 오일 및 수용성의 불수감 추출수를 포함하는 것을 특징으로 하는 항산화 기능성 화장료 조성물.
As a cosmetic composition containing an incombustible extract as an active ingredient,
The inability to extract,
Cooling the boiled steam into distilled water to obtain a condensed liquid insoluble extract;
A primary fermentation step in which the extracted extract is naturally aerobic fermented for 12 to 36 hours at a temperature of 17 to 32°C; And
Obtained through a second fermentation step of vacuum anaerobic fermentation at a temperature of 32 to 54°C for 72 to 120 hours,
The liquid extract is an antioxidant functional cosmetic composition comprising a fat-soluble oil-insoluble oil and water-soluble water-insoluble extract.
상기 화장료 조성물은 피부미백효과 기능성을 포함하는 것을 특징으로 하는 화장료 조성물.
According to claim 1,
The cosmetic composition is a cosmetic composition characterized in that it comprises a skin whitening effect functionality.
상기 화장료 조성물을 불수감 추출물 외에 겨우살이 추출물 및 인동초 추출물에서 선택되는 1종 이상을 더 포함할 수 있는 것을 특징으로 하는 화장료 조성물.According to claim 1,
The cosmetic composition may further include at least one selected from mistletoe extract and Indongcho extract, in addition to the insensibility extract.
상기 화장료 조성물은 향수, 방향제, 비누, 클렌저로 구성된 군으로부터 선택된 제품에 적용하는 것을 특징으로 하는 화장료 조성물.
According to claim 1,
The cosmetic composition is a cosmetic composition, characterized in that applied to a product selected from the group consisting of perfume, fragrance, soap, cleanser.
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| KR101192417B1 (en) * | 2010-08-26 | 2012-10-17 | 김희구 | Antioxidative composition and apparatus for removing reactive oxygen using the same |
| KR20120090339A (en) | 2011-02-07 | 2012-08-17 | 한국식품연구원 | Method for extraction of active ingredient having anti oxidation in ginger |
| KR20170105910A (en) | 2016-03-11 | 2017-09-20 | 호서대학교 산학협력단 | Skin whitening composition comprising extracts of Galla Rhois and use thereof |
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| JP2010106000A (en) * | 2008-10-31 | 2010-05-13 | Kyoei Kagaku Kogyo Kk | Method for producing plant extract and cosmetic |
| CN103622866A (en) * | 2013-06-30 | 2014-03-12 | 金玛瑙香水（明光）有限公司 | Perfume capable of whitening and preparation method thereof |
| CN106267142A (en) * | 2016-08-31 | 2017-01-04 | 安徽新盛中药饮片有限公司 | A kind of appetizing skin care heat clearing away micro-ferment Fructus Citri Sarcodactylis decoction pieces and preparation method thereof |
| KR101884795B1 (en) * | 2018-06-25 | 2018-08-02 | 강원대학교산학협력단 | Cosmetic composition for anti-oxidation or whitening comprising solvent fraction of mistletoe extract and active material isolated therefrom |
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