KR102116737B1 - 속효형 벤조디아제핀을 포함하는 조성물 - Google Patents

속효형 벤조디아제핀을 포함하는 조성물 Download PDF

Info

Publication number
KR102116737B1
KR102116737B1 KR1020147036021A KR20147036021A KR102116737B1 KR 102116737 B1 KR102116737 B1 KR 102116737B1 KR 1020147036021 A KR1020147036021 A KR 1020147036021A KR 20147036021 A KR20147036021 A KR 20147036021A KR 102116737 B1 KR102116737 B1 KR 102116737B1
Authority
KR
South Korea
Prior art keywords
composition
delete delete
lyophilized
formulation
dextran
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
KR1020147036021A
Other languages
English (en)
Korean (ko)
Other versions
KR20150009601A (ko
Inventor
존 에이트킨 그레이엄
알란 제임스 바일리
케빈 리차드 와드
토마스 피코크
Original Assignee
파이온 유케이 리미티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48669863&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=KR102116737(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by 파이온 유케이 리미티드 filed Critical 파이온 유케이 리미티드
Publication of KR20150009601A publication Critical patent/KR20150009601A/ko
Application granted granted Critical
Publication of KR102116737B1 publication Critical patent/KR102116737B1/ko
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A61K31/5517—1,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/40—Cyclodextrins; Derivatives thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
KR1020147036021A 2012-05-22 2013-05-22 속효형 벤조디아제핀을 포함하는 조성물 Active KR102116737B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP12168968 2012-05-22
EP12168968.1 2012-05-22
PCT/EP2013/060543 WO2013174883A1 (en) 2012-05-22 2013-05-22 Compositions comprising short-acting benzodiazepines

Publications (2)

Publication Number Publication Date
KR20150009601A KR20150009601A (ko) 2015-01-26
KR102116737B1 true KR102116737B1 (ko) 2020-05-29

Family

ID=48669863

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020147036021A Active KR102116737B1 (ko) 2012-05-22 2013-05-22 속효형 벤조디아제핀을 포함하는 조성물

Country Status (41)

Country Link
US (2) US20150148338A1 (enrdf_load_stackoverflow)
EP (1) EP2852389B1 (enrdf_load_stackoverflow)
JP (1) JP6313286B2 (enrdf_load_stackoverflow)
KR (1) KR102116737B1 (enrdf_load_stackoverflow)
CN (2) CN104968348B (enrdf_load_stackoverflow)
AP (1) AP2014008084A0 (enrdf_load_stackoverflow)
AR (1) AR092008A1 (enrdf_load_stackoverflow)
AU (1) AU2013265295B2 (enrdf_load_stackoverflow)
BR (1) BR112014029108B1 (enrdf_load_stackoverflow)
CA (1) CA2874247C (enrdf_load_stackoverflow)
CL (1) CL2014003171A1 (enrdf_load_stackoverflow)
CO (1) CO7151503A2 (enrdf_load_stackoverflow)
DK (1) DK2852389T3 (enrdf_load_stackoverflow)
EA (1) EA032119B1 (enrdf_load_stackoverflow)
EC (1) ECSP14032553A (enrdf_load_stackoverflow)
ES (1) ES2651389T3 (enrdf_load_stackoverflow)
FR (1) FR21C1043I2 (enrdf_load_stackoverflow)
GE (1) GEP20186852B (enrdf_load_stackoverflow)
HR (1) HRP20171872T1 (enrdf_load_stackoverflow)
HU (2) HUE037734T2 (enrdf_load_stackoverflow)
IL (1) IL235789B (enrdf_load_stackoverflow)
LT (2) LT2852389T (enrdf_load_stackoverflow)
LU (1) LUC00230I2 (enrdf_load_stackoverflow)
MA (1) MA37581B1 (enrdf_load_stackoverflow)
MX (1) MX368854B (enrdf_load_stackoverflow)
MY (1) MY185117A (enrdf_load_stackoverflow)
NL (1) NL301130I2 (enrdf_load_stackoverflow)
NO (2) NO2852389T3 (enrdf_load_stackoverflow)
NZ (1) NZ702063A (enrdf_load_stackoverflow)
PE (1) PE20150683A1 (enrdf_load_stackoverflow)
PH (1) PH12014502608B1 (enrdf_load_stackoverflow)
PL (1) PL2852389T4 (enrdf_load_stackoverflow)
PT (1) PT2852389T (enrdf_load_stackoverflow)
RS (1) RS56660B1 (enrdf_load_stackoverflow)
SG (1) SG11201407710VA (enrdf_load_stackoverflow)
SI (1) SI2852389T1 (enrdf_load_stackoverflow)
TN (1) TN2014000479A1 (enrdf_load_stackoverflow)
TW (1) TWI590826B (enrdf_load_stackoverflow)
UA (1) UA115063C2 (enrdf_load_stackoverflow)
WO (1) WO2013174883A1 (enrdf_load_stackoverflow)
ZA (1) ZA201408412B (enrdf_load_stackoverflow)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2009000404A (es) 2006-07-10 2009-06-26 Paion Uk Ltd Sales de benzodiazepina de accion corta y sus formas polimorficas.
EP2305647A1 (en) 2009-09-18 2011-04-06 PAION UK Limited Process for preparing 3-[(4S)-8-bromo-1-methyl-6-(2-pyridinyl)-4 H-imidazo[1,2-a][1,4]benzodiazepine-4-yl] propionic acid methyl ester or the benzene sulfonate salt thereof, and compounds useful in that process
EP2450039A1 (en) 2010-11-08 2012-05-09 PAION UK Ltd. Dosing regimen for sedation with CNS 7056 (Remimazolam)
AR094963A1 (es) 2013-03-04 2015-09-09 Ono Pharmaceutical Co Reacción de oxidación excelente en el índice de conversión
WO2015076340A1 (ja) * 2013-11-21 2015-05-28 小野薬品工業株式会社 全身麻酔および／または鎮静のための注射用組成物
US10721875B2 (en) 2014-02-10 2020-07-28 Biolumic Limited Controlling characteristics of photosynthetic organisims
EP3116296B1 (en) 2014-03-14 2020-05-06 Biolumic Limited Method to improve crop yield and/or stress resistance
DK3162804T3 (da) * 2014-07-23 2020-01-13 Jiangsu Nhwaluokang Pharmaceutical Res And Development Co Ltd Nyt benzodiazepinderivat og anvendelse deraf
CN107105625A (zh) 2014-09-17 2017-08-29 拜欧卢米克有限公司 种子处理的方法及所得产物
CN105726495B (zh) * 2014-12-12 2019-03-29 宜昌人福药业有限责任公司 一种注射用短效苯并二氮杂卓盐药物组合物及其制备方法
CN107198691A (zh) * 2016-03-17 2017-09-26 江苏恒瑞医药股份有限公司 一种瑞马唑仑的药物组合物
ES3027652T3 (en) * 2016-04-14 2025-06-16 Paion Uk Ltd Orally inhaled and nasal benzodiazepines
WO2017198224A1 (zh) * 2016-05-20 2017-11-23 江苏恒瑞医药股份有限公司 一种瑞马唑仑的药物组合物
BR112019003577A2 (pt) 2016-08-22 2019-05-21 Biolumic Ltd métodos de tratamento da semente e produtos resultantes
CN108503644B (zh) * 2016-12-09 2019-06-14 成都倍特药业有限公司 一种苯并二氮杂*衍生物的氢溴酸盐及其制备方法和用途
WO2019002946A1 (en) 2017-06-29 2019-01-03 Biolumic Limited METHOD OF ENHANCING YIELD AND / OR CULTURE QUALITY
EP3714884A1 (en) 2019-03-27 2020-09-30 Paion UK Limited Medical uses for benzodiazepines with a particular eeg pattern
CN112209932B (zh) * 2019-07-12 2023-03-24 成都倍特药业股份有限公司 一种化合物氢溴酸盐的新固体形态及其制备方法和用途
ES2803099B2 (es) 2019-07-22 2021-11-08 Moehs Iberica Sl Procedimiento de obtención de besilato de remimazolam amorfo
CN114478535B (zh) * 2020-10-23 2024-02-09 成都苑东生物制药股份有限公司 一种苯磺酸瑞马唑仑ii晶型的制备方法
CN112462015B (zh) * 2020-11-18 2022-07-12 海南倍特药业有限公司 一种氢溴酸瑞马唑仑细菌内毒素的检测方法
CN114624351B (zh) * 2020-12-14 2024-04-09 宜昌人福药业有限责任公司 苯磺酸瑞马唑仑原料药中(r)-(-)-1-氨基-2-丙醇残留的分析方法
WO2024126745A1 (en) * 2022-12-16 2024-06-20 Lts Lohmann Therapie-Systeme Ag Oromucosal delivery system containing remimazolam
CN119101054A (zh) * 2023-06-09 2024-12-10 成都麻沸散医药科技有限公司 一种氮杂䓬类化合物及其组合物和应用
WO2025052259A1 (en) 2023-09-05 2025-03-13 Reena Patel Ready to use compositions of remimazolam

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3520877A (en) 1967-10-02 1970-07-21 Hoffmann La Roche 3-carbonyl amino acetic acid ethyl ester substituted benzodiazepines
WO2011054845A1 (en) 2009-11-05 2011-05-12 Glaxosmithkline Llc Benzodiazepine bromodomain inhibitor

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2143246C (en) 1994-03-16 2000-08-22 Thierry Godel Imidazodiazepines
DE59607274D1 (de) 1995-01-06 2001-08-16 Hoffmann La Roche Hydroxymethyl-imidazodiazepine und deren ester
AU4382896A (en) 1995-02-02 1996-08-21 F. Hoffmann-La Roche Ag Acetylimidazobenzodiazepines
JPH0971533A (ja) * 1995-06-30 1997-03-18 Takeda Chem Ind Ltd 凍結乾燥製剤
GB9911152D0 (en) 1999-05-14 1999-07-14 Glaxo Group Ltd Short-acting benzodiazepines
US7160880B1 (en) * 1999-05-14 2007-01-09 Cenes Limited Short-acting benzodiazepines
TWI233805B (en) * 1999-07-01 2005-06-11 Fujisawa Pharmaceutical Co Stabilized pharmaceutical composition in lyophilized form as antifungal agent
EP1161949A1 (en) * 2000-06-09 2001-12-12 Warner-Lambert Company Use od diazepinoindoles for the treatment of chronic obstructive pulmonary disease
EP2332524A1 (en) * 2005-02-15 2011-06-15 Elan Pharma International Limited Aerosol and injectable formulations of nanoparticulate benzodiazepine
GB0613693D0 (en) * 2006-07-10 2006-08-16 Cenes Ltd Benzodiazepine salts (3)
MX2009000404A (es) * 2006-07-10 2009-06-26 Paion Uk Ltd Sales de benzodiazepina de accion corta y sus formas polimorficas.
GB0613692D0 (en) * 2006-07-10 2006-08-16 Cenes Ltd Benzodiazepine salts
CN101352422B (zh) * 2008-09-17 2011-04-20 厦门朝阳生物工程有限公司 河豚毒素冻干粉针制剂及其制备方法
EP2450039A1 (en) * 2010-11-08 2012-05-09 PAION UK Ltd. Dosing regimen for sedation with CNS 7056 (Remimazolam)
CN102964349A (zh) 2011-08-31 2013-03-13 江苏恒瑞医药股份有限公司 苯并二氮杂*衍生物的托西酸盐及其多晶型、它们的制备方法和用途

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3520877A (en) 1967-10-02 1970-07-21 Hoffmann La Roche 3-carbonyl amino acetic acid ethyl ester substituted benzodiazepines
WO2011054845A1 (en) 2009-11-05 2011-05-12 Glaxosmithkline Llc Benzodiazepine bromodomain inhibitor

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Gregory J. Pacofsky et al., Bioorganic & Medicinal Chemistry Letters, 2002, vol. 12, no. 21. pp. 3219-3222.

Also Published As

Publication number Publication date
EP2852389A1 (en) 2015-04-01
EA032119B1 (ru) 2019-04-30
TWI590826B (zh) 2017-07-11
NL301130I1 (enrdf_load_stackoverflow) 2021-09-22
HUE037734T2 (hu) 2018-09-28
PT2852389T (pt) 2017-12-13
LUC00230I2 (enrdf_load_stackoverflow) 2022-10-07
IL235789B (en) 2019-07-31
IL235789A0 (en) 2015-01-29
JP6313286B2 (ja) 2018-04-18
PL2852389T4 (pl) 2022-02-21
EP2852389B1 (en) 2017-10-18
TW201400119A (zh) 2014-01-01
AP2014008084A0 (en) 2014-11-30
NO2021041I1 (no) 2021-09-20
HUS2100040I1 (hu) 2021-10-28
HK1208164A1 (en) 2016-02-26
MY185117A (en) 2021-04-30
CA2874247C (en) 2020-07-28
EA201492160A1 (ru) 2015-10-30
US20220040198A1 (en) 2022-02-10
ZA201408412B (en) 2016-09-28
CO7151503A2 (es) 2014-12-29
MA20150233A1 (fr) 2015-07-31
BR112014029108A2 (pt) 2017-06-27
CN104968348B (zh) 2018-04-17
CL2014003171A1 (es) 2015-06-19
TN2014000479A1 (en) 2016-03-30
MA37581B1 (fr) 2016-07-29
HRP20171872T1 (hr) 2018-02-23
SI2852389T1 (en) 2018-02-28
MX2014014225A (es) 2015-06-17
BR112014029108B1 (pt) 2022-02-08
WO2013174883A1 (en) 2013-11-28
RS56660B1 (sr) 2018-03-30
MX368854B (es) 2019-10-18
AR092008A1 (es) 2015-03-18
PL2852389T3 (pl) 2018-02-28
CA2874247A1 (en) 2013-11-28
ES2651389T3 (es) 2018-01-26
GEP20186852B (en) 2018-05-25
UA115063C2 (uk) 2017-09-11
ECSP14032553A (es) 2018-11-30
LTPA2021521I1 (enrdf_load_stackoverflow) 2021-10-11
CN104968348A (zh) 2015-10-07
NO2852389T3 (enrdf_load_stackoverflow) 2018-03-17
PH12014502608B1 (en) 2019-11-27
NZ702063A (en) 2016-11-25
KR20150009601A (ko) 2015-01-26
NL301130I2 (nl) 2021-10-25
AU2013265295B2 (en) 2017-08-31
LT2852389T (lt) 2017-12-27
DK2852389T3 (en) 2017-12-18
SG11201407710VA (en) 2015-01-29
AU2013265295A1 (en) 2015-01-22
JP2015517552A (ja) 2015-06-22
FR21C1043I1 (enrdf_load_stackoverflow) 2021-11-19
CN108578413A (zh) 2018-09-28
PE20150683A1 (es) 2015-06-03
PH12014502608A1 (en) 2015-01-21
FR21C1043I2 (fr) 2022-10-07
US20150148338A1 (en) 2015-05-28

Similar Documents

Publication Publication Date Title
KR102116737B1 (ko) 속효형 벤조디아제핀을 포함하는 조성물
TW200944508A (en) Novel solid forms of bendamustine hydrochloride
JP5380549B2 (ja) ボリコナゾール含有の薬物製剤及びその調製方法
EP2870163B1 (en) Pharmaceutical compositions comprising rifaximin and amino acids, preparation method and use thereof
BRPI0715113A2 (pt) formulaÇço de caspofungina
BR112012009660B1 (pt) lipossoma tendo fase de água interna contendo sal de ciclodextrina de éter sulfobutílico, seu processo de preparação, seu uso e preparação farmacêutica lipossômica
US10583087B2 (en) Pharmaceutical composition for oral administration
TWI696469B (zh) 調配物
CA2894935A1 (en) Novel crystalline forms of ceftaroline fosamil
US20120021054A1 (en) Tablet formulation of ezatiostat
US9308174B2 (en) Lyophilized formulations of bendamustine hydrochloride
US20160136148A1 (en) Solid dispersions of amorphous paroxetine mesylate
HK1208164B (en) Compositions comprising short-acting benzodiazepines
CN103012421B (zh) 异喹啉类药物及其制备和用途
OA20108A (en) Compositions Comprising Short-Acting Benzodiazepines.
CN111100122A (zh) 左旋四氢帕马丁新化合物
EP3856151B1 (en) Lyophilisate of treosulfan
Couto Association of capsaicin with local anesthetics to increase analgesia
HK1228392A1 (en) Crystalline forms of rifaximin and their preparation in the presence of amino acids
CN105272913A (zh) 异喹啉类化合物及其组合物和用途

Legal Events

Date Code Title Description
PA0105 International application

Patent event date: 20141222

Patent event code: PA01051R01D

Comment text: International Patent Application

PG1501 Laying open of application
A201 Request for examination
PA0201 Request for examination

Patent event code: PA02012R01D

Patent event date: 20180518

Comment text: Request for Examination of Application

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

Comment text: Notification of reason for refusal

Patent event date: 20190909

Patent event code: PE09021S01D

E701 Decision to grant or registration of patent right
PE0701 Decision of registration

Patent event code: PE07011S01D

Comment text: Decision to Grant Registration

Patent event date: 20200226

GRNT Written decision to grant
PR0701 Registration of establishment

Comment text: Registration of Establishment

Patent event date: 20200525

Patent event code: PR07011E01D

PR1002 Payment of registration fee

Payment date: 20200525

End annual number: 3

Start annual number: 1

PG1601 Publication of registration
A101 Application to extend term of patent right by permit
PA0101 Application to register extension of term of patent right by permit, etc.

Patent event date: 20210407

Patent event code: PA01011R01D

Comment text: Application to Register Extension of Term of Patent Right by Permit, etc.

PR1001 Payment of annual fee

Payment date: 20230518

Start annual number: 4

End annual number: 4

PR1001 Payment of annual fee

Payment date: 20240513

Start annual number: 5

End annual number: 5

PR1001 Payment of annual fee

Payment date: 20250513

Start annual number: 6

End annual number: 6