KR102106310B1 - 벤질벤젠 소듐­의존성 글루코스 공동수송체 2 （ｓｇｌｔ2） 억제제의 제조 방법 - Google Patents

벤질벤젠 소듐­의존성 글루코스 공동수송체 2 （ｓｇｌｔ2） 억제제의 제조 방법 Download PDF

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KR102106310B1
KR102106310B1 KR1020147031540A KR20147031540A KR102106310B1 KR 102106310 B1 KR102106310 B1 KR 102106310B1 KR 1020147031540 A KR1020147031540 A KR 1020147031540A KR 20147031540 A KR20147031540 A KR 20147031540A KR 102106310 B1 KR102106310 B1 KR 102106310B1
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compound
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mixture
alkoxy
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KR20150001811A (ko
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바이후아 수
빈후아 엘브이
게 수
브라이언 시드
자크스 로베지
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테라코스 서브, 엘엘씨
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    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
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    • C07C37/16—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by reactions increasing the number of carbon atoms by condensation involving hydroxy groups of phenols or alcohols or the ether or mineral ester group derived therefrom
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
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    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/01—Preparation of ethers
    • C07C41/18—Preparation of ethers by reactions not forming ether-oxygen bonds
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    • C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
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    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07C39/15—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic with no unsaturation outside the aromatic rings with all hydroxy groups on non-condensed rings, e.g. phenylphenol
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    • Y02P20/00—Technologies relating to chemical industry
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    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Diabetes (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrane Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
KR1020147031540A 2012-04-10 2013-03-14 벤질벤젠 소듐­의존성 글루코스 공동수송체 2 （ｓｇｌｔ2） 억제제의 제조 방법 Expired - Fee Related KR102106310B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
PCT/CN2012/073697 WO2013152476A1 (en) 2012-04-10 2012-04-10 Process for the preparation of benzylbenzene sglt2 inhibitors
CNPCT/CN2012/073697 2012-04-10
PCT/CN2013/072642 WO2013152654A1 (en) 2012-04-10 2013-03-14 Process for preparation of benzylbenzene sodium-dependent glucose cotransporter 2 (sglt2) inhibitors

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Publication Number Publication Date
KR20150001811A KR20150001811A (ko) 2015-01-06
KR102106310B1 true KR102106310B1 (ko) 2020-05-04

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US (2) US9193751B2 (https=)
EP (1) EP2836500A4 (https=)
JP (1) JP6208745B2 (https=)
KR (1) KR102106310B1 (https=)
AR (1) AR090618A1 (https=)
AU (1) AU2013247304B2 (https=)
BR (1) BR112014025105B1 (https=)
CA (1) CA2867057C (https=)
HK (1) HK1207084A1 (https=)
IL (1) IL234800B (https=)
MX (1) MX353307B (https=)
NZ (1) NZ630408A (https=)
RU (1) RU2625795C2 (https=)
SG (1) SG11201406434PA (https=)
TW (1) TWI597289B (https=)
WO (2) WO2013152476A1 (https=)
ZA (1) ZA201406899B (https=)

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CN105611920B (zh) 2013-10-12 2021-07-16 泰拉科斯萨普有限责任公司 羟基-二苯甲烷衍生物的制备
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CN104529970A (zh) * 2015-01-08 2015-04-22 江苏联环药业股份有限公司 制备达格列净的方法
CN104478671B (zh) * 2015-01-15 2016-03-09 佛山市赛维斯医药科技有限公司 一类双烷氧苯基丙二醇衍生物和用途
CN104478674B (zh) * 2015-01-15 2016-03-09 佛山市赛维斯医药科技有限公司 一类烷氧苯基丙二醇衍生物和用途
CN104478675B (zh) * 2015-01-15 2016-01-06 佛山市赛维斯医药科技有限公司 一类含烷氧苯基和三氟甲苯基丙二醇结构的衍生物和用途
EP3256482B1 (en) 2015-02-09 2019-11-27 Indoco Remedies Limited Process for the preparation of sglt inhibitor compounds
CZ2015729A3 (cs) * 2015-10-13 2017-04-26 Zentiva, K.S. Příprava intermediátů pro syntézu Canagliflozinu a Dapagliflozinu
KR101770302B1 (ko) * 2016-06-28 2017-08-22 주식회사 녹십자 다이페닐메탄 유도체의 제조방법
CN107641139A (zh) * 2016-07-22 2018-01-30 江苏豪森药业集团有限公司 达格列净中间体的晶型及其制备方法
WO2018142422A1 (en) * 2017-02-02 2018-08-09 Indoco Remedies Limited Process for the preparation of dapagliflozin
US11312740B2 (en) 2017-05-09 2022-04-26 Piramal Pharma Limited Process for the preparation of SGLT2 inhibitors and intermediates thereof
EP3784231A4 (en) * 2018-04-25 2022-05-11 Theracos Sub, LLC Methods of treating hypertension
MX2022012955A (es) 2020-04-14 2023-02-23 Flagship Pioneering Innovations Vi Llc Composiciones de trem y usos de las mismas.
WO2022073151A1 (en) 2020-10-05 2022-04-14 Theracos Sub, Llc Pharmaceutical formulations
CN114570303A (zh) * 2022-03-02 2022-06-03 南京市计量监督检测院 微通道反应器及基于反应器制备达格列净中间体的方法
WO2025056984A1 (en) * 2023-09-12 2025-03-20 Vijayasri Organics Private Limited A novel process for the preparation of bexagliflozin a sglt2 inhibitor and its intermediates thereof

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