KR102098849B1 - 재조합 미생물 및 이의 용도 - Google Patents

재조합 미생물 및 이의 용도 Download PDF

Info

Publication number
KR102098849B1
KR102098849B1 KR1020147036589A KR20147036589A KR102098849B1 KR 102098849 B1 KR102098849 B1 KR 102098849B1 KR 1020147036589 A KR1020147036589 A KR 1020147036589A KR 20147036589 A KR20147036589 A KR 20147036589A KR 102098849 B1 KR102098849 B1 KR 102098849B1
Authority
KR
South Korea
Prior art keywords
clostridium
ile
lys
bacteria
glu
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
KR1020147036589A
Other languages
English (en)
Korean (ko)
Other versions
KR20150021081A (ko
Inventor
웬디 첸
마이클 퀩케
마이클 ?케
Original Assignee
란자테크 뉴질랜드 리미티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 란자테크 뉴질랜드 리미티드 filed Critical 란자테크 뉴질랜드 리미티드
Publication of KR20150021081A publication Critical patent/KR20150021081A/ko
Application granted granted Critical
Publication of KR102098849B1 publication Critical patent/KR102098849B1/ko
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/52—Propionic acid; Butyric acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/42—Hydroxy-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0008—Oxidoreductases (1.) acting on the aldehyde or oxo group of donors (1.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93—Ligases (6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y102/00—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2)
    • C12Y102/01—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2) with NAD+ or NADP+ as acceptor (1.2.1)
    • C12Y102/01075—Malonyl CoA reductase (malonate semialdehyde-forming)(1.2.1.75)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y604/00—Ligases forming carbon-carbon bonds (6.4)
    • C12Y604/01—Ligases forming carbon-carbon bonds (6.4.1)
    • C12Y604/01002—Acetyl-CoA carboxylase (6.4.1.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/145—Clostridium
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
    • Y02E50/00—Technologies for the production of fuel of non-fossil origin
    • Y02E50/10—Biofuels, e.g. bio-diesel

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
KR1020147036589A 2012-05-30 2013-05-30 재조합 미생물 및 이의 용도 Expired - Fee Related KR102098849B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261653348P 2012-05-30 2012-05-30
US61/653,348 2012-05-30
PCT/NZ2013/000092 WO2013180581A1 (en) 2012-05-30 2013-05-30 Recombinant microorganisms and uses therefor

Publications (2)

Publication Number Publication Date
KR20150021081A KR20150021081A (ko) 2015-02-27
KR102098849B1 true KR102098849B1 (ko) 2020-04-09

Family

ID=49670706

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020147036589A Expired - Fee Related KR102098849B1 (ko) 2012-05-30 2013-05-30 재조합 미생물 및 이의 용도

Country Status (8)

Country Link
US (1) US9994878B2 (https=)
EP (1) EP2855690B1 (https=)
JP (1) JP6445970B2 (https=)
KR (1) KR102098849B1 (https=)
CN (2) CN113832199A (https=)
CA (1) CA2874832C (https=)
IN (1) IN2014DN10168A (https=)
WO (1) WO2013180581A1 (https=)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20130323820A1 (en) 2012-06-01 2013-12-05 Lanzatech New Zealand Limited Recombinant microorganisms and uses therefor
CA2936251C (en) 2014-01-28 2017-11-07 Lanzatech New Zealand Limited Method of producing a recombinant microorganism
FI3209786T3 (fi) 2014-10-22 2023-06-13 Lanzatech Nz Inc Monivaiheisia bioreaktoriprosesseja
US10113194B2 (en) 2014-10-22 2018-10-30 Lanzatech New Zealand Limited Gas testing unit and method
WO2016138050A1 (en) 2015-02-23 2016-09-01 Lanzatech New Zealand Limited Recombinant acetogenic bacterium for the conversion of methane to products
CN104789516B (zh) * 2015-04-22 2017-12-22 天津大学 一种产三羟基丙酸的集胞藻6803基因工程菌及构建方法及应用
DE102016212497B4 (de) * 2015-07-13 2024-04-25 Sk Innovation Co., Ltd. Mutanter Mikroorganismus, der ein Gen umfasst, das Methylmalonyl-CoA-Reductase codiert, und seine Verwendung
CA3151149C (en) 2015-10-13 2024-03-26 Lanzatech Nz, Inc. Genetically engineered bacterium comprising energy-generating fermentation pathway
CN108431208A (zh) 2015-12-03 2018-08-21 朗泽科技新西兰有限公司 增补精氨酸以改善气体发酵产乙酸菌的效率
US10358661B2 (en) 2015-12-28 2019-07-23 Lanzatech New Zealand Limited Microorganism with modified hydrogenase activity
GB201601558D0 (en) 2016-01-28 2016-03-16 Verdant Bioproducts Ltd Method for producing 3-hydroxypropionamide
PT3411489T (pt) 2016-02-01 2023-08-07 Lanzatech Nz Inc Processo de fermentação e eletrólise integrado
EP3420089B1 (en) 2016-02-26 2021-12-29 LanzaTech NZ, Inc. Crispr/cas systems for c-1 fixing bacteria
WO2017200884A1 (en) 2016-05-14 2017-11-23 Lanzatech, Inc. Microorganism with modified aldehyde:ferredoxin oxidoreductase activity and related methods
JPWO2018070141A1 (ja) * 2016-10-13 2019-08-08 積水化学工業株式会社 偏性嫌気性酢酸生成微生物、並びに、組換え微生物
CN111051517B (zh) 2017-09-08 2023-10-27 朗泽科技有限公司 用于使用富氢气的含有c1的底物生产代谢物的方法和系统
US11555209B2 (en) 2017-12-19 2023-01-17 Lanzatech, Inc. Microorganisms and methods for the biological production of ethylene glycol
CN111683731B (zh) 2018-02-12 2022-09-02 朗泽科技有限公司 用于提高碳转化效率的工艺
US11053517B2 (en) 2018-04-20 2021-07-06 Lanzatech, Inc. Intermittent electrolysis streams
CN109112156A (zh) * 2018-09-19 2019-01-01 江苏师范大学 一种生产3-羟基丙酸的重组假单胞菌、其构建方法及其应用
CN112955558A (zh) 2018-11-19 2021-06-11 朗泽科技有限公司 发酵和气化的集成
CN112969795A (zh) 2019-02-08 2021-06-15 朗泽科技有限公司 用于回收沸点接近的产物的方法
WO2020188033A1 (en) 2019-03-20 2020-09-24 Global Bioenergies Improved means and methods for producing isobutene from acetyl-coa
WO2021006995A1 (en) 2019-07-11 2021-01-14 Lanzatech, Inc. Methods for optimizing gas utilization
US11932818B2 (en) 2020-03-16 2024-03-19 Lanzatech, Inc. Tail gas of gas fermentation to dry gasification feedstock
JP2023518045A (ja) 2020-03-18 2023-04-27 ランザテク，インコーポレイテッド ガス基質からの２－フェニルエタノールの発酵産生
KR20220159450A (ko) * 2020-04-29 2022-12-02 란자테크, 인크. 가스성 기질로부터의 β-케토아디페이트의 발효 제조
US11760989B2 (en) 2020-06-06 2023-09-19 Lanzatech, Inc. Microorganism with knock-in at acetolactate decarboxylase gene locus
US11788092B2 (en) * 2021-02-08 2023-10-17 Lanzatech, Inc. Recombinant microorganisms and uses therefor
JP2024513395A (ja) 2021-04-09 2024-03-25 ランザテク，インコーポレイテッド 供給原料を提供するためのプロセス及び装置
US12241105B2 (en) 2021-07-20 2025-03-04 Lanzatech, Inc. Recombinant microorganisms and uses therefor
TW202307202A (zh) 2021-08-06 2023-02-16 美商朗澤科技有限公司 用於改良乙二醇之生物產生的微生物及方法
US12091648B2 (en) 2021-11-03 2024-09-17 Lanzatech, Inc. System and method for generating bubbles in a vessel
US12280331B2 (en) 2022-04-29 2025-04-22 Lanzatech, Inc. Low residence time gas separator
US12077800B2 (en) 2022-06-16 2024-09-03 Lanzatech, Inc. Liquid distributor system and process of liquid distribution
AU2023286621A1 (en) 2022-06-21 2025-01-09 Lanzatech, Inc. Microorganisms and methods for the continuous co-production of tandem repeat proteins and chemical products from c1-substrates
CN119403929A (zh) 2022-06-21 2025-02-07 朗泽科技有限公司 用于由c1底物连续共产生高价值专用蛋白和化学产物的微生物和方法
US12129503B2 (en) 2022-08-10 2024-10-29 Lanzatech, Inc. Carbon sequestration in soils with production of chemical products
WO2024253882A1 (en) 2023-06-05 2024-12-12 Lanzatech, Inc. Integrated gas fermentation
US12359224B2 (en) 2023-06-05 2025-07-15 Lanzatech, Inc. Integrated gas fermentation and carbon black processes
CN121065057B (zh) * 2025-11-05 2026-03-24 珠海麦得发生物科技股份有限公司 一种生产3-羟基丙酸的重组菌及其构建方法和应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110008861A1 (en) 2008-03-03 2011-01-13 Joule Unlimited, Inc. Engineered CO2 Fixing Microorganisms Producing Carbon-Based Products of Interest
US20110125118A1 (en) 2009-11-20 2011-05-26 Opx Biotechnologies, Inc. Production of an Organic Acid and/or Related Chemicals
WO2012019175A2 (en) 2010-08-06 2012-02-09 Mascoma Corporation Production of malonyl-coa drived products via anaerobic pathways

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5173429A (en) 1990-11-09 1992-12-22 The Board Of Trustees Of The University Of Arkansas Clostridiumm ljungdahlii, an anaerobic ethanol and acetate producing microorganism
US5593886A (en) 1992-10-30 1997-01-14 Gaddy; James L. Clostridium stain which produces acetic acid from waste gases
UA72220C2 (uk) 1998-09-08 2005-02-15 Байоенджініерінг Рісорсиз, Інк. Незмішувана з водою суміш розчинник/співрозчинник для екстрагування оцтової кислоти, спосіб одержання оцтової кислоти (варіанти), спосіб анаеробного мікробного бродіння для одержання оцтової кислоти (варіанти), модифікований розчинник та спосіб його одержання
WO2002008438A2 (en) 2000-07-25 2002-01-31 Bioengineering Resources, Inc. Methods for increasing the production of ethanol from microbial fermentation
BR0115877A (pt) * 2000-11-20 2003-10-07 Cargill Inc ácido 3-hidroxipropiÈnico e outros compostos orgánicos
US7704723B2 (en) 2006-08-31 2010-04-27 The Board Of Regents For Oklahoma State University Isolation and characterization of novel clostridial species
JP5600296B2 (ja) 2007-11-13 2014-10-01 ランザテク・ニュージーランド・リミテッド 新規細菌及びその使用法
US8048624B1 (en) * 2007-12-04 2011-11-01 Opx Biotechnologies, Inc. Compositions and methods for 3-hydroxypropionate bio-production from biomass
CN101445813B (zh) * 2007-12-21 2013-03-27 清华大学 一种生产3-羟基丙酸的方法
WO2009089457A1 (en) * 2008-01-11 2009-07-16 Novozymes A/S Methods for producing 3-hydroxypropionic acid and compounds thereof
CA2712779C (en) * 2008-01-22 2021-03-16 Genomatica, Inc. Methods and organisms for utilizing synthesis gas or other gaseous carbon sources and methanol
CN101519635A (zh) * 2009-04-03 2009-09-02 南京工业大学 产3-羟基丙酸的转化微生物及其构建方法和应用
US8715971B2 (en) * 2009-09-09 2014-05-06 Genomatica, Inc. Microorganisms and methods for the co-production of isopropanol and 1,4-butanediol
KR20120120493A (ko) * 2009-12-10 2012-11-01 게노마티카 인코포레이티드 합성 가스 또는 기타 가스상 탄소원 및 메탄올을 1,3-부탄디올로 변환하는 방법 및 변환용 유기체
WO2011088364A2 (en) * 2010-01-15 2011-07-21 Massachuseits Institute Of Technology Bioprocess and microbe engineering for total carbon utilization in biofuelproduction
US8143037B2 (en) 2010-03-19 2012-03-27 Coskata, Inc. Ethanologenic Clostridium species, Clostridium coskatii
JP2012085635A (ja) 2010-03-23 2012-05-10 Nippon Shokubai Co Ltd ３−ヒドロキシプロピオン酸の製造方法
US9090918B2 (en) * 2010-11-22 2015-07-28 Novozymes A/A Compositions and methods for 3-hydroxypropionic acid production
BR112013021524A2 (pt) 2011-02-25 2017-06-13 Lanzatech New Zealand Ltd micro-organismos recombinantes e usos dos mesmos
WO2013043758A2 (en) * 2011-09-19 2013-03-28 Opx Biotechnologies, Inc. Compositions and methods regarding direct nadh utilization to produce 3-hydroxypropionic acid, derived chemicals and further derived products
US8349587B2 (en) * 2011-10-31 2013-01-08 Ginkgo Bioworks, Inc. Methods and systems for chemoautotrophic production of organic compounds
US20130288317A1 (en) * 2012-04-30 2013-10-31 Metabolix, Inc. Chemical Increased yields of phas from hydrogen feeding and diverse carbon fixation pathways

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110008861A1 (en) 2008-03-03 2011-01-13 Joule Unlimited, Inc. Engineered CO2 Fixing Microorganisms Producing Carbon-Based Products of Interest
US20110125118A1 (en) 2009-11-20 2011-05-26 Opx Biotechnologies, Inc. Production of an Organic Acid and/or Related Chemicals
WO2012019175A2 (en) 2010-08-06 2012-02-09 Mascoma Corporation Production of malonyl-coa drived products via anaerobic pathways

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Agarkar, "Production of 3-hydroxypropionate from biomass", 2007, Retrospective Teses and Dissertations, Iowa State University*

Also Published As

Publication number Publication date
CA2874832C (en) 2016-02-02
CN113832199A (zh) 2021-12-24
JP2015517823A (ja) 2015-06-25
US9994878B2 (en) 2018-06-12
JP6445970B2 (ja) 2018-12-26
CN104508136A (zh) 2015-04-08
US20130323806A1 (en) 2013-12-05
WO2013180581A1 (en) 2013-12-05
EP2855690A4 (en) 2016-02-17
IN2014DN10168A (https=) 2015-08-21
CA2874832A1 (en) 2013-12-05
KR20150021081A (ko) 2015-02-27
EP2855690A1 (en) 2015-04-08
EP2855690B1 (en) 2018-07-11

Similar Documents

Publication Publication Date Title
KR102098849B1 (ko) 재조합 미생물 및 이의 용도
KR102015672B1 (ko) 재조합 미생물 및 이의 용도
KR102097844B1 (ko) 바이오디젤을 만드는 재조합 미생물
KR102079275B1 (ko) 재조합 미생물 및 그에 대한 용도
ES2661953T3 (es) Método de selección y microorganismos recombinantes y usos para los mismos
KR20180002704A (ko) 코리스메이트-유도된 산물의 생산을 위한 유전적으로 조작된 미생물들
AU2018204112A1 (en) Recombinant microorganisms exhibiting increased flux through a fermentation pathway
WO2012105853A1 (en) Recombinant microorganisms with increased tolerance to ethanol
Shah et al. Aerobic utilization of crude glycerol by recombinant Escherichia coli for simultaneous production of poly 3-hydroxybutyrate and bioethanol
CA2956204C (en) Genetically engineered bacterium with altered carbon monoxide dehydrogenase (codh) activity
Kita et al. Isolation of thermophilic acetogens and transformation of them with the pyrF and kanr genes
US20150275238A1 (en) Genetically engineered microbes and methods for converting organic acids to alcohols
JP2013042701A (ja) ２−プロパノールを生産するように操作された微生物
NZ614459B2 (en) Recombinant microorganisms and uses therefor

Legal Events

Date Code Title Description
PA0105 International application

St.27 status event code: A-0-1-A10-A15-nap-PA0105

PG1501 Laying open of application

St.27 status event code: A-1-1-Q10-Q12-nap-PG1501

R18-X000 Changes to party contact information recorded

St.27 status event code: A-3-3-R10-R18-oth-X000

A201 Request for examination
P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

PA0201 Request for examination

St.27 status event code: A-1-2-D10-D11-exm-PA0201

R18-X000 Changes to party contact information recorded

St.27 status event code: A-3-3-R10-R18-oth-X000

D13-X000 Search requested

St.27 status event code: A-1-2-D10-D13-srh-X000

D14-X000 Search report completed

St.27 status event code: A-1-2-D10-D14-srh-X000

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

St.27 status event code: A-1-2-D10-D21-exm-PE0902

R17-X000 Change to representative recorded

St.27 status event code: A-3-3-R10-R17-oth-X000

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

E13-X000 Pre-grant limitation requested

St.27 status event code: A-2-3-E10-E13-lim-X000

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

E701 Decision to grant or registration of patent right
PE0701 Decision of registration

St.27 status event code: A-1-2-D10-D22-exm-PE0701

GRNT Written decision to grant
PR0701 Registration of establishment

St.27 status event code: A-2-4-F10-F11-exm-PR0701

PR1002 Payment of registration fee

St.27 status event code: A-2-2-U10-U12-oth-PR1002

Fee payment year number: 1

PG1601 Publication of registration

St.27 status event code: A-4-4-Q10-Q13-nap-PG1601

P22-X000 Classification modified

St.27 status event code: A-4-4-P10-P22-nap-X000

R18-X000 Changes to party contact information recorded

St.27 status event code: A-5-5-R10-R18-oth-X000

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 4

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 5

PC1903 Unpaid annual fee

St.27 status event code: A-4-4-U10-U13-oth-PC1903

Not in force date: 20250403

Payment event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

H13 Ip right lapsed

Free format text: ST27 STATUS EVENT CODE: N-4-6-H10-H13-OTH-PC1903 (AS PROVIDED BY THE NATIONAL OFFICE); TERMINATION CATEGORY : DEFAULT_OF_REGISTRATION_FEE

Effective date: 20250403

PC1903 Unpaid annual fee

St.27 status event code: N-4-6-H10-H13-oth-PC1903

Ip right cessation event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

Not in force date: 20250403