KR102074535B1 - 아미노산 화합물의 제조 방법 - Google Patents

아미노산 화합물의 제조 방법 Download PDF

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KR102074535B1
KR102074535B1 KR1020147035263A KR20147035263A KR102074535B1 KR 102074535 B1 KR102074535 B1 KR 102074535B1 KR 1020147035263 A KR1020147035263 A KR 1020147035263A KR 20147035263 A KR20147035263 A KR 20147035263A KR 102074535 B1 KR102074535 B1 KR 102074535B1
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formula
compound
salt
hydrogen
alkyl
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KR20150013808A (ko
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트레비스 레마처크
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제넨테크, 인크.
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/333—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton
    • C07C67/343—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/30—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and unsaturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C269/04—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups from amines with formation of carbamate groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/313—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by introduction of doubly bound oxygen containing functional groups, e.g. carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/30—Preparation of optical isomers
    • C07C227/32—Preparation of optical isomers by stereospecific synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C269/06—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups by reactions not involving the formation of carbamate groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Peptides Or Proteins (AREA)
KR1020147035263A 2012-05-17 2013-05-17 아미노산 화합물의 제조 방법 Active KR102074535B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261648534P 2012-05-17 2012-05-17
US61/648,534 2012-05-17
PCT/US2013/041687 WO2013173779A1 (en) 2012-05-17 2013-05-17 Process for making amino acid compounds

Publications (2)

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KR20150013808A KR20150013808A (ko) 2015-02-05
KR102074535B1 true KR102074535B1 (ko) 2020-02-06

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US (1) US9278917B2 (cg-RX-API-DMAC7.html)
EP (1) EP2850054B1 (cg-RX-API-DMAC7.html)
JP (1) JP6196294B2 (cg-RX-API-DMAC7.html)
KR (1) KR102074535B1 (cg-RX-API-DMAC7.html)
CN (1) CN104520263B (cg-RX-API-DMAC7.html)
AU (1) AU2013262516B2 (cg-RX-API-DMAC7.html)
BR (1) BR112014028585B1 (cg-RX-API-DMAC7.html)
CA (1) CA2873658C (cg-RX-API-DMAC7.html)
ES (1) ES2668477T3 (cg-RX-API-DMAC7.html)
HR (1) HRP20180948T1 (cg-RX-API-DMAC7.html)
IL (1) IL235630A (cg-RX-API-DMAC7.html)
MA (1) MA37751B1 (cg-RX-API-DMAC7.html)
MX (1) MX350443B (cg-RX-API-DMAC7.html)
MY (1) MY171538A (cg-RX-API-DMAC7.html)
NZ (1) NZ702939A (cg-RX-API-DMAC7.html)
PL (1) PL2850054T3 (cg-RX-API-DMAC7.html)
RU (1) RU2643146C2 (cg-RX-API-DMAC7.html)
SG (1) SG11201407625WA (cg-RX-API-DMAC7.html)
SI (1) SI2850054T1 (cg-RX-API-DMAC7.html)
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PL2861582T3 (pl) 2012-05-17 2016-11-30 Sposób wytwarzania hydroksylowanych związków cyklopentylopirymidynowych
KR102123131B1 (ko) 2012-05-17 2020-06-15 제넨테크, 인크. 하이드록실화 사이클로펜타피리미딘 화합물 및 이의 염의 제조 방법
CA2873663C (en) 2012-05-17 2020-01-14 Genentech, Inc. Amorphous form of an akt inhibiting pyrimidinyl-cyclopentane compound, compositions and methods thereof
MA37649B1 (fr) 2012-05-17 2017-03-31 Array Biopharma Inc Procédé de fabrication de composés cyclopentylpyrimidines hydroxylées
KR102698200B1 (ko) * 2013-11-15 2024-08-26 에프. 호프만-라 로슈 아게 피리미딘일사이클로펜테인 화합물의 제조 방법
EP3626710B1 (en) 2014-09-26 2022-02-16 F. Hoffmann-La Roche AG Process for preparing an intermediate in the synthesis of (cyclopentyl[d]pyrimidin-4-yl)piperazine compounds

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WO2008006040A1 (en) 2006-07-06 2008-01-10 Array Biopharma Inc. Hydroxylated and methoxylated cyclopenta [d] pyrimidines as akt protein kinase inhibitors
US8063050B2 (en) 2006-07-06 2011-11-22 Array Biopharma Inc. Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors

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MA37649B1 (fr) 2012-05-17 2017-03-31 Array Biopharma Inc Procédé de fabrication de composés cyclopentylpyrimidines hydroxylées
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Also Published As

Publication number Publication date
CN104520263A (zh) 2015-04-15
TR201807444T4 (tr) 2018-06-21
BR112014028585B1 (pt) 2020-12-22
MX350443B (es) 2017-09-06
SG11201407625WA (en) 2014-12-30
CN104520263B (zh) 2016-11-09
BR112014028585A2 (pt) 2017-06-27
CA2873658A1 (en) 2013-11-21
US9278917B2 (en) 2016-03-08
MA37751B1 (fr) 2018-08-31
BR112014028585A8 (pt) 2020-09-24
KR20150013808A (ko) 2015-02-05
IL235630A (en) 2017-03-30
JP2015520165A (ja) 2015-07-16
JP6196294B2 (ja) 2017-09-13
AU2013262516B2 (en) 2017-10-19
IL235630A0 (en) 2015-02-01
RU2643146C2 (ru) 2018-01-31
WO2013173779A1 (en) 2013-11-21
ES2668477T3 (es) 2018-05-18
SI2850054T1 (en) 2018-06-29
AU2013262516A1 (en) 2015-01-22
EP2850054A1 (en) 2015-03-25
MA37751A1 (fr) 2018-01-31
MY171538A (en) 2019-10-17
PL2850054T3 (pl) 2018-08-31
RU2014150991A (ru) 2016-07-10
NZ702939A (en) 2016-08-26
EP2850054B1 (en) 2018-03-21
CA2873658C (en) 2021-01-26
MX2014013863A (es) 2015-05-07
HRP20180948T1 (hr) 2018-08-10
US20150148559A1 (en) 2015-05-28
HK1208857A1 (en) 2016-03-18

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