KR102021688B1 - 아포지방단백질 ｃｉｉｉ （ａｐｏｃｉｉｉ） 발현의 조정 - Google Patents

아포지방단백질 ｃｉｉｉ （ａｐｏｃｉｉｉ） 발현의 조정 Download PDF

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KR102021688B1
KR102021688B1 KR1020177033202A KR20177033202A KR102021688B1 KR 102021688 B1 KR102021688 B1 KR 102021688B1 KR 1020177033202 A KR1020177033202 A KR 1020177033202A KR 20177033202 A KR20177033202 A KR 20177033202A KR 102021688 B1 KR102021688 B1 KR 102021688B1
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certain embodiments
apociii
compound
pharmaceutical composition
antisense
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KR20170129964A (ko
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아담 멀릭
로잔 엠. 크룩
마크 제이. 그라함
케네쓰 더블유. 도비
토마스 에이. 벨
리차드 리
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아이오니스 파마수티컬즈, 인코포레이티드
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
    • A61K48/0058—Nucleic acids adapted for tissue specific expression, e.g. having tissue specific promoters as part of a contruct
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
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    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
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    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
    • A61K48/0066—Manipulation of the nucleic acid to modify its expression pattern, e.g. enhance its duration of expression, achieved by the presence of particular introns in the delivered nucleic acid
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
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    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/32—Chemical structure of the sugar
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    • C12N2310/30—Chemical structure
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    • C12N2310/341—Gapmers, i.e. of the type ===---===
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    • C12N2310/30—Chemical structure
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/351—Conjugate

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  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Obesity (AREA)
KR1020177033202A 2011-04-27 2012-04-27 아포지방단백질 ｃｉｉｉ （ａｐｏｃｉｉｉ） 발현의 조정 Active KR102021688B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201161479817P 2011-04-27 2011-04-27
US61/479,817 2011-04-27
US201261595009P 2012-02-03 2012-02-03
US61/595,009 2012-02-03
PCT/US2012/035694 WO2012149495A1 (en) 2011-04-27 2012-04-27 Modulation of apolipoprotein ciii (apociii) expression

Related Parent Applications (1)

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KR1020137030993A Division KR101800333B1 (ko) 2011-04-27 2012-04-27 아포지방단백질 ｃｉｉｉ （ａｐｏｃｉｉｉ） 발현의 조정

Related Child Applications (1)

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KR1020197012680A Division KR20190062511A (ko) 2011-04-27 2012-04-27 아포지방단백질 ｃｉｉｉ （ａｐｏｃｉｉｉ） 발현의 조정

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KR20170129964A KR20170129964A (ko) 2017-11-27
KR102021688B1 true KR102021688B1 (ko) 2019-11-04

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KR1020177033202A Active KR102021688B1 (ko) 2011-04-27 2012-04-27 아포지방단백질 ｃｉｉｉ （ａｐｏｃｉｉｉ） 발현의 조정
KR1020197012680A Ceased KR20190062511A (ko) 2011-04-27 2012-04-27 아포지방단백질 ｃｉｉｉ （ａｐｏｃｉｉｉ） 발현의 조정
KR1020137030993A Active KR101800333B1 (ko) 2011-04-27 2012-04-27 아포지방단백질 ｃｉｉｉ （ａｐｏｃｉｉｉ） 발현의 조정

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KR1020137030993A Active KR101800333B1 (ko) 2011-04-27 2012-04-27 아포지방단백질 ｃｉｉｉ （ａｐｏｃｉｉｉ） 발현의 조정

Country Status (17)

Country Link
US (4) US9157082B2 (https=)
EP (2) EP2701713B1 (https=)
JP (3) JP6203707B2 (https=)
KR (3) KR102021688B1 (https=)
CN (3) CN107854478A (https=)
AU (3) AU2012249324B2 (https=)
BR (1) BR112013027479A8 (https=)
CA (1) CA2834232A1 (https=)
DK (2) DK3357497T3 (https=)
ES (2) ES2833468T3 (https=)
IL (1) IL229010A0 (https=)
MY (1) MY162715A (https=)
NZ (1) NZ710192A (https=)
RU (2) RU2016138742A (https=)
SG (2) SG194671A1 (https=)
UA (1) UA115309C2 (https=)
WO (1) WO2012149495A1 (https=)

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