KR101987861B1 - Nedd-8 활성화 효소 억제제 및 저메틸화제의 투여 - Google Patents

Nedd-8 활성화 효소 억제제 및 저메틸화제의 투여 Download PDF

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KR101987861B1
KR101987861B1 KR1020147014236A KR20147014236A KR101987861B1 KR 101987861 B1 KR101987861 B1 KR 101987861B1 KR 1020147014236 A KR1020147014236 A KR 1020147014236A KR 20147014236 A KR20147014236 A KR 20147014236A KR 101987861 B1 KR101987861 B1 KR 101987861B1
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pharmaceutically acceptable
acceptable salt
cancer
pyrimidin
hydroxycyclopentyl
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KR20140097229A (ko
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피터 쥐. 스미스
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밀레니엄 파머슈티컬스 인코퍼레이티드
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1020147014236A 2011-11-03 2012-11-02 Nedd-8 활성화 효소 억제제 및 저메틸화제의 투여 Expired - Fee Related KR101987861B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161555049P 2011-11-03 2011-11-03
US61/555,049 2011-11-03
PCT/US2012/063382 WO2013067396A2 (en) 2011-11-03 2012-11-02 Administration of nedd8-activating enzyme inhibitor and hypomethylating agent

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KR20140097229A KR20140097229A (ko) 2014-08-06
KR101987861B1 true KR101987861B1 (ko) 2019-06-11

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US (2) US8980850B2 (enExample)
EP (1) EP2773360B1 (enExample)
JP (2) JP6231988B2 (enExample)
KR (1) KR101987861B1 (enExample)
CN (1) CN104245699B (enExample)
AU (1) AU2012321106C1 (enExample)
BR (1) BR112014010699B1 (enExample)
CA (1) CA2854461C (enExample)
EA (1) EA028380B1 (enExample)
ES (1) ES2668272T3 (enExample)
GE (1) GEP20196940B (enExample)
HK (1) HK1201733A1 (enExample)
IL (1) IL232353B (enExample)
MA (1) MA35662B1 (enExample)
MX (1) MX357835B (enExample)
MY (1) MY176125A (enExample)
PH (1) PH12014501001B1 (enExample)
PL (1) PL2773360T3 (enExample)
SG (1) SG11201401895WA (enExample)
TN (1) TN2014000194A1 (enExample)
TR (1) TR201807342T4 (enExample)
UA (1) UA114414C2 (enExample)
WO (1) WO2013067396A2 (enExample)

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RU2562245C2 (ru) 2009-05-14 2015-09-10 Милленниум Фармасьютикалз, Инк. ГИДРОХЛОРИД (1S,2S,4R)-4-{ 4-[(1S)-2,3-ДИГИДРО-1Н-ИНДЕН-1-ИЛАМИНО]-7Н-ПИРРОЛО [2,3-d]ПИРИМИДИН-7-ИЛ} -2-ГИДРОКСИЦИКЛОПЕНТИЛ)МЕТИЛ СУЛЬФАМАТА
HK1199252A1 (en) * 2011-08-24 2015-06-26 Millennium Pharmaceuticals, Inc. Inhibitors of nedd8-activating enzyme
EP2764866A1 (en) * 2013-02-07 2014-08-13 IP Gesellschaft für Management mbH Inhibitors of nedd8-activating enzyme
WO2014186388A2 (en) 2013-05-14 2014-11-20 Millennium Pharmaceutcals, Inc. Administration of nedd8-activating enzyme inhibitor and chemotherapeutic agents
WO2015011235A1 (en) * 2013-07-26 2015-01-29 Boehringer Ingelheim International Gmbh Volasertib in combination with azacitidine for the treatment of acute myeloid leukemia and myelodysplastic syndrome ii
SG11201608303QA (en) 2014-04-04 2016-11-29 Del Mar Pharmaceuticals Use of dianhydrogalactitol and analogs or derivatives thereof to treat non-small-cell carcinoma of the lung and ovarian cancer
CN103948590A (zh) * 2014-05-22 2014-07-30 中国药科大学 Nedd8激活酶抑制剂及其医药用途
EP3362070B1 (en) * 2015-10-15 2021-01-27 Celgene Corporation Combination of a mutant isocitrate dehydrogenase 2 inhibitor with azacitidine and its use for treating acute myelogenous leukemia
WO2018218119A1 (en) * 2017-05-25 2018-11-29 The Board Of Trustees Of The Leland Stanford Junior University Combination of low dose il-2 and an inhibitor of treg il-2r desensitization to treat autoimmune and allergic inflammatory diseases
JP2020534331A (ja) * 2017-09-21 2020-11-26 ミレニアム ファーマシューティカルズ， インコーポレイテッドＭｉｌｌｅｎｎｉｕｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． （（１ｓ，２ｓ，４ｒ）−４−｛４−［（１ｓ）−２，３−ジヒドロ−１ｈ−インデン−１−イルアミノ］−７ｈ−ピロロ［２，３−ｄ］ピリミジン−７−イル｝−２−ヒドロキシシクロペンチル）メチルスルファメートの共結晶形態、その製剤及び使用
US20220017908A1 (en) * 2018-11-20 2022-01-20 Fulcrum Therapeutics, Inc. Compositions and methods for increasing fetal hemoglobin and treating sickle cell disease
EP3938050A1 (en) 2019-03-15 2022-01-19 Fulcrum Therapeutics, Inc. Macrocyclic azolopyridine derivatives as eed and prc2 modulators
WO2023025668A1 (en) 2021-08-25 2023-03-02 Asociación Centro De Investigación Cooperativa En Biociencias-Cic Biogune Methods for the generation of stem cell memory t cells for adoptive t cell therapy
WO2023242235A1 (en) * 2022-06-14 2023-12-21 Scandion Oncology A/S Abcg2 inhibitor and nae inhibitor for the treatment of cancer
CN115007323B (zh) * 2022-06-17 2024-01-23 中南大学 一种抑制矿物中黄铁矿浮选的方法
EP4554608A1 (en) * 2022-07-11 2025-05-21 Westlake University Use of a fbxo42 specific inhibitor in treating notch signaling-dependent disease

Citations (2)

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WO2008019124A1 (en) 2006-08-08 2008-02-14 Millennium Pharmaceuticals, Inc. Heteroaryl compounds useful as inhibitors of e1 activating enzymes
US20100292177A1 (en) 2009-03-23 2010-11-18 Armstrong Robert C Methods of treatment using combination therapy

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US6887855B2 (en) 2003-03-17 2005-05-03 Pharmion Corporation Forms of 5-azacytidine
US6943249B2 (en) 2003-03-17 2005-09-13 Ash Stevens, Inc. Methods for isolating crystalline Form I of 5-azacytidine
US20060063735A1 (en) 2004-09-17 2006-03-23 Supergen, Inc. Salts of 5-azacytidine
US20060128654A1 (en) 2004-12-10 2006-06-15 Chunlin Tang Pharmaceutical formulation of cytidine analogs and derivatives
WO2006084281A1 (en) 2005-02-04 2006-08-10 Millennium Pharmaceuticals, Inc. Inhibitors of e1 activating enzymes
JP5231251B2 (ja) 2006-02-02 2013-07-10 ミレニアム ファーマシューティカルズ， インコーポレイテッド Ｅ１活性化酵素の阻害剤
WO2008028193A2 (en) 2006-09-01 2008-03-06 Pharmion Corporation Colon-targeted oral formulations of cytidine analogs
WO2009058394A1 (en) 2007-11-01 2009-05-07 Celgene Corporation Cytidine analogs for treatment of myelodysplastic syndromes
WO2009106549A2 (en) * 2008-02-26 2009-09-03 Nerviano Medical Sciences S.R.L. Antitumor combination comprising a morpholinyl anthracycline derivative and demethylating agents
SI2695609T1 (sl) 2008-05-15 2020-03-31 Celgene Corporation Oral formulacije anologov citidina in postopki za njihovo uporabo
US8530445B2 (en) * 2008-06-09 2013-09-10 Cyclacel Limited Combinations of sapacitabine or CNDAC with DNA methyltransferase inhibitors such as decitabine and procaine
RU2562245C2 (ru) 2009-05-14 2015-09-10 Милленниум Фармасьютикалз, Инк. ГИДРОХЛОРИД (1S,2S,4R)-4-{ 4-[(1S)-2,3-ДИГИДРО-1Н-ИНДЕН-1-ИЛАМИНО]-7Н-ПИРРОЛО [2,3-d]ПИРИМИДИН-7-ИЛ} -2-ГИДРОКСИЦИКЛОПЕНТИЛ)МЕТИЛ СУЛЬФАМАТА
EP2670396A1 (en) 2011-01-31 2013-12-11 Celgene Corporation Pharmaceutical compositions of cytidine analogs and methods of use thereof
EP2773322A1 (en) 2011-11-01 2014-09-10 Celgene Corporation Methods for treating cancers using oral formulations of cytidine analogs

Patent Citations (2)

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WO2008019124A1 (en) 2006-08-08 2008-02-14 Millennium Pharmaceuticals, Inc. Heteroaryl compounds useful as inhibitors of e1 activating enzymes
US20100292177A1 (en) 2009-03-23 2010-11-18 Armstrong Robert C Methods of treatment using combination therapy

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Current Opinion in Oncology, 20(6), 705-710, 2008.
Expert Opinion on Therapeutic Targets, 15(3), 253-264, 2011.

Also Published As

Publication number Publication date
CN104245699A (zh) 2014-12-24
JP6231988B2 (ja) 2017-11-15
PL2773360T3 (pl) 2018-09-28
AU2012321106C1 (en) 2016-11-24
KR20140097229A (ko) 2014-08-06
BR112014010699B1 (pt) 2020-12-15
ES2668272T3 (es) 2018-05-17
TR201807342T4 (tr) 2018-06-21
IL232353A0 (en) 2014-06-30
MY176125A (en) 2020-07-24
MA35662B1 (fr) 2014-11-01
WO2013067396A2 (en) 2013-05-10
US20130116208A1 (en) 2013-05-09
AU2012321106B2 (en) 2016-08-04
UA114414C2 (uk) 2017-06-12
EA028380B1 (ru) 2017-11-30
IL232353B (en) 2018-11-29
EA201400539A1 (ru) 2014-12-30
EP2773360B1 (en) 2018-02-28
PH12014501001A1 (en) 2014-06-09
CA2854461A1 (en) 2013-05-10
TN2014000194A1 (en) 2015-09-30
JP2015505816A (ja) 2015-02-26
MX2014005323A (es) 2014-06-05
AU2012321106A1 (en) 2013-05-23
EP2773360A4 (en) 2015-09-23
US8980850B2 (en) 2015-03-17
GEP20196940B (en) 2019-01-10
SG11201401895WA (en) 2014-05-29
PH12014501001B1 (en) 2018-05-04
CA2854461C (en) 2021-01-19
MX357835B (es) 2018-07-26
HK1201733A1 (en) 2015-09-11
EP2773360A2 (en) 2014-09-10
BR112014010699A2 (pt) 2017-04-25
US20150366886A1 (en) 2015-12-24
CN104245699B (zh) 2017-06-27
NZ624881A (en) 2016-10-28
JP2018009035A (ja) 2018-01-18
WO2013067396A3 (en) 2014-10-16

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