KR101966484B1 - 인슐린 및 인슐린 유사체의 약동학 및 약역학과 주사 통증을 조절하기 위한 마그네슘 조성물 - Google Patents

인슐린 및 인슐린 유사체의 약동학 및 약역학과 주사 통증을 조절하기 위한 마그네슘 조성물 Download PDF

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KR101966484B1
KR101966484B1 KR1020147032221A KR20147032221A KR101966484B1 KR 101966484 B1 KR101966484 B1 KR 101966484B1 KR 1020147032221 A KR1020147032221 A KR 1020147032221A KR 20147032221 A KR20147032221 A KR 20147032221A KR 101966484 B1 KR101966484 B1 KR 101966484B1
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insulin
magnesium
edta
acid
formulation
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KR20140146209A (ko
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로데리크 폴
로버트 하우저
밍 리
브라이언 알. 윌슨
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일라이 릴리 앤드 캄파니
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Inorganic Chemistry (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
KR1020147032221A 2012-04-16 2013-04-16 인슐린 및 인슐린 유사체의 약동학 및 약역학과 주사 통증을 조절하기 위한 마그네슘 조성물 Active KR101966484B1 (ko)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201261624844P 2012-04-16 2012-04-16
US61/624,844 2012-04-16
US201261704066P 2012-09-21 2012-09-21
US61/704,066 2012-09-21
US13/826,806 US9381247B2 (en) 2012-04-16 2013-03-14 Magnesium compositions for modulating the pharmacokinetics and pharmacodynamics of insulin and insulin analogs, and injection site pain
US13/826,806 2013-03-14
PCT/US2013/036742 WO2013158618A1 (en) 2012-04-16 2013-04-16 Magnesium compositions for modulating the pharmacokinetics and pharmacodynamics of insulin and insulin analogs, and injection site pain

Publications (2)

Publication Number Publication Date
KR20140146209A KR20140146209A (ko) 2014-12-24
KR101966484B1 true KR101966484B1 (ko) 2019-04-05

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KR1020147032221A Active KR101966484B1 (ko) 2012-04-16 2013-04-16 인슐린 및 인슐린 유사체의 약동학 및 약역학과 주사 통증을 조절하기 위한 마그네슘 조성물

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Country Link
US (1) US9381247B2 (https=)
EP (2) EP2838506B1 (https=)
JP (2) JP6422855B2 (https=)
KR (1) KR101966484B1 (https=)
CN (1) CN104394847A (https=)
AU (1) AU2013249495B2 (https=)
CA (1) CA2869883A1 (https=)
CY (1) CY1123825T1 (https=)
DK (1) DK2838506T3 (https=)
ES (1) ES2854874T3 (https=)
HK (2) HK1207577A1 (https=)
HR (1) HRP20210417T1 (https=)
HU (1) HUE053303T2 (https=)
IL (1) IL234987A0 (https=)
IN (1) IN2014DN08417A (https=)
LT (1) LT2838506T (https=)
MX (1) MX2014012245A (https=)
PL (1) PL2838506T3 (https=)
PT (1) PT2838506T (https=)
RS (1) RS61533B1 (https=)
RU (1) RU2014145846A (https=)
SG (1) SG11201406491PA (https=)
SI (1) SI2838506T1 (https=)
WO (1) WO2013158618A1 (https=)
ZA (1) ZA201407410B (https=)

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KR102351111B1 (ko) * 2014-01-13 2022-01-14 써멀린 다이어비티즈, 엘엘씨 초속효성 인슐린 제형 및 약제학적 전달 시스템
WO2015120457A1 (en) * 2014-02-10 2015-08-13 Biodel Inc. Stabilized ultra-rapid-acting insulin formulations
TWI685348B (zh) * 2014-05-08 2020-02-21 美國禮來大藥廠 速效胰島素組合物
WO2016007935A2 (en) 2014-07-10 2016-01-14 Companion Medical, Inc. Medicine administering system including injection pen and companion device
TW201630622A (zh) 2014-12-16 2016-09-01 美國禮來大藥廠 速效胰島素組合物
KR20170106373A (ko) * 2015-01-20 2017-09-20 케이스 웨스턴 리저브 유니버시티 선택적 신호전달 특성 및 감소된 유사분열촉진을 갖는 인슐린 유사체
JO3749B1 (ar) * 2015-08-27 2021-01-31 Lilly Co Eli تركيبات إنسولين سريعة المفعول
US10864327B2 (en) 2016-01-29 2020-12-15 Companion Medical, Inc. Automatic medication delivery tracking
GB201607918D0 (en) 2016-05-06 2016-06-22 Arecor Ltd Novel formulations
JP2019529506A (ja) 2016-09-29 2019-10-17 アレコル リミテッド 新規の製剤
GB201707189D0 (en) * 2017-05-05 2017-06-21 Arecor Ltd Novel formulations
CN110662551B (zh) 2017-06-01 2023-07-18 伊莱利利公司 速效胰岛素组合物
US11484657B2 (en) 2017-06-09 2022-11-01 Medtronic Minimed, Inc. Intelligent medication delivery systems and methods
US11568975B2 (en) 2017-10-12 2023-01-31 Medtronic Minimed, Inc. Intelligent medication delivery systems and methods for dose recommendation and management
JP7512203B2 (ja) 2017-12-12 2024-07-08 ビッグフット バイオメディカル インコーポレイテッド 治療支援情報及び／又は追跡装置並びに関連する方法及びシステム
US11083852B2 (en) 2017-12-12 2021-08-10 Bigfoot Biomedical, Inc. Insulin injection assistance systems, methods, and devices
US11197964B2 (en) 2017-12-12 2021-12-14 Bigfoot Biomedical, Inc. Pen cap for medication injection pen having temperature sensor
US11116899B2 (en) 2017-12-12 2021-09-14 Bigfoot Biomedical, Inc. User interface for diabetes management systems and devices
US10987464B2 (en) 2017-12-12 2021-04-27 Bigfoot Biomedical, Inc. Pen cap for insulin injection pens and associated methods and systems
US11464459B2 (en) 2017-12-12 2022-10-11 Bigfoot Biomedical, Inc. User interface for diabetes management systems including flash glucose monitor
US11077243B2 (en) 2017-12-12 2021-08-03 Bigfoot Biomedical, Inc. Devices, systems, and methods for estimating active medication from injections
US12357562B2 (en) 2018-04-04 2025-07-15 Arecor Limited Injection pen system for the delivery of an insulin compound
US11664107B2 (en) 2018-05-08 2023-05-30 Medtronic Minimed, Inc. Intelligent medication delivery systems and methods using a prescription-regulated software application
US10898653B2 (en) 2018-05-08 2021-01-26 Companion Medical, Inc. Intelligent medication delivery systems and methods for dose setting and dispensing monitoring
USD893020S1 (en) 2018-05-11 2020-08-11 Companion Medical, Inc. Injection pen
USD892819S1 (en) 2018-06-20 2020-08-11 Companion Medical, Inc. Display screen with graphical user interface
US11587663B2 (en) 2018-06-20 2023-02-21 Medtronic Minimed, Inc. Intelligent medication delivery systems and methods for medicine dose calculation and reporting
WO2019243627A1 (fr) 2018-06-23 2019-12-26 Adocia Dispositif pour injecter une solution d'insuline(s)
FR3083985A1 (fr) 2018-07-23 2020-01-24 Adocia Dispositif pour injecter une solution d'insuline(s)
FR3083984A1 (fr) 2018-07-23 2020-01-24 Adocia Dispositif pour injecter une solution d'insuline(s)
US12205699B1 (en) 2018-10-30 2025-01-21 Bigfoot Biomedical, Inc. Method of pairing therapy devices using shared secrets, and related systems, methods and devices
US11948671B2 (en) 2019-04-11 2024-04-02 Medtronic Minimed, Inc. Intelligent accessories for medicine dispensing device
CN116847869A (zh) * 2020-10-08 2023-10-03 美商玛丽莫里斯博士联合有限责任公司 用于治疗和预防1型糖尿病的方法和组合物
US11701473B2 (en) 2021-06-23 2023-07-18 Medtronic Minimed, Inc. Reusable injection pens

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WO1999034821A1 (en) 1998-01-09 1999-07-15 Novo Nordisk A/S Stabilised insulin compositions
US20090280532A1 (en) 1996-08-30 2009-11-12 Life Technologies Corporation Serum-free mammalian cell culture medium, and uses thereof
US20100151435A1 (en) 2007-02-17 2010-06-17 President And Fellows Of Harvard College Compositions and methods for tissue preservation
JP2011500581A (ja) 2007-10-09 2011-01-06 バイオデル， インコーポレイテッド 即効型注射可能インスリン組成物

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WO1999034821A1 (en) 1998-01-09 1999-07-15 Novo Nordisk A/S Stabilised insulin compositions
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JP2011500581A (ja) 2007-10-09 2011-01-06 バイオデル， インコーポレイテッド 即効型注射可能インスリン組成物

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ES2854874T3 (es) 2021-09-23
US9381247B2 (en) 2016-07-05
SG11201406491PA (en) 2014-11-27
EP2838506A1 (en) 2015-02-25
CY1123825T1 (el) 2022-05-27
EP3827813A1 (en) 2021-06-02
LT2838506T (lt) 2021-03-25
HUE053303T2 (hu) 2021-06-28
EP2838506B1 (en) 2021-01-06
ZA201407410B (en) 2015-06-24
JP2015512952A (ja) 2015-04-30
HRP20210417T1 (hr) 2021-04-30
CA2869883A1 (en) 2013-10-24
SI2838506T1 (sl) 2021-02-26
WO2013158618A1 (en) 2013-10-24
CN104394847A (zh) 2015-03-04
HK1203371A1 (en) 2015-10-30
MX2014012245A (es) 2015-06-05
RS61533B1 (sr) 2021-04-29
DK2838506T3 (da) 2021-01-18
KR20140146209A (ko) 2014-12-24
IN2014DN08417A (https=) 2015-05-08
PT2838506T (pt) 2021-02-23
JP2019023223A (ja) 2019-02-14
HK1207577A1 (en) 2016-02-05
US20140113856A1 (en) 2014-04-24
IL234987A0 (en) 2014-12-31
RU2014145846A (ru) 2016-06-10
AU2013249495B2 (en) 2016-05-12
PL2838506T3 (pl) 2021-06-28
JP6422855B2 (ja) 2018-11-14

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