KR101952467B1 - 변경된 점성 표현형을 갖는 사상균 - Google Patents

변경된 점성 표현형을 갖는 사상균 Download PDF

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KR101952467B1
KR101952467B1 KR1020137030474A KR20137030474A KR101952467B1 KR 101952467 B1 KR101952467 B1 KR 101952467B1 KR 1020137030474 A KR1020137030474 A KR 1020137030474A KR 20137030474 A KR20137030474 A KR 20137030474A KR 101952467 B1 KR101952467 B1 KR 101952467B1
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KR20140033046A (ko
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엘리자베스 에이 보디
2세 로버트 제임스 프랫
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다니스코 유에스 인크.
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/36—Adaptation or attenuation of cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C12N9/2405—Glucanases

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Mycology (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Botany (AREA)
  • Cell Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
KR1020137030474A 2011-04-22 2012-04-20 변경된 점성 표현형을 갖는 사상균 Active KR101952467B1 (ko)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US201161478160P 2011-04-22 2011-04-22
US201161478162P 2011-04-22 2011-04-22
US61/478,162 2011-04-22
US61/478,160 2011-04-22
US201161480602P 2011-04-29 2011-04-29
US201161480610P 2011-04-29 2011-04-29
US201161480629P 2011-04-29 2011-04-29
US61/480,629 2011-04-29
US61/480,602 2011-04-29
US61/480,610 2011-04-29
PCT/US2012/034405 WO2012145596A1 (en) 2011-04-22 2012-04-20 Filamentous fungi having an altered viscosity phenotype

Publications (2)

Publication Number Publication Date
KR20140033046A KR20140033046A (ko) 2014-03-17
KR101952467B1 true KR101952467B1 (ko) 2019-02-26

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Application Number Title Priority Date Filing Date
KR1020137030474A Active KR101952467B1 (ko) 2011-04-22 2012-04-20 변경된 점성 표현형을 갖는 사상균
KR1020137030475A Ceased KR20140033047A (ko) 2011-04-22 2012-04-20 변경된 점성 표현형을 갖는 사상균
KR1020137030515A Active KR101952469B1 (ko) 2011-04-22 2012-04-20 변경된 점성 표현형을 갖는 사상균

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KR1020137030475A Ceased KR20140033047A (ko) 2011-04-22 2012-04-20 변경된 점성 표현형을 갖는 사상균
KR1020137030515A Active KR101952469B1 (ko) 2011-04-22 2012-04-20 변경된 점성 표현형을 갖는 사상균

Country Status (10)

Country Link
US (3) US9587242B2 (https=)
EP (3) EP2699668B1 (https=)
JP (3) JP6042867B2 (https=)
KR (3) KR101952467B1 (https=)
CN (3) CN103517981B (https=)
AU (4) AU2012245319A1 (https=)
BR (3) BR112013025434A2 (https=)
CA (3) CA2833756C (https=)
DK (3) DK2673290T3 (https=)
WO (3) WO2012145596A1 (https=)

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CN103517981B (zh) 2011-04-22 2017-02-15 丹尼斯科美国公司 具有粘度改变表型的丝状真菌
EP3000870B1 (en) * 2011-04-22 2018-01-24 Danisco US Inc. Filamentous fungi having an altered viscosity phenotype
CA2884573A1 (en) 2012-10-22 2014-05-01 Merck Sharp & Dohme Corp. Crz1 mutant fungal cells
WO2018226900A2 (en) 2017-06-06 2018-12-13 Zymergen Inc. A htp genomic engineering platform for improving fungal strains
EP3755710A1 (en) 2018-04-24 2020-12-30 Danisco US Inc. Filamentous fungal strains comprising reduced viscosity phenotypes
WO2019236848A1 (en) 2018-06-06 2019-12-12 Zymergen Inc. Manipulation of genes involved in signal transduction to control fungal morphology during fermentation and production
KR20210018354A (ko) * 2018-06-08 2021-02-17 에멀쥐 아이엔씨 진균성 균사체를 성장시키는 방법 및 식용 산물을 만드는 방법
JP7459509B2 (ja) 2018-07-30 2024-04-02 東レ株式会社 トリコデルマ属糸状菌の変異株およびタンパク質の製造方法
JP2021532775A (ja) * 2018-07-30 2021-12-02 ダニスコ・ユーエス・インク タンパク質生産性が強化された表現型を含む突然変異及び遺伝子改変糸状菌株並びにそれらの方法
BR112021006248A2 (pt) * 2018-10-11 2021-07-06 Toray Industries cepa mutante de trichoderma reesei e métodos para produzir uma proteína e para produzir uma celulase
US20200354756A1 (en) * 2019-04-03 2020-11-12 Danisco Us Inc Disruption of mvb12 in yeast is associated with increased alcohol production and tolerance
FR3104169B1 (fr) * 2019-12-04 2022-10-21 Ifp Energies Now Souche de champignon ayant une viscosite diminuee
AU2021219964A1 (en) * 2020-02-14 2022-09-29 Inbiose N.V. Production of glycosylated product in host cells
EP3926039A1 (en) 2020-06-17 2021-12-22 AB Enzymes GmbH Use of a nuclease for reducing the viscosity and/or preventing an increase in viscosity of a fermentation broth
US11479779B2 (en) 2020-07-31 2022-10-25 Zymergen Inc. Systems and methods for high-throughput automated strain generation for non-sporulating fungi
CN111944779B (zh) * 2020-08-28 2022-06-21 山东省科学院生物研究所 一种海藻糖合成双功能酶编码基因TvTPS/TPP及其应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040224388A1 (en) 1999-03-24 2004-11-11 Nigel Dunn-Coleman Hyphal growth in fungi

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FI943133A0 (fi) * 1994-06-29 1994-06-29 Alko Ab Oy Transgena vaexter
KR20020059350A (ko) 1999-07-30 2002-07-12 추후제출 재조합 단백질 생산용 숙주로서 아스페르길루스 소재의 용도
MXPA02010155A (es) * 2000-04-13 2004-08-19 Mark Aaron Emalfarb Nuevas secuencias reguladoras de expresion y productos de expresion en el campo de hongos filamentosos.
AU5354401A (en) * 2000-04-13 2001-10-30 Emalfarb, Mark Aaron High-throughput screening of expressed DNA libraries in filamentous fungi
AU2002303138A1 (en) 2001-03-14 2002-10-15 Genencor International, Inc. Regulatable growth of filamentous fungi
EP1502103B1 (en) * 2002-05-03 2006-09-13 DSM IP Assets B.V. Process for the monitoring of contaminant removal during the purification process of a pharmaceutical product produced by a host cell
EP1627049B1 (en) 2003-05-29 2010-02-17 Genencor International, Inc. Novel trichoderma genes
EP1689766B1 (en) * 2003-11-06 2012-04-25 Danisco US Inc. Expression in filamentous fungi of protease inhibitors and variants thereof
US20090117227A1 (en) * 2006-02-28 2009-05-07 Suntory Limited Gene encoding trehalose-6-phosphate phosphatase and use thereof
CA2808777C (en) * 2010-08-25 2019-10-29 Danisco Us Inc. Filamentous fungi having an altered viscosity phenotype
EP3000870B1 (en) 2011-04-22 2018-01-24 Danisco US Inc. Filamentous fungi having an altered viscosity phenotype
CN103517981B (zh) * 2011-04-22 2017-02-15 丹尼斯科美国公司 具有粘度改变表型的丝状真菌

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040224388A1 (en) 1999-03-24 2004-11-11 Nigel Dunn-Coleman Hyphal growth in fungi

Non-Patent Citations (1)

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Title
Eukaryotic Cell,제7권,584-601면(2008.04.)*

Also Published As

Publication number Publication date
AU2012245323B2 (en) 2017-06-29
WO2012145592A1 (en) 2012-10-26
JP6042867B2 (ja) 2016-12-14
US20140315313A1 (en) 2014-10-23
EP2673290B1 (en) 2016-07-20
DK2699668T3 (en) 2018-02-26
CN103502266B (zh) 2016-10-19
US9593341B2 (en) 2017-03-14
CN103517981B (zh) 2017-02-15
JP2014513532A (ja) 2014-06-05
CN103502266A (zh) 2014-01-08
EP2699668A1 (en) 2014-02-26
BR112013025434A2 (pt) 2016-11-29
CA2833765C (en) 2021-05-11
AU2012245325B2 (en) 2017-05-25
JP6042870B2 (ja) 2016-12-14
EP2699667A1 (en) 2014-02-26
US9587242B2 (en) 2017-03-07
JP2014513530A (ja) 2014-06-05
DK2699667T3 (en) 2016-08-01
WO2012145598A1 (en) 2012-10-26
AU2012245323A1 (en) 2013-09-19
AU2017235968A1 (en) 2017-10-19
BR112013026535A2 (pt) 2016-11-29
BR112013026559A2 (pt) 2016-11-29
KR20140033046A (ko) 2014-03-17
AU2017235968B2 (en) 2018-07-05
CA2833765A1 (en) 2012-10-26
KR20140033049A (ko) 2014-03-17
JP2014513533A (ja) 2014-06-05
WO2012145596A1 (en) 2012-10-26
KR101952469B1 (ko) 2019-02-26
US20140220689A1 (en) 2014-08-07
DK2673290T3 (en) 2016-11-14
CA2833756A1 (en) 2012-10-26
CA2833539C (en) 2021-04-27
CA2833756C (en) 2021-06-22
EP2699667B1 (en) 2016-04-13
JP6042869B2 (ja) 2016-12-14
CN103502430B (zh) 2017-03-29
EP2699668B1 (en) 2017-11-29
US20140127817A1 (en) 2014-05-08
EP2673290A1 (en) 2013-12-18
US9868958B2 (en) 2018-01-16
KR20140033047A (ko) 2014-03-17
AU2012245325A1 (en) 2013-09-19
CN103517981A (zh) 2014-01-15
CA2833539A1 (en) 2012-10-26
CN103502430A (zh) 2014-01-08
AU2012245319A1 (en) 2013-08-22

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