CN103517981B - 具有粘度改变表型的丝状真菌 - Google Patents
具有粘度改变表型的丝状真菌 Download PDFInfo
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- CN103517981B CN103517981B CN201280019432.6A CN201280019432A CN103517981B CN 103517981 B CN103517981 B CN 103517981B CN 201280019432 A CN201280019432 A CN 201280019432A CN 103517981 B CN103517981 B CN 103517981B
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- gene
- tps2
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- disruption
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/14—Fungi; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/36—Adaptation or attenuation of cells
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
- C12N9/2405—Glucanases
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- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Mycology (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Botany (AREA)
- Cell Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161478160P | 2011-04-22 | 2011-04-22 | |
| US201161478162P | 2011-04-22 | 2011-04-22 | |
| US61/478,162 | 2011-04-22 | ||
| US61/478,160 | 2011-04-22 | ||
| US201161480602P | 2011-04-29 | 2011-04-29 | |
| US201161480610P | 2011-04-29 | 2011-04-29 | |
| US201161480629P | 2011-04-29 | 2011-04-29 | |
| US61/480,629 | 2011-04-29 | ||
| US61/480,602 | 2011-04-29 | ||
| US61/480,610 | 2011-04-29 | ||
| PCT/US2012/034409 WO2012145598A1 (en) | 2011-04-22 | 2012-04-20 | Filamentous fungi having an altered viscosity phenotype |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103517981A CN103517981A (zh) | 2014-01-15 |
| CN103517981B true CN103517981B (zh) | 2017-02-15 |
Family
ID=46018122
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201280019432.6A Active CN103517981B (zh) | 2011-04-22 | 2012-04-20 | 具有粘度改变表型的丝状真菌 |
| CN201280019710.8A Active CN103502266B (zh) | 2011-04-22 | 2012-04-20 | 具有粘度改变表型的丝状真菌 |
| CN201280019665.6A Active CN103502430B (zh) | 2011-04-22 | 2012-04-20 | 具有粘度改变表型的丝状真菌 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201280019710.8A Active CN103502266B (zh) | 2011-04-22 | 2012-04-20 | 具有粘度改变表型的丝状真菌 |
| CN201280019665.6A Active CN103502430B (zh) | 2011-04-22 | 2012-04-20 | 具有粘度改变表型的丝状真菌 |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US9587242B2 (https=) |
| EP (3) | EP2699668B1 (https=) |
| JP (3) | JP6042867B2 (https=) |
| KR (3) | KR101952467B1 (https=) |
| CN (3) | CN103517981B (https=) |
| AU (4) | AU2012245319A1 (https=) |
| BR (3) | BR112013025434A2 (https=) |
| CA (3) | CA2833756C (https=) |
| DK (3) | DK2673290T3 (https=) |
| WO (3) | WO2012145596A1 (https=) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103517981B (zh) | 2011-04-22 | 2017-02-15 | 丹尼斯科美国公司 | 具有粘度改变表型的丝状真菌 |
| EP3000870B1 (en) * | 2011-04-22 | 2018-01-24 | Danisco US Inc. | Filamentous fungi having an altered viscosity phenotype |
| CA2884573A1 (en) | 2012-10-22 | 2014-05-01 | Merck Sharp & Dohme Corp. | Crz1 mutant fungal cells |
| WO2018226900A2 (en) | 2017-06-06 | 2018-12-13 | Zymergen Inc. | A htp genomic engineering platform for improving fungal strains |
| EP3755710A1 (en) | 2018-04-24 | 2020-12-30 | Danisco US Inc. | Filamentous fungal strains comprising reduced viscosity phenotypes |
| WO2019236848A1 (en) | 2018-06-06 | 2019-12-12 | Zymergen Inc. | Manipulation of genes involved in signal transduction to control fungal morphology during fermentation and production |
| KR20210018354A (ko) * | 2018-06-08 | 2021-02-17 | 에멀쥐 아이엔씨 | 진균성 균사체를 성장시키는 방법 및 식용 산물을 만드는 방법 |
| JP7459509B2 (ja) | 2018-07-30 | 2024-04-02 | 東レ株式会社 | トリコデルマ属糸状菌の変異株およびタンパク質の製造方法 |
| JP2021532775A (ja) * | 2018-07-30 | 2021-12-02 | ダニスコ・ユーエス・インク | タンパク質生産性が強化された表現型を含む突然変異及び遺伝子改変糸状菌株並びにそれらの方法 |
| BR112021006248A2 (pt) * | 2018-10-11 | 2021-07-06 | Toray Industries | cepa mutante de trichoderma reesei e métodos para produzir uma proteína e para produzir uma celulase |
| US20200354756A1 (en) * | 2019-04-03 | 2020-11-12 | Danisco Us Inc | Disruption of mvb12 in yeast is associated with increased alcohol production and tolerance |
| FR3104169B1 (fr) * | 2019-12-04 | 2022-10-21 | Ifp Energies Now | Souche de champignon ayant une viscosite diminuee |
| AU2021219964A1 (en) * | 2020-02-14 | 2022-09-29 | Inbiose N.V. | Production of glycosylated product in host cells |
| EP3926039A1 (en) | 2020-06-17 | 2021-12-22 | AB Enzymes GmbH | Use of a nuclease for reducing the viscosity and/or preventing an increase in viscosity of a fermentation broth |
| US11479779B2 (en) | 2020-07-31 | 2022-10-25 | Zymergen Inc. | Systems and methods for high-throughput automated strain generation for non-sporulating fungi |
| CN111944779B (zh) * | 2020-08-28 | 2022-06-21 | 山东省科学院生物研究所 | 一种海藻糖合成双功能酶编码基因TvTPS/TPP及其应用 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1159833A (zh) * | 1994-06-29 | 1997-09-17 | 阿尔科集团公司 | 产生海藻糖的转基因植物 |
| CN1380905A (zh) * | 2000-04-13 | 2002-11-20 | 马克·阿龙·埃马尔法尔布 | 丝状真菌中dna表达文库的高通量筛选 |
| WO2007099749A1 (en) * | 2006-02-28 | 2007-09-07 | Suntory Limited | Gene encoding trehalose-6-phosphate phosphatase and use thereof |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7189538B2 (en) | 1999-03-24 | 2007-03-13 | Genencor International, Inc. | Hyphal growth in fungi |
| KR20020059350A (ko) | 1999-07-30 | 2002-07-12 | 추후제출 | 재조합 단백질 생산용 숙주로서 아스페르길루스 소재의 용도 |
| MXPA02010155A (es) * | 2000-04-13 | 2004-08-19 | Mark Aaron Emalfarb | Nuevas secuencias reguladoras de expresion y productos de expresion en el campo de hongos filamentosos. |
| AU2002303138A1 (en) | 2001-03-14 | 2002-10-15 | Genencor International, Inc. | Regulatable growth of filamentous fungi |
| EP1502103B1 (en) * | 2002-05-03 | 2006-09-13 | DSM IP Assets B.V. | Process for the monitoring of contaminant removal during the purification process of a pharmaceutical product produced by a host cell |
| EP1627049B1 (en) | 2003-05-29 | 2010-02-17 | Genencor International, Inc. | Novel trichoderma genes |
| EP1689766B1 (en) * | 2003-11-06 | 2012-04-25 | Danisco US Inc. | Expression in filamentous fungi of protease inhibitors and variants thereof |
| CA2808777C (en) * | 2010-08-25 | 2019-10-29 | Danisco Us Inc. | Filamentous fungi having an altered viscosity phenotype |
| EP3000870B1 (en) | 2011-04-22 | 2018-01-24 | Danisco US Inc. | Filamentous fungi having an altered viscosity phenotype |
| CN103517981B (zh) * | 2011-04-22 | 2017-02-15 | 丹尼斯科美国公司 | 具有粘度改变表型的丝状真菌 |
-
2012
- 2012-04-20 CN CN201280019432.6A patent/CN103517981B/zh active Active
- 2012-04-20 JP JP2014506564A patent/JP6042867B2/ja active Active
- 2012-04-20 US US14/113,930 patent/US9587242B2/en active Active
- 2012-04-20 US US14/113,799 patent/US9593341B2/en active Active
- 2012-04-20 KR KR1020137030474A patent/KR101952467B1/ko active Active
- 2012-04-20 KR KR1020137030475A patent/KR20140033047A/ko not_active Ceased
- 2012-04-20 EP EP12717561.0A patent/EP2699668B1/en active Active
- 2012-04-20 AU AU2012245319A patent/AU2012245319A1/en not_active Abandoned
- 2012-04-20 WO PCT/US2012/034405 patent/WO2012145596A1/en not_active Ceased
- 2012-04-20 WO PCT/US2012/034399 patent/WO2012145592A1/en not_active Ceased
- 2012-04-20 JP JP2014506567A patent/JP6042870B2/ja active Active
- 2012-04-20 DK DK12717558.6T patent/DK2673290T3/en active
- 2012-04-20 CA CA2833756A patent/CA2833756C/en active Active
- 2012-04-20 CA CA2833539A patent/CA2833539C/en active Active
- 2012-04-20 DK DK12717560.2T patent/DK2699667T3/en active
- 2012-04-20 WO PCT/US2012/034409 patent/WO2012145598A1/en not_active Ceased
- 2012-04-20 CN CN201280019710.8A patent/CN103502266B/zh active Active
- 2012-04-20 US US14/113,549 patent/US9868958B2/en active Active
- 2012-04-20 AU AU2012245323A patent/AU2012245323B2/en not_active Ceased
- 2012-04-20 DK DK12717561.0T patent/DK2699668T3/en active
- 2012-04-20 CN CN201280019665.6A patent/CN103502430B/zh active Active
- 2012-04-20 BR BR112013025434A patent/BR112013025434A2/pt not_active Application Discontinuation
- 2012-04-20 BR BR112013026559A patent/BR112013026559A2/pt not_active Application Discontinuation
- 2012-04-20 EP EP12717560.2A patent/EP2699667B1/en active Active
- 2012-04-20 JP JP2014506566A patent/JP6042869B2/ja active Active
- 2012-04-20 EP EP12717558.6A patent/EP2673290B1/en active Active
- 2012-04-20 AU AU2012245325A patent/AU2012245325B2/en not_active Ceased
- 2012-04-20 CA CA2833765A patent/CA2833765C/en active Active
- 2012-04-20 BR BR112013026535A patent/BR112013026535A2/pt not_active Application Discontinuation
- 2012-04-20 KR KR1020137030515A patent/KR101952469B1/ko active Active
-
2017
- 2017-09-28 AU AU2017235968A patent/AU2017235968B2/en not_active Ceased
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1159833A (zh) * | 1994-06-29 | 1997-09-17 | 阿尔科集团公司 | 产生海藻糖的转基因植物 |
| CN1380905A (zh) * | 2000-04-13 | 2002-11-20 | 马克·阿龙·埃马尔法尔布 | 丝状真菌中dna表达文库的高通量筛选 |
| WO2007099749A1 (en) * | 2006-02-28 | 2007-09-07 | Suntory Limited | Gene encoding trehalose-6-phosphate phosphatase and use thereof |
Non-Patent Citations (2)
| Title |
|---|
| The orlA gene from Aspergillus nidulans encodes a trehalose-6-phosphate phosphatase necessary for normal growth and chitin synthesis at elevated temperatures;Peter T. Borgia 等;《Molecular Microbiology》;19961231;第20卷(第6期);第1287页右栏，第1290页右栏，第1293页左栏第3段、右栏第1段，第1294页左栏第3段 * |
| 球孢白僵菌tps2基因的克隆和生物信息学分析;谢翎 等;《激光生物学报》;20100630;第19卷(第3期);363-372 * |
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| CN103517981B (zh) | 具有粘度改变表型的丝状真菌 | |
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| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant |