KR101946104B1 - 개선된 오피오이드 합성을 위한 방법 - Google Patents
개선된 오피오이드 합성을 위한 방법 Download PDFInfo
- Publication number
- KR101946104B1 KR101946104B1 KR1020157003909A KR20157003909A KR101946104B1 KR 101946104 B1 KR101946104 B1 KR 101946104B1 KR 1020157003909 A KR1020157003909 A KR 1020157003909A KR 20157003909 A KR20157003909 A KR 20157003909A KR 101946104 B1 KR101946104 B1 KR 101946104B1
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- KR
- South Korea
- Prior art keywords
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- solvate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 0 CC(C1)(C1C(C[C@@]12C(C(C=C3)=O)O4)c(cc5)c1c4c5O*)C23O Chemical compound CC(C1)(C1C(C[C@@]12C(C(C=C3)=O)O4)c(cc5)c1c4c5O*)C23O 0.000 description 8
- XTERVMJRMFEJRO-WUVYSRKJSA-N COc1ccc(CC(CCC(C2)C=O)C2C23C[C@@H](C4)O)c2c1O[C@H]3C4=O Chemical compound COc1ccc(CC(CCC(C2)C=O)C2C23C[C@@H](C4)O)c2c1O[C@H]3C4=O XTERVMJRMFEJRO-WUVYSRKJSA-N 0.000 description 1
- CZSRUNMAGGWFKF-UUOHUNOPSA-N COc1ccc(CCC(CC2C3)C3C34[C@]2(C=C2)O)c3c1O[C@H]4C2=O Chemical compound COc1ccc(CCC(CC2C3)C3C34[C@]2(C=C2)O)c3c1O[C@H]4C2=O CZSRUNMAGGWFKF-UUOHUNOPSA-N 0.000 description 1
- CZSRUNMAGGWFKF-JZIPDHBBSA-N COc1ccc(CCC(C[C@@H]2C3)C3C34[C@]2(C=C2)O)c3c1O[C@H]4C2=O Chemical compound COc1ccc(CCC(C[C@@H]2C3)C3C34[C@]2(C=C2)O)c3c1O[C@H]4C2=O CZSRUNMAGGWFKF-JZIPDHBBSA-N 0.000 description 1
- WNULMPITDIHCOY-JZIPDHBBSA-N COc1ccc(CCC(C[C@@H]2C3)C3C34[C@]2(CC2)O)c3c1O[C@H]4C2=O Chemical compound COc1ccc(CCC(C[C@@H]2C3)C3C34[C@]2(CC2)O)c3c1O[C@H]4C2=O WNULMPITDIHCOY-JZIPDHBBSA-N 0.000 description 1
- WLCLEYWHKKKRQU-HVAYZDEISA-N COc1ccc(CCC(C[C@@H]2C3)C3C34[C@]2([C@H](C2)O)O)c3c1O[C@H]4C2=O Chemical compound COc1ccc(CCC(C[C@@H]2C3)C3C34[C@]2([C@H](C2)O)O)c3c1O[C@H]4C2=O WLCLEYWHKKKRQU-HVAYZDEISA-N 0.000 description 1
- WLCLEYWHKKKRQU-WAGPAEEKSA-N COc1ccc(CCC(C[C@@H]2C3)[C@@H]3C34[C@]2([C@H](C2)O)O)c3c1O[C@H]4C2=O Chemical compound COc1ccc(CCC(C[C@@H]2C3)[C@@H]3C34[C@]2([C@H](C2)O)O)c3c1O[C@H]4C2=O WLCLEYWHKKKRQU-WAGPAEEKSA-N 0.000 description 1
- FTNXDWPMFOFIJZ-KYZZLPJYSA-N COc1ccc(C[C@@H](CCCC234)C2([C@H](C2)O)O)c3c1O[C@H]4C2=O Chemical compound COc1ccc(C[C@@H](CCCC234)C2([C@H](C2)O)O)c3c1O[C@H]4C2=O FTNXDWPMFOFIJZ-KYZZLPJYSA-N 0.000 description 1
- FTNXDWPMFOFIJZ-BGSZQZBVSA-N COc1ccc(C[C@@H](CCCC234)[C@@]2([C@@H](C2)O)O)c3c1O[C@H]4C2=O Chemical compound COc1ccc(C[C@@H](CCCC234)[C@@]2([C@@H](C2)O)O)c3c1O[C@H]4C2=O FTNXDWPMFOFIJZ-BGSZQZBVSA-N 0.000 description 1
- UKVXRQLHYPJCPG-JSUKCAFUSA-N C[C@@]([C@H](C1)CC2C1CCc1ccc3OC)([C@@H](C4)O)C22c1c3O[C@H]2C4=O Chemical compound C[C@@]([C@H](C1)CC2C1CCc1ccc3OC)([C@@H](C4)O)C22c1c3O[C@H]2C4=O UKVXRQLHYPJCPG-JSUKCAFUSA-N 0.000 description 1
- HCNDZQVVPQUFHP-LENLQWGZSA-N C[C@H](C1(C=C2)O)N(C)CC[C@@]11c(c(C)ccc3OC)c3OC1C2=O Chemical compound C[C@H](C1(C=C2)O)N(C)CC[C@@]11c(c(C)ccc3OC)c3OC1C2=O HCNDZQVVPQUFHP-LENLQWGZSA-N 0.000 description 1
- JRNOTTMGURFDBT-VPLBFTPRSA-N C[C@H]1N(C)CC[C@@]2(c(c(C)ccc3OC)c3OC22)C1=CC=C2OC Chemical compound C[C@H]1N(C)CC[C@@]2(c(c(C)ccc3OC)c3OC22)C1=CC=C2OC JRNOTTMGURFDBT-VPLBFTPRSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
- C07D489/08—Oxygen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Pain & Pain Management (AREA)
- Pulmonology (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicinal Preparation (AREA)
- Saccharide Compounds (AREA)
- Emergency Medicine (AREA)
- Epidemiology (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261672265P | 2012-07-16 | 2012-07-16 | |
| US61/672,265 | 2012-07-16 | ||
| US201361762657P | 2013-02-08 | 2013-02-08 | |
| US61/762,657 | 2013-02-08 | ||
| PCT/IB2013/001538 WO2014013311A1 (en) | 2012-07-16 | 2013-07-15 | Process for improved opioid synthesis |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20150029753A KR20150029753A (ko) | 2015-03-18 |
| KR101946104B1 true KR101946104B1 (ko) | 2019-02-08 |
Family
ID=48916126
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020157003909A Active KR101946104B1 (ko) | 2012-07-16 | 2013-07-15 | 개선된 오피오이드 합성을 위한 방법 |
Country Status (21)
| Country | Link |
|---|---|
| US (4) | US20150259355A1 (enExample) |
| EP (1) | EP2877473B1 (enExample) |
| JP (1) | JP6236446B2 (enExample) |
| KR (1) | KR101946104B1 (enExample) |
| CN (1) | CN104507947B (enExample) |
| AR (1) | AR091779A1 (enExample) |
| AU (2) | AU2013291723B2 (enExample) |
| BR (1) | BR112015000867A2 (enExample) |
| CA (1) | CA2879268C (enExample) |
| CO (1) | CO7180189A2 (enExample) |
| EA (1) | EA029925B1 (enExample) |
| ES (1) | ES2638178T3 (enExample) |
| IL (1) | IL236711B (enExample) |
| IN (1) | IN2015DN01164A (enExample) |
| MX (1) | MX362186B (enExample) |
| NZ (2) | NZ628695A (enExample) |
| PH (1) | PH12015500088B1 (enExample) |
| SG (1) | SG11201407986QA (enExample) |
| TW (2) | TW201639855A (enExample) |
| UA (1) | UA117226C2 (enExample) |
| WO (1) | WO2014013311A1 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR091779A1 (es) | 2012-07-16 | 2015-02-25 | Rhodes Technologies | Procedimiento para la sintesis mejorada de opioides |
| UA117225C2 (uk) * | 2012-07-16 | 2018-07-10 | Родес Текнолоджіс | Спосіб покращеного синтезу опіоїду |
| US9062062B1 (en) | 2013-12-18 | 2015-06-23 | Cody Laboratories, Inc. | Synthesis of oxycodone hydrochloride |
| CA2934527A1 (en) * | 2013-12-18 | 2015-06-25 | Cody Laboratories, Inc. | Synthesis of oxycodone hydrochloride |
| US10227354B2 (en) | 2013-12-18 | 2019-03-12 | Cody Laboratories, Inc. | Conversion of oxycodone base to oxycodone hydrochloride |
| US8846923B1 (en) | 2013-12-18 | 2014-09-30 | Cody Laboratories, Inc. | Preparation of 14-hydroxycodeinone sulfate |
| KR101868724B1 (ko) | 2014-01-15 | 2018-06-18 | 로드스 테크놀로지즈 | 개선된 옥시모르폰 합성을 위한 방법 |
| JP2017502991A (ja) | 2014-01-15 | 2017-01-26 | ローズ テクノロジーズ | 改良されたオキシコドン合成のための方法 |
| US20160052932A1 (en) * | 2014-08-25 | 2016-02-25 | Johnson Matthey Public Limited Company | Processes for Making Opioids Including 14-Hydroxycodeinone and 14-hydroxymorphinone |
| CN110770238B (zh) | 2017-06-20 | 2022-10-04 | 庄信万丰股份有限公司 | 用于从14-羟可待因酮制备盐酸氧可酮的氢化方法 |
| KR102445512B1 (ko) | 2018-03-30 | 2022-09-21 | 삼성디스플레이 주식회사 | 지문 센서 패키지 및 이를 포함하는 표시 장치 |
| KR102120720B1 (ko) * | 2018-07-16 | 2020-06-10 | 연성정밀화학(주) | 날푸라핀 함유 구강붕해정 |
| CN114573508B (zh) * | 2020-12-01 | 2024-07-23 | 绍兴赜军生物医药科技有限公司 | 羟考酮类化合物、其中间体及制备方法 |
| US11247999B1 (en) | 2021-07-02 | 2022-02-15 | Joseph DeGraw | Facile conversion of morphine to normorphine |
| CN114276358B (zh) * | 2022-01-07 | 2023-09-12 | 北京华素制药股份有限公司 | 羟考酮盐酸盐的多晶型物及其制备方法和用途 |
| WO2025174540A1 (en) * | 2024-02-17 | 2025-08-21 | The Regents Of The University Of California | Novel morphine framework derivatives |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008130553A1 (en) * | 2007-04-16 | 2008-10-30 | Mallinckrodt Inc. | Novel opiate reduction utilizing catalytic hydrogen transfer reaction |
| WO2011117172A1 (en) * | 2010-03-23 | 2011-09-29 | Siegfried Ltd. | Preparation of low impurity opiates in a continuous flow reactor |
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|---|---|---|---|---|
| US2772270A (en) | 1954-10-21 | 1956-11-27 | M J Lewenstein | 14-hydroxymorphinone and 8, 14-dihydroxydihydromorphinone |
| US3173876A (en) | 1960-05-27 | 1965-03-16 | John C Zobrist | Cleaning methods and compositions |
| NL271831A (enExample) | 1960-11-29 | |||
| US3276586A (en) | 1963-08-30 | 1966-10-04 | Rosaen Filter Co | Indicating means for fluid filters |
| NL6714885A (enExample) | 1967-11-02 | 1969-05-06 | ||
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| TWI471289B (zh) | 2010-06-11 | 2015-02-01 | Rhodes Technologies | 使三級胺進行ｎ－脫烷反應之方法 |
| EP2588481B1 (en) * | 2010-07-02 | 2017-11-15 | Johnson Matthey Public Limited Company | Process for the synthesis and purification of oxycodone |
| JP5728084B2 (ja) | 2010-07-08 | 2015-06-03 | アルカーメス ファーマ アイルランド リミテッド | 置換モルフィナンの合成のための方法 |
| JP5780933B2 (ja) | 2010-12-01 | 2015-09-16 | 高砂香料工業株式会社 | 光学活性メントールの製造方法 |
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| UA117225C2 (uk) | 2012-07-16 | 2018-07-10 | Родес Текнолоджіс | Спосіб покращеного синтезу опіоїду |
| AR091779A1 (es) | 2012-07-16 | 2015-02-25 | Rhodes Technologies | Procedimiento para la sintesis mejorada de opioides |
| CN103113378B (zh) | 2013-02-20 | 2016-04-06 | 北京华素制药股份有限公司 | 一种盐酸羟吗啡酮的合成方法 |
| CN103433076B (zh) | 2013-09-02 | 2015-06-24 | 浙江新和成股份有限公司 | 一种固载型不对称催化剂及其在不对称氢化反应中的应用 |
| US9060620B1 (en) | 2013-12-04 | 2015-06-23 | Yogi Realty LLC | Baby restraining article |
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| US10227354B2 (en) | 2013-12-18 | 2019-03-12 | Cody Laboratories, Inc. | Conversion of oxycodone base to oxycodone hydrochloride |
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| KR101868724B1 (ko) | 2014-01-15 | 2018-06-18 | 로드스 테크놀로지즈 | 개선된 옥시모르폰 합성을 위한 방법 |
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| WO2008130553A1 (en) * | 2007-04-16 | 2008-10-30 | Mallinckrodt Inc. | Novel opiate reduction utilizing catalytic hydrogen transfer reaction |
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| US20230130617A1 (en) | Process for improved opioid synthesis | |
| US10844072B2 (en) | Process for improved oxycodone synthesis | |
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