CN104507947B - 用于改进的阿片样物质合成的方法 - Google Patents

用于改进的阿片样物质合成的方法 Download PDF

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Publication number
CN104507947B
CN104507947B CN201380037927.6A CN201380037927A CN104507947B CN 104507947 B CN104507947 B CN 104507947B CN 201380037927 A CN201380037927 A CN 201380037927A CN 104507947 B CN104507947 B CN 104507947B
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compound
formula
ppm
solvate
acid
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Chinese (zh)
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CN104507947A (zh
Inventor
基思·麦卡西
约舒亚·R·吉格尔
斯图亚特·詹姆斯·格比
隆·S·里德
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Rhodes Technologies Inc
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Rhodes Technologies Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/14—Antitussive agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Saccharide Compounds (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
CN201380037927.6A 2012-07-16 2013-07-15 用于改进的阿片样物质合成的方法 Active CN104507947B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261672265P 2012-07-16 2012-07-16
US61/672,265 2012-07-16
US201361762657P 2013-02-08 2013-02-08
US61/762,657 2013-02-08
PCT/IB2013/001538 WO2014013311A1 (en) 2012-07-16 2013-07-15 Process for improved opioid synthesis

Publications (2)

Publication Number Publication Date
CN104507947A CN104507947A (zh) 2015-04-08
CN104507947B true CN104507947B (zh) 2017-06-27

Family

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CN201380037927.6A Active CN104507947B (zh) 2012-07-16 2013-07-15 用于改进的阿片样物质合成的方法

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US (4) US20150259355A1 (enExample)
EP (1) EP2877473B1 (enExample)
JP (1) JP6236446B2 (enExample)
KR (1) KR101946104B1 (enExample)
CN (1) CN104507947B (enExample)
AR (1) AR091779A1 (enExample)
AU (2) AU2013291723B2 (enExample)
BR (1) BR112015000867A2 (enExample)
CA (1) CA2879268C (enExample)
CO (1) CO7180189A2 (enExample)
EA (1) EA029925B1 (enExample)
ES (1) ES2638178T3 (enExample)
IL (1) IL236711B (enExample)
IN (1) IN2015DN01164A (enExample)
MX (1) MX362186B (enExample)
NZ (2) NZ628695A (enExample)
PH (1) PH12015500088B1 (enExample)
SG (1) SG11201407986QA (enExample)
TW (2) TW201639855A (enExample)
UA (1) UA117226C2 (enExample)
WO (1) WO2014013311A1 (enExample)

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AR091779A1 (es) 2012-07-16 2015-02-25 Rhodes Technologies Procedimiento para la sintesis mejorada de opioides
UA117225C2 (uk) * 2012-07-16 2018-07-10 Родес Текнолоджіс Спосіб покращеного синтезу опіоїду
US9062062B1 (en) 2013-12-18 2015-06-23 Cody Laboratories, Inc. Synthesis of oxycodone hydrochloride
CA2934527A1 (en) * 2013-12-18 2015-06-25 Cody Laboratories, Inc. Synthesis of oxycodone hydrochloride
US10227354B2 (en) 2013-12-18 2019-03-12 Cody Laboratories, Inc. Conversion of oxycodone base to oxycodone hydrochloride
US8846923B1 (en) 2013-12-18 2014-09-30 Cody Laboratories, Inc. Preparation of 14-hydroxycodeinone sulfate
KR101868724B1 (ko) 2014-01-15 2018-06-18 로드스 테크놀로지즈 개선된 옥시모르폰 합성을 위한 방법
JP2017502991A (ja) 2014-01-15 2017-01-26 ローズ テクノロジーズ 改良されたオキシコドン合成のための方法
US20160052932A1 (en) * 2014-08-25 2016-02-25 Johnson Matthey Public Limited Company Processes for Making Opioids Including 14-Hydroxycodeinone and 14-hydroxymorphinone
CN110770238B (zh) 2017-06-20 2022-10-04 庄信万丰股份有限公司 用于从14-羟可待因酮制备盐酸氧可酮的氢化方法
KR102445512B1 (ko) 2018-03-30 2022-09-21 삼성디스플레이 주식회사 지문 센서 패키지 및 이를 포함하는 표시 장치
KR102120720B1 (ko) * 2018-07-16 2020-06-10 연성정밀화학(주) 날푸라핀 함유 구강붕해정
CN114573508B (zh) * 2020-12-01 2024-07-23 绍兴赜军生物医药科技有限公司 羟考酮类化合物、其中间体及制备方法
US11247999B1 (en) 2021-07-02 2022-02-15 Joseph DeGraw Facile conversion of morphine to normorphine
CN114276358B (zh) * 2022-01-07 2023-09-12 北京华素制药股份有限公司 羟考酮盐酸盐的多晶型物及其制备方法和用途
WO2025174540A1 (en) * 2024-02-17 2025-08-21 The Regents Of The University Of California Novel morphine framework derivatives

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Publication number Publication date
US20190308986A1 (en) 2019-10-10
UA117226C2 (uk) 2018-07-10
KR101946104B1 (ko) 2019-02-08
CN104507947A (zh) 2015-04-08
WO2014013311A1 (en) 2014-01-23
TW201639855A (zh) 2016-11-16
US20180111946A1 (en) 2018-04-26
SG11201407986QA (en) 2015-02-27
AU2013291723A1 (en) 2014-12-18
CA2879268C (en) 2018-05-08
PH12015500088A1 (en) 2015-03-02
KR20150029753A (ko) 2015-03-18
NZ715111A (en) 2016-12-23
ES2638178T3 (es) 2017-10-19
CO7180189A2 (es) 2015-02-09
MX362186B (es) 2019-01-08
IL236711B (en) 2018-04-30
IN2015DN01164A (enExample) 2015-06-26
US10202396B2 (en) 2019-02-12
JP2015524406A (ja) 2015-08-24
EP2877473A1 (en) 2015-06-03
US11390627B2 (en) 2022-07-19
AU2013291723B2 (en) 2016-07-28
EA201590221A1 (ru) 2016-05-31
AU2016204929A1 (en) 2016-08-04
JP6236446B2 (ja) 2017-11-22
BR112015000867A2 (pt) 2019-10-15
IL236711A0 (en) 2015-02-26
NZ628695A (en) 2016-02-26
HK1210171A1 (en) 2016-04-15
CA2879268A1 (en) 2014-01-23
AR091779A1 (es) 2015-02-25
US20210094964A1 (en) 2021-04-01
EA029925B1 (ru) 2018-05-31
EP2877473B1 (en) 2017-06-14
TWI588147B (zh) 2017-06-21
TW201416368A (zh) 2014-05-01
PH12015500088B1 (en) 2015-03-02
US20150259355A1 (en) 2015-09-17
MX2015000880A (es) 2016-09-07

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