KR101946103B1 - 개선된 오피오이드 합성을 위한 방법 - Google Patents

개선된 오피오이드 합성을 위한 방법 Download PDF

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KR101946103B1
KR101946103B1 KR1020157003907A KR20157003907A KR101946103B1 KR 101946103 B1 KR101946103 B1 KR 101946103B1 KR 1020157003907 A KR1020157003907 A KR 1020157003907A KR 20157003907 A KR20157003907 A KR 20157003907A KR 101946103 B1 KR101946103 B1 KR 101946103B1
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KR20150029752A (ko
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키스 매카시
조슈아 알. 기구에르
스튜어트 제임스 게비
론 에스. 라이더
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로드스 테크놀로지즈
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Medicinal Preparation (AREA)
KR1020157003907A 2012-07-16 2013-07-15 개선된 오피오이드 합성을 위한 방법 Active KR101946103B1 (ko)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201261672260P 2012-07-16 2012-07-16
US61/672,260 2012-07-16
US201261741480P 2012-07-19 2012-07-19
US61/741,480 2012-07-19
US201361762637P 2013-02-08 2013-02-08
US61/762,637 2013-02-08
PCT/IB2013/001541 WO2014013313A1 (en) 2012-07-16 2013-07-15 Process for improved opioid synthesis

Publications (2)

Publication Number Publication Date
KR20150029752A KR20150029752A (ko) 2015-03-18
KR101946103B1 true KR101946103B1 (ko) 2019-02-08

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US (3) US10316042B2 (https=)
EP (1) EP2872516B1 (https=)
JP (1) JP6236447B2 (https=)
KR (1) KR101946103B1 (https=)
CN (1) CN104470928B (https=)
AR (1) AR092858A1 (https=)
AU (2) AU2013291725B2 (https=)
BR (1) BR112015000944A2 (https=)
CA (2) CA2974010A1 (https=)
CO (1) CO7180188A2 (https=)
EA (1) EA028092B1 (https=)
ES (1) ES2647949T3 (https=)
IL (1) IL236710B (https=)
IN (1) IN2015DN01165A (https=)
MX (1) MX363610B (https=)
NZ (1) NZ628699A (https=)
PH (1) PH12015500089A1 (https=)
SG (1) SG11201407988UA (https=)
TW (2) TWI643859B (https=)
UA (1) UA117225C2 (https=)
WO (1) WO2014013313A1 (https=)

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KR101868723B1 (ko) 2014-01-15 2018-06-18 로드스 테크놀로지즈 개선된 옥시코돈 합성을 위한 방법
EP3094633B1 (en) * 2014-01-15 2018-03-14 Rhodes Technologies Process for improved oxymorphone synthesis
MA40332A (fr) * 2014-07-09 2021-04-28 Rhodes Tech Réduction des niveaux de cétone alpha, beta-insaturée dans des compositions de dérivés de morphinane
US20160052932A1 (en) 2014-08-25 2016-02-25 Johnson Matthey Public Limited Company Processes for Making Opioids Including 14-Hydroxycodeinone and 14-hydroxymorphinone
US20160340362A1 (en) * 2015-05-20 2016-11-24 Noramco, Inc. Process For The Preparation Of Oxymorphone Freebase
EP3252055B1 (en) 2016-05-31 2018-09-19 Alcaliber Investigacion Desarrollo e Innovacion SLU Process for obtaining 3,14-diacetyloxymorphone from oripavine
US10935314B2 (en) * 2019-03-21 2021-03-02 Evan Prout Heating values of cellulosic waste
CN113493460A (zh) * 2020-03-20 2021-10-12 江苏恩华药业股份有限公司 盐酸羟考酮杂质b的制备方法
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AU2016204926A1 (en) 2016-07-28
CA2879270C (en) 2017-09-05
EA201590222A1 (ru) 2015-05-29
PH12015500089B1 (en) 2015-03-02
US20190367526A1 (en) 2019-12-05
MX2015000879A (es) 2017-02-14
CN104470928A (zh) 2015-03-25
AU2013291725A1 (en) 2014-12-18
CN104470928B (zh) 2017-08-11
US20230130617A1 (en) 2023-04-27
US10316042B2 (en) 2019-06-11
TW201641502A (zh) 2016-12-01
AU2013291725B2 (en) 2016-07-28
UA117225C2 (uk) 2018-07-10
IN2015DN01165A (https=) 2015-06-26
NZ628699A (en) 2016-05-27
WO2014013313A1 (en) 2014-01-23
CA2974010A1 (en) 2014-01-23
EP2872516B1 (en) 2017-08-30
SG11201407988UA (en) 2015-01-29
IL236710A0 (en) 2015-02-26
EA028092B1 (ru) 2017-10-31
TW201416369A (zh) 2014-05-01
IL236710B (en) 2018-04-30
ES2647949T3 (es) 2017-12-27
JP6236447B2 (ja) 2017-11-22
HK1210170A1 (en) 2016-04-15
JP2015524407A (ja) 2015-08-24
KR20150029752A (ko) 2015-03-18
TWI643860B (zh) 2018-12-11
TWI643859B (zh) 2018-12-11
EP2872516A1 (en) 2015-05-20
MX363610B (es) 2019-03-28
CA2879270A1 (en) 2014-01-23
US20150315203A1 (en) 2015-11-05
CO7180188A2 (es) 2015-02-09
PH12015500089A1 (en) 2015-03-02
BR112015000944A2 (pt) 2019-10-15
AR092858A1 (es) 2015-05-06

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