KR101900435B1 - 인간 사이토메갈로바이러스 gB 단백질에 대한 고친화도 인간 항체 - Google Patents

인간 사이토메갈로바이러스 gB 단백질에 대한 고친화도 인간 항체 Download PDF

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KR101900435B1
KR101900435B1 KR1020137001220A KR20137001220A KR101900435B1 KR 101900435 B1 KR101900435 B1 KR 101900435B1 KR 1020137001220 A KR1020137001220 A KR 1020137001220A KR 20137001220 A KR20137001220 A KR 20137001220A KR 101900435 B1 KR101900435 B1 KR 101900435B1
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로렌스 엠. 카우바르
스토테 엘스워쓰
윌리엄 우싱어
크리스타 마우린 맥커체온
잉-핑 지앙
펜 장
보 첸
기제트 스페린데
민하 박
오리트 푸르드
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트렐리스 바이오싸이언스 인코포레이티드
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07K16/08—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/081—DNA viruses
    • C07K16/085—Orthoherpesviridae (F), e.g. pseudorabies virus or Epstein-Barr virus
    • C07K16/089—Cytomegalovirus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
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    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
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KR1020137001220A 2010-06-16 2011-06-16 인간 사이토메갈로바이러스 gB 단백질에 대한 고친화도 인간 항체 Active KR101900435B1 (ko)

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Application Number Priority Date Filing Date Title
US35549910P 2010-06-16 2010-06-16
US61/355,499 2010-06-16
PCT/US2011/040761 WO2011159938A2 (en) 2010-06-16 2011-06-16 High affinity human antibodies to human cytomegalovirus (cmv) gb protein

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KR20130086036A KR20130086036A (ko) 2013-07-30
KR101900435B1 true KR101900435B1 (ko) 2018-09-20

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US (3) US9017668B2 (https=)
EP (1) EP2582389B1 (https=)
JP (2) JP6055763B2 (https=)
KR (1) KR101900435B1 (https=)
CN (1) CN103221063B (https=)
AU (1) AU2011268277B2 (https=)
BR (1) BR112012032182A2 (https=)
CA (1) CA2839420C (https=)
IL (1) IL223665B (https=)
RU (1) RU2613421C2 (https=)
WO (1) WO2011159938A2 (https=)

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AU2009223688B2 (en) * 2008-03-10 2014-12-11 Theraclone Sciences, Inc. Compositions and methods for the therapy and diagnosis of cytomegalovirus infections
EA201270662A1 (ru) 2009-12-23 2013-01-30 4-Антибоди Аг Связывающие элементы для человеческого цитамегаловируса
EP2582389B1 (en) * 2010-06-16 2018-02-21 Trellis Bioscience, LLC High affinity human antibodies to human cytomegalovirus (cmv) gb protein
US10611800B2 (en) 2016-03-11 2020-04-07 Pfizer Inc. Human cytomegalovirus gB polypeptide
US11440951B2 (en) 2017-03-13 2022-09-13 The Government Of The United States, As Represented By The Secretary Of The Army Therapeutic antibodies to Marburg virus
US11629172B2 (en) 2018-12-21 2023-04-18 Pfizer Inc. Human cytomegalovirus gB polypeptide
CN118465272B (zh) * 2019-12-04 2025-08-19 珠海泰诺麦博制药股份有限公司 抗人巨细胞病毒抗体及其用途
TWI810589B (zh) 2020-06-21 2023-08-01 美商輝瑞股份有限公司 人巨細胞病毒糖蛋白Ｂ（ｇＢ）多肽

Citations (1)

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WO2009114560A2 (en) * 2008-03-10 2009-09-17 Spaltudaq Corporation Compositions and methods for the therapy and diagnosis of cytomegalovirus

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US7427469B2 (en) * 2002-11-05 2008-09-23 Institut Pasteur Method of treating cytomegalovirus with DC-SIGN blockers
RU2239453C2 (ru) * 2002-12-03 2004-11-10 Федеральное государственное унитарное предприятие " Научно-производственное объединение по медицинским иммунобиологическим препаратам " Микроген" Препарат иммуноглобулина человека против цитомегаловируса и способ его получения
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US20170204165A1 (en) 2017-07-20
RU2013101769A (ru) 2014-07-27
WO2011159938A2 (en) 2011-12-22
EP2582389A2 (en) 2013-04-24
WO2011159938A3 (en) 2012-04-19
US20150252099A1 (en) 2015-09-10
JP2013531991A (ja) 2013-08-15
RU2613421C2 (ru) 2017-03-16
CA2839420C (en) 2023-06-13
IL223665B (en) 2020-01-30
AU2011268277A1 (en) 2013-01-31
JP2017038612A (ja) 2017-02-23
BR112012032182A2 (pt) 2016-10-25
US20120020980A1 (en) 2012-01-26
CN103221063B (zh) 2016-08-24
US10030069B2 (en) 2018-07-24
KR20130086036A (ko) 2013-07-30
JP6055763B2 (ja) 2016-12-27
EP2582389B1 (en) 2018-02-21
CN103221063A (zh) 2013-07-24
US9017668B2 (en) 2015-04-28
AU2011268277B2 (en) 2016-10-27
AU2011268277A2 (en) 2013-07-25
EP2582389A4 (en) 2014-01-08
US9688744B2 (en) 2017-06-27
CA2839420A1 (en) 2011-12-22

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