KR101899015B1 - L-카르니틴 타르트레이트의 제조방법 - Google Patents

L-카르니틴 타르트레이트의 제조방법 Download PDF

Info

Publication number
KR101899015B1
KR101899015B1 KR1020137008825A KR20137008825A KR101899015B1 KR 101899015 B1 KR101899015 B1 KR 101899015B1 KR 1020137008825 A KR1020137008825 A KR 1020137008825A KR 20137008825 A KR20137008825 A KR 20137008825A KR 101899015 B1 KR101899015 B1 KR 101899015B1
Authority
KR
South Korea
Prior art keywords
carnitine
tartrate
ethanol
reaction mixture
temperature
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
KR1020137008825A
Other languages
English (en)
Korean (ko)
Other versions
KR20140019769A (ko
Inventor
토마스 뷔히너
우베 자허
Original Assignee
론자 리미티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 론자 리미티드 filed Critical 론자 리미티드
Publication of KR20140019769A publication Critical patent/KR20140019769A/ko
Application granted granted Critical
Publication of KR101899015B1 publication Critical patent/KR101899015B1/ko
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/38—Separation; Purification; Stabilisation; Use of additives
    • C07C227/40—Separation; Purification
    • C07C227/42—Crystallisation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/22—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
KR1020137008825A 2010-09-06 2011-09-06 L-카르니틴 타르트레이트의 제조방법 Active KR101899015B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP10009218.8 2010-09-06
EP10009218A EP2425834A1 (en) 2010-09-06 2010-09-06 Process for the production of l-carnitine tartrate
US38039210P 2010-09-07 2010-09-07
US61/380,392 2010-09-07
PCT/EP2011/004469 WO2012031736A1 (en) 2010-09-06 2011-09-06 Process for the production of l-carnitine tartrate

Publications (2)

Publication Number Publication Date
KR20140019769A KR20140019769A (ko) 2014-02-17
KR101899015B1 true KR101899015B1 (ko) 2018-09-14

Family

ID=43638725

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020137008825A Active KR101899015B1 (ko) 2010-09-06 2011-09-06 L-카르니틴 타르트레이트의 제조방법

Country Status (8)

Country Link
US (1) US8779188B2 (https=)
EP (2) EP2425834A1 (https=)
JP (1) JP5964831B2 (https=)
KR (1) KR101899015B1 (https=)
CN (1) CN103167872B (https=)
ES (1) ES2531069T3 (https=)
TW (1) TWI574938B (https=)
WO (1) WO2012031736A1 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6421161B2 (ja) * 2015-11-27 2018-11-07 株式会社タムラ製作所 感光性樹脂組成物
WO2017105090A1 (ko) * 2015-12-14 2017-06-22 제이투에이치바이오텍 (주) 오로트산 l-카르니틴의 결정질 다형체, 이의 제조방법 또는 용도
CN109096129B (zh) * 2018-09-30 2021-04-27 东北制药集团股份有限公司 一种左旋肉碱酒石酸盐的制备方法
CN114181101A (zh) * 2021-11-26 2022-03-15 开原亨泰营养科技有限公司 能够控制产品晶型的左旋肉碱酒石酸盐的制备方法
CN115745818B (zh) * 2022-11-22 2024-08-09 安徽泰格生物科技有限公司 一种左旋肉碱盐酸盐的制备方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006028068A1 (ja) * 2004-09-08 2006-03-16 Wako Pure Chemical Industries, Ltd. Ｌ－カルニチンの精製方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1212785B (it) * 1983-11-02 1989-11-30 Isom Spa Procedimento industriale per la separazione della d.l. carnitina nei suoi isomeri ottici.
US5073376A (en) * 1989-12-22 1991-12-17 Lonza Ltd. Preparations containing l-carnitine
IT1289974B1 (it) * 1997-02-25 1998-10-19 Aldo Fassi Procedimento per la produzione di sali stabili e non igroscopici di l(-)carnitina e di alcanoli l(-)-carnitine
DE69704561T2 (de) * 1996-05-31 2001-08-09 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A., Rom/Roma Stabile nicht-hygroskopische salze von l(-)carnitin und alkanoyl-l(-)carnitinen,ein verfahren zu deren herstellung und feste, oral verabreichbare zusammensetzungen, die solche salze enthalten
IT1291133B1 (it) * 1997-04-07 1998-12-29 Sigma Tau Ind Farmaceuti Composizioni solide atte alla somministrazione orale comprendenti l-carnitina e alcanoil l-carnitine magnesio tartrato
CN1167669A (zh) 1997-04-09 1997-12-17 周觉民 一种藤皮片材及其制作方法
IT1312018B1 (it) * 1999-03-19 2002-04-04 Fassi Aldo Procedimento migliorato per la produzione di sali non igroscopicidella l(-)-carnitina.
IT1317013B1 (it) * 2000-04-12 2003-05-26 Biosalts Srl Sostanze dolcificanti, particolarmente per il caffe' ed il the'.
CN1167669C (zh) * 2000-10-20 2004-09-22 东北制药总厂 制备左旋肉碱酒石酸盐的新方法

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006028068A1 (ja) * 2004-09-08 2006-03-16 Wako Pure Chemical Industries, Ltd. Ｌ－カルニチンの精製方法

Also Published As

Publication number Publication date
EP2425834A1 (en) 2012-03-07
EP2613778B1 (en) 2014-12-03
HK1186391A1 (zh) 2014-03-14
ES2531069T3 (es) 2015-03-10
CN103167872A (zh) 2013-06-19
TW201217311A (en) 2012-05-01
US20120059189A1 (en) 2012-03-08
TWI574938B (zh) 2017-03-21
US8779188B2 (en) 2014-07-15
EP2613778A1 (en) 2013-07-17
CN103167872B (zh) 2016-01-20
WO2012031736A1 (en) 2012-03-15
JP5964831B2 (ja) 2016-08-03
JP2013536814A (ja) 2013-09-26
KR20140019769A (ko) 2014-02-17

Similar Documents

Publication Publication Date Title
KR101046905B1 (ko) 염기성 아미노산 염산염 결정의 수득 방법
KR101899015B1 (ko) L-카르니틴 타르트레이트의 제조방법
CN104844488B (zh) 一种n-乙酰-l-半胱氨酸的生产方法
CN106916138A (zh) 一种甲烷二磺酸亚甲酯的合成方法
CN109503441B (zh) 高含量半胱胺盐酸盐的制备方法
CN101607892A (zh) 枸橼酸钠的生产方法
CN102408347A (zh) 一种分离制备l-天门冬氨酸螯合钾二水物的方法
CN109836344B (zh) 一种有机溶剂生产甘氨酸的方法
CN105949111B (zh) 一种高纯高透光l-色氨酸的制备工艺
HK1186391B (en) Process for the production of l-carnitine tartrate
US4613688A (en) Optical resolution process for DL-cysteine
CN102656139B (zh) 制造l-肉毒碱的方法
CN102234225B (zh) 一种一水柠檬酸晶体的生产方法
CN104693073A (zh) 肌酸硝酸盐的制备方法
CN112250621A (zh) 炔草酯的合成方法
RU2402241C1 (ru) Способ получения пищевой добавки - лактата магния
CN102850232A (zh) L-丝氨酸硝酸盐的制备方法
CN104326901B (zh) D-乙酯生产中回收和套用l-(+)-酒石酸的方法
CN112979451B (zh) 一种壬二酸氢铵的制备方法
CN112979450B (zh) 一种壬二酸氢铵的制备方法
EP0090866B1 (en) Optical resolution process for dl-cysteine
CN121248400A (zh) 一种柠檬酸氢镁的制备方法
JP2008156281A (ja) α−リポ酸Ｌ−リジン塩結晶およびその製造法
CN105481771A (zh) 一种奥扎格雷中间体(e)-4-(咪唑基甲基)肉桂酸甲酯的制备工艺
CN110407711A (zh) 一种d-天冬氨酸衍生物及其制备方法

Legal Events

Date Code Title Description
PA0105 International application

St.27 status event code: A-0-1-A10-A15-nap-PA0105

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

PG1501 Laying open of application

St.27 status event code: A-1-1-Q10-Q12-nap-PG1501

A201 Request for examination
P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

PA0201 Request for examination

St.27 status event code: A-1-2-D10-D11-exm-PA0201

PN2301 Change of applicant

St.27 status event code: A-3-3-R10-R13-asn-PN2301

St.27 status event code: A-3-3-R10-R11-asn-PN2301

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

St.27 status event code: A-1-2-D10-D21-exm-PE0902

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

PE0801 Dismissal of amendment

St.27 status event code: A-2-2-P10-P12-nap-PE0801

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

E701 Decision to grant or registration of patent right
PE0701 Decision of registration

St.27 status event code: A-1-2-D10-D22-exm-PE0701

GRNT Written decision to grant
PR0701 Registration of establishment

St.27 status event code: A-2-4-F10-F11-exm-PR0701

PR1002 Payment of registration fee

St.27 status event code: A-2-2-U10-U12-oth-PR1002

Fee payment year number: 1

PG1601 Publication of registration

St.27 status event code: A-4-4-Q10-Q13-nap-PG1601

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 4

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 5

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 6

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 7

PN2301 Change of applicant

St.27 status event code: A-5-5-R10-R11-asn-PN2301

R11 Change to the name of applicant or owner or transfer of ownership requested

Free format text: ST27 STATUS EVENT CODE: A-5-5-R10-R11-ASN-PN2301 (AS PROVIDED BY THE NATIONAL OFFICE)

PN2301 Change of applicant

St.27 status event code: A-5-5-R10-R14-asn-PN2301

R14 Transfer of ownership recorded

Free format text: ST27 STATUS EVENT CODE: A-5-5-R10-R14-ASN-PN2301 (AS PROVIDED BY THE NATIONAL OFFICE)