CN102408347A - 一种分离制备l-天门冬氨酸螯合钾二水物的方法 - Google Patents
一种分离制备l-天门冬氨酸螯合钾二水物的方法 Download PDFInfo
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- CN102408347A CN102408347A CN2011103383083A CN201110338308A CN102408347A CN 102408347 A CN102408347 A CN 102408347A CN 2011103383083 A CN2011103383083 A CN 2011103383083A CN 201110338308 A CN201110338308 A CN 201110338308A CN 102408347 A CN102408347 A CN 102408347A
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- potassium
- aspartase
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- 238000000034 method Methods 0.000 title claims abstract description 33
- 238000000926 separation method Methods 0.000 title claims abstract description 20
- ARZPTLCWDBMSJH-SQGDDOFFSA-M potassium (3S)-3-amino-4-hydroxy-4-oxobutanoate dihydrate Chemical compound O.O.[K+].N[C@@H](CC(O)=O)C([O-])=O ARZPTLCWDBMSJH-SQGDDOFFSA-M 0.000 title abstract description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 64
- 238000006243 chemical reaction Methods 0.000 claims abstract description 33
- 239000013078 crystal Substances 0.000 claims abstract description 29
- 238000002425 crystallisation Methods 0.000 claims abstract description 27
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims abstract description 25
- 229960005261 aspartic acid Drugs 0.000 claims abstract description 25
- CKLJMWTZIZZHCS-UHFFFAOYSA-N D-OH-Asp Natural products OC(=O)C(N)CC(O)=O CKLJMWTZIZZHCS-UHFFFAOYSA-N 0.000 claims abstract description 24
- CKLJMWTZIZZHCS-UWTATZPHSA-N L-Aspartic acid Natural products OC(=O)[C@H](N)CC(O)=O CKLJMWTZIZZHCS-UWTATZPHSA-N 0.000 claims abstract description 24
- 230000008025 crystallization Effects 0.000 claims abstract description 22
- 239000008367 deionised water Substances 0.000 claims abstract description 14
- 229910021641 deionized water Inorganic materials 0.000 claims abstract description 14
- 238000001914 filtration Methods 0.000 claims abstract description 12
- 239000003960 organic solvent Substances 0.000 claims abstract description 11
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 claims abstract description 11
- 238000001816 cooling Methods 0.000 claims abstract description 8
- 239000002994 raw material Substances 0.000 claims abstract description 7
- 239000007788 liquid Substances 0.000 claims abstract description 6
- 239000000463 material Substances 0.000 claims abstract description 6
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims description 50
- 239000011591 potassium Substances 0.000 claims description 50
- 229910052700 potassium Inorganic materials 0.000 claims description 50
- 238000000638 solvent extraction Methods 0.000 claims description 18
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 claims description 9
- 235000015320 potassium carbonate Nutrition 0.000 claims description 9
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical group CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 7
- 239000012452 mother liquor Substances 0.000 claims description 6
- 230000008569 process Effects 0.000 claims description 5
- 239000000376 reactant Substances 0.000 claims description 5
- 238000000746 purification Methods 0.000 claims description 4
- 239000002904 solvent Substances 0.000 claims description 4
- 238000007792 addition Methods 0.000 claims description 2
- 239000008398 formation water Substances 0.000 claims 1
- 238000001035 drying Methods 0.000 abstract description 6
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 abstract 3
- 150000004683 dihydrates Chemical class 0.000 abstract 1
- 230000001939 inductive effect Effects 0.000 abstract 1
- 229910000027 potassium carbonate Inorganic materials 0.000 abstract 1
- TXXVQZSTAVIHFD-DKWTVANSSA-M potassium;(2s)-2-aminobutanedioate;hydron Chemical compound [K+].[O-]C(=O)[C@@H](N)CC(O)=O TXXVQZSTAVIHFD-DKWTVANSSA-M 0.000 abstract 1
- 238000003825 pressing Methods 0.000 abstract 1
- 238000002791 soaking Methods 0.000 abstract 1
- 238000000967 suction filtration Methods 0.000 description 14
- 210000004027 cell Anatomy 0.000 description 7
- 238000005352 clarification Methods 0.000 description 7
- 238000005070 sampling Methods 0.000 description 6
- 239000011343 solid material Substances 0.000 description 6
- 238000003756 stirring Methods 0.000 description 6
- 238000012856 packing Methods 0.000 description 5
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 4
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 4
- NPYPAHLBTDXSSS-UHFFFAOYSA-N Potassium ion Chemical compound [K+] NPYPAHLBTDXSSS-UHFFFAOYSA-N 0.000 description 4
- 238000003760 magnetic stirring Methods 0.000 description 4
- 229910001414 potassium ion Inorganic materials 0.000 description 4
- 239000000243 solution Substances 0.000 description 4
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 3
- 230000006870 function Effects 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 238000005507 spraying Methods 0.000 description 3
- 208000019025 Hypokalemia Diseases 0.000 description 2
- 230000001154 acute effect Effects 0.000 description 2
- 239000000654 additive Substances 0.000 description 2
- 230000000996 additive effect Effects 0.000 description 2
- 229910021529 ammonia Inorganic materials 0.000 description 2
- 230000000052 comparative effect Effects 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 208000006454 hepatitis Diseases 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 230000028161 membrane depolarization Effects 0.000 description 2
- 230000002107 myocardial effect Effects 0.000 description 2
- 208000024896 potassium deficiency disease Diseases 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- 229910001220 stainless steel Inorganic materials 0.000 description 2
- 239000010935 stainless steel Substances 0.000 description 2
- YTDJTZGUTCBZCT-DKWTVANSSA-N (2s)-2-aminobutanedioic acid;potassium Chemical compound [K].OC(=O)[C@@H](N)CC(O)=O YTDJTZGUTCBZCT-DKWTVANSSA-N 0.000 description 1
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 description 1
- 208000024172 Cardiovascular disease Diseases 0.000 description 1
- 206010008909 Chronic Hepatitis Diseases 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 206010019280 Heart failures Diseases 0.000 description 1
- 208000000857 Hepatic Insufficiency Diseases 0.000 description 1
- 206010019663 Hepatic failure Diseases 0.000 description 1
- JLVVSXFLKOJNIY-UHFFFAOYSA-N Magnesium ion Chemical compound [Mg+2] JLVVSXFLKOJNIY-UHFFFAOYSA-N 0.000 description 1
- 208000009525 Myocarditis Diseases 0.000 description 1
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 1
- FKNQFGJONOIPTF-UHFFFAOYSA-N Sodium cation Chemical compound [Na+] FKNQFGJONOIPTF-UHFFFAOYSA-N 0.000 description 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 235000003704 aspartic acid Nutrition 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 229910001424 calcium ion Inorganic materials 0.000 description 1
- 239000004202 carbamide Substances 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
- 235000011089 carbon dioxide Nutrition 0.000 description 1
- 230000000747 cardiac effect Effects 0.000 description 1
- 230000019522 cellular metabolic process Effects 0.000 description 1
- 208000026106 cerebrovascular disease Diseases 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 230000008602 contraction Effects 0.000 description 1
- 208000029078 coronary artery disease Diseases 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 230000002526 effect on cardiovascular system Effects 0.000 description 1
- 238000005265 energy consumption Methods 0.000 description 1
- 208000019622 heart disease Diseases 0.000 description 1
- 231100000283 hepatitis Toxicity 0.000 description 1
- 210000003494 hepatocyte Anatomy 0.000 description 1
- 150000001261 hydroxy acids Chemical class 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 230000001788 irregular Effects 0.000 description 1
- 210000005229 liver cell Anatomy 0.000 description 1
- 230000003908 liver function Effects 0.000 description 1
- 229910001425 magnesium ion Inorganic materials 0.000 description 1
- 239000012567 medical material Substances 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 230000004118 muscle contraction Effects 0.000 description 1
- 230000010016 myocardial function Effects 0.000 description 1
- 210000004165 myocardium Anatomy 0.000 description 1
- 238000006386 neutralization reaction Methods 0.000 description 1
- KHPXUQMNIQBQEV-UHFFFAOYSA-N oxaloacetic acid Chemical compound OC(=O)CC(=O)C(O)=O KHPXUQMNIQBQEV-UHFFFAOYSA-N 0.000 description 1
- 230000036284 oxygen consumption Effects 0.000 description 1
- 230000035479 physiological effects, processes and functions Effects 0.000 description 1
- 239000001103 potassium chloride Substances 0.000 description 1
- 235000011164 potassium chloride Nutrition 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 229910001415 sodium ion Inorganic materials 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 238000001694 spray drying Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-N succinic acid Chemical compound OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 1
- 230000004143 urea cycle Effects 0.000 description 1
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Description
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CN201110338308.3A CN102408347B (zh) | 2011-10-31 | 2011-10-31 | 一种分离制备l-天门冬氨酸螯合钾二水物的方法 |
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CN102408347A true CN102408347A (zh) | 2012-04-11 |
CN102408347B CN102408347B (zh) | 2014-04-09 |
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Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102875403A (zh) * | 2012-10-31 | 2013-01-16 | 宜兴市前成生物有限公司 | 一种制备l-天门冬氨酸钾的方法 |
CN105037185A (zh) * | 2015-06-24 | 2015-11-11 | 安徽万邦医药科技有限公司 | 一种天门冬氨酸钾半水合物的制备方法 |
CN106117069A (zh) * | 2016-06-17 | 2016-11-16 | 宜兴市前成生物有限公司 | 一种制备l‑谷氨酸螯合钾一水物的方法 |
CN106117070A (zh) * | 2016-06-17 | 2016-11-16 | 宜兴市前成生物有限公司 | 一种制备l‑天门冬氨酸二钠的方法 |
CN110511155A (zh) * | 2019-08-15 | 2019-11-29 | 河北力维素科技有限公司 | 一种天门冬氨酸矿物质螯合物及其盐的制备方法 |
CN117924105A (zh) * | 2024-03-25 | 2024-04-26 | 成都新恒创药业有限公司 | 一种门冬氨酸钾的制备方法 |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101863789A (zh) * | 2010-06-30 | 2010-10-20 | 宜兴市前成生物有限公司 | 一种分离提纯l-谷氨酸钾一水物的方法 |
-
2011
- 2011-10-31 CN CN201110338308.3A patent/CN102408347B/zh active Active
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101863789A (zh) * | 2010-06-30 | 2010-10-20 | 宜兴市前成生物有限公司 | 一种分离提纯l-谷氨酸钾一水物的方法 |
Non-Patent Citations (1)
Title |
---|
HUBERT SCHMIDBAUR等: "Preparation and Crystal Structures of Lithium Hydrogen L-Aspartate Hydrate and Potassium Hydrogen L-Aspartate Dihydrate", 《CHEM. BER.》, vol. 122, no. 8, 31 December 1989 (1989-12-31), pages 1427 - 1431 * |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102875403A (zh) * | 2012-10-31 | 2013-01-16 | 宜兴市前成生物有限公司 | 一种制备l-天门冬氨酸钾的方法 |
CN105037185A (zh) * | 2015-06-24 | 2015-11-11 | 安徽万邦医药科技有限公司 | 一种天门冬氨酸钾半水合物的制备方法 |
CN106117069A (zh) * | 2016-06-17 | 2016-11-16 | 宜兴市前成生物有限公司 | 一种制备l‑谷氨酸螯合钾一水物的方法 |
CN106117070A (zh) * | 2016-06-17 | 2016-11-16 | 宜兴市前成生物有限公司 | 一种制备l‑天门冬氨酸二钠的方法 |
CN110511155A (zh) * | 2019-08-15 | 2019-11-29 | 河北力维素科技有限公司 | 一种天门冬氨酸矿物质螯合物及其盐的制备方法 |
CN117924105A (zh) * | 2024-03-25 | 2024-04-26 | 成都新恒创药业有限公司 | 一种门冬氨酸钾的制备方法 |
CN117924105B (zh) * | 2024-03-25 | 2024-05-24 | 成都新恒创药业有限公司 | 一种门冬氨酸钾的制备方法 |
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CN102408347B (zh) | 2014-04-09 |
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Denomination of invention: Method for preparing monopotassium L-aspartate dihydrate by separation process Effective date of registration: 20150520 Granted publication date: 20140409 Pledgee: Jiangsu Yixing rural commercial bank Limited by Share Ltd new sub branch Pledgor: Yixing Qiancheng Biological Co., Ltd. Registration number: 2015990000390 |
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Date of cancellation: 20160120 Granted publication date: 20140409 Pledgee: Jiangsu Yixing rural commercial bank Limited by Share Ltd new sub branch Pledgor: Yixing Qiancheng Biological Co., Ltd. Registration number: 2015990000390 |
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Denomination of invention: Method for preparing monopotassium L-aspartate dihydrate by separation process Effective date of registration: 20160120 Granted publication date: 20140409 Pledgee: Jiangsu Yixing rural commercial bank Limited by Share Ltd new sub branch Pledgor: Yixing Qiancheng Biological Co., Ltd. Registration number: 2016990000063 |
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Date of cancellation: 20180516 Granted publication date: 20140409 Pledgee: Jiangsu Yixing rural commercial bank Limited by Share Ltd new sub branch Pledgor: Yixing Qiancheng Biological Co., Ltd. Registration number: 2016990000063 |
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Denomination of invention: Method for preparing monopotassium L-aspartate dihydrate by separation process Effective date of registration: 20180516 Granted publication date: 20140409 Pledgee: Jiangsu Yixing rural commercial bank Limited by Share Ltd new sub branch Pledgor: Yixing Qiancheng Biological Co., Ltd. Registration number: 2018990000365 |
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