KR101889742B1 - 피리미딘 사이클로헥실 글루코코르티코이드 수용체 조절제 - Google Patents
피리미딘 사이클로헥실 글루코코르티코이드 수용체 조절제 Download PDFInfo
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- 0 *CC(C(N1*)=O)=C(C(CC2)CCC2c2ccccc2)NC1=O Chemical compound *CC(C(N1*)=O)=C(C(CC2)CCC2c2ccccc2)NC1=O 0.000 description 1
- YHOWWNJYIMLDGJ-MXVIHJGJSA-N Cc1cc(CC(C(N2)=O)=C([C@H](CC3)CC[C@@H]3c3ccccc3)NC2=S)ccc1 Chemical compound Cc1cc(CC(C(N2)=O)=C([C@H](CC3)CC[C@@H]3c3ccccc3)NC2=S)ccc1 YHOWWNJYIMLDGJ-MXVIHJGJSA-N 0.000 description 1
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| US8859774B2 (en) | 2012-05-25 | 2014-10-14 | Corcept Therapeutics, Inc. | Heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators |
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| US10183949B2 (en) | 2014-08-29 | 2019-01-22 | The University Of Tokyo | Pyrimidinone derivative having autotaxin-inhibitory activity |
| PT3206692T (pt) * | 2014-10-15 | 2024-04-30 | Corcept Therapeutics Inc | Tratamento da doença hepática gordurosa utilizando antagonistas dos recetores de glicocorticoides e mineralocorticoides |
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| AU2016243625B2 (en) | 2015-03-30 | 2020-09-10 | Corcept Therapeutics, Inc. | Use of glucocorticoid receptor antagonists in combination with glucocorticoids to treat adrenal insufficiency |
| CA2994422A1 (en) | 2015-08-13 | 2017-02-16 | Corcept Therapeutics, Inc. | Method for differentially diagnosing acth-dependent cushing's syndrome |
| RS60007B1 (sr) * | 2015-09-15 | 2020-04-30 | Leo Pharma As | Ne-steroidni modulatori glukokortikoidnog receptora za lokalnu isporuku leka |
| MX2018008849A (es) | 2016-01-19 | 2019-01-31 | Corcept Therapeutics Inc | Diagnostico diferencial de sindrome de cushing ectopico. |
| WO2018165460A1 (en) | 2017-03-09 | 2018-09-13 | Corcept Therapeutics, Inc. | Use of glucocorticoid receptor modulators in the treatment of catecholamine-secreting tumors |
| PT3600282T (pt) | 2017-03-31 | 2025-11-05 | Corcept Therapeutics Inc | Moduladores de recetores de glucocorticoides para tratar cancro cervical |
| EP3641780B1 (en) * | 2017-06-20 | 2025-09-10 | Corcept Therapeutics Incorporated | Treatment of neuroepithelial tumors using selective glucocorticoid receptor modulators |
| JP7196201B2 (ja) * | 2018-06-04 | 2022-12-26 | コーセプト セラピューティクス, インコーポレイテッド | ピリミジンシクロヘキセニル糖質コルチコイドレセプター調節因子 |
| IL263184A (en) | 2018-11-21 | 2020-05-31 | Yarden Yosef | Method of treating cancer and compositions for same |
| US11234971B2 (en) | 2018-12-19 | 2022-02-01 | Corcept Therapeutics Incorporated | Methods of treating cancer comprising administration of a glucocorticoid receptor modulator and a cancer chemotherapy agent |
| US11389432B2 (en) | 2018-12-19 | 2022-07-19 | Corcept Therapeutics Incorporated | Methods of treating cancer comprising administration of a glucocorticoid receptor modulator and a cancer chemotherapy agent |
| CN117281790A (zh) | 2018-12-19 | 2023-12-26 | 科塞普特治疗公司 | 含有瑞拉可兰、杂芳基-酮稠合的氮杂十氢化萘化合物的药物制剂 |
| WO2021119432A1 (en) * | 2019-12-11 | 2021-06-17 | Corcept Therapeutics Incorporated | Methods of treating antipsychotic-induced weight gain with miricorilant |
| US20230358768A1 (en) | 2019-12-21 | 2023-11-09 | Corcept Therapeutics Incorporated | Treatment of, and differential diagnosis between, acth-dependent cushing's syndrome and acth-independent cushing's syndrome |
| CA3182272A1 (en) | 2020-05-06 | 2021-11-11 | Corcept Therapeutics Incorporated | Polymorphs of pyrimidine cyclohexyl glucocorticoid receptor modulators |
| AU2021266739B2 (en) * | 2020-05-06 | 2024-11-28 | Corcept Therapeutics Incorporated | Formulations of pyrimidine cyclohexyl glucocorticoid receptor modulators |
| KR20230124020A (ko) * | 2020-12-21 | 2023-08-24 | 코어셉트 쎄라퓨틱스 인코포레이티드 | 피리미딘 시클로헥실 글루코코르티코이드 수용체 조절제의제조 방법 |
| WO2022134033A1 (en) | 2020-12-25 | 2022-06-30 | Corcept Therapeutics Incorporated | Methods of preparing heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators |
| AU2022271209A1 (en) * | 2021-05-05 | 2023-11-09 | Corcept Therapeutics Incorporated | Methods for reducing liver fat and for treating fatty liver disorders |
| WO2023122600A1 (en) * | 2021-12-21 | 2023-06-29 | Corcept Therapeutics Incorporated | Piperazine indazole glucocorticoid receptor antagonists |
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| EP4608402A1 (en) | 2022-10-28 | 2025-09-03 | Corcept Therapeutics Incorporated | Treatments for amyotrophic lateral sclerosis using dazucorilant |
| AU2024283493A1 (en) * | 2023-05-30 | 2025-12-11 | Corcept Therapeutics Incorporated | Sulfone method of preparing pyrimidine cyclohexyl glucocorticoid receptor modulators |
| CN121219270A (zh) * | 2023-05-30 | 2025-12-26 | 科赛普特治疗公司 | 制备嘧啶环己基糖皮质激素受体调节剂的吡喃鎓方法 |
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| DE102006033109A1 (de) * | 2006-07-18 | 2008-01-31 | Grünenthal GmbH | Substituierte Heteroaryl-Derivate |
| SA08280783B1 (ar) * | 2007-01-11 | 2011-04-24 | استرازينيكا ايه بي | مشتقات بيريدوبيريميدين كمثبطات pde4 |
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