CL2013002667A1 - Compuestos derivados de ciclohexil-pirimidinona; composicion farmaceutica y su uso como moduladores de receptores de glucocorticoides para el tratamiento de hipertension, obesidad, diabetes, depresion psicotica mayor, vih, enfermedad de alzheimer, enfermedad de parkinson y estres. - Google Patents
Compuestos derivados de ciclohexil-pirimidinona; composicion farmaceutica y su uso como moduladores de receptores de glucocorticoides para el tratamiento de hipertension, obesidad, diabetes, depresion psicotica mayor, vih, enfermedad de alzheimer, enfermedad de parkinson y estres.Info
- Publication number
- CL2013002667A1 CL2013002667A1 CL2013002667A CL2013002667A CL2013002667A1 CL 2013002667 A1 CL2013002667 A1 CL 2013002667A1 CL 2013002667 A CL2013002667 A CL 2013002667A CL 2013002667 A CL2013002667 A CL 2013002667A CL 2013002667 A1 CL2013002667 A1 CL 2013002667A1
- Authority
- CL
- Chile
- Prior art keywords
- disease
- obesity
- hypertension
- diabetes
- cyclohexyl
- Prior art date
Links
- 229940117965 Glucocorticoid receptor modulator Drugs 0.000 title abstract 2
- 206010020772 Hypertension Diseases 0.000 title abstract 2
- 208000008589 Obesity Diseases 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 206010012601 diabetes mellitus Diseases 0.000 title abstract 2
- 208000024714 major depressive disease Diseases 0.000 title abstract 2
- 235000020824 obesity Nutrition 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- SESZFKNCJOCABX-UHFFFAOYSA-N 6-cyclohexyl-1h-pyrimidin-2-one Chemical compound C1=CNC(=O)N=C1C1CCCCC1 SESZFKNCJOCABX-UHFFFAOYSA-N 0.000 title 1
- 208000024827 Alzheimer disease Diseases 0.000 title 1
- 208000018737 Parkinson disease Diseases 0.000 title 1
- 208000024172 Cardiovascular disease Diseases 0.000 abstract 1
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- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
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Abstract
Se describen compuestos derivados de ciclohexil-primidinonas, sus composiciones farmacéuticas y su uso como moduladores de receptores de glucocorticoides para el tratamiento de hipertensión, obesidad, diabetes, enfermedad cardiovascular, depresión psicótica mayor y estrés.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161454289P | 2011-03-18 | 2011-03-18 |
Publications (1)
Publication Number | Publication Date |
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CL2013002667A1 true CL2013002667A1 (es) | 2014-05-16 |
Family
ID=46879684
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Application Number | Title | Priority Date | Filing Date |
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CL2013002667A CL2013002667A1 (es) | 2011-03-18 | 2013-09-16 | Compuestos derivados de ciclohexil-pirimidinona; composicion farmaceutica y su uso como moduladores de receptores de glucocorticoides para el tratamiento de hipertension, obesidad, diabetes, depresion psicotica mayor, vih, enfermedad de alzheimer, enfermedad de parkinson y estres. |
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US (3) | US8685973B2 (es) |
EP (1) | EP2685827B1 (es) |
JP (1) | JP6039587B2 (es) |
KR (2) | KR101925955B1 (es) |
CN (1) | CN103596431B (es) |
AU (1) | AU2012231265B2 (es) |
BR (1) | BR112013023689B1 (es) |
CA (1) | CA2830411C (es) |
CL (1) | CL2013002667A1 (es) |
CO (1) | CO6821943A2 (es) |
DK (1) | DK2685827T3 (es) |
ES (1) | ES2563444T3 (es) |
HK (1) | HK1192411A1 (es) |
IL (1) | IL228466A (es) |
MX (1) | MX347862B (es) |
MY (1) | MY161170A (es) |
PE (1) | PE20141378A1 (es) |
PL (1) | PL2685827T3 (es) |
RU (1) | RU2599253C2 (es) |
SG (1) | SG193509A1 (es) |
UA (1) | UA109931C2 (es) |
WO (1) | WO2012129074A1 (es) |
ZA (1) | ZA201307245B (es) |
Cited By (1)
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US11903945B2 (en) | 2019-12-11 | 2024-02-20 | Corcept Therapeutics Incorporated | Methods of treating antipsychotic-induced weight gain with miricorilant |
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EP2685827B1 (en) * | 2011-03-18 | 2016-02-03 | Corcept Therapeutics, Inc. | Pyrimidine cyclohexyl glucocorticoid receptor modulators |
US8859774B2 (en) | 2012-05-25 | 2014-10-14 | Corcept Therapeutics, Inc. | Heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators |
US10183949B2 (en) | 2014-08-29 | 2019-01-22 | The University Of Tokyo | Pyrimidinone derivative having autotaxin-inhibitory activity |
JP6761410B2 (ja) * | 2014-10-15 | 2020-09-23 | コーセプト セラピューティクス, インコーポレイテッド | グルココルチコイドおよびミネラル・コルチコイドレセプターアンタゴニストを使用する脂肪肝疾患の処置 |
EP3265127B1 (en) * | 2015-03-02 | 2024-02-21 | Corcept Therapeutics, Inc. | Mifepristone and octreotide for use in the treatment of cushing's syndrome in a patient having an adrenocorticotropic hormone (acth)-secreting pancreatic neuroendocrine tumor |
WO2016160969A1 (en) | 2015-03-30 | 2016-10-06 | Corcept Therapeutics, Inc. | Use of glucocorticoid receptor antagonists in combination with glucocorticoids to treat adrenal insufficiency |
KR20180052120A (ko) | 2015-08-13 | 2018-05-17 | 코어셉트 쎄라퓨틱스, 잉크. | Acth-의존성 쿠싱 증후군을 감별 진단하는 방법 |
LT3350175T (lt) * | 2015-09-15 | 2020-02-25 | Leo Pharma A/S | Nesteroidiniai gliukokortikoidų receptoriaus moduliatoriai, skirti vietiniam vaistų tiekimui |
WO2017127448A1 (en) | 2016-01-19 | 2017-07-27 | Corcept Therapeutics, Inc. | Differential diagnosis of ectopic cushing's syndrome |
CA3053806A1 (en) | 2017-03-09 | 2018-09-13 | Corcept Therapeutics, Inc. | Use of glucocorticoid receptor modulators in the treatment of catecholamine-secreting tumors |
WO2018183947A1 (en) | 2017-03-31 | 2018-10-04 | Corcept Therapeutics, Inc. | Glucocorticoid receptor modulators to treat cervical cancer |
MX2020012831A (es) * | 2018-06-04 | 2021-04-28 | Corcept Therapeutics Inc | Moduladores del receptor de glucocorticoide de pirimidina ciclohexenilo. |
IL263184A (en) | 2018-11-21 | 2020-05-31 | Yarden Yosef | Method of treating cancer and compositions for same |
US11389432B2 (en) | 2018-12-19 | 2022-07-19 | Corcept Therapeutics Incorporated | Methods of treating cancer comprising administration of a glucocorticoid receptor modulator and a cancer chemotherapy agent |
US11234971B2 (en) | 2018-12-19 | 2022-02-01 | Corcept Therapeutics Incorporated | Methods of treating cancer comprising administration of a glucocorticoid receptor modulator and a cancer chemotherapy agent |
CN117281790A (zh) | 2018-12-19 | 2023-12-26 | 科塞普特治疗公司 | 含有瑞拉可兰、杂芳基-酮稠合的氮杂十氢化萘化合物的药物制剂 |
EP4076470A4 (en) | 2019-12-21 | 2023-11-22 | Corcept Therapeutics Incorporated | DIFFERENTIAL TREATMENT AND DIAGNOSIS BETWEEN ACTH-DEPENDENT CUSHING SYNDROME AND ACTH-INDEPENDENT CUSHING SYNDROME |
CN115551836A (zh) * | 2020-05-06 | 2022-12-30 | 科赛普特治疗公司 | 嘧啶环己基糖皮质激素受体调节剂的多晶型物 |
EP4146173A4 (en) * | 2020-05-06 | 2024-05-29 | Corcept Therapeutics Inc | FORMULATIONS OF PYRIMIDINE-CYCLOHEXYL-GLUCOCORTICOID RECEPTOR MODULATORS |
US11827608B2 (en) | 2020-12-21 | 2023-11-28 | Corcept Therapeutics Incorporated | Method of preparing pyrimidine cyclohexyl glucocorticoid receptor modulators |
EP4333848A1 (en) * | 2021-05-05 | 2024-03-13 | Corcept Therapeutics Incorporated | Methods for reducing liver fat and for treating fatty liver disorders |
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DE102006033109A1 (de) * | 2006-07-18 | 2008-01-31 | Grünenthal GmbH | Substituierte Heteroaryl-Derivate |
SA08280783B1 (ar) * | 2007-01-11 | 2011-04-24 | استرازينيكا ايه بي | مشتقات بيريدوبيريميدين كمثبطات pde4 |
EP2685827B1 (en) | 2011-03-18 | 2016-02-03 | Corcept Therapeutics, Inc. | Pyrimidine cyclohexyl glucocorticoid receptor modulators |
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US11903945B2 (en) | 2019-12-11 | 2024-02-20 | Corcept Therapeutics Incorporated | Methods of treating antipsychotic-induced weight gain with miricorilant |
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