KR101888475B1 - Compostions for reducing weight using herb medicine - Google Patents

Abstract

A composition for weight loss according to one embodiment of the present invention includes: Ephedra sinica, Coix lacryma-jobi, malt, Liriope muscari, liriope rhizome, Salicis radicis cortex, white atractylis, and Longanae Arillus. The composition for weight loss of the present invention has an effect of preventing obesity and weight loss, is convenient to be eaten, and has a high absorption rate, and thus is highly effective in treating obesity.

Description

≪ Desc / Clms Page number 1 > Compositions for reducing weight using herbal medicine [

The present invention relates to a composition for weight loss, and more particularly, to a composition for weight loss which is capable of treating obesity without using a herbal medicine or fasting or fasting.

Overweight and obesity, which are increasing rapidly due to the increase in high fat and high calorie diets and inactive lifestyle, are one of the most important independent risk factors for morbidity and mortality worldwide in place of conventional malnutrition and infectious diseases.

Obesity is an accumulation of excess fat tissue, but the accumulation of adipose tissue increases the risk of developing metabolic syndrome such as hypertension and diabetes, and it is related to the occurrence of cardiovascular disease. Recently, it has been known that not only this metabolic disorder but also oxidative stress increases the risk of neurological dysfunction and tumor development.

In particular, excessive body fat in females induces hyperandrogenic state of the blood and increase of female hormone, thereby affecting the onset of menarche, ovulation disorder, luteal phase defects, postmenopausal health, thereby causing sexual dyslipidemia, menstrual irregularities, infertility, polycystic ovary syndrome and female Hormone-dependent cancer and the like.

Dietary changes and genetic causes or abnormal regimens due to stress have led to an increase in the number of obese patients, which is becoming a social problem, and diverse methods such as diet, exercise, and diet for treating obesity have been proposed.

Weight loss through exercise is known to be the most effective method without side effects, but in busy modern life it is very difficult to exercise regularly enough to treat obesity. As another method, pharmacotherapy is used, but side effects of pharmacotherapy are not clearly known, and it is difficult to take it for a long time.

The treatment of obesity using diet is disadvantageous in that it is difficult to carry out with patience over a long period of time due to the inconvenience of carefully selecting and preparing various foods.

As the interest of obesity increases, various drug therapies, surgery therapies, exercise therapies, diet and behavior modification therapies are overflowing. In Oriental medicine clinics, prescription-oriented herbal medicine therapy, acupuncture therapy, acupuncture stimulation therapy, In addition to general obesity through the treatment of partial obesity is a reality.

Considering the disadvantages or difficulties of the conventional methods used for the treatment of obesity, it is an object of the present invention to provide a method of treating obesity which can reliably obtain the effect of obesity treatment without side effects and can be easily applied without any special efforts. It is necessary to develop a composition.

It should be understood that the foregoing description of the background art is merely for the purpose of promoting an understanding of the background of the present invention and is not to be construed as adhering to the prior art already known to those skilled in the art.

Disclosure of Invention Technical Problem [8] Accordingly, the present invention has been made keeping in mind the above problems occurring in the prior art, and it is an object of the present invention to provide a composition for weight loss, which uses a medicinal herb as a main ingredient.

In order to achieve the above object, the composition for weight loss according to an embodiment of the present invention includes Maqiang, Nuyin, Malt, Maekmundong, Yukuni, Baekjoo, Sukjihwang and Meat.

10 to 20% by weight of the malt, 10 to 20% by weight of the malt, 10 to 20% by weight of the malt, 10 to 20% by weight of the malt, 10 to 20% 20% by weight of the raw meat, 10 to 20% by weight of the raw meat sauce, and 10 to 20% by weight of the raw meat.

Each of the components may include the same amount.

Each component except for the above-mentioned saccharin contains the same amount, and the saccharin may be 1 to 3 times as much as the individual content of each component.

The composition for weight loss may be a hot-water extract.

The composition for weight loss may be a powder or a pill obtained by drying a hot-water extract.

According to the composition for weight loss according to the present invention, it is possible to prevent obesity and weight loss by using a medicinal herb as a main ingredient, to be easy to take,

FIG. 1 is a graph showing the average treatment period according to the degree of obesity.
2 is a graph showing an average weight loss according to the degree of obesity.
FIG. 3 is a graph showing the average muscle reduction amount according to the degree of obesity.
4 is a graph showing an average body fat reduction amount according to the degree of obesity.
FIG. 5 is a graph showing the mean BMI reduction amount according to the degree of obesity.

The terminology used herein is for the purpose of describing particular embodiments only and is not intended to limit the invention. The singular forms as used herein include plural forms as long as the phrases do not expressly express the opposite meaning thereto. Means that a particular feature, region, integer, step, operation, element and / or component is specified, and that other specific features, regions, integers, steps, operations, elements, components, and / And the like.

Unless otherwise defined, all terms including technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. Commonly used predefined terms are further interpreted as having a meaning consistent with the relevant technical literature and the present disclosure, and are not to be construed as ideal or very formal meanings unless defined otherwise.

The composition for weight loss according to one embodiment of the present invention includes Maquina, Nuyin, Malt, Maekmundong, Yukunpie, Baekjoo, Sukjihwang and Meat.

It has the effect of sweating, coughing, and swelling. It stimulates the sympathetic nerves directly to cause vasoconstriction and elevation of blood pressure in the cardiovascular system. It has psycho-excitatory, arousal and appetite suppressant effects in the central nervous system, To reduce digestion and absorption of food, to inhibit cholesterol absorption in the small intestine, to increase energy consumption of fat tissue, and to break down body fat

Nausea reduces body edema and reduces diarrhea. In addition, it acts on feeding control center to have dietary control effect. It suppresses the change of hormone and neurotransmitter related to stress to lower appetite, relieve hunger, inhibit carbohydrate degradation and absorption by inhibiting carbohydrase activity .

Malt is effective against digestive disorders caused by weakness, especially for carbohydrates. Digestive stimulation and hypoglycemic action.

McMundong is effective in treating diseases of the respiratory system such as dry cough, blood clots, and hemoptysis. It also helps prevent constipation in the body and helps prevent constipation in the diet.

It has the effect of making the urine come out well and reducing edema. Recently, it has been known to be effective for sinusitis, rhinitis, dermatitis, and eczema.

Chrysanthemum has a good digestive function and is good for chronic indigestion, enteritis and diarrhea. It also has diuretic action, so it is also used for swelling of the kidneys and edema of pregnant women. Although it is weak, it has an effect of lowering blood sugar and also has the effect of activating the function of the liver.

Sookjyunghwang is a good place to show the sound and blood, and to supplement people's desires. It also has a protective effect against gastritis and gastric ulcer. It acts on the central nervous system to increase dopamine synthesis, and glycogen inhibits the liver from decreasing. One of the side effects of Sukjihwang is to inhibit digestion and make it feel defective, which can make you feel full and make you feel full of obesity.

There is an anthropomorphic effect on the raw meat. It helps when your chest is pounding or not sleeping well. It reduces chest throbbing or insomnia which can be caused by side effects of mahwang.

The content of the composition is 10 to 30 wt%, the content of the composition is 10 to 30 wt%, the content of the composition is 10 to 20 wt%, the content of the malt is 10 to 20 wt%, the content of the composition is 10 to 20 wt% 20 to 20% by weight of the whole milk, 10 to 20% by weight of the whole milk, 10 to 20% by weight of the whole milk, and 10 to 20% by weight of the whole milk.

In case of mahwang, the content can be increased up to 30% by weight according to the necessity of dehumidifying dimension. For example, each composition can be mixed in the same amount ratio, and according to the need of dehumidifying dimension, mahwine can be adjusted to 1 to 3 times as much as each ingredient content.

The composition for weight loss using the medicinal herb according to an embodiment of the present invention can be prepared by hot water extraction, pill, powder or the like.

In the case of hot water extraction, the herbal medicines are first prepared and mixed. 10 to 20% by weight of maltose, 10 to 20% by weight of maltose, 10 to 20% by weight of maltose, 10 to 20% by weight of maltose, 10 to 20% , 10 to 20 wt% of water extract, 10 to 20 wt% of steamed spinach, and 10 to 20 wt% of raw meat.

All of these ingredients use herbal medicines specified in Korean Pharmacopoeia or Korean Pharmacopoeia (Medicinal Herb) Standard Specification, and the medicaments to be mixed means that they are in the usual dry form.

The drug substance mixture is placed in a nonwoven fabric, placed in a water bath, circulated under pressure for about 2 hours to about 100 ° C, and the drug is filtered. The amount of water during the drying process is calculated by adding the amount of water to be extracted and the amount of the drug to be extracted at the time of the boiling to about 1.3 to 1.5 times of the total amount of the pharmaceutical preparation. At this time, the amount of water lost during the bathing is determined by the time of dwelling and is about 1000 ml.

The prepared medicinal material is boiled for a predetermined period of time, and when the bathing is completed, the medicinal substance contained in the nonwoven fabric is taken out, and the medicament is filtered with a filter of 150 mesh. After that, as the packaging step, the drug delivered to the packing machine is boiled at a temperature of about 100 ° C and packed individually in the pouch at a capacity of about 120 cc.

In the case of manufacturing by the ring, the medicinal materials are mixed and placed in a hot water bath for 5 hours, then concentrated again in a concentrator for about 6 hours and concentrated to about 10 times the hot water extract form. Mix 2600cc of concentrated milk and put in a kneader and repeat the dough about 4 times. Put the fermentation liquid (emulsion) into the dough and put it in a fermentation room and mature for about 24 hours. After aging, put it in a single type of dough roll, spread the dough thinly like a noodle, put it in a drier and dry it at 50 ℃ for about 1 hour. It is then pulled back into a monolithic roller and thinly drained, then placed in a ventilator to a size of about 4.5 mm. In the process, 90% of alcohol is sprayed and sterilized. The poured ring is put into a molding machine to form a good appearance, and then dried again at a temperature of 50 ° C for about 24 hours. Finally, about 5 grams are packed into the ring.

Hereinafter, the present invention will be described in more detail by way of examples.

In order to confirm the efficacy of the composition for weight loss according to the present invention, we retrospectively analyzed the progress of obesity treatment of obesity and overweight women of various ages and diverse ages, including Seoul, by using acupuncture and low frequency treatment only as adjuvant therapy. The results of this study showed that the treatment effect was similar to that of the high or early prescription, and the clinical results showed that the onset of the obesity treatment was significantly related to the achievement of the treatment goal.

The data were analyzed for patients who were prescribing the weight loss composition according to the present invention in the form of hot water extract as an address for obesity or hyperostosis. The selection criteria of analysis data are as follows. Body mass index (BMI, kg / ㎡), body weight (kg), body fat (kg), and muscle mass (kg) were measured by using a bioelectrical impedance meter (InBody-770, Biospace, Seoul, Korea) ), Etc. ⑵? Patients who met the criteria for obesity treatment (adult 1-day dose; Table 1) for more than 15 days were included.

The daily dose of the prescribed weight loss composition is shown in Table 1 below.

Composition Content (g) Mahwang 4 Wisdom 4 malt 4 McMundong 4 Yugunpi 4 Boiled 4 Sookmyung 4 Raw meat 4

BMI, body weight, body fat mass, and muscle mass were measured by a bioelectrical impedance meter on the height and weight of the patient through an elongation and an automatic weight measuring device (DS-102, Jenix, Korea) At least once a month, and at the end of treatment.

All the patients took the hydrothermal treatment extract of the composition for weight loss as above, and acupuncture and low frequency treatment were performed according to the judgment of the medical staff, and exercise therapy or diet therapy was made by self-teaching according to the situation of the patient, Or fasting.

   Patients were limited to less than two times per week to limit the role of low-frequency therapy, and the duration of therapy continued until the treatment goal was achieved.

The purpose of this study was to analyze the relationship between measured BMI, body weight, body fat mass, and muscle mass, and the age of the patients (19 years or younger, 20-29 years, 30-39 years old, 40 years old or older)

   First, to evaluate the results of obesity treatment, weight and BMI before and after treatment were measured and their significance was analyzed and compared according to age.

   Body mass index (BMI) and body mass index (BMI) were calculated according to the age group, body weight, fat mass and muscle mass. / ㎡) and high obesity group (BMI 30 ㎏ / ㎡).

Finally, monthly weight loss and BMI reduction were calculated to set monthly target weight loss goals for each group. For this analysis, GraphPad PRISM® 7.00 (GraphPad Software, Inc. California, USA) was used in this study. Results were calculated using paired and unpaired T-test and multiplecomparison normal one-way ANOVA as needed, and significance was considered to be significant if the significance was less than 0.05.

In this study, medical records of 197 cases selected according to the criteria were analyzed. The mean age of the patients was 31.90 years, ranging from 17 to 57 years. The mean duration of treatment was 34 days to 437 days, which was 102.5 days. The mean BMI before the treatment was 28.70 ㎏ / ㎡ at 22.30 ㎏ / ㎡ and 41.30 ㎏ / ㎡, respectively. The mean body weight was 76.80 ㎏ from 52.60 ㎏ to 140.1 ㎏.

(1) Changes in BMI and body weight

Table 2 shows changes in BMI and body weight before and after treatment. As shown in Table 2, it was confirmed that both the BMI and the weight change before and after treatment were significantly decreased

Before Treatment After treatment P value BMI (kg / m 2) 28.70 + - 0.24 24.50 ± 0.25 p < 0.0001 Weight (kg) 76.80 ± 0.68 64.96 + - 0.56 p < 0.0001

(2) Changes in body fat and muscle mass

Table 3 shows changes in body fat mass and muscle mass after treatment. Referring to Table 3, it can be seen that the body fat amount and the muscle amount decrease.

Body fat reduction (kg) Amount of muscle loss (kg) After treatment 10.12 ± 0.27 1.68 ± 0.15

(3) Comparison of treatment results by age

Body weight and BMI were divided into two groups: age group (F19), 20 (20-29, F <29), 30 (30-39, F <39) , There was no difference between the age groups in all items

There was no difference in the mean BMI, mean treatment duration, mean body weight change, mean body fat mass change, and mean muscle mass change after treatment.

(4) Comparison of treatment results according to degree of obesity

Obesity group (n = 82, BMI 25, <30 ㎏ / ㎡), and obesity group (n = 41, BMI < Severe group (n = 74, BMI 30 ㎏ / ㎡) were classified as obese group.

First, there was no significant difference in the age distribution according to obesity as a result of analysis to confirm the age distribution of the groups

We also compared the mean BMI reductions, the mean duration of treatment, the mean weight loss, the average body fat reduction, and the mean increase in muscle mass.

FIG. 1 is a graph showing the average treatment period according to the degree of obesity. 1, there was a significant difference (P = 0.0276) between the overweight group and the obesity group (89.40 ± 4.25 days, 100.61 ± 6.53 days, and 118.46 ± 7.54 days, respectively) (P = 0.0331) between the overweight group and the high obesity group.

2 is a graph showing an average weight loss according to the degree of obesity. 2, there was a significant difference (P <0.0001) between the overweight group and the obese group (9.04 ± 0.45 ㎏, 12.24 ± 0.36 ㎏ and 16.04 ± 0.54 ㎏, respectively) In comparison, there was a significant difference between all groups.

FIG. 3 is a graph showing the average muscle reduction amount according to the degree of obesity. 3, there was a significant difference (P = 0.0022) between the overweight group and the obese group (1.02 ± 0.35 ㎏, 1.71 ± 0.30 ㎏ and 2.35 ± 0.22 ㎏, respectively) In comparison, there was a significant difference in obesity group and altitude obesity group (P = 0.0017)

4 is a graph showing an average body fat reduction amount according to the degree of obesity. 4, there was a significant difference (P <0.0001) between the overweight group and the obesity group (7.52 ± 0.45 ㎏, 9.89 ± 0.27 ㎏ and 13.15 ± 0.57 ㎏, respectively) In comparison, there was a significant difference between the overweight group and the high obesity group, the obese group and the high obesity group (P <0.0001).

FIG. 5 is a graph showing the mean BMI reduction amount according to the degree of obesity. Referring to FIG. 5, there was a significant difference in the mean BMI reduction between the groups in the overweight group, the obese group, and the obesity group, which were 3.12 ± 0.16 ㎏ / ㎡, 4.15 ± 0.16 ㎏ / ㎡ and 5.64 ± 0.21 ㎏ / ㎡ respectively .

We retrospectively analyzed the results of 197 cases of female obesity included in the study. The age distribution of the patients was 16 to 59 years old. The most frequent distribution was in the 20s and 30s.

The mean BMI before the start of treatment was 28.70 ± 0.24 ㎏ / ㎡, which means that the proportion of obese patients who were treated with oriental medicine treatment was higher than those who were obese or obese. Many women have experienced weight control, and regardless of the moderate level of BMI, women have been found to be stressed about weight control.

There was no significant difference in the distribution of overweight, obesity, and obesity groups at all ages, suggesting that access to or preference for oriental medicine therapy is low at low age groups.

As a result of measuring BMI and body weight change before and after treatment, a significant reduction of about 11.80 ㎏ was observed for an average of 102.5 days. As a result, when the weight loss of about 12 kg is aimed at, It is reasonable to consider the treatment period to be 16 weeks in consideration of the on-the-spot treatment, the drug wash-out period, and the examination.

In order to determine whether there is a difference in the effect of composition for weight loss according to age, it is important to consider the effects of age (F19), 20 (F <29), 30 (F <39), and 40 or more (F40).

The results of this study were as follows: First, there was no significant difference between pre - treatment group and obesity group. There was no significant difference in mean BMI, mean treatment duration, mean body weight change, mean body fat change, There was no significant difference between all groups.

This suggests that there is no difference between the goal setting and the period setting for the age group. The number of patients in each group is relatively small, so that a large scale clinical study will be needed to represent the entire population of obesity treatment.

To determine the factors affecting the deviation of treatment effect, we divided into obese group, obese group, and obesity group according to the degree of obesity measured immediately before treatment. The mean BMI change, mean treatment period, mean weight change, mean body fat change, The mean BMI of overweight, obesity, and obesity groups were significantly lower in the overweight group, and significantly lower in the obese group than in the obese group.

The mean duration of treatment, as expected, was the shortest in the overweight group and the longest in the obese obese group. The mean weight change, mean body fat change, and mean muscle mass change also showed similar changes in BMI Significant differences were found.

While the present invention has been described in connection with what is presently considered to be practical exemplary embodiments, it is to be understood that the invention is not limited to the disclosed embodiments, but, on the contrary, You will understand.

It is therefore to be understood that the above-described embodiments are illustrative in all aspects and not restrictive. The scope of the present invention is defined by the appended claims rather than the detailed description, and all changes or modifications derived from the meaning and scope of the claims and their equivalents should be interpreted as being included in the scope of the present invention .

Claims (6)

Wherein the weight loss composition comprises at least one selected from the group consisting of Chinese cabbage, Chinese cabbage, Chinese cabbage, Chinese cabbage, Chinese cabbage, Chinese cabbage, Chinese cabbage,
The method according to claim 1,
10 to 20% by weight of the malt, 10 to 20% by weight of the malt, 10 to 20% by weight of the malt, 10 to 20% by weight of the malt, 10 to 20% 20 weight% of the raw meat, 10 to 20 weight% of the raw meat sauce, and 10 to 20 weight% of the raw meat.
The method according to claim 1,
Wherein each of the components is contained in the same weight.
The method according to claim 1,
Each component except for the above-mentioned magma is contained in the same weight,
Wherein the weight loss of the composition is 1 to 3 times the weight of the individual components.
The method according to claim 1,
Wherein the weight loss composition is a hot water extract.
The method according to claim 1,
Wherein the composition for weight loss is a powder or a pill which is a dried hot water extract.

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