KR20050027506A - Chegameuiintang composit for treatment of fatness and manufacturing method of the same - Google Patents

Abstract

A composition for treatment of obesity comprising medicinal herbs of Chegameuiintang and a manufacturing method thereof are provided, which composition minimizes side effects of obesity treatment including hunger, enervation, dizziness, nausea, stomach disorder and constipation as well as treats obesity. The Chegameuiintang composition for treatment of obesity comprises 30 to 50 wt.% of Rehmanniae Radix Preparata, 8 to 15 wt.% of Coix lachryma-jobi var. ma-yuen, 3 to 8 wt.% of Stephania tetrandra S.MOORE., 3 to 5 wt.% of Glycyrrhiza glabra Linne, 3 to 5 wt.% of Akebia quinata DECNE., 3 to 5 wt.% of Polyporus umbellatus FRIES., 3 to 5 wt.% of Alisma canaliculatum, 3 to 5 wt.% of Raphanus sativus var., 3 to 5 wt.% of Morus alba L., 2 to 4 wt.% of Angelica gigas Nakai, 2 to 4 wt.% of Lycium chinense Miller, 2 to 4 wt.% of Cornus officinalis Siebold et Zuccarini, 1.5 to 2.5 wt.% of Cnidium officinale Makino, 1.5 to 2.5 wt.% of Carthamus tinctorius L., 1.5 to 2.5 wt.% of Sinapis alba L., and 1 to 2 wt.% of Sisyrinchium angustifolium Miller.

Description

Cheonguiintang composit for treatment of obesity and its manufacturing method {Chegameuiintang composit for treatment of fatness and manufacturing method of the same}

The present invention relates to a yigintang composition for the treatment of obesity, and to a method for producing the same, more specifically sujijihwang and uiyiin as a main component, Banggi, licorice, neck, herb, taeksa, nabokja, baekbaekpi, Angelica, Gugija, Cornus The present invention relates to a composition of yigintang for bodily sensation treatment using an active ingredient extracted from a herbal mixture comprising cheonggung, sulphide, joiner, and sirloin as an auxiliary component.

Obesity refers to a condition in which body fat is higher than normal among water, protein, minerals, and fats that make up the human body. When excess calories are consumed by physical activity, excess calories are body fat. If it accumulates.

Obesity, by itself, causes so-called 5D phenomena such as disease, death, disfigurement, discomfort, and inability, especially those who are in an obese state for a long time Is known to be an important cause of threat to the health of modern people by causing adult diseases such as heart disease, high blood pressure, arteriosclerosis, hyperlipidemia, stroke, diabetes, fatty liver, and the like.

Obesity is associated with various factors such as energy imbalances, such as imbalances in energy consumption and consumption, hormonal changes, lack of exercise, and genetic, mental, and socioeconomic factors. It is well known that it is necessary to maintain desirable lifestyles through behavioral therapy.

In particular, there are low calorie diets (also called "LCDs") and ultra low calorie diets (also called "VLCDs"). Although there is a rapid advantage, various short-term or long-term side effects due to electrolyte, mineral deficiency, loss of body fat amount, etc. have been reported. Therefore, pharmacotherapy through herbal medicine minimizes side effects such as severe fasting, lethargy, dizziness, nausea, gastrointestinal disorders and constipation resulting from reducing the amount of meals along with the suppression of appetite caused by the use of diet, thereby activating internal functions of the body It has been reported to reduce the incidence of chronic diseases and loss of resistance caused by weight loss.

The present invention has been devised in the course of research and development for the development of herbal medicines to reduce the body fat through the treatment of the herbal while minimizing the various side effects known in the past while reducing the effects of obesity.

The technical problem to be achieved by the present invention is to minimize the side effects caused by various known medications or diets for reducing obesity, and to achieve a special effect on obesity reduction, in order to achieve such a technical problem, Contains active ingredients extracted from medicinal herb mixture containing Sukjihwang and Euiin as main ingredients, and containing assorted ingredients such as Banggi, Licorice, Keg, Garyeong, Taekja, Lokbokja, Sangbaekpi, Angelica, Gugija, Cornus, Cheongung, Sulfur, Joiner and Sirloin It is an object of the present invention to provide a yiintang composition for the treatment of obesity to use and a method for producing the same.

Yiintang composition of bodily sensation for the treatment of obesity to achieve the object of the present invention, the main components of sujijihwang and yiinin, Bangui, licorice, neck, spirits, taxa, nagyeokja, baekryepi, donkey, gojija, cornus, cheongung, sulphi Characterized by using the active ingredient extracted from the herbal mixture consisting of joiner and sirloin as a secondary component.

In this case, the sulfur content of Sukji is included 30 to 50% by weight relative to the total weight of the herbal medicine mixture, the Euiyiin is included 8 to 15% by weight relative to the total weight of the herbal medicine mixture, the airtight 3 to 8 relative to the total weight of the herbal medicine mixture The weight percent is included, the licorice, neck, herb, talc, moth, and baekpipi each contain 3 to 5% by weight based on the total weight of the herbal mixture, the donkey, wolfberry and cornus milk 2 to the total weight of the herbal mixture 4% by weight each is included, the cheonggung, safflower and joiner is 1.5 to 2.5% by weight relative to the total weight of the herbal medicine mixture, respectively, the fillet is a herbal medicine comprising 1 to 2% by weight relative to the total weight of the herbal medicine mixture It is preferable to use the active ingredient extracted from the mixture.

On the other hand, the composition for treating obesity is preferably prepared in a liquid form and used in an oral administration manner, and the liquid composition for treating obesity is more preferable if it is individually packaged in 80 to 120ml and drinking 2 to 4 times a day.

Obesity treatment yigintang composition for achieving the object of the present invention, (a) weighing each component of the herbal medicine mixture according to claim 2, and then washed with purified water and placed in the extractor; (b) adding purified water to the herbal mixture placed in the extractor; (c) heating the extractor for a predetermined time to maintain a predetermined temperature to reduce the total weight of the mixture in the extractor to a predetermined degree; And (d) separating the liquid extract from the mixture in the extractor.

At this time, the purified water added to the herbal medicine mixture in step (b) is added 1.5 to 2 times the weight of the total weight of the herbal medicine mixture before washing, and then 15 times of the initial purified water input by the heating loss step of (c) It is preferable to proceed to reduce to 35%. On the other hand, the internal temperature of the extractor of the step (c) is also preferred to proceed while heating for 1 to 4 hours to maintain 100 to 120 ℃. In addition, it is more preferable to further include the step of individually packaging the separated liquid extract in units of 80 to 120ml after the step (d).

On the other hand, since the numerically limited content is for optimizing the practice of the present invention, it is not preferable in relation to the object and effect of the present invention if it is outside the limited range, the implementation within the numerically limited range in the specific implementation is made. Special care should be taken to ensure that this is possible.

Hereinafter, specific examples will be described in more detail to help understand the present invention. However, embodiments according to the present invention may be modified in many different forms, and the scope of the present invention should not be construed as being limited to the embodiments described below. Embodiments of the present invention are provided to more completely explain the present invention to those skilled in the art.

First, the herbal medicines used in the bodily tang of the obese treatment of obesity treatment of the present invention can be easily purchased on the market, and the well-known literature on the ingredients and the use of herbs (Ilwolseok, 1991), 『Korean Herbal Paintings』 ( The pharmacological effects known through the Kyohaksa, 1998), Medicinal Herbal Botany (Hakhak Publication, 1999) and the Medicinal Herbal Medicines Standards Collection (Korea Pharmaceutical Manufacturers and Exporters Association & Korea Research Institute of Medicine, 2000) are as follows.

Rehmanniae Radix Prepaparat is used as a blood donor and is known to reduce appetite, prevent constipation in small doses, and maintain endurance. Coicis Semen is used as an endorsement medicine, and it is known to remove unnecessary water and moisture in the body, to clear blood, promote circulation, reduce appetite, and have diuretic and antibacterial effects. Bangui (Stephania tetrandra S. Moore) is known for diuretic and analgesic, it is used in neuralgia, rheumatism, arthritis and species. Licorice (Glycyrrhizae Radix) is used as an herbal medicine and is known to reduce the toxicity of Chinese medicine and reduce appetite. Akebiae Lignum is used as a diuretic disinfectant, and it is known to release the decomposed waste products into the urine and to prevent disease. Polypours are known to have diuretic and antipyretic effects. Taxa (Alisma canaliculatum) is known to diuretic, hypoglycemic, hypotensive, yellow staphylococcus aureus, pneumococcal, tuberculosis, bacillus suppression. Raphani Semen is known to promote digestive function and improve symptoms such as indigestion, bloating, planting, and gas in the stomach. MoriCortex Radicis is known to be effective in relieving coughing and asthma, reducing thirst, helping diuretic activity, and reducing bad breath in the mouth. Angelica gigantis Radix is a medicine that is used as a blood donor, has blood circulation, hematopoiesis, and is known to have diuretic, antibacterial, soothing, and antiviral effects. Gojija (Lycii Fructus) is known to clear the eyes, prevent hair loss and maintain the gloss, and enhance the sexual function. Cornus Fructus is known to relieve weakness and fatigue, and to strengthen energy, energy and endurance. In particular, it is known that there is an effect of increasing the strength of the muscle and preventing the decrease in physical strength and endurance, or the lowering of resistance to diseases, which are likely to occur when the amount of meals is drastically reduced or exercise is increased more than usual for weight loss. Cnidii Rhizoma promotes blood circulation and is known to eliminate head pain, which is likely to occur when a significant reduction in food intake for weight loss. Safflower (Carthami Flos) promotes blood circulation, Sappan Lignum is known for promoting blood circulation and removing fat and lipids in the blood. Due to the reduction, the wastes produced when large amounts of fat are broken down are efficiently discharged through urine, and it is known to have an immune boosting effect.

Production of bodily tang

Each herbal ingredient known various effects as described above were prepared by weighing a material selected in a specific amount as follows. Hwangjihwang 3kg, Euiin 1kg, Banggi 400g, licorice, tree barrel, aging, 300g for taeksa, nabokjak and baekbaekpi, 200g for Angelica, Gugija and Cornus, respectively, 150g for Cheonggung, Sulphide and Joiner, 100g .

After washing the prepared herbal medicines with purified water, and then put into a pressure vessel, 11 liters of purified water was added, and 13 liters was used when using a general water bath. In the case of manufacturing a bath in a pressure vessel, since the loss rate to water vapor is small, a small amount may be added compared to a general bath. In the case of preparing the hot water in the pressure vessel, sufficient hot water is produced by maintaining the temperature of 120 ° C. for about 4 hours. In the case of the general water spraying machine, the hot water is melted for 2 hours at the temperature of 105 ° C., and then re-heated at 105 ° C. for 1 hour. It prepared by the method. As described above, about 9 liters of the remaining liquid solution, except for the amount of vapor evaporated during the preparation of the liquid preparation, can be obtained by taking 100 liters of 3 times a day for 30 days. Can be. It is obvious that the beverage packaging can be facilitated by drinking the container packaging for 100 ㏄ for convenience.

The prepared liquid solution is preferably in liquid form, taken three times a day after meals, and after the liquid solution is taken, 100 to 200 cc of water is preferably added.

As described above, the prepared tang ui tang was commissioned by the Korea Food Research Institute and analyzed each carbon powder, crude fat, and crude protein by using the Association of difficial ananlytical chemists (AOAC) method. After calculating the amount of carbohydrates calculated by the formula, carbohydrates and protein 4g per 1g, fat was calculated as 9㎉ per 1g calories are shown in Table 1 below.

division moisture Charcoal protein Fat Final calories Iin bath of bodily sensation 83.9 0.7 1.8 0.1 62.1

Clinical trial of bodily tang

Dividing the prepared tang tang of the bodily sensation as described above into 90 packaging units per person, 54 men, 5 males and 49 females were selected as the clinical experimental group three times a day 30 minutes after meals. The sex age distribution of the clinical experimental group was as shown in Table 2 below. On the other hand, all the clinical experimental groups were allowed to perform ultra low calorie diet, and they were limited to intake of 600㎉ per day, and if they felt fasting, they allowed low-calorie vegetables, and aerobic exercise focused on breaking (Pyung-gun 250㎉) ) And 50% increase in average daily activity (250㎉ average) to consume 500㎉ calories per day. All of these clinical trial groups were prescribed for two months in parallel with the diet and exercise regimen, and their implementation was checked by bioelectrical impedence analysis.

division female male Sum Number of people ratio(%) Number of people ratio(%) Number of people ratio(%) 10 3 5.6 - - 3 5.6 20's 27 50.0 3 5.6 30 55.6 30 spaces 10 18.4 - - 10 18.4 40 spaces 5 9.3 2 3.7 7 13.0 50 spaces 4 7.4 - - 4 7.4 sub Total 49 90.7 5 9.3 54 100

Average physical characteristics of the clinical trial group immediately before the clinical trial were analyzed as shown in Table 3 below. Body weight, lean body mass (LBM) and body fat mass were measured immediately before the clinical trial and at 1 month and 2 months after the start of the clinical trial, and other factors such as obesity, body mass index (BMI), basic metabolic rate (BMR), body fat percentage and abdominal fat were measured. Rate (WHR) and the size of each part of the body (upper arm, chest, abdomen, hips, thighs) was measured separately, and then divided by gender and the average values are shown in Tables 3 and 4, respectively. On the other hand, multi-frequency, site-specific impedance measuring instrument (Inbody 2.0, Biospace Co., Ltd., Korea) was used for body composition analysis. This means that the microprocess switches the switch after the subject takes an upright position and presses the start button. While operating, the impedance measuring device measures fat-free and body fat mass by measuring the electrical resistance of each part of the human body in the right arm, left arm, torso, right leg and left leg in four frequency bands (5, 50, 250 and 500 Hz). It was.

division Overall average Female average Male average Average age (years) 30.90 30.55 34.00 Average height (cm) 161.49 160.73 168.90 Average weight (㎏) 74.46 72.09 97.68 Average Obesity Degree (PIBW,%) 136.15 134.55 151.80 Body Mass Index (BMI, ㎏ / ㎥) 28.44 27.97 33.06 Basic metabolic rate (BMR, ㎉) 1459.48 1420.31 1843.40 Lean body mass (LBM, kg) 46.90 44.90 66.44 Body fat amount (㎏) 27.56 27.19 31.24 % Of body fat 36.55 37.08 31.46 Abdominal fat percentage (WHR, kg) 0.919 0.912 0.984 Average upper arm circumference (AMC, ㎝) 22.85 22.31 28.20 Average upper circumference (cm) 32.33 31.78 37.70 Average chest measurement (cm) 96.97 95.48 111.58 Average abdominal circumference (cm) 96.39 95.15 108.52 Average hip circumference (cm) 104.34 103.55 112.06 Average thigh circumference (cm) 54.95 54.22 62.12

One month and two months after the clinical trial was in progress, the changes in the physical characteristics of the clinical trial group were observed as shown in Table 4 below.

division all female male 1 month 2 months 1 month 2 months 1 month 2 months Average weight (㎏) 66.78 62.87 64.78 61.04 86.38 80.78 Average Obesity Degree (PIBW,%) 121.98 114.96 120.71 113.88 134.40 125.60 Body Mass Index (BMI, ㎏ / ㎥) 25.44 23.92 25.05 23.57 29.24 27.32 Basic metabolic rate (BMR, ㎉) 1395.13 1375.78 1358.63 1340.51 1752.80 1721.40 Lean body mass (LBM, kg) 44.23 43.34 42.40 41.58 62.22 60.54 Body fat amount (㎏) 22.55 19.53 22.38 19.46 24.16 20.24 % Of body fat 33.27 30.54 33.89 31.19 27.24 24.18 Abdominal fat percentage (WHR, kg) 0.876 0.852 0.870 0.847 0.930 0.902 Average upper arm circumference (AMC, ㎝) 21.62 21.11 21.14 20.67 26.30 25.44 Average upper circumference (cm) 29.70 28.39 29.27 28.02 33.90 32.00 Average chest measurement (cm) 94.64 89.11 90.37 87.84 104.02 101.50 Average abdominal circumference (cm) 88.16 84.04 87.29 83.22 96.66 92.04 Average hip circumference (cm) 99.29 96.88 98.74 96.41 104.68 101.46 Average thigh circumference (cm) 51.88 50.28 51.28 49.81 57.74 54.86

Analyzing the results of the clinical trials as described above, in contrast to the data of Table 4, which are various values measured in the state 2 months after the clinical trials and the various reference values of Table 3 measured before the clinical trials, By expressing the absolute decrease and the relative decrease (expressed as a percentage) of the measured value, the specific effects of the bodily sensation of the present invention can be confirmed, and related analysis data are shown in Table 5 below.

division Overall reduction Women decline Male reduction Decrease percentage(%) Decrease percentage(%) Decrease percentage(%) Average weight (㎏) 11.59 15.57 11.05 15.32 16.90 17.30 Average Obesity Degree (PIBW,%) 21.19 15.56 20.67 15.36 26.20 17.26 Body Mass Index (BMI, ㎏ / ㎥) 4.52 15.89 4.40 15.73 5.74 17.36 Basic metabolic rate (BMR, ㎉) 83.70 5.73 79.80 5.62 122.00 6.62 Lean body mass (LBM, kg) 3.56 7.59 3.32 7.39 5.90 8.88 Body fat amount (㎏) 8.03 29.14 7.73 27.43 11.00 35.21 % Of body fat 6.01 16.44 5.889 15.88 7.28 23.14 Abdominal fat percentage (WHR, kg) 0.067 7.29 0.065 7.13 0.082 8.33 Average upper arm circumference (AMC, ㎝) 1.74 7.61 1.64 7.35 2.76 9.79 Average upper circumference (cm) 3.94 12.19 3.76 11.83 5.70 15.12 Average chest measurement (cm) 7.86 8.11 7.64 8.00 10.08 9.03 Average abdominal circumference (cm) 12.35 12.81 11.93 12.54 16.48 15.19 Average hip circumference (cm) 7.46 7.15 7.14 6.90 10.60 9.46 Average thigh circumference (cm) 4.67 8.50 4.41 8.13 7.26 11.69

As can be seen in Table 5, it can be seen that the decrease of the overall measurement is higher in the male sample group than in the female. As can be seen in Table 5 above, it can be seen that a sufficient degree of obesity reduction effect occurred to a significant degree.

Optimal embodiments of the present invention described above have been disclosed. Although specific terms have been used herein, they are used only for the purpose of describing the present invention and are not intended to limit the scope of the invention as defined in the claims or the claims.

According to the present invention, while minimizing fasting, lethargy, dizziness, nausea, gastrointestinal disorders, constipation, etc. caused by side effects in the obesity treatment process according to the conventional drug therapy to activate the internal functions of the body, chronic diet and weight loss It is desirable to present the possibility that it can be used as an effective obesity treatment agent because it can reduce the occurrence of disease or decrease the resistance. In particular, since the effect of the present invention is based on obtaining a sufficient clinical effect on a specific person, the effect thereof will be sufficiently verified objectively.

Claims (8)

It contains active ingredients extracted from medicinal herb mixture containing Sukjihwang and Euiin as main ingredients, and containing assorted ingredients such as Banggi, Licorice, Keg, Garyeong, Taeksa, Lokbokja, Sangbaekpi, Angelica, Gugija, Cornus, Cheongung, Sulfur, Joiner and Sirloin Yiintang composition of bodily sensation for obesity treatment, characterized in that it is used. The method of claim 1, The riped sulfur is 30 to 50% by weight based on the total weight of the herbal medicine mixture, the Euiin is included 8 to 15% by weight relative to the total weight of the herbal medicine mixture, the air-proof is 3 to 8% by weight relative to the total weight of the herbal medicine mixture Is included, the licorice, keg, nyok, taeksa, nabokjak and baekpipi contains 3 to 5% by weight of the total weight of the herbal medicine mixture, respectively, the Angelica, wolfberry and cornus milk is 2 to 4% by weight of the total weight of the herbal medicine mixture % Is included, respectively, the cheonggung, safflower and joiner is 1.5 to 2.5% by weight based on the total weight of the herbal medicine mixture, respectively, and the sirloin from the herbal medicine mixture comprising 1 to 2% by weight relative to the total weight of the herbal medicine mixture Eintang composition for the treatment of obesity, characterized in that using the extracted active ingredient. According to claim 2, The composition for treating obesity is a liquid composition for bodily sensation of obesity treatment, characterized in that used in the oral administration method. The composition of claim 4, wherein the liquid type obesity treatment composition is individually packaged in 80-120 ml and is drunk two to four times a day. (a) weighing each component of the herbal medicine mixture according to claim 2, and then washing with purified water and placing it in an extractor; (b) adding purified water to the herbal mixture placed in the extractor; (c) heating the extractor for a predetermined time to maintain a predetermined temperature to reduce the total weight of the mixture in the extractor to a predetermined degree; And (d) separating the liquid extract from the mixture in the extractor; a method of producing a composition of yitangtang for obesity treatment, characterized in that proceeding, including. According to claim 5, The purified water added to the herbal medicine mixture in step (b) is added 1.5 to 2 times the weight of the total weight of the herbal medicine mixture before washing, the initial step by the heating loss step (c) Method for producing a lyetang composition of bodily sensation for obesity treatment, characterized in that to proceed to reduce the amount of purified water 15 to 35%. The method of claim 5 or 6, wherein the internal temperature of the extractor of step (c) is heated for 1 to 4 hours to maintain 100 to 120 ° C, characterized in that the method for producing a lyetang composition for treating obesity. The method of claim 5, wherein after the step (d) further comprises the step of individually packaging the separated liquid extract in units of 80 to 120ml.