KR101855737B1 - Aroma composition with buleberry flavor for relaxation and uses thereof - Google Patents

Abstract

The present invention relates to a blueberries fragrance composition for relieving tension, a health functional food and a cosmetic composition for relieving tensions comprising the fragrance composition, wherein the perfume composition of the present invention contains, when perfume is inhaled, the left and right prefrontal, And Absolute Theta power spectrum (AT) in the right parietal lobe, and increase in the absolute fast alpha power spectrum (AFA) in the left and right prefrontal and left and right frontal lobes, Which is an effect of relaxation.

Description

≪ Desc / Clms Page number 2 > Aroma composition for buleberry flavor for relaxation and uses thereof,

The present invention relates to a blueberries fragrance composition for relaxation and to its use.

Food flavor is added to scent food or to eliminate odor. It is an additive that enhances the value of a product by giving it a unique personality, elegance and charm.

Food fragrances are classified into natural fragrances and synthetic fragrances depending on the origin of the fragrance. Natural fragrances are fragrances obtained from plants and animals. Natural fragrances obtained from animals include musk, civet, castorum, , Ambergris, musk rat and the like, and the natural flavors used in the present foods are mostly derived from plants. Synthetic fragrance is obtained by chemical synthesis of organic compounds.

In addition, food flavorings are classified into water-soluble flavors, oil-soluble flavors, oil-based flavors and powder flavors, depending on the solvent. The water-soluble fragrance is prepared by dissolving spice which is not soluble in water in water by using alcohol and propylene glycol (PG). It is mainly used for soft drinks, ice cream, confectionery, etc. It is characterized by high volatility. It is not suitable for use in food. Oil-soluble fragrances are fragrances dissolved in vegetable oils and synthetic oils, and dissolved in solvents with high boiling points such as PG and glycerine. The emulsion fragrance is strong in heat resistance and is used in foods which are heat treated such as cookies, candies, confectionery, etc. Generally, the flavor is weaker than the water-soluble flavor. The powder flavor is sprayed on the excipient such as natural gum and starch, , Because fragrance is surrounded by excipients, it is safe for oxidation because of low contact with air and is used in powdered foods and so on. However, there is a disadvantage that the freshness is insufficient because the heat treatment must be performed in the manufacturing process.

The fragrance composition contained in the food when the food containing the fragrant food is finely crushed or drunk is met with the air raised in the lung at the time of expiration and moves to the nasal cavity at this time, It is known that the olfactory neurons in the olfactory epithelium transmit electrical signals to the brain by sensing the perfume composition. The signals from the olfactory neurons are analyzed in the olfactory bulb, and two olfactory signal pathways (Amygdala) and the medial hypothalamus through the cerebral cortex without passing through the thalamus, and the other is the pathway through which the olfactory cortex (pyriform cortex) It is a pathway that passes through the thalamus to the cerebral cortex.

In 2014, the Food and Drug Administration's Guide to Functional Food Functional Assessment, "Can Help Strain Relief," suggests that mechanisms to determine that spices composed of volatile organic compounds in foods affect the brain include physiological Indicators, behavioral indicators, and psychological indicators. Biomarkers for functional confirmation are presented on each indicator. Serotonin, 5-hydroxy indolacetic acid, dopamine, 3,4-dihydroxy phenyl acetic acid (DOPAC) HVA (homovanillic acid), norepinephrine, cortisol, corticosteroids, salivary amylase, saliva IgA, blood pressure measurement, heart rate measurement, and brain wave measurement.

EEG, one of the biomarkers that evaluate the function of health functional foods, is an electric activity that occurs constantly in the neurons of the brain and occurs on the scalp that covers the cortex of the cerebral cortex. Electroencephalogram (EEG) is an electroencephalogram (EEG) result obtained by attaching an electrode on the scalp and inputting electrical signals generated from the brain into the brain wave system and recording the potential according to time. Can be recorded in spatiotemporal and noninvasive, continuous and simple to measure the function of the brain, and thus widely used in cognitive science, medicine, and pharmacy such as brain activity record, disease diagnosis, sleep research, and psychotherapy.

Human brainwaves have amplitudes of 5 ~ 300 μV and frequencies between 0 and 60 Hz. Delta waves (0.5 ~ 3 Hz), theta waves (4-7 Hz) It is divided into alpha (8 ~ 13 Hz), beta (14 ~ 30 Hz) and gamma wave (30 Hz and above). A slow wave is a delta wave and a seta wave having a smaller frequency than an alpha wave based on an alpha wave, and a beta wave and a gamma wave having a larger frequency than an alpha wave are called a fast wave. It is known that the sweater appears when the amplitude is high and the activity of the brain is decreased during the sleeping period, and the slow wave is low and the brain activity is promoted.

The alpha wave is a fundamental wave with a frequency of 8 ~ 13 Hz and an amplitude of 10 ~ 150 μV. It occurs mainly in arousal, stabilization, and closed state of normal adult. The Health Functional Food Functional Evaluation Guide of the Food and Drug Administration It is stated that a statistically significant increase in alpha waves in EEG measurements may help to relieve tension.

In Korea, blueberry flavors are used in various foods. However, there is no report on the influence of blueberry flavoring composition, its preparation method and blueberry flavoring composition on brain activity. Accordingly, the present invention provides a process for producing a poly (ethylene glycol), which comprises reacting triacetine, propylene glycol, raspberry ketone, ethyl maltol, ethyl butyrate, triethyl citrate, acid, and blueberry fragrances composed of 26 compounds were inhaled into the subject, and then measured by EEG. The left and right frontal lobes, left frontal and right frontal lobes, and right temporal lobes were RFA (Relative Fast Alpha power spectrum ), Increased Absolute Fast Alpha power spectrum (AFA) in the left and right prefrontal and left and right frontal lobes, and increased AT (Absolute Theta power spectrum) in the right parietal lobe. It was confirmed that it had mitigation effect.

On the other hand, Korean Patent No. 0423885 discloses a 'beverage containing a blueberry juice and a composition for promoting an alpha-brewer', but it has not been described that a blueberry flavoring has an effect on a brain wave and has a relaxation effect .

SUMMARY OF THE INVENTION The present invention has been made in view of the above-mentioned needs, and the present inventors have made intensive studies to provide a perfume composition which is prepared by using 26 compounds including triacetine and steering a blueberry- The results showed that the blueberry fragrance composition of the present invention increased the relative fast alpha power spectrum (RFA) in the left and right prefrontal regions, the left and right frontal lobes, and the right temporal lobe, Confirming that the increase of Absolute Fast Alpha power spectrum (AFA) in the left and right frontal lobes and the increase of AT (Absolute Theta power spectrum) in the right parietal lobe lead to completion of the present invention.

In order to solve the above-mentioned problems, the present invention relates to a process for the preparation of a pharmaceutical composition containing triacetine, propylene glycol, raspberry ketone, ethyl maltol, vanillin, maltol, ethyl butyrate ethyl butyrate, isoamyl acetate, triethyl citrate, acetic acid, ethyl acetate, acetal, ethyl lactate, lactic acid, isoamyl alcohol, dimethyl benzyl carbinyl butyrate, benzyl acetate, butyl acetate, ethyl propionate, propyl acetate, propyl acetate, propyl acetate, acetate, benzyl alcohol, ethyl vanillin, alpha ionone, geranyl acetate, gamma-undecalactone and butano (butano) l) as an active ingredient.

In addition, the present invention provides a health functional food for relaxation comprising the above-mentioned perfume composition.

The present invention also provides a cosmetic composition for relaxation comprising the perfume composition.

The blueberry flavoring compositions of the present invention induce an increase in RFA in the left and right prefrontal, left and right frontal lobes, and right temporal lobe via perfume inhalation and induce an increase in AFA in the left and right prefrontal and left and right frontal lobes And an increase in AT is induced in the right parietal lobe to obtain a relaxation effect. In addition, the blueberry flavoring composition of the present invention can be used not only for flavor fragrance and food flavor ingredients, but also for the development of NeuroFood capable of inducing relaxation by adding to foods.

FIG. 1 is a photograph showing a 10-20 international standard electrode attaching method showing a region where an electrode is attached to a human brain for EEG measurement.
FIG. 2 is a photograph showing an EGG cap placed on a subject's brain and measuring brain waves.
FIG. 3 shows the brain map mapping results showing changes in relative fast alpha power spectrum (RFA) before inhalation (left) and inhalation (right) of blueberry perfume.
FIG. 4 is a map of a brain map showing changes in absolute fast alpha power spectrum (AFA) before inhalation (left side) and inhalation (right side) of blueberry perfume.
Figure 5 is a map of the brain map showing changes in AT (absolute theta power spectrum) before inhalation (left) and inhalation (right) of blueberry perfume.

In order to accomplish the object of the present invention, the present invention provides a process for the production of a pharmaceutical composition comprising triacetine, propylene glycol, raspberry ketone, ethyl maltol, vanillin, maltol, ethyl But are not limited to, ethyl butyrate, isoamyl acetate, triethyl citrate, acetic acid, ethyl acetate, acetal, ethyl lactate, lactic acid, isoamyl alcohol, dimethyl benzyl carbinyl butyrate, benzyl acetate, butyl acetate, ethyl propionate, propyl acetate propyl acetate, benzyl alcohol, ethyl vanillin, alpha ionone, geranyl acetate, gamma-undecalactone, and butane (EN) Disclosed is a blueberry perfume composition for relaxation containing butanol as an active ingredient.

The blueberry flavoring composition according to one embodiment of the present invention specifically includes,

Wherein the emulsifier comprises 79.8 to 80.5% by weight of triacetin, 8 to 12% by weight of propylene glycol, 0.5 to 1.5% by weight of raspberry ketone, 0.95 to 1.05% by weight of ethyl maltol, 0.17 to 0.23% by weight of vanillin, 0.15 to 0.25% By weight of ethyl acetate, 0.7 to 0.9% by weight of acetal, 0.35 to 0.9% by weight of ethyl lactate, 0.8 to 1.2% by weight of isoamyl acetate, 0.8 to 1.2% by weight of triethyl citrate, 0.75 to 0.65 wt% of lactic acid, 0.35 to 0.45 wt% of isoamyl alcohol, 0.09 to 0.11 wt% of dimethylbenzylcarbylbutyrate, 0.09 to 0.11 wt% of benzyl acetate, 0.075 to 0.085 wt% of butyl acetate, 0.09-0.11% by weight of propylene glycol, 0.09-0.11% by weight of propyl acetate, 0.09-0.11% by weight of benzyl alcohol, 0.01-0.03% by weight of ethyl vanillin, 0.03-0.05% by weight of alphaironone, 0.015-0.025% by weight of geranyl acetate, 0.01 to 0.03% by weight undecalactone and 0.015 to 0.025% , And more specifically,

A mixture of 80% by weight of triacetin, 10% by weight of propylene glycol, 1.0% by weight of raspberry ketone, 1.0% by weight of ethyl maltol, 0.20% by weight of vanillin, 0.20% by weight of maltol, 1.0% by weight of ethyl butyrate, A mixture of 1.0% by weight of lactate, 1.0% by weight of acetic acid, 0.7% by weight of ethyl acetate, 0.8% by weight of acetal, 0.4% by weight of ethyl lactate, 0.6% by weight of lactic acid, 0.4% by weight of isoamyl alcohol, 0.1% by weight of ethyl acetate, 0.1% by weight of butyl acetate, 0.1% by weight of ethyl propionate, 0.1% by weight of propyl acetate, 0.02% by weight of ethyl vanillin, 0.04% by weight of alphaironone, 0.02% by weight of geranyl acetate, 0.02% by weight of gamma-undecalactone, and 0.02% by weight of butanol.

The blueberry fragrance composition of the present invention induces an increase in relative fast alpha power spectrum (RFA) in the left and right prefrontal regions, the left and right frontal lobes, and the right temporal lobe, and the left and right prefrontal and left and right frontal lobes And increases absolute absolute alpha power spectrum (AFA) and induces an increase in AT (absolute theta power spectrum) in the right parietal lobe to exhibit a relaxation effect.

RFA refers to the ratio of fast alpha wave in total, and AFA means absolute power of fast alpha wave. The increase of RFA and AFA is known to relieve tension in the brain by blueberry stimulation (incense suction). This means that the fast alpha wave has increased. The AT power spectrum refers to the absolute power spectral value of theta wave field, which is related to the quiet state of physical, emotional, and thought activities, and is known to provide an idea of problem solving by awakening the attention, And related to the rise of creative thinking and problem-solving abilities, it is associated with pleasant, relaxed moods and extreme arousal, and is known to occur in meditation. Thus, it can be seen that the inhalation of the blueberry flavoring composition of the present invention through the above-described EEG changes can induce the effect of relaxation.

The perfume composition may include cosmetics including perfumes, soap cleansing products including bath soaps, indoor cleaning products including glass cleaners, aroma products including car perfumes, bath products including herbal bath salts, stationery Such as perfumes, fragrances, perfumes for offices, perfumes for office use, or industrial products containing synthetic resins.

The formulation of the perfume composition is not particularly limited, but may be any one selected from powders, granules, liquid spray, solid and gel type formulations.

The present invention also provides a health functional food for relaxation comprising the blueberry flavoring composition of the present invention.

The health functional food may contain various nutrients, vitamins, minerals (electrolytes), synthetic and natural flavors, colorants and enhancers (cheese, chocolate etc.), pectic acid and its salts, alginic acid and its salts, pH adjusting agents, stabilizers, preservatives, glycerin, alcohols, carbonating agents used in carbonated drinks, and the like. It may also contain flesh for the production of natural fruit juices and vegetable drinks. These components may be used independently or in combination.

The health functional food of the present invention may contain various flavors or natural carbohydrates as an additional ingredient. The natural carbohydrates are sugar saccharides such as monosaccharides such as glucose and fructose, disaccharides such as maltose and sucrose, polysaccharides such as dextrin and cyclodextrin, xylitol, sorbitol and erythritol. Examples of sweeteners include natural sweeteners such as tau martin and stevia extract, synthetic sweeteners such as saccharin and aspartame, and the like.

The present invention also provides a cosmetic composition for relaxation comprising the blueberry flavoring composition of the present invention.

The cosmetic composition of the present invention can be used for cosmetics such as softening lotion, convergent lotion, nutritional lotion, nutrition lotion, nutrition essence, nutritional cream, massage cream, essence, eye cream, eye essence, cleansing cream, cleansing foam, cleansing water, , A body lotion, a body cream, a body oil, a body essence, a lotion, an ointment, a gel, a cream, a patch, and a spray.

Hereinafter, the present invention will be described in detail by way of examples. However, the following examples are illustrative of the present invention, and the present invention is not limited to the following examples.

Example 1. Sample preparation

Propylene glycol, raspberry ketone, ethyl maltol, vanillin, maltol, xanthan gum, and the like, which are used to make the blueberry flavoring used in the present invention, But are not limited to, ethyl butyrate, isoamyl acetate, triethyl citrate, acetic acid, ethyl acetate, acetal, ethyl lactate, But are not limited to, lactic acid, isoamyl alcohol, dimethyl benzyl carbinyl butyrate, benzyl acetate, butyl acetate, ethyl propionate, But are not limited to, propyl acetate, benzyl alcohol, ethyl vanillin, alpha ionone, geranyl acetate, gamma-undecalacto ne) and butanol were provided by Food Aroma Company of Seoul, Korea.

In the present example, the samples for research were used for steering blueberry flavoring while being stored in a refrigerator at 4 ° C as soon as they were provided.

Example 2. Development and Preference Survey of Blueberry Scent

2-1. Blueberry incense spice steering

To control the blueberry flavoring, the compounds mentioned in Example 1 were mixed as shown in the following Table 1 to develop eight combined flavors.

Blueberry flavor combination Spice (unit:%) Perfume composition Combination Spices 1 Combination Spices 2 Combination Spices 3 Combination Spices 4 Combination Spices 5 Combination Spices 6 Combination Spices 7 Combination Spices 8 Butanol 0.00 0.00 0.00 0.01 0.01 0.02 0.02 0.02 Gamma-undecalactone
(gamma-undecalactone) 0.02 0.02 0.02 0.02 0.02 0.02 0.02 0.02 Geranyl acetate
(geranyl acetate) 0.00 0.00 0.00 0.01 0.01 0.02 0.02 0.02 Alpha ionone 0.00 0.00 0.01 0.01 0.02 0.02 0.04 0.04 Ethyl vanillin 0.02 0.02 0.02 0.02 0.02 0.02 0.02 0.02 Benzyl alcohol 0.00 0.02 0.03 0.04 0.05 0.06 0.08 0.10 Propyl acetate
(propyl acetate) 0.00 0.02 0.03 0.04 0.05 0.06 0.08 0.10 Ethyl propionate
(ethyl propionate) 0.00 0.02 0.03 0.04 0.05 0.06 0.08 0.10 Butyl acetate
(butyl acetate) 0.01 0.02 0.03 0.04 0.05 0.06 0.07 0.08 Benzyl acetate
(benzyl acetate) 0.01 0.02 0.03 0.04 0.05 0.06 0.08 0.10 Dimethylbenzylcarbylbutyrate
(dimethyl benzyl carbinyl butyrate) 0.01 0.02 0.03 0.04 0.05 0.06 0.08 0.10 Isoamyl alcohol
(isoamyl alcohol) 0.10 0.10 0.20 0.20 0.30 0.30 0.40 0.40 Lactic acid 0.10 0.10 0.25 0.25 0.50 0.50 0.60 0.60 Ethyl lactate 0.80 0.80 0.70 0.70 0.50 0.50 0.40 0.40 Acetal 2.00 2.00 1.50 1.50 1.00 1.00 0.80 0.80 Ethyl acetate
(ethyl acetate) 5.60 5.60 2.80 2.80 1.40 1.40 0.70 0.70 Acetic acid 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 Triethyl citrate
(triethyl citrate) 0.02 0.03 0.04 0.05 0.06 0.07 0.08 1.00 Isoamyl acetate
(isoamyl acetate) 0.02 0.03 0.04 0.05 0.06 0.07 0.08 1.00 Ethyl butyrate
(ethyl butyrate) 0.02 0.03 0.04 0.05 0.06 0.07 0.08 1.00 Maltol 0.20 0.20 0.20 0.20 0.20 0.20 0.20 0.20 Vanillin 0.00 0.02 0.04 0.06 0.08 0.10 0.15 0.20 Ethyl maltol 0.20 0.40 0.50 0.60 0.70 0.80 0.90 1.00 Raspberry ketone 8.00 7.00 6.00 5.00 4.00 3.00 2.00 1.00 Propylene glycol 10.00 10.00 10.00 10.00 10.00 10.00 10.00 10.00 Triacetine 71.87 72.53 76.46 77.23 79.76 80.53 82.02 80.00 total 100 100 100 100 100 100 100 100

2-2. Consumer preference survey on blueberry flavor combination fragrance 1-8

Consumer preference studies were conducted to investigate consumer responses to the combined fragrances 1-8. 10 of Rose of Sharon panel of Kangwon National University, which had olfactory training for fragrance, were soaked with a sponge (0.5 cm x 5 cm) of combined fragrance 1 ~ 8, placed 5 cm from the nose of the panel, And then given 10 points to the most preferred flavor and 1 point to the least favorite flavor using the 1 to 10 olfactory preference system. The results of the preference survey are shown in Table 2 below. The highest consumer preference was blueberry fragrance 8 and the average value was 9.10. The average value of the other seven combined perfumes was significantly lower than that of blueberry flavoring 8, so that the effect of blueberry flavoring of Example 3 on EEG was performed with blueberry flavoring 8.

Consumer Preference Survey on 8 Blueberries Combination Spices Consumer number Blueberry incense combination spices One 2 3 4 5 6 7 8 One 2 2 4 3 6 6 8 10 2 6 3 5 8 7 6 6 10 3 5 6 3 4 7 5 6 9 4 3 3 4 5 6 6 7 10 5 4 4 4 4 4 5 6 8 6 5 3 4 5 6 7 7 10 7 5 4 5 7 8 5 5 9 8 6 4 3 5 5 6 6 8 9 8 3 3 5 6 8 8 10 10 6 2 4 3 7 6 5 7 Average 5.00 3.40 3.90 4.90 6.20 6.00 6.40 9.10

Example 3: Analysis of effect of blueberry flavoring on EEG

The blueberry flavor combination fragrance 8 (hereinafter, "blueberry flavor fragrance"), which had the highest consumer preference through Example 2, was selected, and the brain waves were measured by knowing how the blueberry flavoring had an effect on the human brain activity Respectively.

EEG measurements were performed on a total of 20 subjects, 10 of each male and female, in a laboratory of 32.4 m ^{2 in} which the noise was not mixed and the temperature was maintained at 23 ° C and 50% humidity. The brain waves were measured using a QEEG-8 system (LXE3208, LAXTHA Inc. Korea). EEG data were collected using LAXTHA's data collection equipment and analysis program (Telescan). 8 electrodes were connected to the left and right prefrontal cords (Fp1, Fp2) using Electro-Gel (Electro-Cap Internationals, Inc. USA) One electrode (Covidien ^™ ) was attached to the left and right frontal lobes (F3 and F4), left and right temporal lobes (T3 and T4), left and right parietal lobes (P3 and P4) (Fig. 2). (100%) was soaked in a tissue paper (0.5 cm x 5 cm), placed at a position 5 cm from the nose of the subject, and the incense was taken. Then, And an inhalation state (fragrance stimulation).

Only EEG data of the middle 30 seconds except for the data of 5 seconds in the first half and 10 seconds in the latter half of the data obtained by EEG measurement were extracted and processed by batch processing of brain waves, and statistical analysis software program SPSS (version 18.0) To perform a corresponding sample T test.

Table 3 shows the types of EEG indicators for data analysis obtained before inhalation (irritation) and during inhalation (incense stimulation) of blueberry flavoring in this example, and the meanings of the EEG indices are shown in Table 4.

Types of EEG indicators used in data analysis No. Analysis index Full name of EEG indicator Waveband (Hz) One AT Absolute Theta Power Spectrum 4 to 8 2 AA Absolute Alpha Power Spectrum 8-13 3 AB Absolute Beta Power Spectrum 13 to 30 4 AG Absolute Gamma Power Spectrum 30 to 50 5 AFA Absolute Fast Alpha Power Spectrum 11-13 6 ASA Absolute Slow Alpha Power Spectrum 8 ~ 11 7 ALB Absolute Low Beta Power Spectrum 12 to 15 8 AMB Absolute Mid Beta Power Spectrum 15-20 9 AHB Absolute High Beta Power Spectrum 20 ~ 30 10 RT Relative Theta Power Spectrum (4 to 8) / (4 to 50) 11 RA Relative Alpha Power Spectrum (8 to 13) / (4 to 50) 12 RB Relative Beta Power Spectrum (13 to 30) / (4 to 50) 13 RG Relative Gamma Power Spectrum (30 to 50) / (4 to 50) 14 RFA Relative Fast Alpha Power Spectrum (11 to 13) / (4 to 50) 15 RSA Relative Slow Alpha Power Spectrum (8 to 11) / (4 to 50) 16 RLB Relative Low Beta Power Spectrum (12 to 15) / (4 to 50) 17 RMB Relative Mid Beta Power Spectrum (15 to 20) / (4 to 50) 18 RHB Relative High Beta Power Spectrum (20 to 30) / (4 to 50) 19 RST Ratio of SMR to Theta (12 to 15) / (4 to 8) 20 RMT Ratio of Mid Beta to Theta (15 to 20) / (4 to 8) 21 RSMT Ratio of (SMR-Mid Beta) to Theta (12 to 20) / (4 to 8) 22 RAHB Ratio of Alpha to High Beta (8 to 13) / (20 to 30) 23 SEF50 Spectral Edge Frequency 50% 4 to 50 24 SEF 90 Spectral Edge Frequency 90% 4 to 50 25 ASEF Spectral Edge Frequency 50% of Alpha Spectrum Band 8-13

Meaning of EEG indices used in data analysis No. Analysis index meaning One AT Absolute power of theta wave (meditation, sleepy) 2 AA Absolute power of Alpha wave (relaxation, stability) 3 AB The absolute power of Beta waves (tension, arousal, activity, cognitive function) 4 AG Absolute power of the Gamma wave (highly cognitive or anxious, excited) 5 AFA Fast alpha Absolute power of wave (comfortable and immersive) 6 ASA Absolute power of Slow alpha wave (relaxation) 7 ALB Absolute power of the low beta wave, SMR parameter (caution or boundary) 8 AMB Mid beta wave absolute power (concentration, attention) 9 AHB High beta Absolute power (stress, mental load, tension) 10 RT Percentage of theta waves in total 11 RA The ratio of Alpha waves in total 12 RB The ratio of Beta waves in total 13 RG Percentage of Gamma waves in total 14 RFA The percentage of Fast Alpha waves in total 15 RSA Slow Alpha ratio in all 16 RLB The ratio of Low Beta waves in total 17 RMB Percentage of Mid Beta waves in total 18 RHB The ratio of High Beta waves in total 19 RST The ratio of theta wave in SMR wave 20 RMT The ratio of theta wave in Mid Beta wave 21 RSMT SMR ~ Mid Beta wave / Theta wave (EEG concentration indicator) 22 RAHB Alpha wave / High Beta wave (stable and relaxed) 23 SEF50 Median Frequency Brain activity (EEG) 24 SEF 90 Median Frequency Brain activity (mental stress, stress) 25 ASEF Alpha SEF50 (Comfort: Fast Alpha wave)

In the present embodiment, EEG was measured before and after inhalation of blueberry flavoring (intact stimulation) and power spectral analysis was performed. As a result, the relative fast alpha power spectrum (RFA) fast alpha power spectrum and AT (absolute theta power spectrum) were statistically significant (p <0.05). The remaining 22 power spectra are not described in this embodiment because no difference is found.

The RFA power spectrum of 20 subjects was significantly increased in the left prefrontal (Fp1) and right prefrontal (Fp2), left frontal (F3), right frontal (F4), and right temporal (T4) The power spectral change is shown in Table 5 and the brain mapping result is shown in FIG. RFA is the ratio of the absolute power of each frequency based on the absolute power of the whole frequency band in the EEG spectrum. It is the relative frequency of the relative frequency divided by the entire frequency range (4 ~ 50 Hz) Power spectral value.

As shown in Table 5, inhalation of blueberry flavoring in the present embodiment is broadly classified into fast alpha (Fp1), fulminant (Fp2), left frontal (Fp2), left frontal (F3), right frontal And the tensions of the subjects were alleviated. In the present example, the prefrontal cortex stimulated by the inhalation of blueberry flavor is known as the non-motor area of the frontal cortex, which is known to be the most conspicuous cognitive part in human and occupies about 1/3 of the whole cortex. The prefrontal cortex can be used to initiate activities, plan, maintain key information, change sets from one thought to another, monitor their behavioral effects, explore and resolve conflicting elements of planning, and inhibit ineffective planning or behavior. Is known to be responsible for. And the frontal lobe is the area that controls other parts of the brain. It is the area where attention is focused, language, memory, space time ability, exercise function, executive function, personality and emotion, emotion recognition, reasoning and judgment, action plan, (Carter et al . (2009) The Human Brain Book, DK Publishing Co. Ltd. p.256). In addition, the inhalation of blueberry flavoring increased the RFA power spectrum of the right temporal lobe (T4) region. The right temporal lobe (T4) region functions as a personal memory and language, and when activated, realizes something and demonstrates its creativity (2008) Analysis of changes in EEG according to the moxibustion stimulation method of oriental medicine.

Brain mapping was performed to visualize the RFA changes before and after inhalation of the blueberry flavor perfume. The left prefrontal cortex (Fp1), the right prefrontal cortex (Fp2), the left frontal cortex (F3) And the left frontal lobe (F3) area was changed from deep blue to inhaled light green, and the right temporal lobe (T4) area changed from pale yellowish red to inhaled deep red before inhalation (Fig. 3) .

Changes in RFA before inhalation of blueberry flavoring perfume and during inhalation RFA (Relative Fast Alpha Power Spectrum) Brain location Suction state Number of subjects Average Standard Deviation t-test Significance ( p ) Left prefrontal cortex
(Fp1) Before inhalation 20 0.092 0.095 -2.603 0.017 Inhalation 20 0.122 0.129 Right frontal lobe
(Fp2) Before inhalation 20 0.089 0.093 -2.567 0.018 Inhalation 20 0.121 0.129 Left frontal lobe
(F3) Before inhalation 20 0.101 0.115 -2.421 0.025 Inhalation 20 0.127 0.138 Right frontal lobe
(F4) Before inhalation 20 0.094 0.102 -3.165 0.005 Inhalation 20 0.128 0.135 Left temporal lobe
(T3) Before inhalation 20 0.118 0.115 -0.404 0.690 Inhalation 20 0.121 0.120 Right temporal lobe
(T4) Before inhalation 20 0.084 0.073 -2.100 0.049 Inhalation 20 0.107 0.108 Left parietal lobe
(P3) Before inhalation 20 0.172 0.129 -1.181 0.252 Inhalation 20 0.186 0.141 Right parietal lobe
(P4) Before inhalation 20 0.158 0.106 -1.579 0.130 Inhalation 20 0.181 0.135

AFA of 20 subjects showed a significant increase in the left prefrontal (Fp1), right prefrontal (Fp2), left frontal (F3) and right frontal (F4) areas by inhalation of blueberry flavor. The AFA changes are shown in Table 6 below and the brain map mapping results are shown in FIG. AFA has been associated with an increase in fast alpha waves, and fast alpha waves are known to relieve tension. The results of the increase in AFA in the brain area responsible for cognitive function by inhalation of blueberry flavor fragrance show that the subjects' tensions are relaxed.

In order to visually confirm AFA changes before and after inhalation of blueberry flavorings, brain mapping was performed. The left frontal lobe (Fp1) and the right frontal lobe (Fp2), the left frontal lobe (F3) (F4) area was light blue before the perfume was inhaled, and turned to light green during inhalation (FIG. 4).

Changes in AFA before inhalation of blueberry flavoring fragrance and during inhalation Absolute Fast Alpha Power Spectrum (AFA) Brain location Suction state Number of subjects Average Standard Deviation t-test Significance ( p ) Left prefrontal cortex
(Fp1) Before inhalation 20 6.680 7.280 -2,279 0.034 Inhalation 20 8.728 10.232 Right frontal lobe
(Fp2) Before inhalation 20 6.185 7.089 -2.336 0.031 Inhalation 20 8.158 9.797 Left frontal lobe
(F3) Before inhalation 20 8.624 10.357 -2.387 0.028 Inhalation 20 11.205 13.504 Right frontal lobe
(F4) Before inhalation 20 7.376 8.995 -2.762 0.012 Inhalation 20 10.330 12.673 Left temporal lobe
(T3) Before inhalation 20 7.118 7.227 -0.353 0.728 Inhalation 20 7.267 7.146 Right temporal lobe
(T4) Before inhalation 20 3.233 3.061 -1.571 0.133 Inhalation 20 3.979 4.280 Left parietal lobe
(P3) Before inhalation 20 15.518 14.011 -0.940 0.359 Inhalation 20 16.645 14.145 Right parietal lobe
(P4) Before inhalation 20 11.436 9.641 -1.399 0.178 Inhalation 20 13.174 11.875

In addition, the AT power spectrum of 20 subjects was increased in the right parietal lobe (P4) by inhalation of blueberry flavoring (Table 7). The AT power spectrum refers to the absolute power spectral value of theta wave field (4 to 8 Hz), which is related to the quiet state of physical, emotional, and thought activities, and is known to provide an idea of problem solving And related to the deep insights of human beings and related to the rise of creative thinking and problem-solving abilities, there are also features related to pleasant and relaxed moods and extreme awakening, and appearing in meditation state (2014) Brain scientific understanding of mind and body healing through Buddhist meditation. Buddhist Journal 68: 24-49).

In order to visually confirm the change of the AT power spectrum before and after the inhalation of the blueberry flavoring, brain mapping mapping showed that the right parietal region (P4) was dark green before inhalation, (Fig. 5).

Changes in AT pau spectra before inhalation of blueberry flavoring and inhalation AT (Absolute Theta Power Spectrum) Brain location Suction state Number of subjects Average Standard Deviation t-test Significance ( p ) Left prefrontal cortex
(Fp1) Before inhalation 20 13.492 6.654 -0.151 0.881 Inhalation 20 13.642 9.058 Right frontal lobe
(Fp2) Before inhalation 20 12.505 7.191 -0.732 0.473 Inhalation 20 13.286 9.713 Left frontal lobe
(F3) Before inhalation 20 17.157 9.080 -0.593 0.560 Inhalation 20 18.054 13.101 Right frontal lobe
(F4) Before inhalation 20 15.488 9.816 -0.774 0.448 Inhalation 20 16.453 13.194 Left temporal lobe
(T3) Before inhalation 20 10.674 5.044 -0.743 0.466 Inhalation 20 11.422 7.283 Right temporal lobe
(T4) Before inhalation 20 5.866 5.227 -1.894 0.074 Inhalation 20 6.599 6.659 Left parietal lobe
(P3) Before inhalation 20 14.482 8.502 -1.513 0.147 Inhalation 20 17.365 14.946 Right parietal lobe
(P4) Before inhalation 20 11.823 8.767 -2.191 0.041 Inhalation 20 12.971 9.904

Based on the above results, it was found that the blueberry flavoring of the present invention can induce a change of EEG through inhalation to show the effect of relaxation.

Claims (8)

A mixture of 79.8 to 80.5% by weight of triacetine, 8 to 12% by weight of propylene glycol, 0.5 to 1.5% by weight of raspberry ketone, 0.95 to 1.05% by weight of ethyl maltol, 0.1 to 0.23 wt% of maltol, 0.1 to 0.25 wt% of maltol, 0.8 to 1.2 wt% of ethyl butyrate, 0.8 to 1.2 wt% of isoamyl acetate, triethyl citrate, 0.8 to 1.2% by weight of acetic acid, 0.5 to 1.5% by weight of acetic acid, 0.5 to 1.0% by weight of ethyl acetate, 0.7 to 0.9% by weight of acetal and 0.35 to 0.45 of ethyl lactate 0.55 to 0.65% by weight of lactic acid, 0.35 to 0.45% by weight of isoamyl alcohol, 0.09 to 0.11% by weight of dimethylbenzyl carbinyl butyrate, 0.09 to 0.11% by weight of benzyl acetate, 0.09% 0.11% by weight, butyl acetate 0.075-0.085% by weight, ethyl propionate e) from 0.09 to 0.11% by weight of propyl acetate, 0.09 to 0.11% by weight of propyl acetate, 0.09 to 0.11% by weight of benzyl alcohol, 0.01 to 0.03% by weight of ethyl vanillin, ) 0.03 to 0.05% by weight, geranyl acetate 0.015 to 0.025% by weight, gamma-undecalactone 0.01 to 0.03% by weight and butanol 0.015 to 0.025% by weight as active ingredients Wherein the composition further comprises at least one compound selected from the group consisting of: delete The perfume composition of claim 1, wherein the perfume composition increases the relative fast alpha power spectrum (RFA) in the left and right prefrontal regions, the left and right frontal lobes, and the right temporal lobe, alpha power spectrum and increasing the absolute theta power spectrum (AT) in the right parietal lobe. The perfume composition according to claim 1, wherein the formulation of the perfume composition is any one of powder, granule, liquid spray, solid and gel type. A health functional food for relaxation comprising a perfume composition according to any one of claims 1, 3 and 4. The cosmetic composition according to claim 5, further comprising at least one selected from the group consisting of vitamins, minerals, flavors, colorants, pectic acid and salts thereof, alginic acid and salts thereof, organic acids, protective colloid thickening agents, pH adjusting agents, stabilizers, And a carbonating agent for use in alcohol and carbonated beverages. &Lt; RTI ID = 0.0 &gt; 11. &lt; / RTI &gt; A cosmetic composition for relaxation comprising a perfume composition according to any one of claims 1, 3 and 4. The cosmetic composition according to claim 7, wherein the cosmetic composition is at least one selected from the group consisting of softening agents, astringent lotion, nutritional lotion, nutritional lotion, nutritional essence, nutritional cream, massage cream, essence, eye cream, eye essence, cleansing cream, cleansing foam, Wherein the composition has a formulation selected from the group consisting of gels, powders, makeup bases, body lotions, body creams, body oils, body essences, lotions, ointments, gels, creams, patches and sprays.

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