KR102151758B1 - Aromatic aroma composition for enhancing concentration of human brain and uses thereof - Google Patents

Abstract

The present invention relates to a perfume composition for increasing concentration, a health functional food and cosmetic composition for increasing concentration including the perfume composition and a method for preparing a perfume mixture having an effect of increasing concentration, and a perfume mixture having an effect of increasing concentration prepared by the method As such, the fragrance composition of the present invention has an increase in RG (relative gamma power spectrum) in the central and right frontal lobes, an increase in RLB (relative low beta power spectrum) in the central and right frontal lobes, and SEF50 (Spectral edge) in the right frontal lobe frequency 50%) increases and has an effect of strengthening concentration.

Description

Aromatic aroma composition for enhancing concentration of human brain and uses thereof

The present invention relates to a perfume composition for increasing concentration, a health functional food and cosmetic composition for increasing concentration including the perfume composition and a method for preparing a perfume mixture having an effect of increasing concentration, and a perfume mixture having an effect of increasing concentration prepared by the method will be.

Perfume is a product obtained by diluting essential oils, a raw material of volatile fragrance compounds, with ethanol. The fragrances used to make them are divided into natural fragrances and synthetic fragrances. Natural fragrances are divided into animal fragrances obtained from animals and plant fragrances obtained from plants. Animal flavors include ambergris from sperm whales, musk from musk deer, vivette from musk cats, and castorium from beavers, but these days are not used well. Plant fragrances can be obtained by distilling, extracting, and compressing flowers, leaves, fruits, seeds, resins, roots, and stems of about 1,500 kinds of plants, but the purity is low, and the scent change is severe during extraction and distillation. Depending on the region, harvest time and post-harvest storage method, the intensity and quality vary greatly, and supply uncertainty is large, so about 200 species are currently on the market.

Organic-synthetic fragrances can be obtained through organic synthesis in a laboratory. They are more pure than natural fragrances, so they are cheap to use, are stable, have a long shelf life, have a high concentration, and have no problems with seasonal supply, so they are mostly preferred in the fragrance industry. . Representative examples of organic synthetic fragrances include aldehydes used in Chanel No.5.

Each fragrance represents a unique and unique fragrance, which is called a fragrance or note. Flavor is generally citrus, floral, green, fruity, aldehyde, oriental, spicy, woody, psypre, and Denoted as fougere, marine, and gourmand. Mixing several flavors changes the scent of each flavor. Mixing several single flavors is called scent, and through this, you can make a combination fragrance product with a variety of flavors. Combination fragrances are divided into fragrance (fragrance) and flavor (food fragrance) depending on the purpose. According to the content of essential oils, fragrances are named perfume (15-30%), eau de parfum (15-18%), eau de toilette (4-8%), and eau de cologne (3-5%). It is distinguished. In general, when you want to make a new fragrance product by mixing combination fragrances, the top note that the fragrance immediately appears when sprayed, the middle note that shows the characteristics of the fragrance well, and the last note that gives depth and volume to the fragrance must be in harmony with each other.

When humans inhale perfume, scent molecules move along the nasal cavity and bind to olfactory receptors, generating electrical signals. When the electrical signal generated at this time is transmitted to the cerebral cortex along the olfactory tract in the olfactory bulb, the brain is activated. Smell molecules contained in perfume are known to affect the human brain to change brain waves and induce physiological and psychological changes.

When the cerebral cortex is activated by a certain stimulus, brain waves are generated, which are electrical signals generated between neurons in the nervous system of the human cerebral cortex. Electrodes that can amplify cerebral electrical activity are attached to the scalp, and the obtained waveform is recorded as a graph and analyzed. EEG, an electrical signal generated by the brain's autonomous activity, records and observes the activity of the brain. It is used as an indicator of human psychophysiological functions such as arousal, activity, anxiety and stability. Since EEG has the advantage of being able to record and measure objectively, non-invasively, and continuously, it is used in cognitive science, medicine, pharmacy, and criminal investigations.

EEG mainly shows a frequency of 0 to 60 Hz and an amplitude of 5 to 300 uV, depending on the frequency range, delta wave (0 to 4 Hz), theta wave (4 to 8 Hz), alpha wave (8 to 13 Hz), beta It is divided into wave (13~30 Hz) and gamma wave (30~50 Hz). Delta waves and theta waves are slow waves and appear when you think and act using information inside your brain. Beta waves higher than Alpha waves are fast waves. In EEG analysis, not only absolute power, but also relative power, which can reduce individual differences such as skull thickness difference, scalp electrical state, and tension, and analyze accurate EEG responses, are used.

Korean Patent Registration No.1349592 discloses a combination perfume composition that relaxes the mind and body and induces stability, and Korean Patent Publication No. 2012-0131970 discloses a perfume composition having stress relief and soothing effects, but the brain of the present invention It is different from the aromatic fragrance composition that improves the concentration of the body.

The present invention was derived from the above requirements, and the inventors of the present invention provide dihydro myrcenol, linalul, linalyl acetate, methyl pamplemos, verdox, ethyl linalul, beta ionone, cedrember, lilyal, Isoi Super, Calon, Ambrofix, Cis-3-Hexenyl Silicylate, Hedione, Galaxolide, Tonalide, Helional, Bakdanol, Lemon Oil, Cedarwood Oil, Rosemary Oil, Bergamot Oil, D A fragrance composition containing 24 substances of propylene glycol and black pepper oil showed an increase in the relative gamma power spectrum (RG) in the central and right frontal lobe, and the relative low beta power spectrum (RLB) in the central and right frontal lobe. , By confirming inducing an increase in SEF50 (Spectral edge frequency 50%) in the right frontal lobe, the present invention was completed.

In order to solve the above problems, the present invention provides dihydro myrsenol, linalul, linalyl acetate, methyl pamplemos, verdox, ethyl linalul, beta ionone, cedrember, lilial, isoi super, calon, Ambrofix, cis-3-hexenyl silicylate, hedione, galaxolide, tonalide, helional, bakdanol, lemon oil, cedarwood oil, rosemary oil, bergamot oil, dipropylene glycol and black pepper oil It provides a perfume composition for increasing concentration containing the mixed perfume mixture as an active ingredient.

In addition, the present invention provides a health functional food for increasing concentration comprising the fragrance composition.

In addition, the present invention provides a cosmetic composition for increasing concentration comprising the perfume composition.

In addition, the present invention is dihydro myrsenol, linalul, linalyl acetate, methyl pamphlemos, verdox, ethyl linalul, beta ionone, cedrember, lilial, isoi super, calon, ambrofix, cis -3-Hexenyl silicylate, hedione, galaxolide, tonalide, helional, bakdanol, lemon oil, cedarwood oil, rosemary oil, bergamot oil, dipropylene glycol and black pepper oil It provides a method for producing a flavor mixture having a concentration increasing effect, characterized in that.

In addition, the present invention provides a fragrance mixture having an effect of increasing concentration prepared by the above method.

The perfume composition of the present invention increases the relative gamma power spectrum (RG) in the central frontal lobe and the right frontal lobe, increases the RLB (Relative low beta power spectrum) in the central frontal lobe and the right frontal lobe, and SEF50 in the right frontal lobe. (Spectral edge frequency 50%) can be increased to increase concentration. In addition, the fragrance composition of the present invention can be used as a raw material such as fragrance and food flavor, so it can be used not only in a variety of products for the fragrance industry, but also added to food to increase concentration. NeuroFood) can also be used.

1 is a photograph showing a 10-20 international standard electrode attachment method showing a region where electrodes are attached to a human brain for EEG measurements.
FIG. 2 is a photograph showing an electroencephalogram (EEG) cap on a subject's brain and measuring an EEG.

In order to achieve the object of the present invention, the present invention is dihydro myrcenol (dihydro myrcenol), linalool (linalool), linalyl acetate (linalyl acetate), methyl pamplemousse (methyl pamplemousse), verdox (verdox), Ethyl linalool, beta ionone, cedramber, lilial, iso e super, calone, ambrofix, cis -3-hexenyl salicylate (cis-3-hexenyl salicylate), hedione, galaxolide (50 ipm), tonalide (helional), bacdanol (bacdanol), A flavoring mixture of lemon oil, cedarwood oil, rosemary oil, bergamot oil, dipropylene glycol and black pepper oil It provides a fragrance composition for increasing concentration containing as an active ingredient.

In the perfume composition of the present invention, the perfume mixture is preferably dihydro myrcenol 2.2 to 2.8 wt%, linalool 0.8 to 1.2 wt%, linalyl acetate 0.8 to 1.2 wt% %, methyl pamplemousse 2.3~2.7 wt%, verdox 2.8~3.2 wt%, ethyl linalool 1.3~1.7 wt%, beta ionone 2.8~3.2 Wt%, Cedramber 1.7~2.1 wt%, lilial 7.7~8.3 wt%, isoe super 9.2~9.8 wt%, Calone 0.35~0.45 wt%, cancer Brofix 1.8 to 2.2 wt%, cis-3-hexenyl salicylate 3.3 to 3.7 wt%, hedione 10 to 11 wt%, galaxolide 50 ipm) 9.5 to 10.5 wt%, tonalide 3.5 to 4.5 wt%, helial 0.4 to 0.6 wt%, bacdanol 0.8 to 1.2 wt%, lemon oil 4.7 to 5.3 wt%, cedarwood oil 0.8~1.2 wt%, rosemary oil 0.8~1.2 wt%, bergamot oil 0.8~1.2 wt%, dipropylene glycol 25~ It may be composed of 26.5% by weight and 0.4 to 0.6% by weight of black pepper oil,

More preferably dihydro myrcenol (dihydro myrcenol) 2.5% by weight, linalool (linalool) 1% by weight, linalyl acetate (linalyl acetate) 1% by weight, methyl pamplemousse (methyl pamplemousse) 2.5% by weight, Burdox (verdox) 3 wt%, ethyl linalool 1.5 wt%, beta ionone 3 wt%, cedramber 1.9 wt%, lilial 8 wt%, isoi super (iso e super) 9.5 wt%, calone 0.4 wt%, ambrofix 2 wt%, cis-3-hexenyl salicylate 3.5 wt%, hedione (hedione) 10.5% by weight, galaxolide (50 ipm) 10% by weight, tonalide (tonalide) 4% by weight, helional (helional) 0.5% by weight, bacdanol (bacdanol) 1% by weight, lemon oil (lemon oil) 5% by weight, cedarwood oil 1% by weight, rosemary oil 1% by weight, bergamot oil 1% by weight, dipropylene glycol 25.7% by weight and black pepper Oil (black pepper oil) may be made of 0.5% by weight.

The fragrance composition of the present invention has an increase in RG (relative gamma power spectrum) in the central and right frontal lobes, an increase in RLB (relative low beta power spectrum) in the central and right frontal lobes, and SEF50 (Spectral edge frequency 50) in the right frontal lobe. %) to increase concentration.

RG means the ratio of Gamma waves among the total, and Gamma waves are known to be activated during highly cognitive actions such as reasoning and judgment. RLB refers to the ratio of low beta waves in the whole, and beta waves appear when you perform general tasks or conscious actions, and are activated when there is mental activity. SEF50 means a specific frequency value in which the area up to a specific frequency value occupies 50% of the area for the frequency domain.

The present invention also provides a health functional food for increasing concentration comprising a perfume composition.

The health functional food includes various nutrients, vitamins, minerals (electrolytes), synthetic and natural flavoring agents, coloring agents and enhancers (cheese, chocolate, etc.), pectic acid and salts thereof, alginic acid and salts thereof, organic acids, protective colloidal thickeners, It may contain pH adjusters, stabilizers, preservatives, glycerin, alcohols, carbonates used in carbonated beverages, and the like. In addition, it may contain pulp for the manufacture of natural fruit juices and vegetable beverages. These components may be used independently or in combination.

The health functional food of the present invention may contain various flavoring agents or natural carbohydrates as additional ingredients. The natural carbohydrates are monosaccharides such as glucose and fructose, disaccharides such as maltose and sucrose, and polysaccharides such as dextrin and cyclodextrin, and sugar alcohols such as xylitol, sorbitol, and erythritol. As the sweetener, natural sweeteners such as taumatin and stevia extract, and synthetic sweeteners such as saccharin and aspartame can be used.

The present invention also provides a cosmetic composition for increasing concentration comprising the perfume composition of the present invention.

The cosmetic composition is a softening lotion, astringent lotion, nourishing lotion, nourishing lotion, nourishing essence, nourishing cream, massage cream, essence, eye cream, eye essence, cleansing cream, cleansing foam, cleansing water, pack, gel, powder, makeup base , Body lotion, body cream, body oil, body essence, lotion, ointment, gel, cream, patch, and spray, it is preferable to have a formulation selected from the group consisting of, but is not limited thereto.

The present invention also provides dihydro myrcenol, linalool, linalyl acetate, methyl pamplemousse, verdox, ethyl linalool , Beta ionone, cedramber, lilial, iso e super, calone, ambrofix, cis-3-hexenyl silicyl Rate (cis-3-hexenyl salicylate), hedione, galaxolide (50 ipm), tonalide, helional (helional), bacdanol, lemon oil, The effect of increasing concentration, characterized by mixing cedarwood oil, rosemary oil, bergamot oil, dipropylene glycol and black pepper oil It provides a method for producing a flavor mixture having a.

The method for producing a perfume mixture having an effect of increasing concentration of the present invention is more specifically, based on the total weight of the perfume mixture, dihydro myrcenol 2.2 to 2.8 wt%, linalool 0.8 to 1.2 wt% , Linalyl acetate 0.8 to 1.2 wt%, methyl pamplemousse 2.3 to 2.7 wt%, verdox 2.8 to 3.2 wt%, ethyl linalool 1.3 to 1.7 wt %, beta ionone 2.8-3.2 wt%, cedramber 1.7-2.1 wt%, lilial 7.7-8.3 wt%, isoe super 9.2-9.8 wt% , Calone 0.35 to 0.45 wt%, ambrofix 1.8 to 2.2 wt%, cis-3-hexenyl salicylate 3.3 to 3.7 wt%, hedione ) 10-11 wt%, galaxolide 50 ipm 9.5-10.5 wt%, tonalide 3.5-4.5 wt%, helial 0.4-0.6 wt%, bacdanol 0.8- 1.2 wt%, lemon oil 4.7~5.3 wt%, cedarwood oil 0.8~1.2 wt%, rosemary oil 0.8~1.2 wt%, bergamot oil 0.8~1.2 It can be prepared by mixing wt%, dipropylene glycol 25~26.5 wt% and black pepper oil 0.4~0.6 wt%,

More specifically, based on the total weight of the fragrance mixture, dihydro myrcenol 2.5% by weight, linalool 1% by weight, linalyl acetate 1% by weight, methyl pamplemousse ) 2.5 wt%, verdox 3 wt%, ethyl linalool 1.5 wt%, beta ionone 3 wt%, cedramber 1.9 wt%, lilial 8% by weight, iso e super (9.5% by weight), calone (0.4% by weight), ambrofix (2% by weight), cis-3-hexenyl silicylate (cis-3-hexenyl salicylate) ) 3.5 wt%, hedione 10.5 wt%, galaxolide 50 ipm 10 wt%, tonalide 4 wt%, helial 0.5 wt%, bacdanol 1 Wt%, lemon oil 5 wt%, cedarwood oil 1 wt%, rosemary oil 1 wt%, bergamot oil 1 wt%, dipropylene glycol ) It can be prepared by mixing 25.7% by weight and 0.5% by weight of black pepper oil.

The present invention also provides a fragrance mixture having an effect of increasing concentration prepared by the above method.

Hereinafter, the present invention will be described in detail by examples. However, the following examples are only illustrative of the present invention, and the contents of the present invention are not limited to the following examples.

Preparation of fragrance samples

Dihydro myrcenol, linalool, linalyl acetate, methyl pamplemousse, verdox, used to develop the aromatic marine tonic fragrance of the present invention Ethyl linalool, beta ionone, cedramber, lilial, iso e super, calone, ambrofix, cis Three hexenyl silicylate (cis-3-hexenyl salicylate), hedione, galaxolide (50 ipm), tonalide (helional), bacdanol (bacdanol), lemon oil (lemon oil), cedarwood oil, rosemary oil, bergamot oil, and dipropylene glycol are samples whose CAS Number is clearly specified. Purchased from a raw material supplier.

And black pepper oil (blackpepper oil) was carried out using a steam distillation apparatus (EssenLab-Plus, HANIL LABTECH, Korea). 2 L of distilled water was put in the steam generating part of the steam distillation apparatus, 1 kg of black pepper sample was put in the generating part of the refinery, and then the cooling water of 4℃ was continuously flowed through the cooling pipe. Water vapor was generated while maintaining the temperature of the steam generating part at 100°C for 90 minutes, and the essential oil contained in the black pepper was condensed in a cooling tube and then collected in a distilled water layer and a refined oil layer in the receiver. In order to collect only pure essential oil, the essential oil layer was passed through a triangular funnel containing anhydrous sodium sulfate to remove moisture and impurities, and the collected essential oil was stored in a refrigerator at 4℃.

Manufacturing example One. Aromatic Marine tonic Development of fragrance composition of fragrance

The aromatic marine tonic scent of the present invention is a complex expression of the scent of the cool sea and the scent of rich aroma. To develop a composition having a novel aromatic marine tonic scent, dihydro myrcenol, linalool, linalyl acetate, methyl pamplemousse, and verdox , Ethyl linalool, beta ionone, cedramber, lilial, iso e super, calone, ambrofix, Cis-3-hexenyl salicylate, hedione, galaxolide 50 ipm, tonalide, helional, bacdanol, lemon Oil (lemon oil), cedarwood oil (cedarwood oil), rosemary oil (rosemary oil), bergamot oil (bergamot oil), dipropylene glycol (dipropylene glycol), black pepper oil (black pepper oil) as shown in Table 1 below. Seven kinds were developed by mixing.

Composition and composition ratio for developing new aromatic marine tonic fragrance Flavoring ingredients Combination
Spices
One Combination
Spices
2 Combination
Spices
3 Combination
Spices
4 Combination
Spices
5 Combination
Spices
6 Combination
Spices
7 One dihydro myrcenol 1.5 1.5 1.0 1.0 2.5 2.5 2.0 2 linalool 0.5 0.5 2.0 2.0 1.0 1.0 1.0 3 linalyl acetate 1.5 1.5 2.0 2.0 0.5 1.0 1.0 4 methyl pamplemousse 3.0 3.0 1.5 1.5 2.5 2.5 2.5 5 verdox 5.0 5.0 4.0 4.0 3.0 3.0 2.0 6 ethyl linalool 0.5 0.5 1.0 1.0 1.5 1.5 1.5 7 beta-ionone 1.0 1.0 2.0 2.0 3.0 3.0 2.0 8 cedramber 0.5 1.0 1.0 1.2 1.2 1.9 0.5 9 lilial 10.0 10.0 7.0 7.0 8.0 8.0 9.0 10 iso e super 8.0 9.5 8.5 9.5 9.0 9.5 10.0 11 calone 0.1 0.1 0.3 0.3 0.2 0.4 0.4 12 ambrofix 3.5 3.5 2.0 2.0 2.5 2.0 1.5 13 cis-3-hexenyl slicylate 2.0 2.0 2.5 2.5 3.5 3.5 4.5 14 hedion 8.5 8.5 9.5 9.5 10.5 10.5 12.5 15 galaxolide 50 ipm 11.0 11.0 11.5 11.5 10.0 10.0 9.0 16 tonalide 4.0 4.0 3.0 3.0 2.0 4.0 2.0 17 helional 1.0 1.0 1.0 0.5 0.5 0.5 0.5 18 bacdanol 1.5 1.5 1.5 1.5 1.0 1.0 1.0 19 lemon oil 4.0 4.0 4.5 4.5 5.0 5.0 5.5 20 cedarwood oil 1.5 1.5 1.5 1.5 1.0 1.0 1.0 21 rosemary oil 0.5 0.5 0.5 1.0 1.0 1.0 1.0 22 bergamot oil 1.9 1.9 1.0 1.0 1.3 1.0 1.3 23 dipropylene glycol 29.0 27.0 31.2 30.0 29.3 25.7 28.3 24 black pepper oil 0.5 1.0 1.0 0.5 1.0 0.5 1.0 Sum 100 100 100 100 100 100 100

Example One. Aromatic Marine tonic Consumer preference survey for perfume composition

The preference survey for the 7 combination perfumes steered in Preparation Example 1 was conducted for 50 general consumers in their 10s and 30s, soaked in a vision paper (0.5 cm × 13 cm), and smelled at a position 5 cm from the nose. The most preferred fragrance was given 10 points and the most unfavorable fragrance was given 0 points. The average value was calculated based on the preference result, and it is shown in Table 2.

As a result of the preference survey for 7 kinds of aromatic marine tonic fragrance composition, the composition of the combination perfume 6 showed the highest score with 8.9 points, and the preference was the highest, and the lowest preference was the combination perfume 5 with a preference of 3.4 points.

Consumer Preference for 7 Combination Flavors Consumer preference Combination spices 1 Combination spices 2 Combination spices 3 Combination spices 4 Combination spices 5 Combination fragrance 6 Combination spices 7 medium 3.4 7.3 5.4 8.0 3.4 8.9 6.4

Example 2. Aromatic Marine tonic The Effect of Fragrance 6 of Fragrance on Human EEG

EEG (Electroencephalogram, EEG) was measured to find out what effect the combination perfume 6, which had the highest consumer preference, on human brain activity when inhaled through Example 1. EEG measurements were performed on a total of 20 subjects, 10 males and females each, in a 32.4 m ² laboratory with a temperature of 23° C. and 50% humidity in which noise was not mixed as much as possible.

In this example, the EEG measurement device used for EEG measurement was the QEEG-32 System (LAXTHA Inc. Korea), and the data collection equipment and analysis program (Telescan) of LAXTHA were used to measure the EEG signal of the subject. To the subjects, 32 grounding electrodes were attached to the left and right frontal lobes (Fp1, Fp2, Fpz, Af3, Af4) using Electro-Gel (Electro-Cap Internationals, Inc. USA) for EEG using 10-20 international standard electrode attachment method. , Afz), left and right frontal lobes (F3, F4, F7, F8, Fz, Fc1, Fc2, Fc5, Fc6), left and right temporal lobes (T3, T4, T7, T8, Cp5, Cp6), left and right parietal lobes (P3, P4, P7, P8, Cp1, Cp2, Cz, Pz), left and right occipital lobes (O1, O2, Oz) were attached, and one reference electrode was attached to the left and right earlobe, respectively. Put gauze 3.5 cm wide and 4 cm long into a paper cup with a top diameter of 5 cm, a height of 4.8 cm, and a bottom diameter of 3.5 cm, add flavoring using a pipette, and spread it evenly on the gauze, keeping a distance of about 5 cm from the subject's nose. The subjects were measured for 60 seconds each before inhalation (no stimulation) and inhalation condition (scent stimulation) with the subject's eyes closed.

In the present embodiment, the data processing obtained through the EEG measurement for the aromatic marine tonic combination fragrance 6 is performed by extracting only the representative EEG signals for 50 seconds from the EEG signals of the subject, and then performing a brain file processing program (batch processing), and then statistical analysis software Correspondence sample T test was performed using the program SPSS (SPSS 18.0 version). In this example, the types of EEG indicators for data analysis obtained before (no stimulation) and during inhalation (scent stimulation) of aromatic marine tonic fragrance are shown in Table 3, and the meaning of each EEG indicator is shown in Table 4.

Types of EEG indicators used for data analysis No. Analysis indicator Full name of EEG analysis indicator Wavelength band (Hz) One AT Absolute Theta Power Spectrum 4~8 2 AA Absolute Alpha Power Spectrum 8~13 3 AB Absolute Beta Power Spectrum 13~30 4 AG Absolute Gamma Power Spectrum 30-50 5 AFA Absolute Fast Alpha Power Spectrum 11~13 6 ASA Absolute Slow Alpha Power Spectrum 8~11 7 ALB Absolute Low Beta Power Spectrum 12-15 8 AMB Absolute Mid Beta Power Spectrum 15-20 9 AHB Absolute High Beta Power Spectrum 20~30 10 RT Relative Theta Power Spectrum (4~8)/(4~50) 11 RA Relative Alpha Power Spectrum (8~13)/(4~50) 12 RB Relative Beta Power Spectrum (13~30)/(4~50) 13 RG Relative Gamma Power Spectrum (30~50)/(4~50) 14 RFA Relative Fast Alpha Power Spectrum (11~13)/(4~50) 15 RSA Relative Slow Alpha Power Spectrum (8~11)/(4~50) 16 RLB Relative Low Beta Power Spectrum (12~15)/(4~50) 17 RMB Relative Mid Beta Power Spectrum (15~20)/(4~50) 18 RHB Relative High Beta Power Spectrum (20~30)/(4~50) 19 RST Ratio of SMR to Theta (12~15)/(4~8) 20 RMT Ratio of Mid Beta to Theta (15~20)/(4~8) 21 RSMT Ratio of (SMR-Mid Beta) to Theta (12~20)/(4~8) 22 RAHB Ratio of Alpha to High Beta (8~13)/(20~30) 23 SEF50 Spectral Edge Frequency 50% 4-50 24 SEF90 Spectral Edge Frequency 90% 4-50 25 ASEF Spectral Edge Frequency 50% of Alpha Spectrum Band 8~13

Meaning of EEG indicators used in data analysis No. Analysis indicator meaning One AT Absolute power of Theta wave (meditation, when sleepy) 2 AA Alpha wave absolute power (relaxation, stability) 3 AB Absolute power of Beta wave (tension, arousal, activity, cognitive function) 4 AG Absolute power of Gamma waves (high cognitive function or anxiety, excitement) 5 AFA Absolute power of fast alpha wave (comfortable and immersive) 6 ASA Absolute power of slow alpha wave (relaxation) 7 ALB Absolute power of low beta wave, also called SMR wave (attention or boundary) 8 AMB Absolute power of mid beta wave (concentration, attention) 9 AHB Absolute power of high beta wave (stress, mental load, tension) 10 RT Theta wave's proportion of the total 11 RA Ratio of Alpha wave among all 12 RB Ratio of Beta wave among all 13 RG The ratio of Gamma waves in the total 14 RFA Ratio of Fast Alpha wave in total 15 RSA Ratio of slow alpha wave in the whole 16 RLB Ratio of low beta wave in the whole 17 RMB Ratio of Mid Beta wave in total 18 RHB Ratio of High Beta wave in the whole 19 RST Ratio of SMR wave to Theta wave among all 20 RMT Ratio of Mid Beta wave to Theta wave among all 21 RSMT SMR~Mid Beta wave/Theta wave (EEG concentration indicator) 22 RAHB Alpha wave/High Beta wave (stability and relaxation) 23 SEF50 Median Frequency Brain Activity (EEG Awakening) 24 SEF90 Median Frequency Brain activity (mental load, stress) 25 ASEF Alpha wave SEF50 (comfort: many Fast Alpha waves)

As a result of analyzing the effect of the combination perfume 6, which had the highest preference in Example 1 of the present invention, on human brain waves, among the 25 indicators, only the RG power spectrum, RLB power spectrum, and SEF50 power spectrum were statistically significant. ( P <0.05), and the remaining 22 power spectrums were not described in the present specification because there was no significant difference before and after stimulus stimulation.

1.RG (Relative gamma power spectrum)

As a result of measuring the EEG before and during the inhalation of the combination perfume 6, the RG index increased statistically significantly ( p <0.05) in the frontal lobe Afz and the frontal lobe Fc6, which are the electrode attachment sites (Table 5). The RG index is the ratio of the absolute power of the gamma band to the absolute power of the entire frequency range in the EEG spectrum, and refers to the spectrum value obtained by dividing the gamma wave region (30-50 Hz) by the total frequency domain (4-50 Hz). Gamma waves are among the fastest waves of brain activity, and are known to be activated during emotionally anxious conditions or high cognitive processes such as reasoning and judgment. It can be seen that the increase in RG by inhalation of the combination fragrance 6 increased the cognitive function of the brain.

Changes in Relative gamma power spectrum (RG) before and during inhalation of fragrance of combination fragrance 6 Relative gamma power spectrum (RG) Brain location Number of subjects Suction condition Average Standard Deviation t-test p Central prefrontal lobe (Afz) 20 Before inhalation 0.1197 0.0518 -2.2843 0.0340 Inhaling 0.1294 0.0469 Right frontal lobe (Fc6) 20 Before inhalation 0.1197 0.0518 -2.3012 0.0329 Inhaling 0.1294 0.0469

2. Relative low beta power spectrum (RLB)

As a result of measuring EEG before and during inhalation of the combination perfume 6, the RLB index was increased in the frontal lobe Fc2 and the parietal lobe Cz, which are the areas of the electrode attachment (Table 6). The RLB index is the ratio of the absolute power of the low beta band to the absolute power of the entire frequency region in the EEG spectrum, and refers to the spectrum value obtained by dividing the low beta wave region (12 to 15 Hz) by the total frequency region (4 to 50 Hz). . The increase in RLB by inhalation of the combination fragrance 6 indicates that the concentration of the brain increased.

Changes in RLB (relative low beta power spectrum) before and during inhalation of fragrance in combination fragrance 6 Relative low beta power spectrum (RLB) Brain location Number of subjects Suction condition Average Standard Deviation t-test p Central parietal lobe (Cz) 20 Before inhalation 0.0822 0.0238 -2.2061 0.0399 Inhaling 0.0876 0.0206 Right frontal lobe (Fc2) 20 Before inhalation 0.0820 0.0236 -2.1897 0.0412 Inhaling 0.0873 0.0206

3. SEF50(Spectral edge frequency 50%)

As a result of measuring EEG before and during inhalation of the combination perfume 6, the SEF50 index was increased in the frontal lobe Fc6 region, which is the electrode attachment site (Table 7). The SEF50 is a reference scale for determining the activity of the cerebral cortex for cognitive activities, and it can check the workload or arousal state. It is a method of quantifying how much the EEG power spectrum distribution is deflected toward the high frequency compared to the low frequency, and is expressed as an area ratio to the entire frequency domain.The higher the SEF value, the higher the number of relatively high frequency components in the power spectrum distribution. . The SEF50 index represents the awakening of the brain, and is a sharper and deeper index than the conventional analysis method by domain classification. It means the frequency value at the point where the area is calculated from the lower frequency axis in the power spectrum and the area becomes half of the total frequency area. do. It can be seen that the increase in SEF50 by inhalation of the combination perfume 6 improved the arousal state of the brain.

Changes in SEF50(Spectral edge frequency 50%) before and during inhalation of fragrance of combination fragrance 6 SEF50(Spectral edge frequency 50%) Brain location Number of subjects Suction condition Average Standard Deviation t-test p Right frontal lobe (Fc6) 20 Before inhalation 11.7935 3.8609 -2.2380 0.0374 Inhaling 12.3199 3.7394

As clearly shown in the examples of the present invention, when inhaled, the combination perfume 6 is an RG index in the central frontal lobe (Afz) and right frontal lobe (Fc6), an RLB index in the central parietal lobe (Cz) and right frontal lobe (Fc2), It indicates that the concentration was improved by increasing the SEF50 index in the right frontal lobe (Fc6) region, thereby increasing the brain's cognitive ability and arousal. All the results of the examples of the present invention indicate that the concentration of the brain is highly increased when the combination perfume 6 is inhaled.

Claims (7)

Dihydro myrcenol 2.2 to 2.8 wt%, linalool 0.8 to 1.2 wt%, linalyl acetate 0.8 to 1.2 wt%, methyl pamplemousse 2.3 to 2.7 wt %, verdox 2.8-3.2% by weight, ethyl linalool 1.3-1.7% by weight, beta ionone 2.8-3.2% by weight, cedramber 1.7-2.1% by weight, 7.7~8.3 wt% of lilial, 9.2~9.8 wt% of isoe super, 0.35~0.45 wt% of calone, 1.8~2.2 wt% of ambrofix, cis-3 -Hexenyl silicylate (cis-3-hexenyl salicylate) 3.3 to 3.7% by weight, hedione 10 to 11% by weight, galaxolide (50 ipm) 9.5 to 10.5% by weight, tonalide 3.5 to 4.5 wt%, helial 0.4 to 0.6 wt%, bacdanol 0.8 to 1.2 wt%, lemon oil 4.7 to 5.3 wt%, cedarwood oil 0.8 to 1.2 Wt%, rosemary oil 0.8~1.2 wt%, bergamot oil 0.8~1.2 wt%, dipropylene glycol 25~26.5 wt%, and black pepper oil 0.4~ A perfume composition for increasing concentration, containing a perfume mixture containing 0.6% by weight as an active ingredient. delete The method of claim 1, wherein the fragrance composition increases the relative gamma power spectrum (RG) in the central frontal lobe and the right frontal lobe, increases the relative low beta power spectrum (RLB) in the central and right frontal lobes, and SEF50 ( Fragrance composition for increasing concentration, characterized in that to increase the spectral edge frequency 50%). Health functional food for increasing concentration comprising the fragrance composition according to claim 1 or 3. A cosmetic composition for increasing concentration, comprising the perfume composition according to claim 1 or 3. Based on the total weight of the fragrance mixture, dihydro myrcenol 2.2 to 2.8 wt%, linalool 0.8 to 1.2 wt%, linalyl acetate 0.8 to 1.2 wt%, methyl pamphlemos ( methyl pamplemousse) 2.3~2.7 wt%, verdox 2.8~3.2 wt%, ethyl linalool 1.3~1.7 wt%, beta ionone 2.8~3.2 wt%, cedramber ) 1.7~2.1 wt%, lilial 7.7~8.3 wt%, isoe super 9.2~9.8 wt%, calone 0.35~0.45 wt%, ambrofix 1.8~ 2.2 wt%, cis-3-hexenyl salicylate 3.3-3.7 wt%, hedione 10-11 wt%, galaxolide 50 ipm 9.5-10.5 wt %, tonalide 3.5-4.5% by weight, helional 0.4-0.6% by weight, bacdanol 0.8-1.2% by weight, lemon oil 4.7-5.3% by weight, cedarwood oil (cedarwood oil) 0.8 to 1.2 wt%, rosemary oil 0.8 to 1.2 wt%, bergamot oil 0.8 to 1.2 wt%, dipropylene glycol 25 to 26.5 wt% and black pepper oil (Black pepper oil) A method for producing a flavor mixture having an effect of increasing concentration, characterized in that prepared by mixing 0.4 to 0.6% by weight. A fragrance mixture having an effect of increasing concentration, prepared by the method of claim 6.

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