KR102060957B1 - Deep forest mix aroma composition for enhancing concentration of human brain and uses thereof - Google Patents

Abstract

The present invention relates to a fragrance composition for improving concentration, health functional food and a cosmetic composition for improving concentration by including the fragrance composition, a fragrance mixture producing method having a concentration enhancing effect, and a fragrance mixture having a concentration enhancing effect produced by the method. The fragrance composition of the present invention has a concentration enhancing effect by inducing an increase in relative beta power spectrum (RB) in a right prefrontal lobe, a decrease in relative gamma power spectrum (RG) in right frontal and left temporal lobes, a decrease in relative fast alpha power spectrum (RFA) in a left occipital lobe, an increase in relative high beta power spectrum (RHB) in a right prefrontal lobe and a left frontal lobe, a decrease in the ratio of mid beta to theta power spectrum (RMT) in right frontal and right parietal lobes, and an increase in spectral edge frequency 50% (SEF50) in a right prefrontal lobe, a left frontal lobe, a right parietal lobe, and left and right occipital lobes. The present invention is produced by including 3.5-4.5 wt% of vertenex, 1.8-2.2 wt% of cashmeran, 3.5-4.5 wt% of cedramber, and other components based on the total weight of the fragrance mixture.

Description

Deep forest mix aroma composition for enhancing concentration of human brain and uses algorithm}

The present invention relates to a fragrance composition for increasing concentration, a health functional food and cosmetic composition for increasing concentration, including the fragrance composition, and a method for producing a fragrance mixture having a concentration increasing effect, and a fragrance mixture having a concentration increasing effect prepared by the above method. will be.

Perfume is a ethanol-diluted product of essential oils, a volatile fragrance compound, which is divided into natural and synthetic flavors. Natural flavors are divided into animal flavors obtained from animals and plant flavors obtained from plants. Animal flavors include ambergris from the sperm whale, musk from the musk deer, vivette from the musk cat, and castorium from the beaver, but these days are not used well. Plant flavors can be obtained by distilling, extracting and compressing the flowers, leaves, fruits, seeds, resins, roots and stems of about 1,500 kinds of plants, but they are low in purity and have a high odor change during extraction and distillation. The strength and quality change varies greatly depending on the region, harvest time and post-harvest storage method, and about 200 species are currently on the market due to large supply uncertainty.

Organic synthetic fragrances can be obtained through organic synthesis in laboratories, which are highly preferred in the perfume industry because they are more pure than natural fragrances, are inexpensive to use, stable, have a long shelf life, are high in concentration and have no problems with seasonal supply. . Representative examples of the organic synthetic fragrances include aldehydes used in Chanel No. 5.

Each fragrance represents each unique and unique fragrance, which is called fragrance or knot. Flavors are generally citrus, floral, green, fruity, aldehyde, oriental, spicy, woody, psypre, after It is represented by fogere, marine, and gurumand. Mixing several flavors changes the flavor of each flavor. Mixing a number of single flavors is called steering, which allows you to create combination flavors with different flavors. Combination fragrances are divided into fragrances and flavors according to their use. Fragrance is based on the content of essential oils, namely fragrance (15-30%), eau de parfum (15-18%), eau de toilette (4-8%) and eau de cologne (3-5%). Are distinguished. In general, when preparing a new fragrance product by mixing the combination fragrance, the top note that appears immediately when sprinkled, the middle note that characterizes the fragrance, and the last note that gives depth and volume to the fragrance should be harmonized.

When humans inhale perfume, electrical signals are generated when the fragrance molecules move along the nasal cavity and bind to olfactory receptors. The electrical signal generated at this time is transmitted to the cerebral cortex along the olfactory tract in the olfactory bulb, thereby activating the brain. Odor molecules contained in fragrances are known to affect the brain of the human brain to change the brain waves and induce physiological and psychological changes.

When the cerebral cortex is activated by a stimulus, a brain wave is generated, which is an electrical signal generated between neurons in the nervous system of the human cerebral cortex.

Attach the electrodes that can amplify cerebral electrical activity to the scalp, record the waveforms, analyze them, and analyze them. EEG, an electrical signal generated by the brain's autonomous activity, is recorded in the brain by recording and observing brain activity. It is used as an indicator of human psychophysiological functions such as arousal, activity, anxiety and stability. EEG is used in cognitive science, medicine, pharmacy, and criminal investigation because it has the advantage of being able to record and measure objectively, non-invasively and continuously.

EEG mainly represents the frequency of 0 ~ 60 Hz and the amplitude of 5 ~ 300 V. Depending on the frequency range, delta wave (0 ~ 4 Hz), theta wave (4 ~ 8 Hz), alpha wave (8 ~ 13 Hz), beta It is divided into wave (13 ~ 30 Hz) and gamma wave (30 ~ 50 Hz). Delta and theta waves are slow waves and appear when you think and act using information from your brain. Beta waves higher than alpha waves are fast waves. In EEG analysis, not only absolute power, but also relative power, which can reduce individual differences such as skull thickness difference, electrical condition of the scalp, and tension, and analyze accurate EEG response.

Korean Patent Publication No. 2019-0013668 discloses a stress relief composition containing peppermint lactic acid bacteria fermentation, and Korean Patent Publication No. 2018-0084201 discloses a method for preparing a medicinal crop extract, but the brain of the present invention It is different from the deep forest mix perfume composition which improves concentration.

The present invention is derived from the above requirements, the present invention has a deep forest mixed odor using natural and synthetic fragrances suitable for various odor images, the beta wave expression in most areas of the brain increases An object of the present invention is to provide a combination perfume composition for improving the concentration of the brain.

In order to solve the above problems, the present invention is Bert Nex, cash melan, Cedar amber, Iso Super, Sandalor, Bertofix, methyl dihydro jasmonate, ethylene brasylate, linalul, linalyl acetate, Alphapinene, Hinoki Oil, Cedarwood Oil Texas, Orange Oil, Amyris Oil, Pine Oil Siberian, Elemi Oil, Eucalyptus Oil, Peppermint Essential Oil Extract, Dermal Essential Oil Extract, Sweetened Oil Extract, Dipropylene Glycol and Herbal Base It provides a fragrance composition for increasing concentration containing the fragrance mixture as an active ingredient.

In addition, the present invention provides a health functional food for increasing concentration comprising the perfume composition.

In addition, the present invention provides a cosmetic composition for increasing concentration comprising the perfume composition.

In addition, the present invention is a buttnex, cashmere, cedar amber, isoy super, sandalor, butytopx, methyl dihydro jasmonate, ethylene brasylate, linalul, linalyl acetate, alphapinene, hinoki oil , Cedarwood oil Texas, orange oil, Amisris oil, fine oil Siberian, Elemi oil, eucalyptus oil, peppermint essential oil extract, dermis essential oil extract, gamju essential oil extract, dipropylene glycol and herbal bases It provides a method of preparing a fragrance mixture having an effect of increasing concentration.

The present invention also provides a flavor mixture having a concentration increase effect produced by the above method.

The deep forest mix combination fragrance of the present invention increases the relative beta power spectrum, the relative high beta power spectrum, and the SEF50 (spectral edge frequency 50%) at various points, and the RG index (relative gamma power). Various fragrance industries for consumers who want to improve their concentration because they are characterized by reducing the spectrum, relative fast alpha power spectrum, and ratio of mid beta to theta power spectrum. It can be used to develop products.

Figure 1 is a photograph showing the 10-20 international standard electrode attachment method showing the site for attaching the electrode to the human brain for EEG measurement.
Figure 2 is a photograph showing the appearance of measuring the EEG with a cap for the electroencephalogram (EEG) on the brain of the subject.

In order to achieve the object of the present invention, the present invention is Vernetex, cashmeran (Cedmeran), Ceddamber (iso e super), sandalor (sandalore), vertofix (vertofix) ), Methyl dihydro jasmonate, ethlene brassylate, linalool, linalil acetate, alpha-pinene, hinoki oil oil, cedarwood oil texas, orange oil, amyris oil, pine oil siberian, elemi oil, eucalyptus oil ), Peppermint essential oil extract, dermis essential oil extract, gamyeo essential oil extract, dipropylene glycol (dipropylene glycol) and a herbaceous base is provided a fragrance composition for increasing the concentration containing an active ingredient as an active ingredient.

In the fragrance composition of the present invention, the fragrance mixture is preferably 3.5 to 4.5 wt% of Vernetex, 1.8 to 2.2 wt% of cashmeran, 3.5 to 4.5 wt% of Cerdamber, isoyi 10 to 12% by weight of super (iso e super), 3.5 to 4.5% by weight of sandalor, 2.7 to 3.3% by weight of vertofix, and 8.5 to 9.5 weight of methyl dihydro jasmonate %, Ethylene brassylate 6.5-7.5 wt%, linalool 2.7-3.3 wt%, linalil acetate 5-6 wt%, alpha-pinene 1.8-2.2 Wt%, hinoki oil 1.3-1.7 wt%, cedarwood oil texas 10-12 wt%, orange oil 2.7-3.3 wt%, amyris oil 0.8 ~ 1.2 wt%, pine oil siberian 1.8-2.2 wt%, elemi oil 0.4-0.6 wt%, eucalyptus oil 0.8-1.2 wt%, gourd Essential oil extract 0.4 ~ 0.6 wt%, dermis essential oil extract 0.4 ~ 0.6 wt%, soybean essential oil extract 0.4 ~ 0.6 wt%, dipropylene glycol 17-18 wt% and herbal base 6-7 wt% It may consist of,

More preferably, 4% by weight of vertenex, 2% by weight of cashmeran, 4% by weight of cedaramber, 11% by weight of iso super, sandalore 4 % By weight, 3% by weight of vertofix, 9% by weight of methyl dihydro jasmonate, 7% by weight of ethlene brassylate, 3% by weight of linalool, lina 5.5% by weight of linyll acetate, 2% by weight of alpha-pinene, 1.5% by weight of hinoki oil, 11% by weight of cedarwood oil texas, orange oil 3% by weight, 1% by weight of amyris oil, 2% by weight of pine oil siberian, 0.5% by weight of elemi oil, 1% by weight of eucalyptus oil, peppermint essential oil 0.5 wt% extract, dermis essential oil extract 0.5 wt%, gakguk essential oil extract 0.5 wt%, dipropylene glycol ) 17.5 wt% and herbal base 6.5 wt%.

The fragrance composition of the present invention increases the relative beta power spectrum (RB) in the right frontal lobe, decreases the relative gamma power spectrum (RG) in the right frontal and left temporal lobes, and decreases the relative fast alpha power spectrum (RFA) in the left occipital lobe. The increase in relative high beta power spectrum (RHB) in the right frontal and left frontal lobes, the reduction of the ratio of mid beta to theta power spectrum (RMT) in the right frontal and right parietal lobes, the right frontal lobe, left frontal lobe, right parietal lobe, Induces an increase in SEF50 (spectral edge frequency 50%) in the left occipital lobe and the right occipital lobe, which is characterized by an increase in concentration.

RB refers to the proportion of Beta waves in total. Beta waves appear when doing general tasks or conscious actions and are activated when there is mental activity such as information processing. RG is the ratio of Gamma waves in total, and Gamma waves are known to be activated during high cognitive action such as reasoning and judgment. RHB refers to the ratio of high beta waves in total, and high beta waves appear when performing relatively complex inferences or complex information processing activities with high mental load. RFA is the ratio of fast alpha waves in total, and RMT is the ratio of Mid Beta / Theta waves. SEF50 refers to a specific frequency value whose area up to that frequency value occupies 50% of the area of the frequency domain.

The present invention also provides a health functional food for increasing concentration, including the fragrance composition.

The dietary supplement includes various nutrients, vitamins, minerals (electrolytes), synthetic and natural flavors, colorants and enhancers (such as cheese and chocolate), pectic acid and salts thereof, alginic acid and salts thereof, organic acids, protective colloidal thickeners, pH adjusters, stabilizers, preservatives, glycerin, alcohols, carbonation agents used in carbonated drinks, and the like. Others may contain pulp for the production of natural fruit juices and vegetable drinks. These components can be used independently or in combination.

The dietary supplement of the present invention may contain various flavors or natural carbohydrates as additional ingredients. The natural carbohydrates are sugars such as monosaccharides such as glucose and fructose, disaccharides such as maltose and sucrose and polysaccharides such as dextrin and cyclodextrin, xylitol, sorbitol and erythritol. As the sweetening agent, natural sweetening agents such as tautin and stevia extract, synthetic sweetening agents such as saccharin and aspartame, and the like can be used.

The present invention also provides a cosmetic composition for increasing concentration comprising the perfume composition of the present invention.

The cosmetic composition is supple cosmetics, astringent cosmetics, nourishing cosmetics, nourishing lotion, nutrition essence, nutrition cream, massage cream, essence, eye cream, eye essence, cleansing cream, cleansing foam, cleansing water, pack, gel, powder, makeup base It is preferable to have a formulation selected from the group consisting of body lotion, body cream, body oil, body essence, lotion, ointment, gel, cream, patch and spray, but not limited thereto.

The invention also includes buttresses, cashmere, cedar amber, isoy super, sandalor, buty tox, methyl dihydro jasmonate, ethylene brasylate, linalul, linalyl acetate, alphapinene, hinoki oil. Cedarwood Oil Texas, Orange Oil, Amiris Oil, Fine Oil Siberian, Elemi Oil, Eucalyptus Oil, Peppermint Essential Oil Extract, Dermis Essential Oil Extract, Persimmon Essential Oil Extract, Dipropylene Glycol and Herbal Base Relative beta power spectrum (RB) in the brain, decreases the relative gamma power spectrum (RG) in the right frontal and left temporal lobes, decreases the relative fast alpha power spectrum (RFA) in the left frontal lobe, and in the right frontal and left frontal lobes. Increases the relative high beta power spectrum (RHB), and the ratio of mid beta to theta power spec in the right frontal and right parietal lobes. trum) and increases the concentration of SEF50 (spectral edge frequency 50%) in the right frontal lobe, left frontal lobe, right parietal lobe, left occipital lobe and right occipital lobe.

The method for producing a fragrance mixture having an effect of increasing concentration of the present invention is more specifically, 3.5 to 4.5 wt% of Vernetex, 1.8 to 2.2 wt% of cashmeran, and seedlings based on the total weight of the fragrance mixture. 3.5 to 4.5 weight percent amber, 10 to 12 weight percent iso e super, 3.5 to 4.5 weight percent sandalor, 2.7 to 3.3 weight percent vertofix, methyl dihydro 8.5 to 9.5% by weight of methyl dihydro jasmonate, 6.5 to 7.5% by weight of ethlene brassylate, 2.7 to 3.3% by weight of linalool, 5 to 6% by weight of linalil acetate %, Alpha-pinene 1.8-2.2% by weight, hinoki oil 1.3-1.7%, cedarwood oil texas 10-12% by weight, orange oil 2.7- 3.3% by weight, 0.8-1.2% by weight of amyris oil, 1.8-2.2% by weight of pine oil siberian, 0.4-0.0 of elemi oil. 6 wt%, eucalyptus oil 0.8-1.2 wt%, peppermint essential oil extract 0.4-0.6 wt%, dermis essential oil extract 0.4-0.6 wt%, gamma essential oil extract 0.4-0.6 wt%, dipropylene glycol It can be prepared by mixing 17-18% by weight and 6-7% by weight of herbal base,

More specifically, based on the total weight of the fragrance mixture, 4% by weight of vertenex, 2% by weight of cashmeran, 4% by weight of cedramber, 11% by weight of iso e super. , 4% by weight of sandalore, 3% by weight of vertofix, 9% by weight of methyl dihydro jasmonate, 7% by weight of ethlene brassylate, linalul ( linalool) 3% by weight, linalil acetate 5.5% by weight, alpha-pinene 2% by weight, hinoki oil 1.5% by weight, cedarwood oil texas 11% by weight , 3% by weight of orange oil, 1% by weight of amyris oil, 2% by weight of pine oil siberian, 0.5% by weight of elemi oil, eucalyptus oil ) 1% by weight, peppermint essential oil extract 0.5%, dermis essential oil extract 0.5% by weight, gamju essential oil extract 0.5% by weight, c. It can be prepared by mixing propylene glycol (dipropylene glycol) 17.5% by weight and herbal base (herbal base) 6.5% by weight.

The present invention also provides a perfume mixture having a concentration increasing effect produced by the above method.

Hereinafter, the present invention will be described in detail by way of examples. However, the following examples are merely to illustrate the invention, but the content of the present invention is not limited to the following examples.

Preparation of Fragrance Samples

The fragrance composition of the present invention used to develop the deep forest mix fragrance of the present invention is vernetex, cashmeran, cedaramber, iso e super, sandalor ), Vertofix, methyl dihydro jasmonate, ethlene brassylate, linalool, linalil acetate, alpha-pinene ), Hinoki oil, cedarwood oil texas, orange oil, amyris oil, pine oil siberian, elemi oil Eucalyptus oil, peppermint essential oil extract, dermis essential oil extract, gamyeo essential oil extract and dipropylene glycol were obtained from a domestic raw material supplier with a sample clearly identified by the CAS number.

And gamguk, dermis, peppermint oil was performed using a steam distillation apparatus (EssenLab-Plus, HANIL LABTECH, Korea). 2 L of distilled water was put in the steam generating part of the steam distillation apparatus, 1 kg of the sample was put in the essential oil generating part, and 4 ° C. cooling water was continuously flowed through the cooling tube. Steam was generated while maintaining the temperature of the steam generating part at 100 ° C. for 90 minutes, and the essential oil contained in the sample was condensed in a cooling tube and collected in a distilled water layer and an essential oil layer in a receiver. In order to collect only the essential oil, the essential oil layer was passed through a triangle funnel containing anhydrous sodium sulfate to remove moisture and impurities, and the collected essential oil was stored in a refrigerator at 4 ° C.

Production Example  1. Dip Forrest Mix  Development of fragrance fragrance composition

Deep forest mix scent of the present invention implements the image of the forest using a variety of woody (rawy) raw materials that can enhance the feeling of the forest, and the feeling of natural citrus and natural citrus extract with a strong herb image In addition to dermis essential oil extract and peppermint essential oil extract, it expresses deep forest feeling richly refreshing and green scent felt in coniferous forest. To develop a composition with a novel deep forest mix scent, vernetex, cashmeran, cerdamber, iso e super, sandalor and vertofix vertofix, methyl dihydro jasmonate, ethlene brassylate, linalool, linalil acetate, alpha-pinene, hinoki oil ( hinoki oil, cedarwood oil texas, orange oil, amyris oil, pine oil siberian, elemi oil, eucalyptus oil oil, peppermint essential oil extract, dermis essential oil extract, gamyeo essential oil extract, dipropylene glycol (dipropylene glycol), herbal base (herbal base) was mixed as shown in Table 1 to develop five species.

Composition and Composition Ratio for the Development of New Deep Forest Mix Flavors Fragrance ingredients CAS Combination
Spices
One Combination
Spices
2 Combination
Spices
3 Combination
Spices
4 Combination
Spices
5 One Vertenex 32210-23-4 1.0 2.0 4.0 5.0 8.0 2 Cashmeran 33704-61-9 1.0 1.0 2.0 3.0 4.0 3 Cedramber 19870-74-7 6.0 5.0 4.0 3.0 2.0 4 Iso e super 54464-57-2 5.0 7.0 11 13 13 5 Sandalore 65113-99-7 2.0 3.0 4.0 5.0 6.0 6 Vertofix 32388-55-9 5.0 4.0 3.0 2.0 1.0 7 Methyl dihydro jasmonate 24851-98-7 11 11 9.0 7.0 5.0 8 Ethlene brassylate 105-95-3 11 9.0 7.0 4.0 2.0 9 Linalool 78-70-6 5.0 4.0 3.0 2.0 1.0 10 Linalyl acetate 115-95-7 7.0 6.5 5.5 4.5 3.5 11 Alpha-pine 80-56-8 1.0 1.0 2.0 3.0 3.0 12 Hinoki-oil 91745-97-0 1.0 1.0 1.5 2.0 2.0 13 Cedarwood oil texas 68990-83-0 5.0 7.0 11 13 13 14 Orange oil 8008-57-8 1.0 2.0 3.0 4.0 5.0 15 Amyris oil 8015-65-4 0.5 0.5 1.0 2.0 2.0 16 Pine oil siberian 8021-29-2 1.0 1.0 2.0 3.0 4.0 17 Elemi oil 8023-89-0 2.0 1.0 0.5 0.1 0.1 18 Eucalyptus oil 8000-48-4 5.0 2.5 1.0 0.5 0.5 19 Peppermint Essential Oil Extract 0.1 0.2 0.5 0.7 0.8 20 Dermis essential oil extract 0.1 0.2 0.5 0.7 0.8 21 Persimmon Oil Extract 0.1 0.2 0.5 0.7 0.8 22 Dipropylene glycol 25265-71-8 20.7 23.4 17.5 17.3 19 23 Herbal base 1 8.5 7.5 6.5 4.5 3.5 Sum 100 100 100 100 100

Example  1. Dip Forrest Mix  Investigate consumer preferences for perfume compositions

Preference of the five combination flavors steered in Preparation Example 1 was soaked in a taste paper (0.5 cm × 13 cm) for 30 general consumers in their 30s and 30, and then incense at 5 cm from the nose. 10 points for the most preferred flavor and 0 for the most unfavorable flavor. The average value was calculated based on the preference result, which is shown in Table 2.

According to a preference survey for the five deep forest mix flavor compositions, consumers in their teens to thirties preferred the composition of combination flavor 3 (preferably average 8.9). The lowest preference was the combination flavor 2, with a preference of 4.6.

Consumer Preference for Five Combination Flavors Consumer preference Combination spices 1 Combination spices 2 Combination spices 3 Combination spices 4 Combination spices 5 medium 6.6 4.6 8.9 5.1 6.8

Example  2. Dip Forrest Mix of  Scent evaluation

The taste evaluation of the combination perfume 3, which had the highest consumer preference through Example 1, was performed by four professional panels of Rose of Sharon, a perfume development club of Kangwon National University, who had been trained for more than six months. The fragrance selected in Example 1 was soaked in a sachet (0.5 cm × 5 cm), and then the fragrance was placed at a 5 cm position from the nose of the panel to smell the fragrance, using the fragrance evaluation terminology. It was. The odor types used in sensory evaluation are aldehyde, animalic, balsamic, citrus, coniferous, earthy, floral, and puriti fruity, green, herbal, medical, minty, marine, mosy, musky, oily, oriental , Powdery, smokey, spicy, sweet, woody, and were commonly used by the odor evaluation expert group.

Odor Evaluation for Combination Fragrance 3 Scent Type Aldehyde Animalic Balsamic Citrus Coniferous ○ Earthy ○ Floral Fruity Green ○ Herbal Medicinal Minty Marine Musky ○ Oily Oriental Powdery ○ Smoky Spicy Sweet Woody ○

Example  3. Dip Forrest Mix  Effects of Combination Fragrance 3 on Human Brain Waves

In Example 1, the electroencephalogram (EEG) was measured to know how the combination flavor 3, which had the highest consumer preference, was inhaled upon human brain activity. Electroencephalography was performed on 20 subjects, 10 males and 10 females, in a 32.4 m ² laboratory maintained at a temperature of 23 ° C. and a humidity of 50% without noise.

The EEG measuring instrument used for EEG measurement was Quick-30 Dry EEG Headset (Cognionics, Inc. USA) .The EEG signal measurement of the participants was carried out by Cognionics Cognionics Data Acquisition Software, and EEG data analysis was performed by LAXTHA's data collection equipment and analysis. The program (Telescan) was used. Participants were asked to wear an EEG cap with 29 ground electrodes distributed using the International 10 ~ 20 System, and the ground electrodes were EEG drypad sensors (Cognionics, Inc. USA) on the left and right frontal lobes (Fp1, Fp2). ), Left and right frontal lobes (Af3, Af4, Fc5, Fc6, F3, Fz, F4, F7, F8), left and right temporal lobes (T7, T8, C3, Cz, C4, Cp5, Cp6), left and right Flex Sensors (Cognionics, Inc. USA) were attached to the right parietal lobe (P3, Pz, P4, P7, P8), left and right occipital lobes (Po3, Po4, Po7, Po8, O1, O2). Drypad Sensors were also used to attach the reference electrodes to the left earlobe.

The air bomb outlet was placed 5 cm before the test participant and measured for 120 seconds (2 minutes) for 60 seconds before the inhalation of the perfume (no stimulus) and the inhalation state (fragrance).

Data processing obtained through EEG measurement was performed by extracting only the EEG signals for a typical 50 seconds among the EEG signals of the experiment participants, followed by a batch processing program, and then using SPSS (SPSS 24.0 version), a statistical analysis software program. A paired T test was performed. In the present embodiment, the types of EEG indicators for data analysis before the deep forest mix perfume inhalation (no stimulation) and during inhalation (fragrance stimulation) are shown in Table 4, and the meaning of each EEG indicator is shown in Table 5.

Types of EEG Indicators Used in Data Analysis No. Analysis Full name of EEG indicator Wavelength band (Hz) One AT Absolute Theta Power Spectrum 4 ~ 8 2 AA Absolute Alpha Power Spectrum 8-13 3 AB Absolute Beta Power Spectrum 13-30 4 AG Absolute Gamma Power Spectrum 30-50 5 AFA Absolute Fast Alpha Power Spectrum 11-13 6 ASA Absolute Slow Alpha Power Spectrum 8 ~ 11 7 ALB Absolute Low Beta Power Spectrum 12-15 8 AMB Absolute Mid Beta Power Spectrum 15-20 9 AHB Absolute High Beta Power Spectrum 20-30 10 RT Relative Theta Power Spectrum (4-8) / (4-50) 11 RA Relative Alpha Power Spectrum (8-13) / (4-50) 12 RB Relative Beta Power Spectrum (13-30) / (4-50) 13 RG Relative Gamma Power Spectrum (30-50) / (4-50) 14 RFA Relative Fast Alpha Power Spectrum (11-13) / (4-50) 15 RSA Relative Slow Alpha Power Spectrum (8-11) / (4-50) 16 RLB Relative Low Beta Power Spectrum (12-15) / (4-50) 17 RMB Relative Mid Beta Power Spectrum (15-20) / (4-50) 18 RHB Relative High Beta Power Spectrum (20-30) / (4-50) 19 RST Ratio of SMR to Theta (12-15) / (4-8) 20 RMT Ratio of Mid Beta to Theta (15-20) / (4-8) 21 RSMT Ratio of (SMR-Mid Beta) to Theta (12-20) / (4-8) 22 RAHB Ratio of Alpha to High Beta (8-13) / (20-30) 23 SEF50 Spectral Edge Frequency 50% 4-50 24 SEF90 Spectral Edge Frequency 90% 4-50 25 ASEF Spectral Edge Frequency 50% of Alpha Spectrum Band 8-13

Meaning of EEG Indicators Used in Data Analysis No. Analysis meaning One AT Absolute Power of Theta Wave (when meditating, sleepy) 2 AA Alpha wave absolute power (relaxation, stability) 3 AB Absolute power of beta wave (tension, arousal, activity, cognition) 4 AG Absolute Power of Gamma Wave (High Cognition or Anxiety, Excitement) 5 AFA Absolute power of fast alpha waves (comfort and immersion) 6 ASA Absolute power of slow alpha wave (relaxation) 7 ALB Absolute power of low beta wave, also called SMR wave (attention or boundary) 8 AMB Absolute power of Mid beta wave (focus, attention) 9 AHB Absolute power of high beta wave (stress, mental load, tension) 10 RT Proportion of theta waves in total 11 RA Percentage of Alpha Waves in Total 12 RB Percent of Beta Waves in Total 13 RG Of Gamma waves in total 14 RFA Ratio of Fast Alpha Waves in Total 15 RSA The ratio of Slow Alpha waves to the total 16 RLB The ratio of low beta wave in total 17 RMB The ratio of Mid Beta wave to total 18 RHB The ratio of high beta waves in total 19 RST The ratio of Theta waves to SMR waves in total 20 RMT The ratio of theta wave to mid beta wave 21 RSMT SMR ~ Mid Beta wave / Theta wave (EEG concentration indicator) 22 RAHB Alpha wave / High Beta wave (stability and relaxation) 23 SEF50 Median Frequency Brain Activity (EEG) 24 SEF90 Median Frequency Brain Activity (Mental Load, Stress) 25 ASEF Alpha wave SEF50 (comfort: many Fast Alpha waves)

As a result of analyzing the effect of the combination perfume 3 of the present invention on human brain waves, only the RB power spectrum, the RHB power spectrum, the SEF50 power spectrum, the RG power spectrum, the RFA power spectrum, and the RMT power spectrum were statistically significant. Appears to be present ( p <0.05).

RB (relative beta power spectrum)

As a result of measuring EEG before and during inhalation of the combination perfume 3 of the present invention, the RB index was statistically significantly increased ( p <0.05) at the frontal lobe Af4, the electrode attachment site (Table 6). The RB index is the absolute power ratio of the beta band to the absolute power of the entire frequency domain in the EEG spectrum, which means the relative power spectrum value obtained by dividing the beta wave region (13 to 30 Hz) into the full frequency region (4 to 50 Hz). . Since the RB wave was increased upon inhalation of the combination perfume 3 of the present invention, it was determined that the concentration of the brain was increased.

2. RG (relative gamma power spectrum)

As a result of measuring EEG before and during inhalation of the combination perfume 3 of the present invention, the RG index was decreased in the frontal lobe Fc6 and temporal lobe C3, which are electrode attachment sites (Table 7). The RG index is an absolute power ratio of gamma band to absolute power of the entire frequency domain in the EEG spectrum, and means a spectral value obtained by dividing the gamma wave region (30-50 Hz) into the entire frequency region (4-50 Hz). The Gamma wave is one of the fastest waves in the brain, and it is known to be activated when it is emotionally nervous or at high cognitive effects such as reasoning and judgment.

3.Relative fast alpha power spectrum (RFA)

As a result of measuring EEG before and during inhalation of the combination perfume 3 of the present invention, the RFA index was decreased at the occipital lobe Po3, an electrode attachment site (Table 8). The RFA indicator is the absolute power ratio of the fast alpha band to the absolute power of the entire frequency domain in the EEG spectrum. It is a relative power spectral value obtained by dividing the fast alpha region (11 to 13 Hz) into the full frequency region (4 to 50 Hz). it means.

RHB (relative high beta power spectrum)

As a result of measuring EEG before and during inhalation of the combination perfume 3 of the present invention, the RHB index was increased at the Fc5 and Af4 sites, which are electrode attachment sites (Table 9). The RHB index is the absolute power ratio of the high beta band to the absolute power of the entire frequency domain in the EEG spectrum. It is a spectral value obtained by dividing the high beta wave region (20 to 30 Hz) into the full frequency region (4 to 50 Hz). . Increasing RHB by inhalation of Combination Fragrance 3 indicates an increase in brain activity, ie, increased tension.

5.ratio of mid beta to theta power spectrum

As a result of measuring EEG before and during inhalation of the combination perfume 3 of the present invention, the RMT index was decreased at the frontal lobe Fc6 and the parietal lobe Po4, which are electrode attachment sites (Table 10). The RMT indicator is the mid-beta wave divided by theta wave. Mid beta waves have a 15-20 Hz frequency band and dominate when focusing on one subject, such as calculation or calculation. In this embodiment, the decrease in the RMT index by inhalation of the combination perfume 3 means that the stress state of the brain was alleviated.

6.SEF50 (spectral edge frequency 50%)

As a result of measuring EEG before and during inhalation of the combination perfume 3 of the present invention, the SEF50 index was increased in the frontal lobes Af4 and Fc5, parietal lobe P8, and occipital lobe Po5 and Po6, which are electrode attachment sites (Table 11). SEF50 indicators can be used to determine workload and arousal status as a baseline measure of cerebral cortex activity for cognitive activity. The frequency ratio of how much the EEG power spectral distribution is biased toward the high frequency compared to the low frequency is expressed as the area ratio of the entire frequency domain. The higher the SEF value, the higher the frequency component of the power spectral distribution. . Increased SEF50 indices with inhalation of Combination Fragrance 3 indicates enhanced brain activity.

Claims (8)

delete delete delete delete delete delete Based on the total weight of the fragrance mixture, 3.5-4.5 wt% of vertenex, 1.8-2.2 wt% of cashmeran, 3.5-4.5 wt% of cedaramber, iso e super 10 ~ 12% by weight, Sandalor 3.5-4.5% by weight, Vertofix 2.7-3.3% by weight, methyl dihydro jasmonate 8.5-9.5% by weight, ethylene brasylate ( ethlene brassylate 6.5-7.5 wt%, linalool 2.7-3.3 wt%, linalil acetate 5-6 wt%, alpha-pinene 1.8-2.2 wt%, hinoki oil oil 1.3-1.7% by weight, cedarwood oil texas 10-12% by weight, orange oil 2.7-3.3% by weight, amyris oil 0.8-1.2% by weight, fine oil Siberian (pine oil siberian) 1.8-2.2% by weight, elemi oil (0.4-0.6% by weight), eucalyptus oil (0.8-1.2% by weight), peppermint essential oil extract 0.4-0.6% by weight, dermis It is prepared by mixing 0.4 ~ 0.6 wt% of essential oil extract, 0.4 ~ 0.6 wt% of essential oil extract, 17-18 wt% of dipropylene glycol and 6-7 wt% of herbal base. Increase RB (relative beta power spectrum), decrease relative gamma power spectrum (RG) in the right frontal and left temporal lobes, decrease relative fast alpha power spectrum (RFA) in the left frontal lobe, and RHB in the right frontal and left frontal lobes. increase the relative high beta power spectrum, decrease the ratio of mid beta to theta power spectrum in the right frontal and right parietal lobes, and SEF50 in the right frontal lobe, left frontal lobe, right parietal lobe, left occipital lobe, and right occipital lobe. Edge frequency 50%) method of producing a fragrance mixture having a concentration increase effect, characterized in that to increase. Fragrance mixture having a concentration increase effect prepared by the method of claim 7.

Images